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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2765
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstt1
Name: glutathione S-transferase theta 1
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstt1affects metabolic processingISOGSTT1 (Homo sapiens)6480464CTDGSTT1 gene SNP affects the metabolism of ArsenicPMID:27327299
Gstt1affects methylationISOGSTT1 (Homo sapiens)6480464CTDArsenic affects the methylation of GSTT1 gene; GSTT1 gene polymorphism affects the methylation of ArsenicPMID:24511153 PMID:25304211 PMID:25876999
Gstt1affects response to substanceISOGSTT1 (Homo sapiens)6480464CTDGSTT1 gene affects the susceptibility to Arsenic; GSTT1 gene polymorphism affects the susceptibility to Arsenic; GSTT1 gene SNP affects the susceptibility to ArsenicPMID:16214926 PMID:17284320 PMID:31864032
Gstt1multiple interactionsISOGSTT1 (Homo sapiens)6480464CTD[GSTT1 gene polymorphism affects the metabolism of Arsenic] which affects the abundance of Arsenic; [GSTT1 gene polymorphism affects the metabolism of Arsenic] which affects the abundance of Cacodylic Acid; [GSTT1 gene polymorphism affects the metabolism of Arsenic] which affects the abundance of monomethylarsonic acidPMID:32650499
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