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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2765
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstt1
Name: glutathione S-transferase theta 1
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstt1affects chemical synthesisISOGSTT1 (Homo sapiens)6480464CTDGSTT1 protein polymorphism affects the chemical synthesis of Benzene metabolitePMID:15935803
Gstt1affects metabolic processingISOGSTT1 (Homo sapiens)6480464CTDGSTT1 gene SNP affects the metabolism of Benzene; GSTT1 protein affects the metabolism of BenzenePMID:15226677 PMID:30086327
Gstt1affects response to substanceISOGSTT1 (Homo sapiens)6480464CTDGSTT1 gene polymorphism affects the susceptibility to Benzene; GSTT1 polymorphism affects the susceptibility to Benzene; GSTT1 protein affects the susceptibility to Benzene; GSTT1 protein polymorphism affects the susceptibility to BenzenePMID:12460800 PMID:15226677 PMID:15256146 PMID:15533900 PMID:15591089 PMID:15935803 PMID:18836923 PMID:29204680
Gstt1increases metabolic processingISOGSTT1 (Homo sapiens)6480464CTDGSTT1 protein results in increased metabolism of BenzenePMID:17885617
Gstt1increases response to substanceISOGSTT1 (Homo sapiens)6480464CTDGSTT1 gene polymorphism results in increased susceptibility to BenzenePMID:15226677 PMID:15748501 PMID:17119198 PMID:17178637
Gstt1multiple interactionsISOGSTT1 (Homo sapiens)6480464CTD[GSTT1 gene SNP affects the metabolism of Benzene] which affects the abundance of S-phenyl-N-acetylcysteine; GSTM1 gene polymorphism affects the reaction [GSTT1 gene polymorphism affects the reaction [NQO1 gene SNP results in increased susceptibility to Benzene]]; GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]PMID:15533900 PMID:17178637 PMID:30086327
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