RGD Reference Report - Association of periodontitis with GSTM1/GSTT1-null variants--a pilot study. - Rat Genome Database

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Association of periodontitis with GSTM1/GSTT1-null variants--a pilot study.

Authors: Concolino, Paola  Cecchetti, Francesco  D'Autilia, Caterina  Santonocito, Concetta  Di Stasio, Enrico  Zuppi, Cecilia  Arcuri, Claudio  Deli, Giorgio  Giardina, Bruno  Capoluongo, Ettore  Ameglio, Franco 
Citation: Concolino P, etal., Clin Biochem. 2007 Sep;40(13-14):939-45. doi: 10.1016/j.clinbiochem.2007.04.012. Epub 2007 Apr 27.
RGD ID: 14700939
Pubmed: (View Article at PubMed) PMID:17524385
DOI: Full-text: DOI:10.1016/j.clinbiochem.2007.04.012

OBJECTIVES: To analyze a possible association between glutathione-S-transferase T1 (GSTM1) and/or glutathione-S-transferase M1 (GSTM1) polymorphisms and chronic or aggressive forms of periodontitis in a Caucasian ethnic group.
DESIGN AND METHODS: Sixty-nine chronic, 14 aggressive periodontitis and 61 controls, deeply analyzed from a clinical point of view, were studied for their GSTM1 and GSTT1 polymorphisms by allelic specific PCR techniques. As a second control group, 64 blood donors were also included.
RESULTS: A significant association was found between GSTM1-null genotype and both chronic and aggressive periodontitis. The aggressive forms were associated with the double null GSTM1 and GSTT1 combination. These results were independent of the patients' age, gender, hygienic habits and smoke (evaluated as tobacco smoking yes/no, cigarettes/day and pack years) as confirmed by multivariate logistic regression analysis.
CONCLUSIONS: The GSTM1-null variant is statistically associated with the two forms of periodontitis, while the aggressive one also presents a second null variant: GSTT1.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)
Gstt1  (glutathione S-transferase theta 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)
Gstt1  (glutathione S-transferase, theta 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)
GSTT1  (glutathione S-transferase theta 1)

Additional Information