RGD Reference Report - Glutathione S-transferase: genetics and role in toxicology. - Rat Genome Database

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Glutathione S-transferase: genetics and role in toxicology.

Authors: Strange, RC  Jones, PW  Fryer, AA 
Citation: Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
RGD ID: 1358120
Pubmed: PMID:10720752   (View Abstract at PubMed)

The glutathione S-transferases (GST) are a supergene family of dimeric, enzymes that catalyse the conjugation of glutathione (GSH) to a variety of electrophiles including arene oxides, unsaturated carbonyls, organic halides and other substrates. Their importance is suggested by the finding that GST enzymes are expressed in probably all life forms. In humans, polymorphism in GST genes has been associated with susceptibility to various diseases though some recent data indicate that these genotypes modify disease phenotype. Thus, GST genotypes alone and in combination have been linked with clinical outcome.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Gsta1  (glutathione S-transferase alpha 1)
Gsta2  (glutathione S-transferase alpha 2)
Gsta4  (glutathione S-transferase alpha 4)
Gstk1  (glutathione S-transferase kappa 1)
Gstm1  (glutathione S-transferase mu 1)
Gstm3  (glutathione S-transferase mu 3)
Gstm5  (glutathione S-transferase, mu 5)
Gstm7  (glutathione S-transferase, mu 7)
Gsto1  (glutathione S-transferase omega 1)
Gsto2  (glutathione S-transferase omega 2)
Gstt1  (glutathione S-transferase theta 1)
Gstt2  (glutathione S-transferase theta 2)

Genes (Homo sapiens)
GSTA2  (glutathione S-transferase alpha 2)
GSTA4  (glutathione S-transferase alpha 4)
GSTM1  (glutathione S-transferase mu 1)
GSTM2  (glutathione S-transferase mu 2)
GSTO2  (glutathione S-transferase omega 2)
GSTT1  (glutathione S-transferase theta 1)


Additional Information