PARACETAMOL PHARMACOKINETICS PATHWAY (PW:0001525)

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Description

Paracetamol or N-acetyl-p-aminophenol (APAP), also known as acetaminophen or by its trade in the USA as Tylenol, is a widely used analgesic and antipyretic drug. However, overdose of paracetamol - accidental or intentional - is associated with hepatotoxicity and a leading cause of liver failure. APAP metabolism occurs in the liver where it is primarily subject to glucuronidation and sulfation by members of phase II biotransformation enzymes. To a lesser extent, it is also metabolized by members

Pathway Diagram:

Elsevier Inc. paracetamol sulfate ---> biliary excretion paracetamol glucuronide ---> biliary excretion Abcc2 APAP-GSH ---> biliary excretion paracetamol sulfate ---> basolateral excretion paracetamol glucuronide ---> basolateral excretion glutathione Abcc4 Abcc3 Abcg2 paracetamol ---> paracetamol glucuronide paracetamol ---> paracetamol sulfate Napqi ---> APAP-GSH biliary excretion basolateral excretion glutathione ---- Napqi paracetamol ---> Napqi Cyp2e1 paracetamol sulfate paracetamol paracetamol glucuronide APAP-GSH Napqi UGT1A1 UGT1A6 SULT1A1 SULT1A3 SULT1A4 SULT1E1
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Genes in Pathway:

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paracetamol pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:10402751
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:10402751
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:8552693
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:8552693
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:8552693
RGD:10402751
G Abcc5 ATP binding cassette subfamily C member 5 JBrowse link 11 84,395,982 84,490,215 RGD:10402751
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:8552693
RGD:10402751
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:10402751
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:10402751
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:8552693
RGD:10402751
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link 11 81,741,342 81,757,806 RGD:10402751
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:10402751
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:10402751
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:10402751
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:10402751
G Hspa5 heat shock protein family A member 5 JBrowse link 3 13,838,304 13,842,763 RGD:10402751
G Hyou1 hypoxia up-regulated 1 JBrowse link 8 48,699,796 48,711,912 RGD:10402751
G Pdia2 protein disulfide isomerase family A, member 2 RGD:10402751
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:10402751
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:10402751
G Ppib peptidylprolyl isomerase B JBrowse link 8 71,719,681 71,725,538 RGD:10402751
G Sdf2l1 stromal cell-derived factor 2-like 1 JBrowse link 11 88,122,271 88,124,513 RGD:10402751
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:10402751
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:8552693
RGD:10402751
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:10402751
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:8552693
RGD:10402751
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8552693
RGD:10402751
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the paracetamol pharmacokinetics pathway
Disease TermsGene Symbols
3MC syndrome 1Dnajb11
Abortion, SpontaneousSdf2l1
acoustic neuromaCyp2e1
acute chest syndromeGstt1
Acute Coronary SyndromeGstp1
acute kidney failureCyp1a2 , Cyp2d4 , Gstp1 , Ugt1a1 , Ugt1a9
Acute Liver FailureAbcc2
acute myeloid leukemiaAbcc3 , Abcg2 , Cyp2d4 , Gstp1 , Gstt1
acute promyelocytic leukemiaGstt1
adenocarcinomaCyp2e1
adenomaAbcg2
adrenocortical carcinomaAbcb1a
Airway ObstructionGstp1
alcohol use disorderCyp2e1
Alcoholic Fatty LiverCyp2e1
alcoholic hepatitisSult1e1
alcoholic liver cirrhosisCyp2e1
allergic hypersensitivity diseaseGstp1
allergic rhinitisAbcb1a
alopeciaAbcc2
Alzheimer's diseaseCyp2d4 , Gstp1 , Gstt1
amphetamine abuseCyp2d4 , Gstp1 , Gstt1
amyotrophic lateral sclerosisGstp1
anemiaGstt1
Anthracycline-induced CardiotoxicityAbcb1a
aplastic anemiaGstt1
asbestosisCyp2e1 , Gstt1 , Hspa5
AsthenozoospermiaGstt1
asthmaAbcb1a , Abcc1 , Cyp2e1 , Gstp1 , Gstt1
astrocytomaGstp1
atopic dermatitisGstp1 , Gstt1
AtrophyCyp1a2
autistic disorderGstp1
autoimmune hepatitisCyp2d4
autosomal recessive limb-girdle muscular dystrophy type 2BAbcb1a
autosomal recessive limb-girdle muscular dystrophy type 2JAbcb1a
B-cell lymphomaAbcg2
bacterial pneumoniaAbcc1
basal ganglia diseaseCyp2d4
Behcet's diseaseAbcb1a
benign neoplasmSult1a1
beta thalassemiaGstt1
bilirubin metabolic disorderAbcc2 , Abcc3 , Ugt1a1 , Ugt1a6 , Ugt1a9
bone marrow diseaseGstp1
BradycardiaCyp2d4
breast cancerGstp1 , Sult1a1
Breast Cancer, FamilialAbcc1
Breast NeoplasmsAbcb1a , Abcc1 , Abcg2 , Cyp1a2 , Cyp2d4 , Gstp1 , Gstt1 , Hspa5 , Sult1a1 , Sult1e1 , Ugt1a1
bronchiolo-alveolar adenocarcinomaGstp1
Bronchitis, ChronicCyp2e1 , Gstt1
Bronchopulmonary DysplasiaGstp1 , Gstt1
bronchus carcinomaGstp1
cannabis abuseAbcb1a
carcinomaAbcb1a , Gstp1 , Gstt1
CardiomegalyCyp2e1
cardiovascular system diseaseGstt1
carotid artery diseaseGstp1
cataractGstt1
Chemical and Drug Induced Liver InjuryAbcb1a , Abcc1 , Abcc2 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1 , Hspa5 , Sult1e1 , Ugt1a9
Chemotherapy-Induced Febrile NeutropeniaGstp1
cholangiocarcinomaAbcc2 , Gstp1 , Ugt1a9
CholangiofibrosisGstp1
cholecystolithiasisUgt1a1
cholelithiasisUgt1a1
cholestasisAbcc2 , Abcc3 , Abcc4 , Cyp1a2 , Gstp1
Chromosome AberrationsGstp1 , Gstt1 , Sult1a1
Chronic Cerebral HypoperfusionGstp1
Chronic Lymphocytic Leukemia, B-CellAbcg2
chronic myeloid leukemiaAbcb1a , Abcc2 , Abcg2 , Gstp1 , Hspa5
chronic obstructive pulmonary diseaseAbcc1 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1
clear cell renal cell carcinomaGstp1
Cognition DisordersCyp2d4
Colonic NeoplasmsSult1a1
colorectal adenomaGstp1
Colorectal NeoplasmsAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Cyp1a2 , Gstp1 , Sult1a1
ComaCyp2d4
Congenital AbnormalitiesGstt1
congenital heart diseaseAbcb1a , Gstt1
conjunctivochalasisGstp1
contact dermatitisGstp1 , Ugt1a1 , Ugt1a6
coronary artery diseaseGstt1
CoughGstp1
Crigler Najjar Syndrome, Type 2Ugt1a1 , Ugt1a6 , Ugt1a9
Crigler-Najjar syndromeUgt1a1 , Ugt1a6 , Ugt1a9
Crohn's diseaseAbcb1a , Gstt1 , Ugt1a1
Cronkhite-Canada syndromeAbcb1a
Currarino TriadAbcc5
cystic fibrosisGstp1 , Gstt1
diabetes mellitusAbcg2 , Gstt1
Diabetic NephropathiesGstt1 , Hspa5
diabetic retinopathyGstt1
diffuse large B-cell lymphomaAbcb1a , Abcg2 , Gstp1 , Gstt1
disease of cellular proliferationAbcb1a , Gstt1
disease of mental healthAbcb1a
Disease ProgressionAbcb1a , Abcc1 , Gstp1
dopamine beta-hydroxylase deficiencyHspa5
drug allergyAbcc2 , Gstp1 , Gstt1
Drug EruptionsCyp2e1
Drug-induced AnemiaGstt1
Drug-Induced DyskinesiaCyp2d4
Drug-Induced Immune ThrombocytopeniaAbcc2
Drug-Induced LeukopeniaGstp1
Drug-induced NeutropeniaAbcb1a , Abcc2 , Gstp1 , Gstt1 , Ugt1a1
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Abcc1 , Abcc2 , Abcc4 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Ugt1a1
Dubin-Johnson syndromeAbcc2 , Abcc3
dystoniaCyp2d4
encephalitisAbcb1a
end stage renal failureAbcb1a , Abcc2 , Abcc3 , Gstt1
endometrial cancerSult1a1
Endometrial NeoplasmsSult1a1 , Sult1e1 , Ugt1a1
endometriosisAbcc4
EndotoxemiaAbcb1a , Abcc2
EosinophiliaAbcb1a
epilepsyAbcb1a
epilepsy with generalized tonic-clonic seizuresCyp2d4
EpistaxisGstt1
erythropoietic protoporphyriaAbcg2
Escherichia Coli InfectionsAbcb1a
Esophageal NeoplasmsAbcb1a , Gstt1
esophagus adenocarcinomaGstt1
esophagus squamous cell carcinomaAbcc2 , Gstt1 , Hspa5 , Sult1a1
essential tremorGstp1
exfoliation syndromeGstt1
Experimental ArthritisAbcb1a , Abcg2
Experimental Autoimmune MyocarditisHspa5
Experimental Diabetes MellitusAbcb1a , Abcc2 , Abcc3 , Abcg2 , Cyp2e1
Experimental Liver CirrhosisAbcb1a , Abcc2 , Abcc5 , Cyp1a2 , Cyp2d4 , Sult1e1 , Sult2a1
Experimental SeizuresGstp1
extrinsic allergic alveolitisCyp2e1
familial hyperlipidemiaAbcb1a
familial temporal lobe epilepsy 3Abcb1a
Fanconi anemiaGstt1
fatty liver diseaseAbcc2 , Abcc3 , Cyp2e1 , Hspa5
Female Genital NeoplasmsUgt1a1
Female InfertilityHspa5
Femur Head NecrosisGstt1
Fetal Growth RetardationAbcb1a , Gstt1
Gallbladder NeoplasmsGstp1
GallstonesUgt1a1
Gastrointestinal DiseasesAbcc2
genetic diseaseUgt1a1 , Ugt1a6 , Ugt1a9
Genetic Predisposition to DiseaseAbcb1a
Genomic InstabilitySult1a1
Germ Cell and Embryonal NeoplasmsAbcb1a
Gilbert syndromeUgt1a1 , Ugt1a6 , Ugt1a9
glioblastoma multiformeGstt1
goutAbcg2
Gram-Negative Bacterial InfectionsUgt1a1
Graves' diseaseGstp1
Growth DisordersCyp1a2
head and neck squamous cell carcinomaAbcb1a , Abcc1 , Abcc2 , Abcg2
Hearing Loss, Noise-InducedGstt1
heart diseaseAbcb1a , Abcc1 , Abcc2
Hematologic NeoplasmsAbcb1a , Gstt1 , Hspa5
hematopoietic system diseaseGstp1 , Ugt1a1
Hepatitis C, ChronicCyp2d4
hepatocellular carcinomaAbcb1a , Abcc3 , Cyp2e1 , Erp29 , Gstp1 , Hspa5
HepatomegalyAbcc3 , Cyp1a2
Hirschsprung's diseaseGstt1
Hodgkin's lymphomaGstp1 , Gstt1 , Ugt1a1
human immunodeficiency virus infectious diseaseAbcb1a , Ppib
Hyperbilirubinemia, NeonatalUgt1a1
Hyperbilirubinemia, Transient Familial NeonatalUgt1a1 , Ugt1a6 , Ugt1a9
hyperprolactinemiaAbcc3
hypertensionAbcc1 , Gstp1 , Gstt1
hyperthyroidismUgt1a1
hyperuricemiaAbcg2
hypospadiasGstt1
HypotensionSult1a1
Hypotension, OrthostaticAbcb1a
infectious mononucleosisGstt1
InflammationAbcb1a , Ugt1a1
inflammatory bowel diseaseGstt1 , Hspa5
inflammatory bowel disease 13Abcb1a
interstitial nephritisCyp2d4
invasive ductal carcinomaAbcb1a
Iron OverloadGstt1
JaundiceCyp1a2 , Ugt1a1
juvenile rheumatoid arthritisGstt1
kernicterusUgt1a1
Kidney CalculiGstp1
kidney diseaseAbcb1a , Abcc3 , Gstp1
Kidney NeoplasmsAbcb1a , Gstt1
Kuhnt-Junius degenerationGstp1 , Gstt1
Laryngeal NeoplasmsGstp1
late onset Parkinson's diseaseGstp1
leukemiaGstt1
leukopeniaGstt1
liver cirrhosisCyp1a2
liver diseaseCyp1a2 , Cyp2e1 , Gstp1 , Sult1e1
Liver InjuryAbcg2 , Cyp1a2
liver neoplasmCyp2e1
Liver Neoplasms, ExperimentalCyp1a2 , Cyp2e1 , Gstp1
lung adenocarcinomaErp29 , Sult1a1
lung cancerSult1a1
lung diseaseCyp2e1 , Gstp1 , Gstt1
Lung InjuryCyp1a2
Lung NeoplasmsCyp1a2 , Cyp2e1 , Gstp1 , Gstt1
lung squamous cell carcinomaSult1a1
lymphoid leukemiaGstp1 , Gstt1
Lymphoma, Extranodal NK-T-CellAbcb1a
Lynch syndromeGstt1
malignant gliomaCyp2e1 , Gstp1 , Hspa5
Mammary Neoplasms, ExperimentalAbcb1a , Abcg2
Manganese PoisoningCyp2d4
medulloblastomaGstt1
megakaryocytic leukemiaAbcg2
melanomaGstp1
meningitisGstp1
mental depressionCyp1a2 , Cyp2e1
methemoglobinemiaCyp1a2
Micronuclei, Chromosome-DefectiveCyp2e1 , Gstt1
morbid obesityCyp2e1
motor neuron diseaseGstt1
Mouth AbnormalitiesGstt1
movement diseaseGstp1
multiple myelomaAbcg2 , Cyp2d4 , Gstp1 , Gstt1
multiple sclerosisGstp1 , Gstt1
Muscle RigidityCyp2d4
myelodysplastic syndromeGstp1 , Gstt1
myeloid leukemiaGstp1 , Gstt1 , Ugt1a1
myeloid neoplasmHspa5
myocardial infarctionHspa5
Myocardial IschemiaGstp1 , Sult1a1
Myocardial Reperfusion InjuryHspa5
Nasal PolypsAbcb1a , Gstt1
NauseaAbcb1a
NecrosisCyp2e1 , Gstp1
Neoplasm InvasivenessCyp2e1
Neoplasm MetastasisAbcb1a , Abcc4 , Erp29 , Sult1e1
nephroblastomaAbcb1a
Nerve DegenerationHspa5
nervous system diseaseAbcb1a , Abcc2 , Abcg2
neural tube defectCyp1a2
neuroblastomaAbcb1a
neuronal ceroid lipofuscinosisHspa5
neutropeniaAbcb1a , Gstt1 , Ugt1a1
non-Hodgkin lymphomaCyp2e1
non-small cell lung carcinomaAbcb1a , Abcc2 , Cyp2e1 , Gstp1 , Ugt1a1
nonalcoholic fatty liver diseaseAbcb1a , Abcc3 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1
obesityCyp2e1 , Hspa5
obstructive sleep apneaAbcb1a
Occupational DiseasesCyp2d4
optic neuritisGstt1
oral squamous cell carcinomaGstp1
osteogenesis imperfectaPpib
osteogenesis imperfecta type 9Ppib
osteoporosisGstp1
osteosarcomaGstp1
Ovarian NeoplasmsAbcb1a , Abcg2 , Cyp1a2 , Gstp1 , Gstt1 , Sult1a1 , Ugt1a1
PainAbcb1a
Pain, PostoperativeAbcb1a
pancreatic cancerAbcc2 , Abcc3 , Abcc5 , Gstp1
pancreatic ductal carcinomaGstp1
Pancreatitis, Experimental, Acute Hspa5
Parkinson's diseaseAbcb1a , Cyp2d4 , Cyp2e1 , Gstp1 , Gstt1
Perennial Allergic RhinitisGstp1
Perinatal AsphyxiaGstt1
perinatal necrotizing enterocolitisAbcb1a
Peripheral Nerve InjuriesHspa5
peripheral nervous system diseaseAbcb1a , Abcc1 , Gstp1 , Gstt1
peritonitisGstp1
Plasmodium falciparum malariaGstp1
pleomorphic xanthoastrocytomaAbcb1a
pneumoniaCyp2e1
PoisoningAbcb1a
Poor Drug Metabolism, CYP2D6-RelatedCyp2d4
porphyria cutanea tardaCyp1a2
pre-eclampsiaGstp1
pre-malignant neoplasmGstp1
precursor lymphoblastic lymphoma/leukemiaAbcb1a , Abcc2 , Abcg2 , Cyp1a2 , Cyp2d4 , Gstp1 , Gstt1
precursor T-lymphoblastic lymphoma/leukemiaAbcg2
Premature BirthGstt1
Prenatal Exposure Delayed EffectsCyp2d4
PresbycusisGstt1
primary biliary cirrhosisAbcc2 , Abcg2
primary open angle glaucomaGstt1
prostate cancerAbcc4
prostate carcinoma in situGstp1
prostatic hypertrophyGstp1
Prostatic NeoplasmsAbcc4 , Cyp2d4 , Cyp2e1 , Erp29 , Gstp1 , Gstt1 , Hsp90b1 , Sdf2l1 , Sult1a1 , Sult1e1 , Sult2a1
Pseudomonas InfectionsGstp1
pseudoxanthoma elasticumAbcc1
psoriasisGstp1
pulmonary emphysemaGstp1
pulmonary fibrosisGstp1 , Hspa5
pulmonary tuberculosisGstt1
Raynaud diseaseGstt1
renal cell carcinomaAbcb1a , Abcg2 , Gstp1 , Gstt1
Reperfusion InjuryAbcb1a , Abcc5 , Abcg2 , Cyp2e1 , Gstp1 , Hspa5 , Sult1e1
respiratory allergyHspa5
Respiratory SoundsGstp1
respiratory system diseaseGstp1
rheumatoid arthritisAbcb1a , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Gstt1 , Hspa5
sarcomaGstp1
schizophreniaAbcc1 , Gstt1 , Sult1a1
secondary hyperparathyroidismAbcg2
secondary Parkinson diseaseAbcb1a
senile cataractGstp1
SepsisCyp1a2 , Cyp2e1
sexual disorderCyp2d4
sickle cell anemiaGstt1
skin melanomaGstt1
Skin NeoplasmsGstt1
small cell carcinomaUgt1a1
Smith-Magenis syndromeAbcc3
Spinal Cord InjuriesHspa5
Spinal Cord Reperfusion InjuryHspa5
spinocerebellar ataxia type 17Hspa5 , Hyou1
splenic diseaseCyp1a2
SplenomegalyCyp1a2
squamous cell carcinomaCyp1a2 , Gstp1
StarvationUgt1a1
status epilepticusAbcb1a , Abcc2 , Abcg2
Stomach NeoplasmsGstp1 , Sult1a1
substance-induced psychosisGstp1
substance-related disorderAbcc4 , Cyp2d4
Tardive DyskinesiaCyp1a2
temporal lobe epilepsyAbcb1a
Testicular NeoplasmsGstp1
Therapy-related Acute Myeloid LeukemiaGstt1
toxic encephalopathyAbcb1a , Abcg2 , Gstp1
transient cerebral ischemiaHspa5
transitional cell carcinomaGstt1
Translocation, GeneticAbcb1a
Transplant RejectionGstt1
TremorCyp2d4
type 1 diabetes mellitusCyp2e1 , Gstt1 , Ugt1a1
type 2 diabetes mellitusAbcb1a , Abcc2 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1 , Sdf2l1 , Ugt1a1 , Ugt1a6
ulcerative colitisGstt1
Ureteral CalculiGstp1
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1Abcg2
urinary bladder cancerGstp1 , Gstt1 , Sult1a1
Urologic NeoplasmsSult1a1
Uterine Cervical NeoplasmsGstt1
venous insufficiencyGstt1
vestibular diseaseGstp1
visual epilepsyAbcb1a , Abcc2 , Hspa5
VomitingAbcb1a
Weight GainCyp2d4
Pathway Annotations Associated with Genes in the paracetamol pharmacokinetics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayCyp2e1
antigen processing and presentation pathwayHspa5
antipyrine drug pathwayCyp2e1
arachidonic acid metabolic pathwayCyp2e1
artemether pharmacokinetics pathwayUgt1a9
ascorbate and aldarate metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
azathioprine pharmacodynamics pathwayAbcc4 , Abcc5
bile acid transport pathwayAbcb1a , Abcc2 , Abcc3 , Abcc4 , Abcg2 , Sult2a1
caffeine metabolic pathwayCyp1a2
caffeine pharmacokinetics pathwayCyp1a2 , Cyp2e1
celecoxib pharmacodynamics pathwayCyp2d4 , Cyp2e1
celecoxib pharmacokinetics pathwayCyp2d4
citalopram pharmacodynamics pathwayCyp2d4
citalopram pharmacokinetics pathwayCyp2d4
clomipramine pharmacokinetics pathwayCyp1a2 , Cyp2d4
clopidogrel pharmacodynamics pathwayAbcb1a , Cyp1a2
clopidogrel pharmacokinetics pathwayAbcb1a , Cyp1a2
codeine and morphine pharmacodynamics pathwayCyp2d4 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
codeine and morphine pharmacokinetics pathwayCyp2d4 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
desipramine pharmacodynamics pathwayCyp2d4
desipramine pharmacokinetics pathwayCyp2d4
diclofenac pharmacodynamics pathwayCyp2e1
diflunisal pharmacodynamics pathwayCyp2e1
disulfiram pharmacodynamics pathwayCyp2e1
docetaxel pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
doxepin pharmacokinetics pathwayCyp1a2 , Cyp2d4
doxorubicin pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Endoplasmic Reticulum-associated degradation pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia4 , Pdia6
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
estradiol biosynthetic pathwaySult1e1 , Sult2a1
etodolac pharmacodynamics pathwayCyp2e1
etoposide pharmacodynamics pathwayAbcb1a , Abcc3 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
etoposide pharmacokinetics pathwayAbcb1a , Abcc3 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
felbamate pharmacokinetics pathwayCyp2e1
fenoprofen pharmacodynamics pathwayCyp2e1
fluoxetine pharmacodynamics pathwayCyp2d4
fluoxetine pharmacokinetics pathwayCyp2d4
flurbiprofen pharmacodynamics pathwayCyp2e1
glutathione conjugation pathwayGstp1 , Gstt1
glutathione metabolic pathwayGstp1 , Gstt1
hypoxia inducible factor pathwayAbcb1a , Abcg2
ibuprofen pharmacodynamics pathwayCyp2e1 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ibuprofen pharmacokinetics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
imipramine pharmacodynamics pathwayCyp1a2 , Cyp2d4
imipramine pharmacokinetics pathwayCyp1a2 , Cyp2d4
indometacin pharmacodynamics pathwayCyp2e1
indometacin pharmacodynamics pathwayCyp2e1
interleukin-6 signaling pathwayHsp90b1
irinotecan pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
irinotecan pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ketoprofen pharmacodynamics pathwayCyp2e1
ketorolac pharmacodynamics pathwayCyp2e1
lamivudine pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcg2 , Sult1a1
leukotriene C4 synthase deficiency pathwayCyp2e1
lidocaine pharmacodynamics pathwayCyp1a2
lidocaine pharmacokinetics pathwayCyp1a2
linoleic acid metabolic pathwayCyp1a2 , Cyp2e1
lornoxicam pharmacodynamics pathwayCyp2e1
magnesium salicylate pharmacodynamics pathwayCyp2e1
mefenamic acid pharmacodynamics pathwayCyp2e1
meloxicam pharmacodynamics pathwayCyp2e1
mercaptopurine pharmacodynamics pathwayAbcc4 , Abcc5
mercaptopurine pharmacokinetics pathwayAbcc4 , Abcc5
methadone pharmacodynamics pathwayCyp2d4
methadone pharmacokinetics pathwayCyp2d4
multidrug resistance-associated protein mediated transport pathwayAbcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2 , Ugt1a9
nabumetone pharmacodynamics pathwayCyp2e1
naproxen pharmacodynamics pathwayCyp2e1
neviparine pharmacokinetics pathwayCyp2d4
nicotine pharmacodynamics pathwayUgt1a9
nicotine pharmacokinetics pathwayUgt1a9
NOD-like receptor signaling pathwayHsp90b1
O-linked glycan biosynthetic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
paracetamol drug pathwayCyp2e1
paracetamol pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Dnajb11 , Erp29 , Gstp1 , Gstt1 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Sult1a1 , Sult1e1 , Sult2a1 , Ugt1a1 , Ugt1a6 , Ugt1a9
paracetamol response pathwayCyp2e1
pentose and glucuronate interconversion pathwayUgt1a1 , Ugt1a6 , Ugt1a9
phase I biotransformation pathway via cytochrome P450Cyp1a2 , Cyp2d4 , Cyp2e1 , Gstp1 , Gstt1 , Ugt1a1 , Ugt1a6 , Ugt1a9
phenytoin pharmacodynamics pathwayCyp1a2 , Cyp2e1 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a9
piroxicam pharmacodynamics pathwayCyp2e1
porphyrin and chlorophyll metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
prion disease pathwayHspa5
prostate cancer pathwayGstp1 , Hsp90b1
retinol metabolic pathwayCyp1a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a9
salicylic acid pharmacodynamics pathwayCyp2e1
sodium salicylate pharmacodynamics pathwayCyp2e1
sorafenib pharmacokinetics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
sphingosine 1-phosphate signaling pathwayAbcc1
starch and sucrose metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
steroid hormone biosynthetic pathwaySult1e1 , Ugt1a1 , Ugt1a6 , Ugt1a9
sulfite oxidase deficiency pathwaySult1a1 , Sult1e1
sulfur metabolic pathwaySult1a1 , Sult1e1
sulindac pharmacodynamics pathwayCyp2e1
syndecan signaling pathwayPpib
tamoxifen pharmacodynamics pathwayCyp2d4 , Sult1a1
tamoxifen pharmacokinetics pathwayCyp2d4 , Sult1a1 , Sult2a1
tenoxicam pharmacodynamics pathwayCyp2e1
testosterone biosynthetic pathwaySult2a1
tiaprofenic acid pharmacodynamics pathwayCyp2e1
tioguanine pharmacodynamics pathwayAbcc4 , Abcc5
tolmetin pharmacodynamics pathwayCyp2e1
tramadol pharmacokinetics pathwayAbcc2 , Cyp2d4
tryptophan metabolic pathwayCyp1a2
tyrosinemia type III pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
valdecoxib pharmacodynamics pathwayCyp2e1
venlafaxine pharmacokinetics pathwayAbcb1a , Cyp2d4
vinblastine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vincristine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vindesine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vinorelbine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vitamin A deficiency pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
Phenotype Annotations Associated with Genes in the paracetamol pharmacokinetics pathway

References Associated with the paracetamol pharmacokinetics pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: