RGD Reference Report - Xenobiotic gene polymorphisms and susceptibility to multiple myeloma. - Rat Genome Database

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Xenobiotic gene polymorphisms and susceptibility to multiple myeloma.

Authors: Lincz, LF  Kerridge, I  Scorgie, FE  Bailey, M  Enno, A  Spencer, A 
Citation: Lincz LF, etal., Haematologica. 2004 May;89(5):628-9.
RGD ID: 10450846
Pubmed: PMID:15136237   (View Abstract at PubMed)

Genetic variations in the activity of xenobiotic enzymes may predict susceptibility to multiple myeloma (MM). In a case-control study, 90 Australian Caucasians with MM had significantly higher incidences of GST T1 null, PON1 BB and NAT2 slow acetylation genotypes, but no difference in polymorphism frequencies for GST M1, NAT1, and CYP1A1 when compared to 205 controls.



1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
GSTM1Humanmultiple myeloma no_associationISOGstm1 (Rattus norvegicus) RGD 
GSTT1Humanmultiple myeloma susceptibilityIAGP  RGD 
Gstm1Ratmultiple myeloma no_associationIAGP  RGD 
Gstm1Mousemultiple myeloma no_associationISOGstm1 (Rattus norvegicus) RGD 
Gstt1Ratmultiple myeloma susceptibilityISOGSTT1 (Homo sapiens) RGD 
Gstt1Mousemultiple myeloma susceptibilityISOGSTT1 (Homo sapiens) RGD 
PON1Humanmultiple myeloma susceptibilityIAGP DNA:missense mutation:cds:p.Q192R (human)RGD 
Pon1Ratmultiple myeloma susceptibilityISOPON1 (Homo sapiens)DNA:missense mutation:cds:p.Q192R (human)RGD 
Pon1Mousemultiple myeloma susceptibilityISOPON1 (Homo sapiens)DNA:missense mutation:cds:p.Q192R (human)RGD 
1 to 9 of 9 rows


Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1) Gstt1  (glutathione S-transferase theta 1) Pon1  (paraoxonase 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1) Gstt1  (glutathione S-transferase, theta 1) Pon1  (paraoxonase 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1) GSTT1  (glutathione S-transferase theta 1) PON1  (paraoxonase 1)