Pon1 (paraoxonase 1) - Rat Genome Database

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Gene: Pon1 (paraoxonase 1) Rattus norvegicus
Analyze
Symbol: Pon1
Name: paraoxonase 1
RGD ID: 620062
Description: Enables aryldialkylphosphatase activity. Involved in several processes, including response to fatty acid; response to fluoride; and response to nutrient levels. Located in extracellular space and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; organophosphate response pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A-esterase 1; aromatic esterase 1; PON 1; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Pon1em1Mcwi   Pon1em2Mcwi   Pon1em3Mcwi   Pon1em1Lizh  
Genetic Models: SD-Pon1em1Lizh SS-Pon1em3Mcwi SS-Pon1em2Mcwi SS-Pon1em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2433,294,737 - 33,325,759 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl433,294,722 - 33,321,360 (-)Ensembl
Rnor_6.0430,249,749 - 30,276,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,249,742 - 30,276,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,156,712 - 30,183,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4429,936,314 - 29,964,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1429,975,057 - 30,003,299 (-)NCBI
Celera428,821,674 - 28,848,125 (-)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
Agricultural Workers' Diseases  (ISO)
Albuminuria  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anemia  (ISO)
arteriosclerosis  (ISO)
Arteritis  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
beta-thalassemia major  (ISO)
Birth Weight  (ISO)
bone disease  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
capillary leak syndrome  (ISO)
cardiovascular system disease  (ISO)
cataract  (ISO)
celiac disease  (ISO)
cerebral cavernous malformation  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
constipation  (ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
dementia  (ISO)
Diabetes Complications  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
fatty liver disease  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hematologic Neoplasms  (ISO)
hemorrhoid  (ISO)
Henoch-Schoenlein purpura  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperlipoproteinemias  (IDA,ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (ISO)
iron deficiency anemia  (ISO)
keratoconus  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lung Neoplasms  (ISO)
lymphoma  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
membranoproliferative glomerulonephritis  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Nasal Polyps  (ISO)
non-Hodgkin lymphoma  (ISO)
Occupational Diseases  (ISO)
open-angle glaucoma  (ISO)
Organophosphate Poisoning  (ISO)
periodontal disease  (ISO)
persian gulf syndrome  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary open angle glaucoma  (ISO)
Primitive Neuroectodermal Tumors  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
spina bifida  (ISO)
Spinal Cord Injuries  (IDA)
toxic encephalopathy  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
vitamin B12 deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-mevalonic acid  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nitrophenyl acetate  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldicarb  (EXP,ISO)
alendronic acid  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
angelica lactone  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
cadmium atom  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium dichloride  (ISO)
calcium(0)  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
chromium(3+) trichloride  (ISO)
ciprofibrate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP)
clindamycin phosphate  (ISO)
clodronic acid  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP,ISO)
clopidogrel  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarins  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diazinon  (EXP,ISO)
diazoxon  (ISO)
dichlorvos  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diiodine  (EXP)
diisopropyl fluorophosphate  (ISO)
dimethylarsinic acid  (ISO)
dioleoyl phosphatidylcholine  (ISO)
dioxygen  (ISO)
dipalmitoyl phosphatidylglycerol  (ISO)
disodium selenite  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
erucic acid  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
farnesyl diphosphate  (ISO)
fenitrothion  (EXP)
fenofibrate  (ISO)
flavone  (ISO)
fluticasone  (ISO)
fluvastatin  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gabapentin  (ISO)
gamma-decalactone  (EXP)
glutathione  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
high-density lipoprotein cholesterol  (ISO)
homocysteine  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isorhamnetin  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
levetiracetam  (ISO)
levonorgestrel  (ISO)
linoleic acid  (ISO)
lysophosphatidylglycerol  (ISO)
malaoxon  (ISO)
malonaldehyde  (ISO)
mefenamic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (ISO)
methotrexate  (EXP)
methylglyoxal  (ISO)
mithramycin  (ISO)
montelukast  (ISO)
moxifloxacin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
Nandrolone decanoate  (ISO)
naphthalene  (EXP,ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
organophosphorus compound  (ISO)
orlistat  (ISO)
oxamyl  (EXP,ISO)
ozone  (EXP,ISO)
palladium  (ISO)
palmitoleic acid  (ISO)
pamidronate  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
Paraoxon-methyl  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
pentane-2,3-dione  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phenyl acetate  (EXP,ISO)
phenylacetic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
potassium dichromate  (ISO)
pralidoxime  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
primidone  (ISO)
proanthocyanidin  (EXP)
propanal  (ISO)
pyrrolidine  (ISO)
quercetin  (EXP,ISO)
quinolin-2(1H)-one  (ISO)
quinolin-2-ol  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Risedronate sodium  (EXP)
ritonavir  (EXP)
rutin  (EXP)
salicylates  (ISO)
saquinavir  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenic acid  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
sodium perchlorate  (EXP)
Soman  (ISO)
squalene  (ISO)
streptozocin  (EXP)
sulfisomidine  (ISO)
sulfisoxazole  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
tiotropium bromide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
varenicline  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)
VX nerve agent  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
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82. Ugurlu N, etal., Curr Eye Res. 2013 Apr;38(4):497-502. doi: 10.3109/02713683.2013.774023. Epub 2013 Feb 22.
83. van den Berg SW, etal., Diabet Med. 2008 Feb;25(2):186-93.
84. Wang J, etal., Mol Med Rep. 2013 Dec;8(6):1845-51. doi: 10.3892/mmr.2013.1710. Epub 2013 Oct 2.
85. Wu X, etal., J Nutr. 2010 Sep;140(9):1628-32. doi: 10.3945/jn.110.123927. Epub 2010 Jul 21.
86. Xie Z, etal., Rare Dis. 2013 Dec 12;1(1). pii: e27445.
87. Yagci R, etal., Ophthalmic Res. 2009;42(3):155-9. doi: 10.1159/000229306. Epub 2009 Jul 23.
88. Yamada M, etal., Stroke. 2002 Apr;33(4):896-900.
89. Yilmaz A, etal., J Nephrol. 2009 Nov-Dec;22(6):726-32.
90. Zhang C, etal., Gene Ther. 2010 May;17(5):626-33. Epub 2010 Feb 25.
91. Zhang X, etal., J Nutr. 2011 Jul;141(7):1254-9. doi: 10.3945/jn.111.139576. Epub 2011 May 11.
92. Zhou G and Liu B, Int J Ophthalmol. 2010;3(1):36-42. doi: 10.3980/j.issn.2222-3959.2010.01.09. Epub 2010 Mar 18.
93. Zohaib M, etal., J Clin Pharmacol. 2016 Jul;56(7):869-74. doi: 10.1002/jcph.675. Epub 2015 Dec 28.
Additional References at PubMed
PMID:7638166   PMID:9032442   PMID:9685159   PMID:10479665   PMID:12477932   PMID:15098021   PMID:15342686   PMID:15721011   PMID:15772423   PMID:16641100   PMID:16682745   PMID:16816326  
PMID:17146679   PMID:17460375   PMID:17464102   PMID:17645625   PMID:18458312   PMID:18719679   PMID:19091700   PMID:19144177   PMID:19887391   PMID:20028357   PMID:22516433   PMID:23376485  
PMID:23533145   PMID:24214524   PMID:27499091   PMID:27642496   PMID:27959408   PMID:30503749   PMID:30946296  


Genomics

Comparative Map Data
Pon1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2433,294,737 - 33,325,759 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl433,294,722 - 33,321,360 (-)Ensembl
Rnor_6.0430,249,749 - 30,276,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,249,742 - 30,276,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,156,712 - 30,183,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4429,936,314 - 29,964,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1429,975,057 - 30,003,299 (-)NCBI
Celera428,821,674 - 28,848,125 (-)NCBICelera
Cytogenetic Map4q13NCBI
PON1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl795,297,676 - 95,324,532 (-)EnsemblGRCh38hg38GRCh38
GRCh38795,297,676 - 95,324,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37794,926,988 - 94,953,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,764,924 - 94,791,780 (-)NCBINCBI36hg18NCBI36
Build 34794,571,638 - 94,598,495NCBI
Celera789,626,366 - 89,652,590 (-)NCBI
Cytogenetic Map7q21.3NCBI
HuRef789,534,701 - 89,560,922 (-)NCBIHuRef
CHM1_1794,857,684 - 94,883,916 (-)NCBICHM1_1
CRA_TCAGchr7v2794,256,665 - 94,282,884 (-)NCBI
Pon1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,168,090 - 5,193,987 (-)NCBIGRCm39mm39
GRCm39 Ensembl65,168,090 - 5,193,946 (-)Ensembl
GRCm3865,168,090 - 5,193,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,168,090 - 5,193,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,118,090 - 5,143,946 (-)NCBIGRCm37mm9NCBIm37
MGSCv3665,118,105 - 5,143,824 (-)NCBImm8
Celera65,314,337 - 5,340,485 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
Pon1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,893,473 - 11,923,339 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,893,473 - 11,923,035 (-)NCBIChiLan1.0ChiLan1.0
PON1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17100,841,286 - 100,867,493 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7100,841,286 - 100,867,493 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0787,253,476 - 87,279,650 (-)NCBIMhudiblu_PPA_v0panPan3
PON1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,565,620 - 20,600,774 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,565,641 - 20,642,985 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,124,634 - 20,159,679 (-)NCBI
ROS_Cfam_1.01420,388,041 - 20,423,054 (-)NCBI
UMICH_Zoey_3.11420,532,696 - 20,567,711 (-)NCBI
UNSW_CanFamBas_1.01420,267,821 - 20,302,851 (-)NCBI
UU_Cfam_GSD_1.01420,525,175 - 20,560,208 (-)NCBI
Pon1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,883,628 - 33,908,421 (-)NCBI
SpeTri2.0NW_0049365854,954,871 - 4,979,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PON1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl974,926,048 - 74,974,724 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1974,943,646 - 74,974,720 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,327,318 - 82,339,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PON1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12153,713,434 - 53,739,658 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2153,714,012 - 53,739,875 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604250,595,418 - 50,621,447 (-)NCBIVero_WHO_p1.0
Pon1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248131,953,796 - 1,979,846 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2433,294,874 - 33,295,091 (+)MAPPERmRatBN7.2
Rnor_6.0430,249,879 - 30,250,095NCBIRnor6.0
Rnor_5.0430,156,842 - 30,157,058UniSTSRnor5.0
RGSC_v3.4429,936,444 - 29,936,660UniSTSRGSC3.4
Celera428,821,804 - 28,822,020UniSTS
RH 3.4 Map4218.84UniSTS
Cytogenetic Map4q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat


Genetic Models
This gene Pon1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:119
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000011823
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 20 20 14
Medium 16 15 15 1 3
Low 4 24 10 18 10 6 6 11 7 13 8 6
Below cutoff 1 8 3 2 1 2 2 4 16 11 16 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_032077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO562983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO570909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U94856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000011823   ⟹   ENSRNOP00000011823
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl433,294,722 - 33,314,707 (-)Ensembl
Rnor_6.0 Ensembl430,249,742 - 30,276,372 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113709   ⟹   ENSRNOP00000079524
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl433,301,958 - 33,321,360 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114824   ⟹   ENSRNOP00000090277
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl433,298,944 - 33,321,360 (-)Ensembl
RefSeq Acc Id: NM_032077   ⟹   NP_114466
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2433,294,745 - 33,321,296 (-)NCBI
Rnor_6.0430,249,749 - 30,276,297 (-)NCBI
Rnor_5.0430,156,712 - 30,183,204 (-)NCBI
RGSC_v3.4429,936,314 - 29,964,821 (-)RGD
Celera428,821,674 - 28,848,125 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108462   ⟹   XP_038964390
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2433,294,737 - 33,325,759 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_114466   ⟸   NM_032077
- Peptide Label: precursor
- UniProtKB: P55159 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011823   ⟸   ENSRNOT00000011823
RefSeq Acc Id: XP_038964390   ⟸   XM_039108462
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000090277   ⟸   ENSRNOT00000114824
RefSeq Acc Id: ENSRNOP00000079524   ⟸   ENSRNOT00000113709

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692857
Promoter ID:EPDNEW_R3382
Type:initiation region
Name:Pon1_1
Description:paraoxonase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0430,276,308 - 30,276,368EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620062 AgrOrtholog
Ensembl Genes ENSRNOG00000008902 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000011823 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011823 UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7324332 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  Arylesterase UniProtKB/Swiss-Prot
  Paraoxonase1 UniProtKB/Swiss-Prot
KEGG Report rno:84024 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109526 IMAGE-MGC_LOAD
NCBI Gene 84024 ENTREZGENE
PANTHER PTHR11799:SF16 UniProtKB/Swiss-Prot
Pfam Arylesterase UniProtKB/Swiss-Prot
PharmGKB PON1 RGD
PhenoGen Pon1 PhenoGen
PRINTS PARAOXONASE UniProtKB/Swiss-Prot
  PARAOXONASE1 UniProtKB/Swiss-Prot
UniProt P55159 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O08682 UniProtKB/Swiss-Prot
  Q5BJN6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pon1  paraoxonase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pon1  paraoxonase 1      Symbol and Name status set to provisional 70820 PROVISIONAL