(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA] CTD PMID:31150632 (R)-mevalonic acid multiple interactions ISO RGD:1349272 6480464 Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] more ... CTD PMID:14500290 , PMID:15690306 (S)-naringenin increases expression ISO RGD:1349272 6480464 naringenin results in increased expression of PON1 mRNA CTD PMID:15169886 (S)-nicotine decreases activity ISO RGD:1349272 6480464 Nicotine results in decreased activity of PON1 protein CTD PMID:24478552 (S)-nicotine multiple interactions ISO RGD:1349272 6480464 PON1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 1,2-dilauroyl-sn-glycero-3-phosphocholine(1+) increases activity ISO RGD:1349272 6480464 1, 2-dilauroylphosphatidylcholine results in increased activity of PON1 protein CTD PMID:12963475 1-naphthyl isothiocyanate multiple interactions ISO RGD:1349272 6480464 [1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of PON1 mRNA CTD PMID:27344345 17alpha-ethynylestradiol multiple interactions ISO RGD:733240 6480464 [Ethinyl Estradiol co-treated with Desogestrel] affects the activity of PON1 protein more ... CTD PMID:17541152 , PMID:17942748 17beta-estradiol decreases expression ISO RGD:1349272 6480464 Estradiol results in decreased expression of PON1 mRNA CTD PMID:20106945 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Plant Preparations] results in decreased expression of PON1 mRNA CTD PMID:26945725 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:733240 6480464 [2 more ... CTD PMID:23457121 2,2',4,4',5,5'-hexachlorobiphenyl decreases activity EXP 6480464 2 more ... CTD PMID:26006071 2,2',5,5'-tetrachlorobiphenyl decreases expression EXP 6480464 2 more ... CTD PMID:23829299 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1349272 6480464 Tetrachlorodibenzodioxin results in increased expression of PON1 mRNA CTD PMID:26434531 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1349272 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PON1 mRNA CTD PMID:26159488 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1349272 6480464 Tetrachlorodibenzodioxin affects the expression of PON1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PON1 mRNA CTD PMID:16960034 , PMID:19692669 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:733240 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PON1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1349272 6480464 Tetrachlorodibenzodioxin results in decreased expression of PON1 mRNA CTD PMID:20106945 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of PON1 mRNA CTD PMID:21346803 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO RGD:1349272 6480464 Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] CTD PMID:16052486 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:1349272 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 2-trans,6-trans-farnesyl diphosphate multiple interactions ISO RGD:1349272 6480464 farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA], farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 , PMID:15690306 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:733240 6480464 [3 more ... CTD PMID:23457121 3,3',4,4',5-pentachlorobiphenyl increases activity EXP 6480464 3 more ... CTD PMID:25530946 , PMID:26006071 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:733240 6480464 3 more ... CTD PMID:22653878 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 3 more ... CTD PMID:23644946 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:19692669 more ... 3,4-dihydrocoumarin affects metabolic processing ISO RGD:1349272 6480464 PON1 SNP affects the metabolism of 3, 4-dihydrocoumarin CTD PMID:25027835 3-methylcholanthrene increases activity EXP 6480464 Methylcholanthrene results in increased activity of PON1 protein CTD PMID:26006071 3-methylcholanthrene increases expression ISO RGD:1349272 6480464 Methylcholanthrene results in increased expression of PON1 mRNA CTD PMID:15169886 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of PON1 protein CTD PMID:11551529 3-methylcholanthrene increases activity ISO RGD:1349272 6480464 Methylcholanthrene results in increased activity of PON1 protein CTD PMID:15169886 3-methylcholanthrene multiple interactions ISO RGD:1349272 6480464 7-ketocholesterol inhibits the reaction [Methylcholanthrene results in increased expression of PON1 mRNA] CTD PMID:15169886 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of PON1 mRNA CTD PMID:19162173 4,4'-sulfonyldiphenol decreases expression ISO RGD:1349272 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of PON1 mRNA CTD PMID:30616060 4-hydroxynon-2-enal multiple interactions ISO RGD:1349272 6480464 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon], 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] CTD PMID:15375178 4-hydroxynon-2-enal decreases activity ISO RGD:1349272 6480464 4-hydroxy-2-nonenal results in decreased activity of PON1 protein CTD PMID:15375178 4-hydroxyphenyl retinamide increases expression ISO RGD:733240 6480464 Fenretinide results in increased expression of PON1 mRNA CTD PMID:28973697 4-nitrophenol increases chemical synthesis ISO RGD:1349272 6480464 PON1 protein results in increased chemical synthesis of 4-nitrophenol CTD PMID:16175651 4-nitrophenyl acetate increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of 4-nitrophenyl acetate CTD PMID:21382471 6-propyl-2-thiouracil multiple interactions EXP 6480464 Vitamin E inhibits the reaction [Propylthiouracil results in decreased activity of PON1 protein] CTD PMID:15386442 6-propyl-2-thiouracil decreases activity EXP 6480464 Propylthiouracil results in decreased activity of PON1 protein CTD PMID:15386442 7,9-dihydro-1H-purine-2,6,8(3H)-trione affects abundance ISO RGD:1349272 6480464 PON1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 7-ketocholesterol multiple interactions ISO RGD:1349272 6480464 7-ketocholesterol inhibits the reaction [Methylcholanthrene results in increased expression of PON1 mRNA] more ... CTD PMID:15169886 , PMID:15458977 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of PON1 mRNA CTD PMID:31881176 acetylsalicylic acid increases expression ISO RGD:1349272 6480464 Aspirin results in increased expression of PON1 mRNA CTD PMID:18519978 acetylsalicylic acid increases expression ISO RGD:733240 6480464 Aspirin results in increased expression of PON1 mRNA CTD PMID:18519978 acetylsalicylic acid increases activity EXP 6480464 Aspirin results in increased activity of PON1 mRNA, Aspirin results in increased activity of PON1 protein CTD PMID:18519978 acetylsalicylic acid multiple interactions ISO RGD:733240 6480464 AHR mutant form inhibits the reaction [Aspirin results in increased activity of PON1 protein], AHR mutant form inhibits the reaction [Aspirin results in increased expression of PON1 mRNA] CTD PMID:18519978 acetylsalicylic acid increases activity ISO RGD:1349272 6480464 Aspirin results in increased activity of PON1 protein CTD PMID:18519978 acrolein multiple interactions ISO RGD:1349272 6480464 [PON1 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]] which results in increased chemical synthesis of 5 more ... CTD PMID:20353174 aflatoxin B1 affects expression ISO RGD:1349272 6480464 Aflatoxin B1 affects the expression of PON1 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1349272 6480464 Aflatoxin B1 results in decreased expression of PON1 mRNA CTD PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:1349272 6480464 Aflatoxin B1 results in decreased methylation of PON1 gene CTD PMID:27153756 albuterol decreases activity ISO RGD:1349272 6480464 Albuterol results in decreased activity of PON1 protein CTD PMID:31581362 aldicarb multiple interactions ISO RGD:1349272 6480464 [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb, [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb CTD PMID:27132127 aldicarb multiple interactions EXP 6480464 [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb, [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb CTD PMID:27132127 alendronic acid decreases activity EXP 6480464 Alendronate results in decreased activity of PON1 protein CTD PMID:27387541 alendronic acid multiple interactions EXP 6480464 [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone more ... CTD PMID:27387541 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PON1 mRNA CTD PMID:16483693 ampicillin decreases activity ISO RGD:733240 6480464 Ampicillin results in decreased activity of PON1 protein CTD PMID:16880604 ampicillin decreases activity ISO RGD:1349272 6480464 Ampicillin results in decreased activity of PON1 protein CTD PMID:16880604 , PMID:31581362 angelica lactone decreases activity ISO RGD:1349272 6480464 angelica lactone results in decreased activity of PON1 protein CTD PMID:31209508 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1349272 6480464 pyrazolanthrone inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of PON1 mRNA] more ... CTD PMID:16269825 arachidonic acid multiple interactions ISO RGD:1349272 6480464 Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon], Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] CTD PMID:15375178 arachidonic acid decreases activity ISO RGD:1349272 6480464 Arachidonic Acid results in decreased activity of PON1 protein CTD PMID:15375178 arsane affects response to substance ISO RGD:1349272 6480464 PON1 gene SNP affects the susceptibility to Arsenic, PON1 protein affects the susceptibility to Arsenic CTD PMID:19152805 , PMID:19371607 arsenic atom affects response to substance ISO RGD:1349272 6480464 PON1 gene SNP affects the susceptibility to Arsenic, PON1 protein affects the susceptibility to Arsenic CTD PMID:19152805 , PMID:19371607 atazanavir sulfate decreases activity EXP 6480464 Atazanavir Sulfate results in decreased activity of PON1 protein CTD PMID:27378623 atorvastatin calcium multiple interactions ISO RGD:1349272 6480464 PON1 gene polymorphism affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL] more ... CTD PMID:16238680 atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein] CTD PMID:30273964 atorvastatin calcium increases expression ISO RGD:1349272 6480464 Atorvastatin results in increased expression of PON1 mRNA CTD PMID:15690306 atorvastatin calcium increases activity ISO RGD:1349272 6480464 Atorvastatin results in increased activity of PON1 protein CTD PMID:15324535 , PMID:15969877 benzo[a]pyrene decreases expression ISO RGD:1349272 6480464 Benzo(a)pyrene results in decreased expression of PON1 mRNA CTD PMID:20106945 benzo[a]pyrene increases expression ISO RGD:1349272 6480464 Benzo(a)pyrene results in increased expression of PON1 mRNA CTD PMID:15169886 Benzo[k]fluoranthene increases expression ISO RGD:733240 6480464 benzo(k)fluoranthene results in increased expression of PON1 mRNA CTD PMID:26377693 bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of PON1 mRNA CTD PMID:16648578 bifenthrin increases expression ISO RGD:733240 6480464 bifenthrin results in increased expression of PON1 mRNA CTD PMID:26071804 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PON1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:733240 6480464 bisphenol A results in increased expression of PON1 mRNA CTD PMID:30245210 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PON1 mRNA CTD PMID:30903817 bosentan decreases expression ISO RGD:1349272 6480464 Bosentan results in decreased expression of PON1 mRNA CTD PMID:29761207 cadmium atom decreases activity EXP 6480464 Cadmium results in decreased activity of PON1 protein CTD PMID:22995158 cadmium atom affects binding ISO RGD:1349272 6480464 PON1 protein binds to Cadmium CTD PMID:23896426 cadmium atom increases activity EXP 6480464 Cadmium results in increased activity of PON1 protein CTD PMID:21787725 calcium atom increases activity EXP 6480464 Calcium results in increased activity of PON1 protein CTD PMID:27132127 calcium atom multiple interactions EXP 6480464 [Calcium results in increased activity of PON1 protein] which affects the susceptibility to O more ... CTD PMID:27132127 calcium atom increases activity ISO RGD:1349272 6480464 Calcium results in increased activity of PON1 protein CTD PMID:27132127 calcium atom multiple interactions ISO RGD:1349272 6480464 [Calcium co-treated with 1 more ... CTD PMID:12871208 , PMID:27132127 calcium dichloride multiple interactions ISO RGD:1349272 6480464 Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon] CTD PMID:16052486 calcium(0) multiple interactions EXP 6480464 [Calcium results in increased activity of PON1 protein] which affects the susceptibility to O more ... CTD PMID:27132127 calcium(0) increases activity EXP 6480464 Calcium results in increased activity of PON1 protein CTD PMID:27132127 calcium(0) multiple interactions ISO RGD:1349272 6480464 [Calcium co-treated with 1 more ... CTD PMID:12871208 , PMID:27132127 calcium(0) increases activity ISO RGD:1349272 6480464 Calcium results in increased activity of PON1 protein CTD PMID:27132127 carbamazepine decreases activity ISO RGD:1349272 6480464 Carbamazepine results in decreased activity of PON1 protein CTD PMID:28032682 carbon nanotube decreases expression ISO RGD:733240 6480464 Nanotubes, Carbon analog results in decreased expression of PON1 mRNA, Nanotubes, Carbon results in decreased expression of PON1 mRNA CTD PMID:25554681 , PMID:27106021 chenodeoxycholic acid multiple interactions ISO RGD:1349272 6480464 pyrazolanthrone inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of PON1 mRNA] CTD PMID:16269825 chenodeoxycholic acid decreases expression ISO RGD:1349272 6480464 Chenodeoxycholic Acid results in decreased expression of PON1 mRNA CTD PMID:16269825 chlorpyrifos increases response to substance ISO RGD:1349272 6480464 PON1 protein polymorphism results in increased susceptibility to Chlorpyrifos, PON1 protein results in increased susceptibility to Chlorpyrifos CTD PMID:16007003 , PMID:20176005 chlorpyrifos multiple interactions ISO RGD:733240 6480464 [APOE protein results in increased susceptibility to Chlorpyrifos] which results in decreased expression of PON1 mRNA CTD PMID:29404631 chlorpyrifos decreases expression ISO RGD:733240 6480464 Chlorpyrifos results in decreased expression of PON1 mRNA CTD PMID:29404631 chlorpyrifos increases response to substance ISO RGD:733240 6480464 PON1 gene mutant form results in increased susceptibility to Chlorpyrifos CTD PMID:11022865 chlorpyrifos multiple interactions ISO RGD:1349272 6480464 Chlorpyrifos affects the expression of and results in increased activity of PON1 protein CTD PMID:26948828 chlorpyrifos affects expression ISO RGD:1349272 6480464 Chlorpyrifos affects the expression of PON1 mRNA CTD PMID:26948828 chlorpyrifos affects response to substance ISO RGD:1349272 6480464 PON1 gene polymorphism affects the susceptibility to Chlorpyrifos CTD PMID:19907334 chlorpyrifos increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of Chlorpyrifos CTD PMID:16331452 chlorpyrifos affects metabolic processing ISO RGD:1349272 6480464 PON1 protein affects the metabolism of Chlorpyrifos CTD PMID:16002382 cholesterol increases export ISO RGD:1349272 6480464 PON1 protein results in increased export of Cholesterol CTD PMID:16229851 , PMID:16331452 cholesterol multiple interactions EXP 6480464 [Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein more ... CTD PMID:30273964 cholesterol decreases chemical synthesis ISO RGD:733240 6480464 PON1 protein results in decreased chemical synthesis of Cholesterol CTD PMID:12615663 cholesterol decreases activity ISO RGD:733240 6480464 Cholesterol results in decreased activity of PON1 protein CTD PMID:16115471 cholesterol decreases chemical synthesis ISO RGD:1349272 6480464 PON1 protein results in decreased chemical synthesis of Cholesterol CTD PMID:12615663 cholic acid decreases expression ISO RGD:733240 6480464 Cholic Acid results in decreased expression of PON1 mRNA, Cholic Acid results in decreased expression of PON1 protein CTD PMID:16269825 cholic acid multiple interactions EXP 6480464 [Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein more ... CTD PMID:30273964 chromium(3+) trichloride increases expression ISO RGD:733240 6480464 chromic chloride results in increased expression of PON1 mRNA CTD PMID:12128095 ciprofibrate decreases expression ISO RGD:733240 6480464 ciprofibrate results in decreased expression of PON1 mRNA CTD PMID:22653878 ciprofloxacin decreases activity ISO RGD:1349272 6480464 Ciprofloxacin results in decreased activity of PON1 protein CTD PMID:16880604 , PMID:31581362 ciprofloxacin decreases activity ISO RGD:733240 6480464 Ciprofloxacin results in decreased activity of PON1 protein CTD PMID:16880604 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of PON1 protein CTD PMID:22023808 clindamycin phosphate decreases activity ISO RGD:1349272 6480464 clindamycin phosphate results in decreased activity of PON1 protein CTD PMID:16880604 clindamycin phosphate decreases activity ISO RGD:733240 6480464 clindamycin phosphate results in decreased activity of PON1 protein CTD PMID:16880604 clodronic acid multiple interactions EXP 6480464 [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone more ... CTD PMID:27387541 clodronic acid decreases activity EXP 6480464 Clodronic Acid results in decreased activity of PON1 protein CTD PMID:27387541 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of PON1 protein CTD PMID:16470657 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of PON1 mRNA CTD PMID:15033592 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PON1 mRNA CTD PMID:17602206 clofibric acid decreases expression ISO RGD:733240 6480464 Clofibric Acid results in decreased expression of PON1 mRNA CTD PMID:22653878 clopidogrel affects response to substance ISO RGD:1349272 6480464 PON1 gene polymorphism affects the susceptibility to clopidogrel CTD PMID:21170047 clopidogrel multiple interactions ISO RGD:1349272 6480464 PON1 protein results in increased metabolism of and results in increased activity of clopidogrel CTD PMID:21170047 copper atom decreases activity ISO RGD:1349272 6480464 Copper results in decreased activity of PON1 protein CTD PMID:16112460 copper atom affects binding ISO RGD:1349272 6480464 PON1 protein binds to Copper CTD PMID:23896426 copper atom multiple interactions ISO RGD:1349272 6480464 1 more ... CTD PMID:15104111 copper(0) decreases activity ISO RGD:1349272 6480464 Copper results in decreased activity of PON1 protein CTD PMID:16112460 copper(0) affects binding ISO RGD:1349272 6480464 PON1 protein binds to Copper CTD PMID:23896426 copper(0) multiple interactions ISO RGD:1349272 6480464 1 more ... CTD PMID:15104111 copper(II) sulfate multiple interactions ISO RGD:1349272 6480464 1 more ... CTD PMID:12871208 , PMID:15375178 copper(II) sulfate decreases expression ISO RGD:1349272 6480464 Copper Sulfate results in decreased expression of PON1 mRNA CTD PMID:19549813 coumarins increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of Coumarins CTD PMID:20353174 cyclophosphamide increases activity EXP 6480464 Cyclophosphamide results in increased activity of PON1 protein CTD PMID:17874068 cyclosporin A decreases expression ISO RGD:1349272 6480464 Cyclosporine results in decreased expression of PON1 mRNA CTD PMID:20106945 , PMID:27989131 desogestrel multiple interactions ISO RGD:733240 6480464 [Ethinyl Estradiol co-treated with Desogestrel] affects the activity of PON1 protein CTD PMID:17541152 dexamethasone increases expression ISO RGD:1349272 6480464 Dexamethasone results in increased expression of PON1 mRNA, Dexamethasone results in increased expression of PON1 protein CTD PMID:26434531 Diallyl sulfide decreases expression ISO RGD:733240 6480464 allyl sulfide results in decreased expression of PON1 mRNA CTD PMID:22653878 diazinon affects response to substance ISO RGD:1349272 6480464 PON1 gene polymorphism affects the susceptibility to Diazinon, PON1 protein affects the susceptibility to Diazinon CTD PMID:11888590 more ... diazinon decreases expression EXP 6480464 Diazinon results in decreased expression of PON1 mRNA CTD PMID:29383019 diazinon increases response to substance ISO RGD:733240 6480464 PON1 gene mutant form results in increased susceptibility to Diazinon CTD PMID:11022865 diazinon increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of Diazinon CTD PMID:16331452 diazinon affects metabolic processing ISO RGD:1349272 6480464 PON1 protein affects the metabolism of Diazinon CTD PMID:16002382 , PMID:16027737 diazoxon decreases response to substance ISO RGD:1349272 6480464 PON1 protein polymorphism results in decreased susceptibility to diazoxon, PON1 protein results in decreased susceptibility to diazoxon CTD PMID:19071155 more ... diazoxon increases response to substance ISO RGD:733240 6480464 PON1 gene mutant form results in increased susceptibility to diazoxon CTD PMID:11022865 diazoxon multiple interactions ISO RGD:1349272 6480464 PON1 protein polymorphism affects the reaction [PON1 protein results in increased hydrolysis of diazoxon] CTD PMID:19446239 diazoxon increases hydrolysis ISO RGD:1349272 6480464 PON1 protein polymorphism results in increased hydrolysis of diazoxon, PON1 protein results in increased hydrolysis of diazoxon CTD PMID:10898114 more ... diazoxon decreases hydrolysis ISO RGD:1349272 6480464 PON1 gene polymorphism results in decreased hydrolysis of diazoxon CTD PMID:12563177 diazoxon multiple interactions ISO RGD:733240 6480464 PON1 affects the susceptibility to [diazoxon co-treated with malaoxon] CTD PMID:19371602 diazoxon affects metabolic processing ISO RGD:1349272 6480464 PON1 protein affects the metabolism of diazoxon, PON1 protein polymorphism affects the metabolism of diazoxon CTD PMID:15924216 , PMID:19071155 diazoxon affects hydrolysis ISO RGD:1349272 6480464 PON1 gene polymorphism affects the hydrolysis of diazoxon CTD PMID:10898114 dichlorvos multiple interactions EXP 6480464 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein] more ... CTD PMID:20412842 , PMID:29098328 dichlorvos decreases activity EXP 6480464 Dichlorvos results in decreased activity of PON1 protein CTD PMID:29098328 dichlorvos decreases expression ISO RGD:733240 6480464 Dichlorvos results in decreased expression of PON1 mRNA, Dichlorvos results in decreased expression of PON1 protein CTD PMID:25891459 dichlorvos multiple interactions ISO RGD:733240 6480464 PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of CAT protein] more ... CTD PMID:25891459 , PMID:26814074 dichlorvos decreases response to substance EXP 6480464 PON1 protein results in decreased susceptibility to Dichlorvos CTD PMID:20412842 diclofenac multiple interactions ISO RGD:1349272 6480464 [pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein, [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein CTD PMID:29512227 dieldrin multiple interactions EXP 6480464 [Dieldrin co-treated with NR1I2 protein] results in increased expression of PON1 mRNA more ... CTD PMID:24615737 diiodine multiple interactions EXP 6480464 [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON1 protein, [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of PON1 protein CTD PMID:30090431 diisopropyl fluorophosphate increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of Isoflurophate CTD PMID:20176006 , PMID:21382471 diisopropyl fluorophosphate multiple interactions ISO RGD:1349272 6480464 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate] CTD PMID:21382471 dioleoyl phosphatidylcholine multiple interactions ISO RGD:1349272 6480464 1, 2-oleoylphosphatidylcholine inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] CTD PMID:12871208 dioxygen multiple interactions ISO RGD:1349272 6480464 Oxygen promotes the reaction [PON1 protein affects the metabolism of Paraoxon] CTD PMID:16391483 dioxygen increases activity ISO RGD:1349272 6480464 Oxygen results in increased activity of PON1 protein CTD PMID:16391483 dipalmitoyl phosphatidylglycerol multiple interactions ISO RGD:1349272 6480464 1, 2-dipalmitoylphosphatidylglycerol inhibits the reaction [Copper promotes the reaction [Ascorbic Acid results in decreased activity of PON1 protein]] CTD PMID:15104111 disodium selenite decreases expression ISO RGD:1349272 6480464 Sodium Selenite results in decreased expression of PON1 mRNA CTD PMID:18175754 doramapimod decreases expression EXP 6480464 BIRB 796 results in decreased expression of PON1 mRNA CTD PMID:24303162 dorsomorphin multiple interactions ISO RGD:1349272 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 elemental selenium multiple interactions ISO RGD:1349272 6480464 Selenium inhibits the reaction [Mercury results in decreased activity of PON1 protein], Selenium inhibits the reaction [Methylmercury Compounds results in decreased activity of PON1 protein] CTD PMID:21543280 endosulfan multiple interactions ISO RGD:1349272 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PON1 mRNA CTD PMID:26159488 entinostat increases expression ISO RGD:1349272 6480464 entinostat results in increased expression of PON1 mRNA CTD PMID:27188386 erucic acid multiple interactions ISO RGD:1349272 6480464 erucic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] CTD PMID:12871208 ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions ISO RGD:1349272 6480464 [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb more ... CTD PMID:27132127 ethylene glycol bis(2-aminoethyl)tetraacetic acid decreases activity ISO RGD:1349272 6480464 Egtazic Acid results in decreased activity of PON1 protein CTD PMID:27132127 ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions EXP 6480464 [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to O more ... CTD PMID:27132127 ethylene glycol bis(2-aminoethyl)tetraacetic acid decreases activity EXP 6480464 Egtazic Acid results in decreased activity of PON1 protein CTD PMID:27132127 farnesyl diphosphate multiple interactions ISO RGD:1349272 6480464 farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA], farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 , PMID:15690306 fenofibrate increases expression ISO RGD:1349272 6480464 Fenofibrate results in increased expression of PON1 protein CTD PMID:16123850 flavone increases expression ISO RGD:1349272 6480464 flavone results in increased expression of PON1 mRNA CTD PMID:15169886 fluticasone decreases activity ISO RGD:1349272 6480464 Fluticasone results in decreased activity of PON1 protein CTD PMID:31581362 fluvastatin multiple interactions EXP 6480464 fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon], fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] CTD PMID:14668577 fluvastatin decreases activity EXP 6480464 fluvastatin results in decreased activity of PON1 protein CTD PMID:14668577 fumonisin B1 decreases expression ISO RGD:733240 6480464 fumonisin B1 results in decreased expression of PON1 mRNA CTD PMID:16221962 furan decreases expression EXP 6480464 furan results in decreased expression of PON1 mRNA CTD PMID:15120968 gabapentin decreases activity ISO RGD:1349272 6480464 gabapentin results in decreased activity of PON1 protein CTD PMID:28032682 gamma-decalactone increases hydrolysis EXP 6480464 PON1 protein results in increased hydrolysis of decan-4-olide CTD PMID:15829432 glutathione multiple interactions ISO RGD:1349272 6480464 PON1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] CTD PMID:20079818 GW 4064 multiple interactions ISO RGD:1349272 6480464 pyrazolanthrone inhibits the reaction [GW 4064 results in decreased expression of PON1 mRNA] CTD PMID:16269825 GW 4064 decreases expression ISO RGD:1349272 6480464 GW 4064 results in decreased expression of PON1 mRNA CTD PMID:16269825 high-density lipoprotein cholesterol affects abundance ISO RGD:1349272 6480464 PON1 gene polymorphism affects the abundance of Cholesterol, HDL, PON1 polymorphism affects the abundance of Cholesterol, HDL CTD PMID:16030523 more ... high-density lipoprotein cholesterol multiple interactions ISO RGD:1349272 6480464 PON1 gene polymorphism affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL] more ... CTD PMID:16238680 high-density lipoprotein cholesterol increases activity ISO RGD:1349272 6480464 Cholesterol, HDL results in increased activity of PON1 protein CTD PMID:16128586 high-density lipoprotein cholesterol affects binding ISO RGD:1349272 6480464 PON1 protein binds to [APOA1 protein binds to Cholesterol, HDL] CTD PMID:16128586 homocysteine multiple interactions ISO RGD:733240 6480464 [Methionine results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein, [resveratrol results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein CTD PMID:19028542 hydrazine decreases expression EXP 6480464 hydrazine results in decreased expression of PON1 mRNA, hydrazine results in decreased expression of PON1 protein CTD PMID:15370871 hydrogen peroxide multiple interactions ISO RGD:1349272 6480464 Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] more ... CTD PMID:12871208 , PMID:15375178 hydrogen peroxide decreases activity ISO RGD:1349272 6480464 Hydrogen Peroxide results in decreased activity of PON1 protein CTD PMID:12871208 , PMID:15375178 hypochlorous acid decreases activity ISO RGD:1349272 6480464 Hypochlorous Acid results in decreased activity of PON1 protein CTD PMID:14671042 hypochlorous acid increases oxidation ISO RGD:1349272 6480464 Hypochlorous Acid results in increased oxidation of PON1 protein CTD PMID:15104111 hypochlorous acid multiple interactions ISO RGD:1349272 6480464 Hypochlorous Acid promotes the reaction [Copper promotes the reaction [Ascorbic Acid results in decreased activity of PON1 protein]] CTD PMID:15104111 iron atom multiple interactions ISO RGD:1349272 6480464 [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein more ... CTD PMID:16052486 iron atom multiple interactions EXP 6480464 [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein, [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein CTD PMID:16052486 iron(0) multiple interactions EXP 6480464 [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein, [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein CTD PMID:16052486 iron(0) multiple interactions ISO RGD:1349272 6480464 [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein more ... CTD PMID:16052486 iron(2+) sulfate (anhydrous) multiple interactions ISO RGD:1349272 6480464 [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] more ... CTD PMID:12871208 , PMID:15375178 isorhamnetin increases expression ISO RGD:1349272 6480464 3-methylquercetin results in increased expression of PON1 mRNA CTD PMID:20228421 L-ascorbic acid multiple interactions ISO RGD:1349272 6480464 1 more ... CTD PMID:12871208 more ... L-ascorbic acid decreases activity ISO RGD:1349272 6480464 Ascorbic Acid results in decreased activity of PON1 protein CTD PMID:15104111 L-ascorbic acid multiple interactions EXP 6480464 [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein, [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein CTD PMID:16052486 L-methionine multiple interactions ISO RGD:733240 6480464 [Methionine results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein CTD PMID:19028542 lead diacetate affects expression EXP 6480464 lead acetate affects the expression of PON1 mRNA CTD PMID:21864555 lead(0) decreases activity ISO RGD:1349272 6480464 Lead results in decreased activity of PON1 protein CTD PMID:16882531 lead(0) increases response to substance ISO RGD:1349272 6480464 PON1 gene SNP results in increased susceptibility to Lead CTD PMID:16882531 lead(2+) decreases activity ISO RGD:1349272 6480464 Lead results in decreased activity of PON1 protein CTD PMID:16882531 lead(2+) increases response to substance ISO RGD:1349272 6480464 PON1 gene SNP results in increased susceptibility to Lead CTD PMID:16882531 levetiracetam affects activity ISO RGD:1349272 6480464 Levetiracetam affects the activity of PON1 protein CTD PMID:28032682 levonorgestrel multiple interactions ISO RGD:733240 6480464 [Ethinyl Estradiol co-treated with Levonorgestrel] affects the activity of PON1 protein CTD PMID:17541152 linoleic acid multiple interactions ISO RGD:1349272 6480464 Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon], Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] CTD PMID:15375178 linoleic acid decreases activity ISO RGD:1349272 6480464 Linoleic Acid results in decreased activity of PON1 protein CTD PMID:12871208 , PMID:15375178 lysophosphatidylglycerol decreases activity ISO RGD:1349272 6480464 lysophosphatidylglycerol results in decreased activity of PON1 protein CTD PMID:15375178 lysophosphatidylglycerol multiple interactions ISO RGD:1349272 6480464 lysophosphatidylglycerol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] CTD PMID:15375178 malaoxon multiple interactions ISO RGD:733240 6480464 PON1 affects the susceptibility to [diazoxon co-treated with malaoxon] more ... CTD PMID:19371602 malonaldehyde multiple interactions ISO RGD:1349272 6480464 PON1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde] CTD PMID:20079818 mefenamic acid multiple interactions ISO RGD:1349272 6480464 [pyrrolidine analog binds to Palladium binds to Mefenamic Acid] which results in decreased activity of PON1 protein, [pyrrolidine analog binds to Platinum binds to Mefenamic Acid] which results in decreased activity of PON1 protein CTD PMID:29512227 mercury atom multiple interactions ISO RGD:1349272 6480464 Selenium inhibits the reaction [Mercury results in decreased activity of PON1 protein] CTD PMID:21543280 mercury atom decreases activity ISO RGD:1349272 6480464 Mercury results in decreased activity of PON1 protein CTD PMID:21543280 mercury(0) multiple interactions ISO RGD:1349272 6480464 Selenium inhibits the reaction [Mercury results in decreased activity of PON1 protein] CTD PMID:21543280 mercury(0) decreases activity ISO RGD:1349272 6480464 Mercury results in decreased activity of PON1 protein CTD PMID:21543280 metformin increases response to substance ISO RGD:733240 6480464 PON1 gene mutant form results in increased susceptibility to Metformin CTD PMID:26945512 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of PON1 mRNA CTD PMID:30467583 methimazole increases activity ISO RGD:1349272 6480464 Methimazole results in increased activity of PON1 protein CTD PMID:14678291 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of PON1 mRNA CTD PMID:15120968 methylglyoxal multiple interactions ISO RGD:1349272 6480464 Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon], Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] CTD PMID:15375178 methylglyoxal decreases activity ISO RGD:1349272 6480464 Pyruvaldehyde results in decreased activity of PON1 protein CTD PMID:15375178 mithramycin multiple interactions ISO RGD:1349272 6480464 Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 montelukast decreases activity ISO RGD:1349272 6480464 montelukast results in decreased activity of PON1 protein CTD PMID:31581362 moxifloxacin decreases activity ISO RGD:1349272 6480464 Moxifloxacin results in decreased activity of PON1 protein CTD PMID:31581362 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine affects the reaction [3 more ... CTD PMID:23644946 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PON1 mRNA, [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of PON1 protein CTD PMID:17602206 , PMID:20935162 N-nitrosodiethylamine multiple interactions ISO RGD:733240 6480464 [2 more ... CTD PMID:23457121 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of PON1 mRNA CTD PMID:19041683 N-nitrosodiethylamine decreases expression ISO RGD:733240 6480464 Diethylnitrosamine results in decreased expression of PON1 mRNA CTD PMID:24535843 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of PON1 protein CTD PMID:19716841 Nandrolone decanoate decreases activity ISO RGD:1349272 6480464 nandrolone decanoate results in decreased activity of PON1 protein CTD PMID:16153628 naphthalene decreases expression EXP 6480464 naphthalene analog results in decreased expression of PON1 mRNA CTD PMID:24976557 naphthalene decreases expression ISO RGD:733240 6480464 naphthalene results in decreased expression of PON1 mRNA CTD PMID:18757308 nickel atom decreases expression ISO RGD:733240 6480464 Nickel results in decreased expression of PON1 mRNA CTD PMID:12540486 nickel atom affects binding ISO RGD:1349272 6480464 PON1 protein binds to Nickel CTD PMID:23896426 nicotine decreases activity ISO RGD:1349272 6480464 Nicotine results in decreased activity of PON1 protein CTD PMID:24478552 nicotine multiple interactions ISO RGD:1349272 6480464 PON1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of PON1 mRNA CTD PMID:12700408 oleic acid multiple interactions ISO RGD:1349272 6480464 [Calcium co-treated with Oleic Acid] results in increased stability of PON1 protein more ... CTD PMID:12871208 more ... oleic acid decreases activity ISO RGD:1349272 6480464 Oleic Acid results in decreased activity of PON1 protein CTD PMID:15375178 organophosphorus compound increases hydrolysis ISO RGD:733240 6480464 PON1 protein results in increased hydrolysis of Organophosphorus Compounds CTD PMID:22209767 organophosphorus compound increases metabolic processing ISO RGD:1349272 6480464 PON1 protein results in increased metabolism of Organophosphorus Compounds CTD PMID:17078098 organophosphorus compound decreases expression ISO RGD:1349272 6480464 Organophosphorus Compounds results in decreased expression of PON1 protein CTD PMID:26340881 organophosphorus compound affects metabolic processing ISO RGD:1349272 6480464 PON1 protein affects the metabolism of Organophosphorus Compounds CTD PMID:15982977 organophosphorus compound multiple interactions ISO RGD:1349272 6480464 Oximes analog promotes the reaction [PON1 protein results in increased hydrolysis of and results in decreased activity of Organophosphorus Compounds], PON1 protein results in increased hydrolysis of and results in decreased activity of Organophosphorus Compounds CTD PMID:25304213 organophosphorus compound increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of Organophosphorus Compounds CTD PMID:22209767 organophosphorus compound affects response to substance ISO RGD:1349272 6480464 PON1 gene SNP affects the susceptibility to Organophosphorus Compounds, PON1 protein polymorphism affects the susceptibility to Organophosphorus Compounds CTD PMID:25867687 more ... orlistat increases activity ISO RGD:1349272 6480464 orlistat results in increased activity of PON1 protein CTD PMID:11820148 , PMID:17134960 oxamyl multiple interactions ISO RGD:1349272 6480464 [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to oxamyl, [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl CTD PMID:27132127 oxamyl multiple interactions EXP 6480464 [Calcium results in increased activity of PON1 protein] which affects the susceptibility to oxamyl, [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl CTD PMID:27132127 ozone decreases expression ISO RGD:733240 6480464 Ozone results in decreased expression of PON1 mRNA CTD PMID:12763052 palladium multiple interactions ISO RGD:1349272 6480464 [pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein, [pyrrolidine analog binds to Palladium binds to Mefenamic Acid] which results in decreased activity of PON1 protein CTD PMID:29512227 palmitoleic acid multiple interactions ISO RGD:1349272 6480464 palmitoleic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein], palmitoleic acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] CTD PMID:12871208 , PMID:15375178 palmitoleic acid decreases activity ISO RGD:1349272 6480464 palmitoleic acid results in decreased activity of PON1 protein CTD PMID:15375178 pamidronate multiple interactions EXP 6480464 [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone more ... CTD PMID:27387541 pamidronate decreases activity EXP 6480464 pamidronate results in decreased activity of PON1 protein CTD PMID:27387541 panobinostat multiple interactions ISO RGD:1349272 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PON1 mRNA CTD PMID:27188386 panobinostat decreases expression ISO RGD:1349272 6480464 panobinostat results in decreased expression of PON1 mRNA CTD PMID:26272509 paracetamol affects expression ISO RGD:733240 6480464 Acetaminophen affects the expression of PON1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1349272 6480464 Acetaminophen results in decreased expression of PON1 mRNA CTD PMID:29067470 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of PON1 protein CTD PMID:16099942 paraoxon increases activity ISO RGD:1349272 6480464 Paraoxon results in increased activity of PON1 protein CTD PMID:18519978 paraoxon decreases response to substance EXP 6480464 PON1 results in decreased susceptibility to Paraoxon CTD PMID:11022865 paraoxon multiple interactions ISO RGD:1349272 6480464 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] more ... CTD PMID:15375178 more ... paraoxon multiple interactions EXP 6480464 [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon more ... CTD PMID:14668577 more ... paraoxon decreases response to substance ISO RGD:1349272 6480464 PON1 protein mutant form results in decreased susceptibility to Paraoxon CTD PMID:23159884 paraoxon increases hydrolysis ISO RGD:1349272 6480464 PON1 protein mutant form results in increased hydrolysis of Paraoxon, PON1 protein results in increased hydrolysis of Paraoxon CTD PMID:15375178 more ... paraoxon affects metabolic processing ISO RGD:1349272 6480464 PON1 protein affects the metabolism of Paraoxon, PON1 protein polymorphism affects the metabolism of Paraoxon CTD PMID:11304470 more ... paraoxon increases metabolic processing ISO RGD:1349272 6480464 PON1 protein results in increased metabolism of Paraoxon CTD PMID:21629682 paraoxon affects response to substance ISO RGD:1349272 6480464 PON1 gene polymorphism affects the susceptibility to Paraoxon CTD PMID:20839225 paraoxon affects hydrolysis ISO RGD:1349272 6480464 PON1 3' UTR SNP affects the hydrolysis of Paraoxon more ... CTD PMID:20839225 , PMID:9313934 paraoxon increases metabolic processing ISO RGD:733240 6480464 PON1 protein results in increased metabolism of Paraoxon CTD PMID:23223497 paraoxon increases hydrolysis EXP 6480464 PON1 protein results in increased hydrolysis of Paraoxon CTD PMID:14668577 more ... parathion increases metabolic processing ISO RGD:1349272 6480464 PON1 gene mutant form results in increased metabolism of Parathion CTD PMID:12625227 parathion increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of Parathion CTD PMID:16331452 parathion-methyl multiple interactions ISO RGD:1349272 6480464 Methyl Parathion results in decreased expression of and results in decreased activity of PON1 protein CTD PMID:26948828 parathion-methyl decreases expression ISO RGD:1349272 6480464 Methyl Parathion results in decreased expression of PON1 mRNA CTD PMID:26948828 pentane-2,3-dione decreases expression EXP 6480464 2, 3-pentanedione results in decreased expression of PON1 mRNA CTD PMID:25710175 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of PON1 mRNA CTD PMID:19162173 perfluorooctanoic acid decreases expression ISO RGD:733240 6480464 perfluorooctanoic acid results in decreased expression of PON1 mRNA CTD PMID:17681415 more ... perfluorooctanoic acid multiple interactions ISO RGD:733240 6480464 [perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of PON1 mRNA, PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of PON1 mRNA] CTD PMID:20118188 , PMID:23626681 phenobarbital multiple interactions EXP 6480464 [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of PON1 protein CTD PMID:20935162 phenobarbital increases expression ISO RGD:733240 6480464 Phenobarbital results in increased expression of PON1 mRNA, Phenobarbital results in increased expression of PON1 protein CTD PMID:28218408 , PMID:28541575 phenobarbital multiple interactions ISO RGD:733240 6480464 NR1I3 gene mutant form inhibits the reaction [Phenobarbital results in increased expression of PON1 mRNA] CTD PMID:28218408 phenobarbital decreases expression ISO RGD:733240 6480464 Phenobarbital results in decreased expression of PON1 mRNA CTD PMID:22653878 phenobarbital affects expression ISO RGD:1349272 6480464 Phenobarbital affects the expression of PON1 mRNA CTD PMID:19159669 phenyl acetate affects hydrolysis ISO RGD:1349272 6480464 PON1 3' UTR SNP affects the hydrolysis of phenyl acetate more ... CTD PMID:20839225 phenyl acetate multiple interactions ISO RGD:1349272 6480464 [Polyethylene Glycols binds to PON1 protein] which results in increased hydrolysis of phenyl acetate CTD PMID:22414384 phenyl acetate increases hydrolysis EXP 6480464 PON1 protein results in increased hydrolysis of phenyl acetate CTD PMID:22414384 phenyl acetate multiple interactions EXP 6480464 [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate more ... CTD PMID:27387541 phenyl acetate affects metabolic processing ISO RGD:1349272 6480464 PON1 SNP affects the metabolism of phenyl acetate CTD PMID:25027835 phenyl acetate increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of phenyl acetate CTD PMID:22414384 phenylacetic acid multiple interactions ISO RGD:1349272 6480464 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] more ... CTD PMID:15375178 phenylacetic acid affects metabolic processing ISO RGD:1349272 6480464 PON1 protein affects the metabolism of phenylacetic acid, PON1 protein polymorphism affects the metabolism of phenylacetic acid CTD PMID:11304470 more ... phenylacetic acid increases hydrolysis ISO RGD:1349272 6480464 PON1 protein results in increased hydrolysis of phenylacetic acid CTD PMID:15375178 more ... phenylacetic acid increases hydrolysis EXP 6480464 PON1 protein results in increased hydrolysis of phenylacetic acid CTD PMID:14668577 , PMID:16052486 phenylacetic acid multiple interactions EXP 6480464 fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] CTD PMID:14668577 phenylacetic acid decreases hydrolysis ISO RGD:1349272 6480464 PON1 promoter SNP results in decreased hydrolysis of phenylacetic acid CTD PMID:16117861 phenylmercury acetate multiple interactions ISO RGD:1349272 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PON1 mRNA CTD PMID:27188386 phenytoin decreases expression ISO RGD:733240 6480464 Phenytoin results in decreased expression of PON1 mRNA CTD PMID:15136057 phenytoin affects activity ISO RGD:1349272 6480464 Phenytoin affects the activity of PON1 protein CTD PMID:28032682 pirinixic acid multiple interactions ISO RGD:1349272 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PON1 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:733240 6480464 pirinixic acid results in decreased expression of PON1 mRNA CTD PMID:16221962 pitavastatin increases expression ISO RGD:1349272 6480464 pitavastatin results in increased expression of PON1 mRNA CTD PMID:15690306 pitavastatin multiple interactions ISO RGD:1349272 6480464 farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] more ... CTD PMID:15690306 pitavastatin(1-) increases expression ISO RGD:1349272 6480464 pitavastatin results in increased expression of PON1 mRNA CTD PMID:15690306 pitavastatin(1-) multiple interactions ISO RGD:1349272 6480464 farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] more ... CTD PMID:15690306 platinum multiple interactions ISO RGD:1349272 6480464 [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein, [pyrrolidine analog binds to Platinum binds to Mefenamic Acid] which results in decreased activity of PON1 protein CTD PMID:29512227 platinum(0) multiple interactions ISO RGD:1349272 6480464 [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein, [pyrrolidine analog binds to Platinum binds to Mefenamic Acid] which results in decreased activity of PON1 protein CTD PMID:29512227 potassium dichromate affects expression ISO RGD:733240 6480464 Potassium Dichromate affects the expression of PON1 mRNA CTD PMID:23608068 pralidoxime multiple interactions EXP 6480464 pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein] CTD PMID:29098328 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:733240 6480464 Pregnenolone Carbonitrile results in decreased expression of PON1 mRNA CTD PMID:28903501 primidone decreases activity ISO RGD:1349272 6480464 Primidone results in decreased activity of PON1 protein CTD PMID:28032682 proanthocyanidin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein] CTD PMID:30273964 propanal increases expression ISO RGD:1349272 6480464 propionaldehyde results in increased expression of PON1 mRNA CTD PMID:26079696 pyrrolidine multiple interactions ISO RGD:1349272 6480464 [pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein more ... CTD PMID:29512227 quercetin increases expression ISO RGD:733240 6480464 Quercetin results in increased expression of PON1 mRNA, Quercetin results in increased expression of PON1 protein CTD PMID:20228421 quercetin multiple interactions ISO RGD:733240 6480464 Quercetin inhibits the reaction [Dietary Fats results in decreased expression of PON1 mRNA], Quercetin inhibits the reaction [Dietary Fats results in decreased expression of PON1 protein] CTD PMID:22447684 quercetin increases expression ISO RGD:1349272 6480464 Quercetin results in increased expression of PON1 mRNA, Quercetin results in increased expression of PON1 protein CTD PMID:15169886 , PMID:20728021 quercetin increases activity EXP 6480464 Quercetin results in increased activity of PON1 protein CTD PMID:19141295 quercetin increases expression EXP 6480464 Quercetin results in increased expression of PON1 mRNA CTD PMID:19141295 quercetin increases activity ISO RGD:1349272 6480464 Quercetin results in increased activity of PON1 protein CTD PMID:15169886 quercetin multiple interactions ISO RGD:1349272 6480464 7-ketocholesterol inhibits the reaction [Quercetin results in increased expression of PON1 mRNA] more ... CTD PMID:15169886 , PMID:20728021 quinolin-2(1H)-one multiple interactions ISO RGD:1349272 6480464 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate], 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] CTD PMID:21382471 quinolin-2-ol multiple interactions ISO RGD:1349272 6480464 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate], 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] CTD PMID:21382471 reactive oxygen species decreases activity ISO RGD:1349272 6480464 Reactive Oxygen Species results in decreased activity of PON1 protein CTD PMID:16055108 resveratrol multiple interactions ISO RGD:1349272 6480464 7-ketocholesterol inhibits the reaction [resveratrol results in increased expression of PON1 mRNA] more ... CTD PMID:15458977 more ... resveratrol multiple interactions ISO RGD:733240 6480464 [resveratrol results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein CTD PMID:19028542 resveratrol increases expression ISO RGD:733240 6480464 resveratrol results in increased expression of PON1 mRNA, resveratrol results in increased expression of PON1 protein CTD PMID:18930334 resveratrol increases expression ISO RGD:1349272 6480464 resveratrol results in increased expression of PON1 mRNA, resveratrol results in increased expression of PON1 protein CTD PMID:15458977 more ... resveratrol increases activity ISO RGD:1349272 6480464 resveratrol results in increased activity of PON1 protein CTD PMID:15458977 rifampicin increases expression ISO RGD:1349272 6480464 Rifampin results in increased expression of PON1 mRNA CTD PMID:26434531 Risedronate sodium increases activity EXP 6480464 Risedronic Acid results in increased activity of PON1 protein CTD PMID:27387541 Risedronate sodium multiple interactions EXP 6480464 [Risedronic Acid results in increased activity of PON1 protein] which results in increased metabolism of homocysteine thiolactone more ... CTD PMID:27387541 ritonavir decreases activity EXP 6480464 Ritonavir results in decreased activity of PON1 protein CTD PMID:27378623 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA], Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 protein] CTD PMID:25478064 rutin increases expression EXP 6480464 Rutin results in increased expression of PON1 mRNA CTD PMID:25478064 salicylates increases expression ISO RGD:1349272 6480464 Salicylates results in increased expression of PON1 mRNA CTD PMID:18519978 salicylates increases activity ISO RGD:1349272 6480464 Salicylates results in increased activity of PON1 protein CTD PMID:18519978 saquinavir decreases activity EXP 6480464 Saquinavir results in decreased activity of PON1 protein CTD PMID:27378623 sarin multiple interactions ISO RGD:1349272 6480464 PON1 protein inhibits the reaction [Sarin results in decreased activity of ACHE protein], PON1 protein inhibits the reaction [Sarin results in decreased activity of BCHE protein] CTD PMID:21329748 sarin increases hydrolysis ISO RGD:1349272 6480464 PON1 protein mutant form results in increased hydrolysis of Sarin, PON1 protein results in increased hydrolysis of Sarin CTD PMID:16331452 more ... sarin decreases response to substance ISO RGD:1349272 6480464 PON1 protein mutant form results in decreased susceptibility to Sarin CTD PMID:23159884 SB 431542 multiple interactions ISO RGD:1349272 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenic acid increases activity EXP 6480464 Selenic Acid deficiency results in increased activity of PON1 protein CTD PMID:23644946 selenic acid decreases expression EXP 6480464 Selenic Acid results in decreased expression of PON1 mRNA CTD PMID:23644946 selenic acid multiple interactions EXP 6480464 Selenic Acid deficiency inhibits the reaction [3 more ... CTD PMID:23644946 selenium atom multiple interactions ISO RGD:1349272 6480464 Selenium inhibits the reaction [Mercury results in decreased activity of PON1 protein], Selenium inhibits the reaction [Methylmercury Compounds results in decreased activity of PON1 protein] CTD PMID:21543280 silicon dioxide decreases expression ISO RGD:1349272 6480464 Silicon Dioxide results in decreased expression of PON1 mRNA, Silicon Dioxide results in decreased expression of PON1 protein CTD PMID:19679115 simvastatin multiple interactions ISO RGD:1349272 6480464 farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] more ... CTD PMID:14500290 , PMID:16238680 simvastatin increases expression ISO RGD:1349272 6480464 Simvastatin results in increased expression of PON1 mRNA CTD PMID:14500290 , PMID:15690306 sodium arsenite decreases expression ISO RGD:733240 6480464 sodium arsenite results in decreased expression of PON1 mRNA CTD PMID:17350061 sodium arsenite decreases expression ISO RGD:1349272 6480464 sodium arsenite results in decreased expression of PON1 mRNA CTD PMID:29301061 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of PON1 mRNA CTD PMID:12325037 sodium fluoride decreases activity EXP 6480464 Sodium Fluoride results in decreased activity of PON1 protein CTD PMID:24384758 sodium perchlorate multiple interactions EXP 6480464 [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON1 protein, [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of PON1 protein CTD PMID:30090431 Soman decreases response to substance ISO RGD:733240 6480464 PON1 protein results in decreased susceptibility to Soman CTD PMID:15707963 Soman increases hydrolysis ISO RGD:1349272 6480464 PON1 protein mutant form results in increased hydrolysis of Soman, PON1 protein results in increased hydrolysis of Soman CTD PMID:16331452 more ... Soman decreases response to substance ISO RGD:1349272 6480464 PON1 protein mutant form results in decreased susceptibility to Soman CTD PMID:23159884 Soman multiple interactions ISO RGD:1349272 6480464 PON1 protein inhibits the reaction [Soman results in decreased activity of ACHE protein], PON1 protein inhibits the reaction [Soman results in decreased activity of BCHE protein] CTD PMID:21329748 Soman increases hydrolysis ISO RGD:733240 6480464 PON1 protein results in increased hydrolysis of Soman CTD PMID:15707963 squalene multiple interactions ISO RGD:1349272 6480464 Squalene inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 sulfisomidine decreases activity ISO RGD:1349272 6480464 Sulfisomidine results in decreased activity of PON1 protein CTD PMID:28665493 sulfisoxazole decreases activity ISO RGD:1349272 6480464 Sulfisoxazole results in decreased activity of PON1 protein CTD PMID:28665493 tamoxifen decreases expression ISO RGD:733240 6480464 Tamoxifen results in decreased expression of PON1 mRNA CTD PMID:25123088 taurocholic acid multiple interactions ISO RGD:733240 6480464 FGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of PON1 mRNA], NR1H4 protein affects the reaction [Taurocholic Acid results in decreased expression of PON1 mRNA] CTD PMID:16284190 taurocholic acid decreases expression ISO RGD:733240 6480464 Taurocholic Acid results in decreased expression of PON1 mRNA CTD PMID:16284190 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PON1 mRNA, Carbon Tetrachloride results in decreased expression of PON1 protein CTD PMID:25478064 , PMID:31150632 tetrachloromethane decreases response to substance ISO RGD:1349272 6480464 PON1 protein results in decreased susceptibility to Carbon Tetrachloride CTD PMID:20079818 tetrachloromethane multiple interactions ISO RGD:1349272 6480464 PON1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] more ... CTD PMID:20079818 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of PON1 mRNA CTD PMID:12734012 tetrachloromethane multiple interactions EXP 6480464 Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA] more ... CTD PMID:25478064 , PMID:31150632 theophylline decreases activity ISO RGD:1349272 6480464 Theophylline results in decreased activity of PON1 protein CTD PMID:31581362 tiotropium bromide decreases activity ISO RGD:1349272 6480464 Tiotropium Bromide results in decreased activity of PON1 protein CTD PMID:31581362 titanium dioxide decreases expression ISO RGD:733240 6480464 titanium dioxide results in decreased expression of PON1 mRNA CTD PMID:23557971 trichostatin A decreases expression ISO RGD:1349272 6480464 trichostatin A results in decreased expression of PON1 mRNA CTD PMID:24935251 valproic acid affects expression ISO RGD:1349272 6480464 Valproic Acid affects the expression of PON1 mRNA CTD PMID:25979313 valproic acid decreases activity ISO RGD:1349272 6480464 Valproic Acid results in decreased activity of PON1 protein CTD PMID:28032682 valproic acid increases expression ISO RGD:1349272 6480464 Valproic Acid results in increased expression of PON1 mRNA CTD PMID:23179753 more ... valproic acid decreases expression ISO RGD:1349272 6480464 Valproic Acid results in decreased expression of PON1 mRNA CTD PMID:29154799 valproic acid decreases methylation ISO RGD:1349272 6480464 Valproic Acid results in decreased methylation of PON1 gene CTD PMID:29154799 vancomycin decreases activity EXP 6480464 Vancomycin results in decreased activity of PON1 protein CTD PMID:31454121 vancomycin multiple interactions EXP 6480464 zingerone affects the reaction [Vancomycin results in decreased activity of PON1 protein] CTD PMID:31454121 varenicline decreases activity ISO RGD:1349272 6480464 Varenicline results in decreased activity of PON1 protein CTD PMID:31581362 vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [Propylthiouracil results in decreased activity of PON1 protein] CTD PMID:15386442 vitamin E increases activity EXP 6480464 Vitamin E results in increased activity of PON1 protein CTD PMID:15386442 vorinostat decreases expression ISO RGD:1349272 6480464 vorinostat results in decreased expression of PON1 mRNA CTD PMID:26272509 vorinostat multiple interactions ISO RGD:1349272 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PON1 mRNA CTD PMID:27188386 VX nerve agent increases hydrolysis ISO RGD:1349272 6480464 PON1 protein mutant form results in increased hydrolysis of VX, PON1 protein results in increased hydrolysis of VX CTD PMID:20176005 , PMID:23159884 VX nerve agent decreases response to substance ISO RGD:1349272 6480464 PON1 protein mutant form results in decreased susceptibility to VX CTD PMID:23159884 zinc atom affects binding ISO RGD:1349272 6480464 PON1 protein binds to Zinc CTD PMID:23896426 zinc(0) affects binding ISO RGD:1349272 6480464 PON1 protein binds to Zinc CTD PMID:23896426 zingerone multiple interactions EXP 6480464 zingerone affects the reaction [Vancomycin results in decreased activity of PON1 protein] CTD PMID:31454121 zingerone affects activity EXP 6480464 zingerone affects the activity of PON1 protein CTD PMID:31454121 zoledronic acid increases activity EXP 6480464 zoledronic acid results in increased activity of PON1 protein CTD PMID:27387541 zoledronic acid multiple interactions EXP 6480464 [zoledronic acid results in increased activity of PON1 protein] which results in increased metabolism of phenyl acetate CTD PMID:27387541
Gene-Chemical Interaction Annotations
