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Gene: Pon1 (paraoxonase 1) Rattus norvegicus
Symbol: Pon1
Name: paraoxonase 1
Description: Exhibits aryldialkylphosphatase activity. Involved in several processes, including response to fatty acid; response to fluoride; and response to nutrient levels. Localizes to extracellular space and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; organophosphate response pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A-esterase 1; aromatic esterase 1; PON 1; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1
Homo sapiens (human) : PON1 (paraoxonase 1)  HGNC  Alliance
Mus musculus (house mouse) : Pon1 (paraoxonase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pon1 (paraoxonase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PON1 (paraoxonase 1)
Canis lupus familiaris (dog) : PON1 (paraoxonase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pon1 (paraoxonase 1)
Sus scrofa (pig) : PON1 (paraoxonase 1)
Chlorocebus sabaeus (African green monkey) : PON1 (paraoxonase 1)
Heterocephalus glaber (naked mole-rat) : Pon1 (paraoxonase 1)
more info ...
Allele / Splice: Pon1em1Mcwi   Pon1em2Mcwi   Pon1em3Mcwi  
Genetic Models: SS-Pon1em2Mcwi SS-Pon1em3Mcwi SS-Pon1em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0430,249,749 - 30,276,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,249,742 - 30,276,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,156,712 - 30,183,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4429,936,314 - 29,964,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1429,975,057 - 30,003,299 (-)NCBI
Celera428,821,674 - 28,848,125 (-)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Pon1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620062
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.