RGD Reference Report - Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum. - Rat Genome Database

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Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum.

Authors: Rothem, L  Hartman, C  Dahan, A  Lachter, J  Eliakim, R  Shamir, R 
Citation: Rothem L, etal., Free Radic Biol Med. 2007 Sep 1;43(5):730-9. Epub 2007 May 10.
RGD ID: 5509924
Pubmed: PMID:17664137   (View Abstract at PubMed)
DOI: DOI:10.1016/j.freeradbiomed.2007.05.003   (Journal Full-text)

We demonstrated previously that the paraoxonase (PON1/2/3) genes and proteins are expressed in human intestinal biopsies and in Caco-2 cells. The current study aims were to explore whether PON1/2/3 expression is different in inflammatory bowel diseases (IBD) or celiac disease compared to healthy controls, and to explore the intracellular localization of PON1/2/3. Our results showed that significantly fewer biopsies expressed PON1 and PON3 in the duodenum of celiac patients (PON1, P<0.0001; PON3, P=0.03), in the terminal ileum of Crohn's patients (PON1, P=0.001; PON3, P=0.008), and in the colon of UC patients (PON1, P=0.02; PON3, P=0.06) compared to controls. Since all three disorders share markedly elevated inflammatory mediators we explored the PON1/2/3 mRNA expression on cytokine stimulation. No changes were observed in Caco-2 and HT29 cells. Immunofluorescence experiments localized PON1/2/3 exclusively to the endoplasmic reticulum (ER) in both CaCo-2 and HT29 cells. These results demonstrate for the first time a novel relationship between PON1 and PON3 expression and several inflammatory gastrointestinal disorders. Together with the localization of PON1/2/3 enzymes to the ER, it may be suggested that PON1/2/3 may have extracellular functions as part of the host response in IBD and celiac disease.



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Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
PON1Humanceliac disease  IEP mRNA:decreased expression:duodenumRGD 
PON3Humanceliac disease  IEP mRNA:decreased expression:duodenumRGD 
Pon1Ratceliac disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
Pon1Mouseceliac disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
Pon3Ratceliac disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
Pon3Mouseceliac disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
PON1HumanCrohn's disease  IEP mRNA:decreased expression:terminal ileumRGD 
PON3HumanCrohn's disease  IEP mRNA:decreased expression:terminal ileumRGD 
Pon1RatCrohn's disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
Pon1MouseCrohn's disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
Pon3RatCrohn's disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
Pon3MouseCrohn's disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
PON1Humanulcerative colitis  IEP mRNA:decreased expression:colonRGD 
PON3Humanulcerative colitis  IEP mRNA:decreased expression:colonRGD 
Pon1Ratulcerative colitis  ISOPON1 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 
Pon1Mouseulcerative colitis  ISOPON1 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 
Pon3Ratulcerative colitis  ISOPON3 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 
Pon3Mouseulcerative colitis  ISOPON3 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 
1 to 18 of 18 rows


Genes (Rattus norvegicus)
Pon1  (paraoxonase 1) Pon3  (paraoxonase 3)

Genes (Mus musculus)
Pon1  (paraoxonase 1) Pon3  (paraoxonase 3)

Genes (Homo sapiens)
PON1  (paraoxonase 1) PON3  (paraoxonase 3)