RGD Reference Report - Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum. - Rat Genome Database

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Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum.

Authors: Rothem, L  Hartman, C  Dahan, A  Lachter, J  Eliakim, R  Shamir, R 
Citation: Rothem L, etal., Free Radic Biol Med. 2007 Sep 1;43(5):730-9. Epub 2007 May 10.
RGD ID: 5509924
Pubmed: PMID:17664137   (View Abstract at PubMed)
DOI: DOI:10.1016/j.freeradbiomed.2007.05.003   (Journal Full-text)

We demonstrated previously that the paraoxonase (PON1/2/3) genes and proteins are expressed in human intestinal biopsies and in Caco-2 cells. The current study aims were to explore whether PON1/2/3 expression is different in inflammatory bowel diseases (IBD) or celiac disease compared to healthy controls, and to explore the intracellular localization of PON1/2/3. Our results showed that significantly fewer biopsies expressed PON1 and PON3 in the duodenum of celiac patients (PON1, P<0.0001; PON3, P=0.03), in the terminal ileum of Crohn's patients (PON1, P=0.001; PON3, P=0.008), and in the colon of UC patients (PON1, P=0.02; PON3, P=0.06) compared to controls. Since all three disorders share markedly elevated inflammatory mediators we explored the PON1/2/3 mRNA expression on cytokine stimulation. No changes were observed in Caco-2 and HT29 cells. Immunofluorescence experiments localized PON1/2/3 exclusively to the endoplasmic reticulum (ER) in both CaCo-2 and HT29 cells. These results demonstrate for the first time a novel relationship between PON1 and PON3 expression and several inflammatory gastrointestinal disorders. Together with the localization of PON1/2/3 enzymes to the ER, it may be suggested that PON1/2/3 may have extracellular functions as part of the host response in IBD and celiac disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PON1Humanceliac disease  IEP mRNA:decreased expression:duodenumRGD 
PON3Humanceliac disease  IEP mRNA:decreased expression:duodenumRGD 
Pon1Ratceliac disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
Pon1Mouseceliac disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
Pon3Ratceliac disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
Pon3Mouseceliac disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:duodenum (human)RGD 
PON1HumanCrohn's disease  IEP mRNA:decreased expression:terminal ileumRGD 
PON3HumanCrohn's disease  IEP mRNA:decreased expression:terminal ileumRGD 
Pon1RatCrohn's disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
Pon1MouseCrohn's disease  ISOPON1 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
Pon3RatCrohn's disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
Pon3MouseCrohn's disease  ISOPON3 (Homo sapiens)mRNA:decreased expression:terminal ileum (human)RGD 
PON1Humanulcerative colitis  IEP mRNA:decreased expression:colonRGD 
PON3Humanulcerative colitis  IEP mRNA:decreased expression:colonRGD 
Pon1Ratulcerative colitis  ISOPON1 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 
Pon1Mouseulcerative colitis  ISOPON1 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 
Pon3Ratulcerative colitis  ISOPON3 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 
Pon3Mouseulcerative colitis  ISOPON3 (Homo sapiens)mRNA:decreased expression:colon (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pon1  (paraoxonase 1)
Pon3  (paraoxonase 3)

Genes (Mus musculus)
Pon1  (paraoxonase 1)
Pon3  (paraoxonase 3)

Genes (Homo sapiens)
PON1  (paraoxonase 1)
PON3  (paraoxonase 3)


Additional Information