PON1 (paraoxonase 1) - Rat Genome Database

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Gene: PON1 (paraoxonase 1) Homo sapiens
Symbol: PON1
Name: paraoxonase 1
RGD ID: 1349272
HGNC Page HGNC:9204
Description: Enables several functions, including aryldialkylphosphatase activity; arylesterase activity; and protein homodimerization activity. Involved in several processes, including phosphatidylcholine metabolic process; positive regulation of binding activity; and positive regulation of transport. Located in extracellular space. Part of spherical high-density lipoprotein particle. Implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Biomarker of several diseases, including allergic rhinitis; anemia (multiple); artery disease (multiple); autoimmune disease (multiple); and eye disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A-esterase 1; aromatic esterase 1; arylesterase 1; arylesterase B-type; ESA; esterase A; K-45; MVCD5; paraoxonase B-type; PON; PON 1; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38795,297,676 - 95,324,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl795,297,676 - 95,324,532 (-)EnsemblGRCh38hg38GRCh38
GRCh37794,926,988 - 94,953,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,764,924 - 94,791,780 (-)NCBINCBI36hg18NCBI36
Build 34794,571,638 - 94,598,495NCBI
Celera789,626,366 - 89,652,590 (-)NCBI
Cytogenetic Map7q21.3NCBI
HuRef789,534,701 - 89,560,922 (-)NCBIHuRef
CHM1_1794,857,684 - 94,883,916 (-)NCBICHM1_1
T2T-CHM13v2.0796,533,832 - 96,560,687 (-)NCBI
CRA_TCAGchr7v2794,256,665 - 94,282,884 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (EXP)
acute lymphoblastic leukemia  (IAGP)
Agricultural Workers' Diseases  (EXP)
Albuminuria  (IAGP)
allergic rhinitis  (IEP)
Alzheimer's disease  (IAGP)
amyotrophic lateral sclerosis  (EXP,IAGP)
amyotrophic lateral sclerosis type 1  (EXP)
anemia  (IDA,IEP)
arteriosclerosis  (IMP)
Arteritis  (EXP)
atherosclerosis  (EXP,IDA,IEP,ISO)
autistic disorder  (EXP)
Behcet's disease  (IEP)
beta thalassemia  (IEP)
beta-thalassemia major  (IEP)
Birth Weight  (EXP)
bone disease  (IEP)
Brain Neoplasms  (EXP)
breast cancer  (IAGP)
capillary leak syndrome  (IAGP)
cardiovascular system disease  (EXP)
cataract  (IEP)
celiac disease  (IEP)
cerebral cavernous malformation  (IAGP)
cerebral infarction  (IAGP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (EXP)
chronic lymphocytic leukemia  (IAGP)
chronic obstructive pulmonary disease  (IEP)
Colorectal Neoplasms  (EXP)
congestive heart failure  (EXP)
constipation  (EXP)
coronary artery disease  (EXP,IAGP,IEP)
coronary artery vasospasm  (EXP)
Coronary Disease  (EXP,IAGP,IEP)
Crohn's disease  (IEP)
dementia  (IAGP)
Diabetes Complications  (EXP)
diabetes mellitus  (EXP)
diabetic angiopathy  (IAGP)
Diabetic Nephropathies  (EXP,IAGP,IDA)
diabetic retinopathy  (EXP,IAGP,IEP)
disease of metabolism  (EXP)
exfoliation syndrome  (IEP)
Experimental Diabetes Mellitus  (IMP,ISO)
fatty liver disease  (EXP)
glucose intolerance  (IAGP)
heart disease  (EXP)
Hematologic Neoplasms  (EXP,IAGP)
hemorrhoid  (EXP)
Henoch-Schoenlein purpura  (IAGP)
Hypercholesterolemia  (EXP)
hyperglycemia  (IDA)
hyperhomocysteinemia  (EXP)
Hyperlipoproteinemia Type II  (EXP)
Hyperlipoproteinemias  (EXP,IDA)
hyperthyroidism  (EXP)
Insulin Resistance  (IAGP)
iron deficiency anemia  (IDA,IEP)
keratoconus  (IEP)
Kuhnt-Junius degeneration  (IAGP,IEP)
Lung Neoplasms  (EXP)
lymphoma  (EXP)
macular degeneration  (IAGP,IEP)
male infertility  (EXP)
membranoproliferative glomerulonephritis  (EXP)
mental depression  (EXP)
Metabolic Syndrome  (EXP,IEP)
Micronuclei, Chromosome-Defective  (EXP)
multiple myeloma  (IAGP,IDA,IEP)
myocardial infarction  (IAGP)
Nasal Polyps  (IEP)
non-Hodgkin lymphoma  (IAGP)
Occupational Diseases  (EXP)
open-angle glaucoma  (IAGP)
Organophosphate Poisoning  (EXP)
periodontal disease  (EXP)
persian gulf syndrome  (EXP)
pleomorphic xanthoastrocytoma  (IAGP)
Prenatal Exposure Delayed Effects  (EXP)
primary open angle glaucoma  (IAGP)
Primitive Neuroectodermal Tumors  (EXP)
prostate cancer  (IEP)
Prostatic Neoplasms  (EXP)
proteinuria  (IEP)
retinal vein occlusion  (IAGP,IEP)
rheumatoid arthritis  (EXP)
secondary Parkinson disease  (EXP)
sickle cell anemia  (IEP)
Sjogren's syndrome  (IEP)
spina bifida  (EXP)
Spinal Cord Injuries  (ISO)
toxic encephalopathy  (EXP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (IAGP,IEP)
ulcerative colitis  (IEP)
vitamin B12 deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(R)-mevalonic acid  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
2-trans,6-trans-farnesyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydrocoumarin  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (EXP)
4-nitrophenyl acetate  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-ketocholesterol  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP)
aflatoxin B1  (EXP)
albuterol  (EXP)
aldicarb  (EXP,ISO)
alendronic acid  (ISO)
ammonium chloride  (ISO)
ampicillin  (EXP,ISO)
angelica lactone  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arachidonic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
benzo[a]pyrene  (EXP)
Benzo[k]fluoranthene  (ISO)
bexarotene  (ISO)
bifenthrin  (ISO)
bisphenol A  (ISO)
bosentan  (EXP)
cadmium atom  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium dichloride  (EXP)
calcium(0)  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
chromium(3+) trichloride  (ISO)
ciprofibrate  (ISO)
ciprofloxacin  (EXP,ISO)
cisplatin  (ISO)
clindamycin phosphate  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clopidogrel  (EXP)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumarins  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
desogestrel  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (ISO)
diazinon  (EXP,ISO)
diazoxon  (EXP,ISO)
dichlorvos  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diiodine  (ISO)
diisopropyl fluorophosphate  (EXP)
dimethylarsinic acid  (ISO)
dioleoyl phosphatidylcholine  (EXP)
dioxygen  (EXP)
dipalmitoyl phosphatidylglycerol  (EXP)
disodium selenite  (EXP)
doramapimod  (ISO)
dorsomorphin  (EXP)
edaravone  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
entinostat  (EXP)
erucic acid  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
farnesyl diphosphate  (EXP)
fenitrothion  (ISO)
fenofibrate  (EXP)
flavone  (EXP)
fluticasone  (EXP)
fluvastatin  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
gabapentin  (EXP)
gamma-decalactone  (ISO)
glutathione  (EXP)
graphene oxide  (ISO)
GW 4064  (EXP)
high-density lipoprotein cholesterol  (EXP)
homocysteine  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
hypochlorous acid  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isorhamnetin  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
levetiracetam  (EXP)
levonorgestrel  (ISO)
linoleic acid  (EXP)
lysophosphatidylglycerol  (EXP)
malaoxon  (ISO)
malonaldehyde  (EXP)
mefenamic acid  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylglyoxal  (EXP)
mithramycin  (EXP)
montelukast  (EXP)
moxifloxacin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
Nandrolone decanoate  (EXP)
naphthalene  (ISO)
nickel atom  (EXP,ISO)
nicotine  (EXP)
nitrofen  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
oleic acid  (EXP)
organophosphorus compound  (EXP,ISO)
orlistat  (EXP)
oxamyl  (EXP,ISO)
ozone  (ISO)
palladium  (EXP)
palmitoleic acid  (EXP)
pamidronate  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
Paraoxon-methyl  (EXP,ISO)
parathion  (EXP,ISO)
parathion-methyl  (EXP)
pentane-2,3-dione  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenyl acetate  (EXP,ISO)
phenylacetic acid  (EXP,ISO)
phenylmercury acetate  (EXP)
phenytoin  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP)
pitavastatin(1-)  (EXP)
platinum  (EXP)
platinum(0)  (EXP)
potassium dichromate  (ISO)
pralidoxime  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primidone  (EXP)
proanthocyanidin  (ISO)
propanal  (EXP)
pyrrolidine  (EXP)
quercetin  (EXP,ISO)
quinolin-2(1H)-one  (EXP)
quinolin-2-ol  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
Risedronate sodium  (ISO)
ritonavir  (ISO)
rutin  (ISO)
salicylates  (EXP)
saquinavir  (ISO)
sarin  (EXP)
SB 431542  (EXP)
selenic acid  (ISO)
selenium atom  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sodium perchlorate  (ISO)
Soman  (EXP,ISO)
squalene  (EXP)
streptozocin  (ISO)
sulfisomidine  (EXP)
sulfisoxazole  (EXP)
tamoxifen  (ISO)
taurocholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (ISO)
tiotropium bromide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
varenicline  (EXP)
vitamin E  (ISO)
vorinostat  (EXP)
VX nerve agent  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zingerone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers. Abdin AA, etal., J Diabetes Complications. 2009 Mar 26.
2. Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients. Angayarkanni N, etal., Eye (Lond). 2008 Jul;22(7):969-74. Epub 2007 Dec 14.
3. Assessment of paraoxonase and arylesterase activities in patients with iron deficiency anemia. Aslan M, etal., Atherosclerosis. 2007 Apr;191(2):397-402. Epub 2006 May 8.
4. Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration. Ates O, etal., Tohoku J Exp Med. 2009 Jan;217(1):17-22.
5. Risk of myocardial infarction associated with Gln/Arg 192 polymorphism in the human paraoxonase gene and diabetes mellitus. The REGICOR Investigators. Aubo C, etal., Eur Heart J. 2000 Jan;21(1):33-8.
6. Association of lipids, lipoproteins, apolipoproteins and paraoxonase enzyme activity with premature coronary artery disease. Azizi F, etal., Coron Artery Dis. 2002 Feb;13(1):9-16.
7. Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration. Baird PN, etal., Am J Ophthalmol. 2004 Oct;138(4):665-6.
8. LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects. Barbieri M, etal., J Clin Endocrinol Metab. 2002 Jan;87(1):222-5.
9. Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Bradshaw G, etal., Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11029-34. Epub 2005 Jul 25.
10. [Comparative plasma proteomic analysis of patients with multiple myeloma treated with bortezomib-based regimens]. Cumova J, etal., Klin Onkol. 2012;25(1):17-25.
11. NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution. de Aguiar Goncalves BA, etal., Cancer Causes Control. 2012 Nov;23(11):1811-9. doi: 10.1007/s10552-012-0060-5. Epub 2012 Sep 14.
12. Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families. Deakin S, etal., J Clin Endocrinol Metab. 2002 Mar;87(3):1268-73.
13. Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease. Dowling P, etal., BMC Genomics. 2014 Oct 17;15:904. doi: 10.1186/1471-2164-15-904.
14. Oxidant-antioxidant status in Egyptian children with sickle cell anemia: a single center based study. El-Ghamrawy MK, etal., J Pediatr (Rio J). 2014 May-Jun;90(3):286-92. doi: 10.1016/j.jped.2013.09.005. Epub 2014 Feb 5.
15. Decreased HDL-dependent paraoxonase and arylesterase enzyme activity may indicate a worse prognosis in multiple myeloma. Ellidag HY, etal., Asian Pac J Cancer Prev. 2014;15(22):9847-51.
16. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Erlich PM, etal., Hum Mol Genet. 2006 Jan 1;15(1):77-85. Epub 2005 Nov 30.
17. Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients. Eroglu M, etal., Kaohsiung J Med Sci. 2013 Jul;29(7):368-73. doi: 10.1016/j.kjms.2012.11.004. Epub 2013 Jan 16.
18. Association study of detoxification genes in age related macular degeneration. Esfandiary H, etal., Br J Ophthalmol. 2005 Apr;89(4):470-4.
19. Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus. Flekac M, etal., Physiol Res. 2008;57(5):717-26. Epub 2007 Oct 11.
20. Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. Gallicchio L, etal., Cancer Detect Prev. 2007;31(2):95-101. Epub 2007 Apr 10.
21. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
22. Relationship between paraoxonase-1 (PON1) activity and lipoprotein (a) levels in Turkish coronary artery disease patients living in the Antalya region. Gocmen YA, etal., Eur J Cardiovasc Prev Rehabil. 2005 Apr;12(2):185-6.
23. Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp. Hao W, etal., Eur Arch Otorhinolaryngol. 2013 May;270(6):1861-5. doi: 10.1007/s00405-012-2307-x. Epub 2012 Dec 13.
24. Expression and activity of paraoxonase 1 in human cataractous lens tissue. Hashim Z, etal., Free Radic Biol Med. 2009 Apr 15;46(8):1089-95. doi: 10.1016/j.freeradbiomed.2009.01.012. Epub 2009 Jan 23.
25. A polymorphism of the paraoxonase gene associated with variation in plasma lipoproteins in a genetic isolate. Hegele RA, etal., Arterioscler Thromb Vasc Biol. 1995 Jan;15(1):89-95.
26. Paraoxonase 1 gene polymorphisms and dementia in humans. Helbecque N, etal., Neurosci Lett 2004 Mar 18;358(1):41-4.
27. Association between PON 1 polymorphisms, PON activity and diabetes complications. Hofer SE, etal., J Diabetes Complications. 2006 Sep-Oct;20(5):322-8.
28. Serum paraoxonase activity and its relationship to diabetic complications in patients with non-insulin-dependent diabetes mellitus. Ikeda Y, etal., Metabolism. 1998 May;47(5):598-602.
29. Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases. Imai Y, etal., Atherosclerosis. 2000 Apr;149(2):435-42.
30. Paraoxonase 1 gene polymorphisms influence clinical features of open-angle glaucoma. Inagaki Y, etal., Graefes Arch Clin Exp Ophthalmol. 2006 Aug;244(8):984-90. Epub 2006 Jan 13.
31. Trace elements and oxidative stress in chronic obstructive pulmonary disease. Isik B, etal., Saudi Med J. 2005 Dec;26(12):1882-5.
32. Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents. Jokanovic M Toxicol Lett. 2009 Jul 10;188(1):1-10. doi: 10.1016/j.toxlet.2009.03.017. Epub 2009 Mar 31.
33. Serum paraoxonase activity is decreased in the active stage of Behcet's disease. Karakucuk S, etal., Br J Ophthalmol. 2004 Oct;88(10):1256-8.
34. Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk. Kerridge I, etal., Br J Haematol. 2002 Aug;118(2):477-81.
35. The Gln-Arg 191 polymorphism of the human paraoxonase gene is not associated with the risk of coronary artery disease among Chinese in Taiwan. Ko YL, etal., Atherosclerosis. 1998 Dec;141(2):259-64.
36. Paraoxonase and arylesterase activities in children with iron deficiency anemia and vitamin B12 deficiency anemia. Koc A, etal., Pediatr Hematol Oncol. 2012 May;29(4):345-53. doi: 10.3109/08880018.2011.645185.
37. Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population. Kokouva M, etal., Toxicology. 2013 May 10;307:12-6. doi: 10.1016/j.tox.2012.07.003. Epub 2012 Jul 16.
38. Paraoxonase 1 (PON1) status in gastroesophageal malignancies and associated paraneoplastic syndromes - connection with inflammation. Krzystek-Korpacka M, etal., Clin Biochem. 2008 Jul;41(10-11):804-11. doi: 10.1016/j.clinbiochem.2008.03.012. Epub 2008 Apr 4.
39. Paraoxonase-1 and oxidative status in common Mediterranean beta-thalassaemia mutations trait, and their relations to atherosclerosis. Labib HA, etal., J Clin Pathol. 2011 May;64(5):437-42. doi: 10.1136/jcp.2011.090209. Epub 2011 Mar 22.
40. The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. Lawlor DA, etal., BMC Genet. 2004 Jun 23;5:17.
41. Protective effect of paraoxonase 1 of high-density lipoprotein in type 2 diabetic patients with nephropathy. Li C and Gu Q, Nephrology (Carlton). 2009 Aug;14(5):514-20. Epub 2008 Feb 3.
42. Xenobiotic gene polymorphisms and susceptibility to multiple myeloma. Lincz LF, etal., Haematologica. 2004 May;89(5):628-9.
43. The relationships between PON1 activity as well as oxLDL levels and coronary artery lesions in CHD patients with diabetes mellitus or impaired fasting glucose. Lu C, etal., Coron Artery Dis. 2008 Dec;19(8):565-73.
44. Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndrome. Mackness B, etal., Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1545-50. Epub 2006 Apr 20.
45. Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy. Mackness B, etal., Clin Sci (Lond). 2000 Mar;98(3):355-63.
46. Administration of exogenous erythropoietin beta affects lipid peroxidation and serum paraoxonase-1 activity and concentration in predialysis patients with chronic renal disease and anaemia. Marsillach J, etal., Clin Exp Pharmacol Physiol. 2007 Apr;34(4):347-9.
47. Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia. Merono T, etal., Clin Nutr. 2016 Feb 13. pii: S0261-5614(16)00059-5. doi: 10.1016/j.clnu.2016.02.003.
48. Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus. Murata M, etal., Diabet Med. 2004 Aug;21(8):837-44.
49. Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy. Nowak M, etal., Clin Exp Med. 2010 Sep;10(3):185-92. doi: 10.1007/s10238-009-0084-7. Epub 2009 Dec 11.
50. R192Q paraoxonase gene variant is associated with a change in HDL-cholesterol level during dietary caloric restriction in nondiabetic healthy males. Obata T, etal., J Atheroscler Thromb. 2003;10(1):57-62.
51. Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD). Oczos J, etal., Age (Dordr). 2013 Oct;35(5):1651-62. doi: 10.1007/s11357-012-9467-x. Epub 2012 Sep 7.
52. Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus. Odawara M, etal., J Clin Endocrinol Metab. 1997 Jul;82(7):2257-60.
53. The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients. Ombres D, etal., Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1611-6.
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PMID:24057271   PMID:24057998   PMID:24080149   PMID:24123308   PMID:24130171   PMID:24147648   PMID:24167353   PMID:24170778   PMID:24186356   PMID:24200861   PMID:24206655   PMID:24211756  
PMID:24228251   PMID:24229619   PMID:24267244   PMID:24280342   PMID:24301778   PMID:24314997   PMID:24364225   PMID:24384301   PMID:24399815   PMID:24423117   PMID:24440837   PMID:24448003  
PMID:24456870   PMID:24473115   PMID:24477584   PMID:24500802   PMID:24501102   PMID:24504666   PMID:24524596   PMID:24620935   PMID:24665146   PMID:24679385   PMID:24682159   PMID:24700021  
PMID:24704632   PMID:24706428   PMID:24711634   PMID:24719500   PMID:24721823   PMID:24731121   PMID:24763406   PMID:24769273   PMID:24793345   PMID:24813034   PMID:24826966   PMID:24830418  
PMID:24831724   PMID:24833785   PMID:24841661   PMID:24918121   PMID:24920129   PMID:24936519   PMID:24965284   PMID:24972570   PMID:24988089   PMID:25027835   PMID:25036896   PMID:25037113  
PMID:25038992   PMID:25038995   PMID:25070982   PMID:25093614   PMID:25124603   PMID:25155309   PMID:25179377   PMID:25180809   PMID:25218815   PMID:25241610   PMID:25261854   PMID:25264968  
PMID:25297118   PMID:25301263   PMID:25304213   PMID:25367762   PMID:25386619   PMID:25406539   PMID:25420483   PMID:25427726   PMID:25445355   PMID:25459919   PMID:25463530   PMID:25464671  
PMID:25490030   PMID:25500007   PMID:25510689   PMID:25530140   PMID:25575948   PMID:25600530   PMID:25600537   PMID:25668223   PMID:25684529   PMID:25723374   PMID:25734763   PMID:25741997  
PMID:25746376   PMID:25801214   PMID:25814092   PMID:25835425   PMID:25880731   PMID:25935173   PMID:25953737   PMID:25956367   PMID:25962362   PMID:25964115   PMID:25965560   PMID:25966589  
PMID:25968808   PMID:25991559   PMID:26009633   PMID:26016451   PMID:26025407   PMID:26028114   PMID:26039660   PMID:26091975   PMID:26103614   PMID:26149812   PMID:26154629   PMID:26178739  
PMID:26193203   PMID:26218756   PMID:26227792   PMID:26241956   PMID:26251874   PMID:26358807   PMID:26467378   PMID:26549836   PMID:26562028   PMID:26567339   PMID:26573179   PMID:26620773  
PMID:26632904   PMID:26654051   PMID:26656640   PMID:26723569   PMID:26763308   PMID:26769660   PMID:26773174   PMID:26773776   PMID:26780374   PMID:26795139   PMID:26815637   PMID:26829396  
PMID:26870959   PMID:26884296   PMID:26886353   PMID:26888625   PMID:26919159   PMID:26978533   PMID:26993251   PMID:26994915   PMID:27000849   PMID:27004558   PMID:27085770   PMID:27129797  
PMID:27166546   PMID:27167582   PMID:27168012   PMID:27230552   PMID:27238966   PMID:27240017   PMID:27262841   PMID:27309259   PMID:27313824   PMID:27325571   PMID:27337219   PMID:27338244  
PMID:27387094   PMID:27450784   PMID:27461010   PMID:27510818   PMID:27520507   PMID:27546893   PMID:27578362   PMID:27640339   PMID:27668323   PMID:27712128   PMID:27771368   PMID:27805900  
PMID:27812605   PMID:27838376   PMID:27858903   PMID:27863359   PMID:27863895   PMID:28026940   PMID:28027289   PMID:28038449   PMID:28076455   PMID:28145863   PMID:28167245   PMID:28185016  
PMID:28196109   PMID:28278274   PMID:28347194   PMID:28376720   PMID:28396702   PMID:28399619   PMID:28433610   PMID:28441923   PMID:28445984   PMID:28467805   PMID:28477577   PMID:28514442  
PMID:28602123   PMID:28653653   PMID:28657841   PMID:28665493   PMID:28667918   PMID:28689109   PMID:28779954   PMID:28835968   PMID:28862184   PMID:28866115   PMID:29049176   PMID:29049204  
PMID:29050675   PMID:29118461   PMID:29156090   PMID:29168398   PMID:29176871   PMID:29215249   PMID:29215590   PMID:29226640   PMID:29229890   PMID:29233102   PMID:29254890   PMID:29273831  
PMID:29308836   PMID:29314660   PMID:29322801   PMID:29393817   PMID:29409844   PMID:29462797   PMID:29511261   PMID:29546656   PMID:29604466   PMID:29626583   PMID:29682786   PMID:29773198  
PMID:29782842   PMID:29843993   PMID:29848980   PMID:29858231   PMID:29879566   PMID:29945323   PMID:29952962   PMID:29953969   PMID:29970690   PMID:29981194   PMID:30128909   PMID:30129401  
PMID:30130521   PMID:30165052   PMID:30173430   PMID:30178714   PMID:30240501   PMID:30241945   PMID:30244352   PMID:30261890   PMID:30314292   PMID:30359673   PMID:30381540   PMID:30410197  
PMID:30448568   PMID:30455362   PMID:30465883   PMID:30477582   PMID:30500525   PMID:30506510   PMID:30509298   PMID:30529100   PMID:30545386   PMID:30588556   PMID:30618305   PMID:30654664  
PMID:30678610   PMID:30681756   PMID:30853125   PMID:30857497   PMID:30868319   PMID:30875327   PMID:30891852   PMID:30900463   PMID:30903418   PMID:30946296   PMID:30947571   PMID:30975138  
PMID:30977447   PMID:30979955   PMID:30987726   PMID:31005548   PMID:31012132   PMID:31080207   PMID:31102685   PMID:31128980   PMID:31177124   PMID:31180492   PMID:31263978   PMID:31292763  
PMID:31294627   PMID:31336443   PMID:31351988   PMID:31353473   PMID:31374360   PMID:31379240   PMID:31400051   PMID:31430977   PMID:31467900   PMID:31476444   PMID:31531730   PMID:31626760  
PMID:31626928   PMID:31653192   PMID:31737129   PMID:31757567   PMID:31762361   PMID:31768953   PMID:31873734   PMID:31900240   PMID:31967744   PMID:31969002   PMID:31983193   PMID:32002976  
PMID:32034489   PMID:32076459   PMID:32090118   PMID:32114288   PMID:32114577   PMID:32148648   PMID:32326787   PMID:32429655   PMID:32472296   PMID:32519276   PMID:32549522   PMID:32556934  
PMID:32567023   PMID:32570269   PMID:32583675   PMID:32599353   PMID:32638685   PMID:32674726   PMID:32702814   PMID:32721231   PMID:32729307   PMID:32827712   PMID:32855040   PMID:32862511  
PMID:32902236   PMID:32905659   PMID:32930135   PMID:32940564   PMID:33033318   PMID:33144547   PMID:33164855   PMID:33218342   PMID:33284416   PMID:33325062   PMID:33425072   PMID:33484495  
PMID:33485193   PMID:33567022   PMID:33571670   PMID:33579580   PMID:33587860   PMID:33599870   PMID:33628379   PMID:33629320   PMID:33762698   PMID:33831384   PMID:33886674   PMID:33961781  
PMID:34131170   PMID:34351918   PMID:34356595   PMID:34445971   PMID:34452542   PMID:34593900   PMID:34626508   PMID:34628386   PMID:34634315   PMID:34637171   PMID:34698804   PMID:34711951  
PMID:34741558   PMID:34762786   PMID:34764653   PMID:34766662   PMID:35094534   PMID:35242296   PMID:35299679   PMID:35306973   PMID:35443473   PMID:35488563   PMID:35522182   PMID:35646794  


Candidate Gene Status
PON1 is a candidate Gene for QTL BW321_H
PON1 is a candidate Gene for QTL BMD1_H
Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38795,297,676 - 95,324,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl795,297,676 - 95,324,532 (-)EnsemblGRCh38hg38GRCh38
GRCh37794,926,988 - 94,953,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,764,924 - 94,791,780 (-)NCBINCBI36hg18NCBI36
Build 34794,571,638 - 94,598,495NCBI
Celera789,626,366 - 89,652,590 (-)NCBI
Cytogenetic Map7q21.3NCBI
HuRef789,534,701 - 89,560,922 (-)NCBIHuRef
CHM1_1794,857,684 - 94,883,916 (-)NCBICHM1_1
T2T-CHM13v2.0796,533,832 - 96,560,687 (-)NCBI
CRA_TCAGchr7v2794,256,665 - 94,282,884 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3965,168,090 - 5,193,987 (-)NCBIGRCm39mm39
GRCm39 Ensembl65,168,090 - 5,193,946 (-)Ensembl
GRCm3865,168,090 - 5,193,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,168,090 - 5,193,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,118,090 - 5,143,946 (-)NCBIGRCm37mm9NCBIm37
MGSCv3665,118,105 - 5,143,824 (-)NCBImm8
Celera65,314,337 - 5,340,485 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2433,294,737 - 33,325,759 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl433,294,722 - 33,321,360 (-)Ensembl
Rnor_6.0430,249,749 - 30,276,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,249,742 - 30,276,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,156,712 - 30,183,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4429,936,314 - 29,964,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1429,975,057 - 30,003,299 (-)NCBI
Celera428,821,674 - 28,848,125 (-)NCBICelera
Cytogenetic Map4q13NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543211,893,473 - 11,923,339 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,893,473 - 11,923,035 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17100,841,286 - 100,867,493 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7100,841,286 - 100,867,493 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0787,253,476 - 87,279,650 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11420,565,620 - 20,600,774 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,565,641 - 20,642,985 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,124,634 - 20,159,679 (-)NCBI
ROS_Cfam_1.01420,388,041 - 20,423,054 (-)NCBI
ROS_Cfam_1.0 Ensembl1420,388,051 - 20,422,924 (-)Ensembl
UMICH_Zoey_3.11420,532,696 - 20,567,711 (-)NCBI
UNSW_CanFamBas_1.01420,267,821 - 20,302,851 (-)NCBI
UU_Cfam_GSD_1.01420,525,175 - 20,560,208 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511833,883,628 - 33,908,421 (-)NCBI
SpeTri2.0NW_0049365854,954,871 - 4,979,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl974,926,048 - 74,974,723 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1974,943,646 - 74,974,720 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,327,318 - 82,339,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12153,713,434 - 53,739,658 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2153,714,012 - 53,739,875 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604250,595,418 - 50,621,447 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248131,949,614 - 1,979,882 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248131,953,796 - 1,979,846 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37794,936,918 - 94,937,092UniSTSGRCh37
Build 36794,774,854 - 94,775,028RGDNCBI36
Celera789,635,618 - 89,635,792RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,543,951 - 89,544,125UniSTS
CRA_TCAGchr7v2794,265,915 - 94,266,089UniSTS
GeneMap99-GB4 RH Map7492.54UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37794,937,408 - 94,937,521UniSTSGRCh37
Build 36794,775,344 - 94,775,457RGDNCBI36
Celera789,636,108 - 89,636,221RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,544,441 - 89,544,554UniSTS
CRA_TCAGchr7v2794,266,405 - 94,266,518UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37794,937,416 - 94,937,514UniSTSGRCh37
Build 36794,775,352 - 94,775,450RGDNCBI36
Celera789,636,116 - 89,636,214RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,544,449 - 89,544,547UniSTS
CRA_TCAGchr7v2794,266,413 - 94,266,511UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37794,928,112 - 94,928,249UniSTSGRCh37
Build 36794,766,048 - 94,766,185RGDNCBI36
Celera789,626,809 - 89,626,946RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,535,144 - 89,535,281UniSTS
CRA_TCAGchr7v2794,257,108 - 94,257,245UniSTS
GeneMap99-GB4 RH Map7490.51UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37794,927,762 - 94,927,940UniSTSGRCh37
Build 36794,765,698 - 94,765,876RGDNCBI36
Celera789,626,459 - 89,626,637RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,534,794 - 89,534,972UniSTS
CRA_TCAGchr7v2794,256,758 - 94,256,936UniSTS
GeneMap99-GB4 RH Map7496.19UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR616hsa-miR-616-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23497787

Predicted Target Of
Summary Value
Count of predictions:988
Count of miRNA genes:641
Interacting mature miRNAs:719
Transcripts:ENST00000222381, ENST00000433729, ENST00000462594, ENST00000470502, ENST00000542556
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
Medium 1 4 497 410 5 410 17 16 7 1
Low 58 103 456 42 111 37 725 13 1868 40 724 414 7 119 374
Below cutoff 2113 2020 684 160 808 14 3111 1851 1738 207 573 1012 149 1037 2040 2


Nucleotide Sequences
RefSeq Transcripts NG_008779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF402963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF402964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF402965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF539592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV652982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BJ993711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB122285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU499312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN106582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L48710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC160338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC167097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC269857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC269858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN461218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN614098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN614099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S64615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S64696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z70723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000222381   ⟹   ENSP00000222381
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl795,297,676 - 95,324,532 (-)Ensembl
RefSeq Acc Id: ENST00000433729   ⟹   ENSP00000407359
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl795,298,914 - 95,324,476 (-)Ensembl
RefSeq Acc Id: ENST00000462594
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl795,298,749 - 95,302,403 (-)Ensembl
RefSeq Acc Id: ENST00000470502
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl795,311,490 - 95,318,587 (-)Ensembl
RefSeq Acc Id: NM_000446   ⟹   NP_000437
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38795,297,676 - 95,324,532 (-)NCBI
GRCh37794,927,669 - 94,953,884 (-)ENTREZGENE
Build 36794,764,924 - 94,791,780 (-)NCBI Archive
HuRef789,534,701 - 89,560,922 (-)ENTREZGENE
CHM1_1794,857,684 - 94,883,916 (-)NCBI
T2T-CHM13v2.0796,533,832 - 96,560,687 (-)NCBI
CRA_TCAGchr7v2794,256,665 - 94,282,884 (-)ENTREZGENE
Protein Sequences
Protein RefSeqs NP_000437 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA60142 (Get FASTA)   NCBI Sequence Viewer  
  AAA60143 (Get FASTA)   NCBI Sequence Viewer  
  AAA97957 (Get FASTA)   NCBI Sequence Viewer  
  AAB25717 (Get FASTA)   NCBI Sequence Viewer  
  AAB27714 (Get FASTA)   NCBI Sequence Viewer  
  AAB27899 (Get FASTA)   NCBI Sequence Viewer  
  AAB41835 (Get FASTA)   NCBI Sequence Viewer  
  AAB59538 (Get FASTA)   NCBI Sequence Viewer  
  AAC35293 (Get FASTA)   NCBI Sequence Viewer  
  AAD02576 (Get FASTA)   NCBI Sequence Viewer  
  AAH74719 (Get FASTA)   NCBI Sequence Viewer  
  AAL04502 (Get FASTA)   NCBI Sequence Viewer  
  AAL04503 (Get FASTA)   NCBI Sequence Viewer  
  AAL04504 (Get FASTA)   NCBI Sequence Viewer  
  AAM97935 (Get FASTA)   NCBI Sequence Viewer  
  ACA53454 (Get FASTA)   NCBI Sequence Viewer  
  AEO20077 (Get FASTA)   NCBI Sequence Viewer  
  BAA12327 (Get FASTA)   NCBI Sequence Viewer  
  BAG36737 (Get FASTA)   NCBI Sequence Viewer  
  CAA94728 (Get FASTA)   NCBI Sequence Viewer  
  EAL24133 (Get FASTA)   NCBI Sequence Viewer  
  EAW76771 (Get FASTA)   NCBI Sequence Viewer  
  P27169 (Get FASTA)   NCBI Sequence Viewer  
  QGN01419 (Get FASTA)   NCBI Sequence Viewer  
  QGN01420 (Get FASTA)   NCBI Sequence Viewer  
  QMT58487 (Get FASTA)   NCBI Sequence Viewer  
  QMT58488 (Get FASTA)   NCBI Sequence Viewer  
  QMT58489 (Get FASTA)   NCBI Sequence Viewer  
  QMT58490 (Get FASTA)   NCBI Sequence Viewer  
  QMT58491 (Get FASTA)   NCBI Sequence Viewer  
  QMT58492 (Get FASTA)   NCBI Sequence Viewer  
  QMT58493 (Get FASTA)   NCBI Sequence Viewer  
  QMT58494 (Get FASTA)   NCBI Sequence Viewer  
  QMT58495 (Get FASTA)   NCBI Sequence Viewer  
  QMT58496 (Get FASTA)   NCBI Sequence Viewer  
  QMT58497 (Get FASTA)   NCBI Sequence Viewer  
  QMT58498 (Get FASTA)   NCBI Sequence Viewer  
  QMT58499 (Get FASTA)   NCBI Sequence Viewer  
  QMT58500 (Get FASTA)   NCBI Sequence Viewer  
  QMT58501 (Get FASTA)   NCBI Sequence Viewer  
  QMT58502 (Get FASTA)   NCBI Sequence Viewer  
  QMT58503 (Get FASTA)   NCBI Sequence Viewer  
  QMT58504 (Get FASTA)   NCBI Sequence Viewer  
  QMT58505 (Get FASTA)   NCBI Sequence Viewer  
  QMT58506 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_000437   ⟸   NM_000446
- Peptide Label: precursor
- UniProtKB: P27169 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000222381   ⟸   ENST00000222381
RefSeq Acc Id: ENSP00000407359   ⟸   ENST00000433729

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27169-F1-model_v2 AlphaFold P27169 1-355 view protein structure

RGD ID:7211113
Promoter ID:EPDNEW_H11302
Type:initiation region
Description:paraoxonase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38795,324,532 - 95,324,592EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000446.7(PON1):c.575A>G (p.Gln192Arg) single nucleotide variant Coronary artery disease, susceptibility to [RCV000014739]|Coronary artery spasm 2, susceptibility to [RCV000014740]|Enzyme activity finding [RCV000133464]|not provided [RCV001618211] Chr7:95308134 [GRCh38]
Chr7:94937446 [GRCh37]
pathogenic|risk factor|association|benign
NM_000446.7(PON1):c.163T>A (p.Leu55Met) single nucleotide variant Coronary artery disease, susceptibility to [RCV000014742]|Enzyme activity finding [RCV000133465]|Microvascular complications of diabetes, susceptibility to, 5 [RCV000014743]|not provided [RCV001682708] Chr7:95316772 [GRCh38]
Chr7:94946084 [GRCh37]
pathogenic|risk factor|association|benign
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
NM_000446.7(PON1):c.325G>T (p.Val109Leu) single nucleotide variant not provided [RCV000106288] Chr7:95315367 [GRCh38]
Chr7:94944679 [GRCh37]
not provided
NM_000446.6(PON1):c.-108C>T single nucleotide variant Enzyme activity finding [RCV000133466]|not provided [RCV001650832] Chr7:95324583 [GRCh38]
Chr7:94953895 [GRCh37]
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
GRCh38/hg38 7q21.3(chr7:95127070-97873487)x1 copy number loss See cases [RCV000135435] Chr7:95127070..97873487 [GRCh38]
Chr7:94756382..97502799 [GRCh37]
Chr7:94594318..97340735 [NCBI36]
GRCh38/hg38 7q21.2-21.3(chr7:92759144-97568646)x1 copy number loss See cases [RCV000141756] Chr7:92759144..97568646 [GRCh38]
Chr7:92388458..97197958 [GRCh37]
Chr7:92226394..97035894 [NCBI36]
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
GRCh37/hg19 7q21.3(chr7:94309218-95455621)x3 copy number gain See cases [RCV000448904] Chr7:94309218..95455621 [GRCh37]
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
GRCh37/hg19 7q21.2-22.1(chr7:92445452-99686985)x1 copy number loss Split hand-foot malformation 1 [RCV000656540] Chr7:92445452..99686985 [GRCh37]
GRCh37/hg19 7q21.3(chr7:93285237-96280817)x1 copy number loss not provided [RCV000682901] Chr7:93285237..96280817 [GRCh37]
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
GRCh37/hg19 7q21.3(chr7:93700162-96950914)x1 copy number loss not provided [RCV000746898] Chr7:93700162..96950914 [GRCh37]
NM_000446.7(PON1):c.910-146GT[2] microsatellite not provided [RCV001689552] Chr7:95299243..95299244 [GRCh38]
Chr7:94928555..94928556 [GRCh37]
NM_000446.7(PON1):c.202-121G>A single nucleotide variant not provided [RCV001647956] Chr7:95315611 [GRCh38]
Chr7:94944923 [GRCh37]
NM_000446.7(PON1):c.909+267dup duplication not provided [RCV001708089] Chr7:95301923..95301924 [GRCh38]
Chr7:94931235..94931236 [GRCh37]
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
NM_000446.7(PON1):c.603G>A (p.Ala201=) single nucleotide variant not provided [RCV000888420] Chr7:95308106 [GRCh38]
Chr7:94937418 [GRCh37]
NM_000446.7(PON1):c.210G>A (p.Lys70=) single nucleotide variant not provided [RCV000922251] Chr7:95315482 [GRCh38]
Chr7:94944794 [GRCh37]
likely benign
NM_000446.7(PON1):c.707A>G (p.Tyr236Cys) single nucleotide variant Amyotrophic lateral sclerosis [RCV001095522] Chr7:95306358 [GRCh38]
Chr7:94935670 [GRCh37]
uncertain significance
NM_000446.7(PON1):c.498-300AC[14] microsatellite not provided [RCV001659372] Chr7:95308476..95308483 [GRCh38]
Chr7:94937788..94937795 [GRCh37]
NM_000446.7(PON1):c.498-300AC[19] microsatellite not provided [RCV001690860] Chr7:95308475..95308476 [GRCh38]
Chr7:94937787..94937788 [GRCh37]
NM_000446.7(PON1):c.497+284del deletion not provided [RCV001640054] Chr7:95311167 [GRCh38]
Chr7:94940479 [GRCh37]
NM_000446.7(PON1):c.909+83_909+91del deletion not provided [RCV001676626] Chr7:95302114..95302122 [GRCh38]
Chr7:94931426..94931434 [GRCh37]
NM_000446.7(PON1):c.909+246A>G single nucleotide variant not provided [RCV001618811] Chr7:95301959 [GRCh38]
Chr7:94931271 [GRCh37]
NM_000446.7(PON1):c.145+237del deletion not provided [RCV001683951] Chr7:95318086 [GRCh38]
Chr7:94947398 [GRCh37]
NM_000446.7(PON1):c.75-304C>T single nucleotide variant not provided [RCV001698599] Chr7:95318697 [GRCh38]
Chr7:94948009 [GRCh37]
NM_000446.7(PON1):c.780+8G>A single nucleotide variant not provided [RCV000923953] Chr7:95306277 [GRCh38]
Chr7:94935589 [GRCh37]
likely benign
NM_000446.7(PON1):c.699-227T>C single nucleotide variant not provided [RCV001669547] Chr7:95306593 [GRCh38]
Chr7:94935905 [GRCh37]
NM_000446.7(PON1):c.498-101C>T single nucleotide variant not provided [RCV001644011] Chr7:95308312 [GRCh38]
Chr7:94937624 [GRCh37]
NM_000446.7(PON1):c.498-300AC[15] microsatellite not provided [RCV001682212] Chr7:95308476..95308481 [GRCh38]
Chr7:94937788..94937793 [GRCh37]
NM_000446.7(PON1):c.371-149C>A single nucleotide variant not provided [RCV001659549] Chr7:95311726 [GRCh38]
Chr7:94941038 [GRCh37]
NM_000446.7(PON1):c.146-154C>A single nucleotide variant not provided [RCV001608618] Chr7:95316943 [GRCh38]
Chr7:94946255 [GRCh37]
NM_000446.7(PON1):c.909+267_909+268dup duplication not provided [RCV001643235] Chr7:95301923..95301924 [GRCh38]
Chr7:94931235..94931236 [GRCh37]
NM_000446.7(PON1):c.75-264G>A single nucleotide variant not provided [RCV001698923] Chr7:95318657 [GRCh38]
Chr7:94947969 [GRCh37]
NM_000446.7(PON1):c.781-309dup duplication not provided [RCV001656560] Chr7:95302632..95302633 [GRCh38]
Chr7:94931944..94931945 [GRCh37]
NM_000446.7(PON1):c.498-300AC[17] microsatellite not provided [RCV001635846] Chr7:95308476..95308477 [GRCh38]
Chr7:94937788..94937789 [GRCh37]
NM_000446.7(PON1):c.497+176C>T single nucleotide variant not provided [RCV001636289] Chr7:95311275 [GRCh38]
Chr7:94940587 [GRCh37]
Single allele single nucleotide variant not provided [RCV001685810] Chr7:95324637 [GRCh38]
Chr7:94953949 [GRCh37]
NM_000446.7(PON1):c.498-300AC[16] microsatellite not provided [RCV001647741] Chr7:95308476..95308479 [GRCh38]
Chr7:94937788..94937791 [GRCh37]
NM_000446.7(PON1):c.909+130G>A single nucleotide variant not provided [RCV001614329] Chr7:95302075 [GRCh38]
Chr7:94931387 [GRCh37]
NM_000446.7(PON1):c.478A>G (p.Arg160Gly) single nucleotide variant not provided [RCV001650350] Chr7:95311470 [GRCh38]
Chr7:94940782 [GRCh37]
GRCh37/hg19 7q21.3(chr7:93516132-95668733) copy number loss Myoclonic dystonia 11 [RCV001254167] Chr7:93516132..95668733 [GRCh37]
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
NM_000446.7(PON1):c.376G>A (p.Ala126Thr) single nucleotide variant not provided [RCV001355528] Chr7:95311572 [GRCh38]
Chr7:94940884 [GRCh37]
uncertain significance
NM_000446.7(PON1):c.201+302G>A single nucleotide variant not provided [RCV001643423] Chr7:95316432 [GRCh38]
Chr7:94945744 [GRCh37]
NM_000446.7(PON1):c.498-174_498-173insTT insertion not provided [RCV001709179] Chr7:95308384..95308385 [GRCh38]
Chr7:94937696..94937697 [GRCh37]
NM_000446.7(PON1):c.75-94C>T single nucleotide variant not provided [RCV001709202] Chr7:95318487 [GRCh38]
Chr7:94947799 [GRCh37]
NM_000446.7(PON1):c.201+174C>T single nucleotide variant not provided [RCV001614907] Chr7:95316560 [GRCh38]
Chr7:94945872 [GRCh37]
Single allele single nucleotide variant not provided [RCV001686285] Chr7:95324601 [GRCh38]
Chr7:94953913 [GRCh37]
GRCh37/hg19 7q21.3(chr7:94309218-95455621) copy number gain not specified [RCV002053710] Chr7:94309218..95455621 [GRCh37]
uncertain significance
NM_000446.7(PON1):c.866T>A (p.Met289Lys) single nucleotide variant not provided [RCV002223639] Chr7:95302248 [GRCh38]
Chr7:94931560 [GRCh37]
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9204 AgrOrtholog
Ensembl Genes ENSG00000005421 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000222381 ENTREZGENE
  ENSP00000222381.3 UniProtKB/Swiss-Prot
  ENSP00000407359.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000222381 ENTREZGENE
  ENST00000222381.8 UniProtKB/Swiss-Prot
  ENST00000433729.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000005421 GTEx
Human Proteome Map PON1 Human Proteome Map
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paraoxonase1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5444 UniProtKB/Swiss-Prot
OMIM 168820 OMIM
  612633 OMIM
PANTHER PTHR11799:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33529 PharmGKB, RGD
  PARAOXONASE1 UniProtKB/Swiss-Prot
  P27169 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RA40 UniProtKB/Swiss-Prot
  Q16052 UniProtKB/Swiss-Prot
  Q6B0J6 UniProtKB/Swiss-Prot
  Q9UCB1 UniProtKB/Swiss-Prot