RGD Reference Report - Paraoxonase-1 and oxidative status in common Mediterranean beta-thalassaemia mutations trait, and their relations to atherosclerosis. - Rat Genome Database

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Paraoxonase-1 and oxidative status in common Mediterranean beta-thalassaemia mutations trait, and their relations to atherosclerosis.

Authors: Labib, HA  Etewa, RL  Gaber, OA  Atfy, M  Mostafa, TM  Barsoum, I 
Citation: Labib HA, etal., J Clin Pathol. 2011 May;64(5):437-42. doi: 10.1136/jcp.2011.090209. Epub 2011 Mar 22.
RGD ID: 11552582
Pubmed: PMID:21427447   (View Abstract at PubMed)
DOI: DOI:10.1136/jcp.2011.090209   (Journal Full-text)

AIMS: Investigation of paraoxonase-1 (PON1) activity with oxidative status parameters and the increased susceptibility to atherogenesis in beta-thalassaemia-trait (BTT) subjects. METHODS: Sixty BTT subjects and 20 age- and sex-matched healthy controls were enrolled in the study. Serum PON1, total antioxidant capacity (TAC), malondialdehyde (MDA) and carotid artery intima-media thickness (CIMT) were determined. Qualitative detection of beta-thalassaemia mutations was carried out. RESULTS: Serum PON1 activity and TAC were significantly lower in BTT subjects than in controls (p<0.001), while MDA and CIMT were significantly higher (p<0.001). In BTT subjects, TAC, MDA, and CIMT levels were significantly correlated with serum PON1 (r=0.945, -0.900, 0.940 and -0.922 respectively). Serum TAC and MDA were significantly correlated (r=-0.979). CONCLUSIONS: Oxidative stress is increased, while serum PON1 activity is decreased in BTT subjects. Decrease in PON1 activity is associated with the degree of oxidative stress, anaemia and increase in CIMT. Therefore, BTT subjects may be more prone to development of atherosclerosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
atherosclerosis susceptibilityIEP 11552582associated with Beta-Thalassemia and protein:decreased activity:serum (human)RGD 
atherosclerosis susceptibilityISOPON1 (Homo sapiens)11552582; 11552582associated with Beta-Thalassemia and protein:decreased activity:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pon1  (paraoxonase 1)

Genes (Mus musculus)
Pon1  (paraoxonase 1)

Genes (Homo sapiens)
PON1  (paraoxonase 1)


Additional Information