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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1multiple interactionsEXP 6480464CTD[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]PMID:30273964
Pon1decreases expressionISOPon1 (Mus musculus)6480464CTDCholic Acid results in decreased expression of PON1 mRNA; Cholic Acid results in decreased expression of PON1 proteinPMID:16269825
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