Pon1 (paraoxonase 1) - Rat Genome Database

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Gene: Pon1 (paraoxonase 1) Chinchilla lanigera
Analyze
Symbol: Pon1
Name: paraoxonase 1
RGD ID: 8773245
Description: ENCODES a protein that exhibits aryldialkylphosphatase activity (ortholog); arylesterase activity (ortholog); calcium ion binding (ortholog); INVOLVED IN aromatic compound catabolic process (ortholog); carboxylic acid catabolic process (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; organophosphate response pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute lymphoblastic leukemia (ortholog); Agricultural Workers' Diseases (ortholog); FOUND IN extracellular space (ortholog); high-density lipoprotein particle (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serum paraoxonase/arylesterase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,893,473 - 11,923,339 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,893,473 - 11,923,035 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
Agricultural Workers' Diseases  (ISO)
Albuminuria  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anemia  (ISO)
arteriosclerosis  (ISO)
Arteritis  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
beta-thalassemia major  (ISO)
Birth Weight  (ISO)
bone disease  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
capillary leak syndrome  (ISO)
cardiovascular system disease  (ISO)
cataract  (ISO)
celiac disease  (ISO)
cerebral cavernous malformation  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
constipation  (ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
dementia  (ISO)
Diabetes Complications  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
fatty liver disease  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hematologic Neoplasms  (ISO)
hemorrhoid  (ISO)
Henoch-Schoenlein purpura  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperlipoproteinemias  (ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (ISO)
iron deficiency anemia  (ISO)
keratoconus  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lung Neoplasms  (ISO)
lymphoma  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
membranoproliferative glomerulonephritis  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Nasal Polyps  (ISO)
non-Hodgkin lymphoma  (ISO)
Occupational Diseases  (ISO)
open-angle glaucoma  (ISO)
Organophosphate Poisoning  (ISO)
periodontal disease  (ISO)
persian gulf syndrome  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary open angle glaucoma  (ISO)
Primitive Neuroectodermal Tumors  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
spina bifida  (ISO)
Spinal Cord Injuries  (ISO)
toxic encephalopathy  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
vitamin B12 deficiency  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Pon1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,893,473 - 11,923,339 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,893,473 - 11,923,035 (-)NCBIChiLan1.0ChiLan1.0
PON1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl795,297,676 - 95,324,532 (-)EnsemblGRCh38hg38GRCh38
GRCh38795,297,676 - 95,324,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37794,926,988 - 94,953,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,764,924 - 94,791,780 (-)NCBINCBI36hg18NCBI36
Build 34794,571,638 - 94,598,495NCBI
Celera789,626,366 - 89,652,590 (-)NCBI
Cytogenetic Map7q21.3NCBI
HuRef789,534,701 - 89,560,922 (-)NCBIHuRef
CHM1_1794,857,684 - 94,883,916 (-)NCBICHM1_1
CRA_TCAGchr7v2794,256,665 - 94,282,884 (-)NCBI
Pon1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,168,090 - 5,193,987 (-)NCBIGRCm39mm39
GRCm39 Ensembl65,168,090 - 5,193,946 (-)Ensembl
GRCm3865,168,090 - 5,193,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,168,090 - 5,193,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,118,090 - 5,143,946 (-)NCBIGRCm37mm9NCBIm37
MGSCv3665,118,105 - 5,143,824 (-)NCBImm8
Celera65,314,337 - 5,340,485 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
Pon1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2433,294,737 - 33,325,759 (-)NCBI
Rnor_6.0 Ensembl430,249,742 - 30,276,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0430,249,749 - 30,276,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0430,156,712 - 30,183,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4429,936,314 - 29,964,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1429,975,057 - 30,003,299 (-)NCBI
Celera428,821,674 - 28,848,125 (-)NCBICelera
Cytogenetic Map4q13NCBI
PON1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17100,841,286 - 100,867,493 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7100,841,286 - 100,867,493 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0787,253,476 - 87,279,650 (-)NCBIMhudiblu_PPA_v0panPan3
PON1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,565,620 - 20,600,774 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,565,641 - 20,642,985 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,124,634 - 20,159,679 (-)NCBI
ROS_Cfam_1.01420,388,041 - 20,423,054 (-)NCBI
UMICH_Zoey_3.11420,532,696 - 20,567,711 (-)NCBI
UNSW_CanFamBas_1.01420,267,821 - 20,302,851 (-)NCBI
UU_Cfam_GSD_1.01420,525,175 - 20,560,208 (-)NCBI
Pon1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,883,628 - 33,908,421 (-)NCBI
SpeTri2.0NW_0049365854,954,871 - 4,979,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PON1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl974,926,048 - 74,974,724 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1974,943,646 - 74,974,720 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,327,318 - 82,339,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PON1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12153,713,434 - 53,739,658 (+)NCBI
ChlSab1.1 Ensembl2153,714,012 - 53,739,875 (+)Ensembl
Pon1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248131,953,796 - 1,979,846 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000013909   ⟹   ENSCLAP00000013754
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543211,893,473 - 11,923,339 (-)Ensembl
RefSeq Acc Id: XM_005388060   ⟹   XP_005388117
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543211,893,473 - 11,922,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005388062   ⟹   XP_005388119
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543211,893,473 - 11,923,035 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005388117 (Get FASTA)   NCBI Sequence Viewer  
  XP_005388119 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005388119   ⟸   XM_005388062
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005388117   ⟸   XM_005388060
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000013754   ⟸   ENSCLAT00000013909


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009506 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000013754 ENTREZGENE
Ensembl Transcript ENSCLAT00000013909 ENTREZGENE
NCBI Gene Pon1 ENTREZGENE