RGD Reference Report - Paraoxonase 1 gene polymorphisms and dementia in humans. - Rat Genome Database

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Paraoxonase 1 gene polymorphisms and dementia in humans.

Authors: Helbecque, N  Cottel, D  Codron, V  Berr, C  Amouyel, P 
Citation: Helbecque N, etal., Neurosci Lett 2004 Mar 18;358(1):41-4.
RGD ID: 1358562
Pubmed: PMID:15016430   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2003.12.100   (Journal Full-text)

Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high density lipoproteins, has antioxidative potential and was previously associated with an increased risk of cardiovascular diseases. The impact of two polymorphisms in PON1 (Gln192Arg associated with enzyme activity and T-107C associated with enzyme concentration) was examined in a case-control study. The two polymorphisms were independent risk factors for nonAD dementia, particularly in APOE-4 noncarriers. An at-'risk haplotype' could be constructed including the Gln192 and the T-107 alleles, suggesting that subjects at risk have lower plasma paraoxonase levels and this enzyme is less active.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
PON1Humandementia susceptibilityIAGP DNA:snp more ...RGD 
Pon1Ratdementia susceptibilityISOPON1 (Homo sapiens)DNA:snp more ...RGD 
Pon1Mousedementia susceptibilityISOPON1 (Homo sapiens)DNA:snp more ...RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
PON1HumanCognitive impairment susceptibilityIAGP DNA:snp more ...RGD 

Genes (Rattus norvegicus)
Pon1  (paraoxonase 1)

Genes (Mus musculus)
Pon1  (paraoxonase 1)

Genes (Homo sapiens)
PON1  (paraoxonase 1)