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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:71260
Term: pitavastatin(1-)
Definition: A hydroxy monocarboxylic acid anion that is the conjugate base of pitavastatin, obtained by deprotonation of the carboxy group.
Chemical ID: MESH:C108475
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1increases expressionISOPON1 (Homo sapiens)6480464CTDpitavastatin results in increased expression of PON1 mRNAPMID:15690306
Pon1multiple interactionsISOPON1 (Homo sapiens)6480464CTDfarnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]PMID:15690306
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