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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1decreases activityISOPON1 (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased activity of PON1 proteinPMID:12871208 PMID:15375178
Pon1multiple interactionsISOPON1 (Homo sapiens)6480464CTDHydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; Oleic Acid inhibits the reaction [Hydrogen Peroxide results in decreased activity of PON1 protein]PMID:12871208 PMID:15375178
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