GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pon1 | decreases activity | EXP | | 6480464 | CTD | Dichlorvos results in decreased activity of PON1 protein | PMID:29098328 | Pon1 | decreases response to substance | EXP | | 6480464 | CTD | PON1 protein results in decreased susceptibility to Dichlorvos | PMID:20412842 | Pon1 | multiple interactions | EXP | | 6480464 | CTD | 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; asoxime chloride inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; Trimedoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein] | PMID:20412842 PMID:29098328 | Pon1 | decreases expression | ISO | Pon1 (Mus musculus) | 6480464 | CTD | Dichlorvos results in decreased expression of PON1 mRNA; Dichlorvos results in decreased expression of PON1 protein | PMID:25891459 | Pon1 | multiple interactions | ISO | Pon1 (Mus musculus) | 6480464 | CTD | PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of HMOX1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NQO1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of PON1 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of PON1 protein] | PMID:25891459 PMID:26814074 | | ||||||||||||||||||||||
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