RGD Reference Report - Plasma paraoxonase activity and oxidative stress and their relationship to disease severity in children with allergic rhinitis. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Plasma paraoxonase activity and oxidative stress and their relationship to disease severity in children with allergic rhinitis.

Authors: Ozkaya, E  Akduman, H  Erenberk, U  Demir, A  Dundaroz, MR 
Citation: Ozkaya E, etal., Am J Rhinol Allergy. 2013 Jan;27(1):13-7. doi: 10.2500/ajra.2013.27.3837.
RGD ID: 8547583
Pubmed: PMID:23406590   (View Abstract at PubMed)
DOI: DOI:10.2500/ajra.2013.27.3837   (Journal Full-text)

BACKGROUND: Oxidative stress may play a role in the pathophysiology of several diseases including allergic rhinitis (AR). In children with AR an antioxidant enzyme paraoxonase (PON1) has not been previously investigated. The aim of this study was to investigate plasma PON1 activity and plasma total oxidant status (TOS), which are in the form of plasma reactive oxidants, and their association with severity of disease in house-mite-sensitive children with AR. METHODS: This study included 66 children with persistent AR and 40 healthy controls aged between 7 and 12 years old. Plasma PON1, TOS, and total serum immunoglobulin E (IgE) were measured. The nasal symptom scores and body mass index were evaluated at the time of blood collection. RESULTS: Mean serum PON1 levels were significantly lower and, TOS levels were higher in the patient group than in the control group (p




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
PON1Humanallergic rhinitis severityIEP protein:decreased activity:plasma (human)RGD 
Pon1Ratallergic rhinitis severityISOPON1 (Homo sapiens)protein:decreased activity:plasma (human)RGD 
Pon1Mouseallergic rhinitis severityISOPON1 (Homo sapiens)protein:decreased activity:plasma (human)RGD 


Genes (Rattus norvegicus)
Pon1  (paraoxonase 1)

Genes (Mus musculus)
Pon1  (paraoxonase 1)

Genes (Homo sapiens)
PON1  (paraoxonase 1)