RGD Reference Report - Oxidative indices correlate with dyslipidemia and pro-inflammatory cytokine levels in fluoride-exposed rats. - Rat Genome Database
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Oxidative indices correlate with dyslipidemia and pro-inflammatory cytokine levels in fluoride-exposed rats.

Authors: Afolabi, OK  Oyewo, EB  Adekunle, AS  Adedosu, OT  Adedeji, AL 
Citation: Afolabi OK, etal., Arh Hig Rada Toksikol. 2013 Dec;64(4):521-9. doi: 10.2478/10004-1254-64-2013-2351.
RGD ID: 8547691
Pubmed: (View Article at PubMed) PMID:24384758
DOI: Full-text: DOI:10.2478/10004-1254-64-2013-2351

The aim of this study was to establish the effects of fluoride on lipid metabolism and attendant inflammatory response by exposing rats to 50 mg L(-1) and 100 mg L(-1) of fluoride through drinking water for seven weeks. Both concentrations led to hypercholesterolemia while the 100 mg L(-1) concentration induced hypertriglyceridaemia. High density lipoprotein (HDL) cholesterol levels dropped in the exposed rats while interleukin 2 (IL-2) increased more than 1.5-fold (p<0.05) and IL-6 and plasma TNF-alpha more than 2.5 fold (p<0.05). Fluoride-exposed rats also had significantly higher levels of liver malondialdehyde (MDA) and plasma lipid hydroperoxide (LOOH) but lower plasma paraoxonase (PON1) activity. Oxidative stress indices correlated with pro-inflammatory cytokines and plasma cholesterol. In contrast, proinflammatory cytokines inversely correlated with plasma triglyceride, HDL cholesterol and PON1. Our results suggest that the association between fluoride exposure with cardiovascular diseases may be related to its ability to disturb lipid homeostasis, and trigger pro-inflammatory cytokines and oxidative stress.

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Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Pon1  (paraoxonase 1)


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