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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1increases expression EXP 401794573RGD3,3',4,4',5-pentachlorobiphenyl, PCB-126, increases expression of mRNA in rat liver 
Pon1increases activityEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased activity of PON1 proteinPMID:25530946 PMID:26006071
Pon1increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 proteinPMID:19692669 PMID:22266287 PMID:23644946 PMID:25530946 PMID:26006071 PMID:34256052
Pon1multiple interactionsEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of and results in increased activity of PON1 protein; Acetylcysteine affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of PON1 protein]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 mRNA]; Selenic Acid deficiency inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 mRNA]; Selenic Acid deficiency promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of PON1 protein]; Selenic Acid inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 mRNA]PMID:23644946 PMID:34256052
Pon1decreases expressionISOPon1 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PON1 mRNAPMID:22653878
Pon1multiple interactionsISOPon1 (Mus musculus)6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PON1 proteinPMID:23457121
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