Gstm1 (glutathione S-transferase mu 1) - Rat Genome Database

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Gene: Gstm1 (glutathione S-transferase mu 1) Rattus norvegicus
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Symbol: Gstm1
Name: glutathione S-transferase mu 1
RGD ID: 2755
Description: Enables several functions, including glutathione binding activity; glutathione transferase activity; and nickel cation binding activity. Involved in several processes, including glutathione metabolic process; response to ethanol; and response to lead ion. Located in cytosol and extracellular region. Part of protein-containing complex. Used to study cholestasis. Biomarker of hypertension and liver cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1); PARTICIPATES IN cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; glutathione conjugation pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase M1; glutathione S-transferase Yb-1 subunit; glutathione S-transferase, mu 1; glutathione-S-transferase mu type 1 (Yb1); Glutathione-S-transferase, mu type 1 (Yb1); GST 3-3; GST Yb1; GSTA3; GSTM1-1
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22195,649,845 - 195,655,402 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,292,372 - 203,297,745 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02201,174,485 - 201,179,858 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02195,991,446 - 195,996,819 (-)NCBIRnor_WKY
Rnor_6.02210,803,869 - 210,809,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,803,869 - 210,809,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,272,740 - 230,278,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,575,444 - 203,580,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,538,197 - 203,543,575 (-)NCBI
Celera2188,295,244 - 188,300,621 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
aggressive periodontitis  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (ISO)
amphetamine abuse  (ISO)
angle-closure glaucoma  (ISO)
aplastic anemia  (ISO)
asbestosis  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (ISO)
cataract  (ISO)
cervical cancer  (ISO)
cervix carcinoma  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chloracne  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (IDA)
Chromosome Aberrations  (ISO)
Chromosome Breakage  (ISO)
Chronic Bronchitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse large B-cell lymphoma  (ISO)
Disease Susceptibility  (ISO)
drug allergy  (ISO)
Drug-induced Anemia  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
end stage renal disease  (ISO)
erythema nodosum  (ISO)
esophageal atresia  (ISO)
esophageal cancer  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fanconi anemia  (ISO)
Female Infertility  (ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (ISO)
gallbladder cancer  (ISO)
gastritis  (ISO)
Genetic Predisposition to Disease  (ISO)
graft-versus-host disease  (ISO)
head and neck cancer  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hematologic Neoplasms  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 63  (ISO)
high grade glioma  (ISO)
Hirschsprung's disease  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (IEP)
Hypertension Resistant to Conventional Therapy  (ISO)
hypospadias  (ISO)
Hypotension  (IEP)
infectious mononucleosis  (ISO)
inflammatory bowel disease  (ISO)
Iron Overload  (ISO)
keratosis  (ISO)
Kidney Neoplasms  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
larynx cancer  (ISO)
leukemia  (ISO)
leukopenia  (ISO)
Leukoplakia  (ISO)
liver cirrhosis  (IEP,ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (IEP)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lymphoid leukemia  (ISO)
Lynch syndrome  (ISO)
macular degeneration  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
medulloblastoma  (ISO)
Mesothelioma  (ISO)
Metabolic Syndrome  (ISO)
methemoglobinemia  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
Mouth Abnormalities  (ISO)
movement disease  (ISO)
multiple myeloma  (IAGP,ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
Nasal Polyps  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasms, Second Primary  (ISO)
neurodegenerative disease  (ISO)
non-alcoholic fatty liver disease  (ISO)
optic neuritis  (ISO)
oral cavity cancer  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
orofacial cleft  (ISO)
ovarian carcinoma  (ISO)
ovary epithelial cancer  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
periodontitis  (ISO)
polycythemia vera  (ISO)
porphyria cutanea tarda  (ISO)
pre-malignant neoplasm  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pterygium  (ISO)
pulmonary emphysema  (ISO)
pulmonary tuberculosis  (ISO)
Raynaud disease  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
senile cataract  (ISO)
Sjögren-Mikulicz Syndrome  (ISO)
skin disease  (ISO)
skin melanoma  (ISO)
small intestine adenocarcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Temporomandibular Joint Disorders  (ISO)
Testicular Neoplasms  (ISO)
thalassemia  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
Vaso-occlusive Crisis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
1,4-dioxane  (ISO)
1-benzofuran  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
1H-imidazole  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-allylphenol  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-amino-7-methyl-1,7-dihydro-6H-purin-6-one  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-phenylpropanal  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxyphenylacetaldehyde  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
3-methylpyridine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-acetylaminofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-Chloronitrobenzene  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-Propylphenol  (EXP,ISO)
5-fluorouracil  (ISO)
5-Hydroxythalidomide  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-methyl-L-dopa  (ISO)
alpha-tocotrienol  (ISO)
ametryn  (EXP)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
angelica lactone  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzothiazole  (EXP)
benzotriazole  (EXP)
benzyl isothiocyanate  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
bifenthrin  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bromobenzene  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP,ISO)
carbon atom  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (EXP)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
ciprofibrate  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
cytarabine  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
delta-tocopherol  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzoylmethane  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
diquat  (EXP)
diuron  (EXP)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
elemental carbon  (ISO)
endosulfan  (EXP,ISO)
epichlorohydrin  (ISO)
epoxiconazole  (EXP,ISO)
Erucin  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
felbamate  (EXP)
fenamidone  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fluconazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
gabapentin  (EXP)
gamma-tocopherol  (EXP,ISO)
Geniposide  (EXP)
gentamycin  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
herbicide  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hexamethylene diisocyanate  (ISO)
hydrazine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP)
inulin  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
isomethyleugenol  (EXP,ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kahweol  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
lignan  (ISO)
limonene  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (EXP,ISO)
lithocholic acid sulfate  (EXP)
LY294002  (EXP)
mefenamic acid  (ISO)
MeIQx  (ISO)
melatonin  (EXP)
melphalan  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
metiram  (ISO)
microcystin  (EXP)
microcystin RR  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
muconic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(2-carbamoylethyl)-cysteine  (ISO)
N-acetyl-S-phenyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-hydroxy-PhIP  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
naphthalene-1,5-diamine  (ISO)
nefazodone  (EXP,ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
O-methyleugenol  (EXP,ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (ISO)
okadaic acid  (ISO)
oltipraz  (EXP,ISO)
oxfendazole  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (EXP,ISO)
PhIP  (ISO)
phlorizin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (EXP,ISO)
prostaglandin A2  (ISO)
prostaglandin J2  (ISO)
purine-6-thiol  (ISO)
pyrazinecarboxamide  (EXP)
pyrazines  (ISO)
pyrene  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinidine  (ISO)
quinine  (ISO)
rac-1,2-dichloropropane  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (EXP)
riddelliine  (EXP)
rifampicin  (ISO)
rifamycins  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
spermidine  (ISO)
spironolactone  (ISO)
styrene  (ISO)
styrene oxide  (EXP,ISO)
sulfinpyrazone  (ISO)
sulforaphane  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thiazoles  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-caffeic acid  (EXP)
triadimefon  (EXP)
triazoles  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression. 't Hoen PA, etal., Eur J Biochem. 2002 May;269(10):2574-83.
2. Oxidative stress in the denervated muscle. Abruzzo PM, etal., Free Radic Res. 2010 May;44(5):563-76. doi: 10.3109/10715761003692487.
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103. Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis. Kim JS, etal., J Clin Periodontol. 2004 Nov;31(11):959-64. doi: 10.1111/j.1600-051X.2004.00587.x.
104. Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma. Kim JW, etal., Cancer. 2000 May 1;88(9):2082-91.
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108. L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas. Kondratieva TV, etal., J Exp Clin Cancer Res. 2000 Jun;19(2):197-200.
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132. Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Mastalerz L, etal., Br J Dermatol. 2006 Feb;154(2):256-60.
133. Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. McBride MW, etal., Hypertension. 2005 Apr;45(4):786-92. Epub 2005 Feb 7.
134. Glutathione S-transferase genotype GSTM1 as a predictor of elevated angiogenic phenotype in patients with early onset breast cancer. Medeiros R, etal., Angiogenesis. 2004;7(1):53-8. doi: 10.1023/B:AGEN.0000037330.20121.d8.
135. Analysis of polymorphisms of tumor necrosis factor-alpha and polymorphic xenobiotic metabolizing enzymes in inflammatory bowel disease: study from northern India. Mittal RD, etal., J Gastroenterol Hepatol. 2007 Jun;22(6):920-4.
136. Association Study of Glutathione S-transferases Gene Polymorphisms (GSTM1 and GSTT1) with Ulcerative Colitis and Crohn's Disease in the South of Iran. Moini M, etal., Adv Biomed Res. 2017 Jun 6;6:67. doi: 10.4103/2277-9175.190981. eCollection 2017.
137. Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer. Moisio AL, etal., Gastroenterology. 1998 Dec;115(6):1387-94.
138. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Moore LE, etal., Carcinogenesis. 2007 Sep;28(9):1960-4. Epub 2007 Jul 7.
139. Role of glutathione-S-transferase (GST) polymorphisms in patients with advanced Hodgkin lymphoma: results from the HD2000 GISL trial. Morabito F, etal., Leuk Lymphoma. 2012 Mar;53(3):406-10. doi: 10.3109/10428194.2011.623254.
140. Association of the glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjogren's syndrome in Japanese individuals. Morinobu A, etal., Arthritis Rheum. 1999 Dec;42(12):2612-5.
141. Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis. Morinobu S, etal., Clin Exp Rheumatol. 2006 May-Jun;24(3):268-73.
142. Impact of cephaloridine on glutathione and related enzymes: comparison of in vivo and in vitro rat models. Moritz F, etal., Arch Toxicol. 1995;70(2):104-11.
143. Secretion of glutathione S-transferase isoforms in the seminiferous tubular fluid, tissue distribution and sex steroid binding by rat GSTM1. Mukherjee SB, etal., Biochem J 1999 May 15;340 ( Pt 1):309-20.
144. Gene-environment interaction in preterm delivery with special reference to organochlorine pesticides. Mustafa MD, etal., Mol Hum Reprod. 2013 Jan;19(1):35-42. doi: 10.1093/molehr/gas039. Epub 2012 Sep 3.
145. CYP1AI, glutathione S-transferase gene polymorphisms and risk of Polycythemia vera. Naffa RG, etal., Cancer Epidemiol. 2012 Feb;36(1):68-72. doi: 10.1016/j.canep.2011.05.001. Epub 2011 Oct 21.
146. The role of glutathione-S-transferase polymorphisms in ovarian cancer survival. Nagle CM, etal., Eur J Cancer. 2007 Jan;43(2):283-90. Epub 2006 Nov 3.
147. The Interaction between GSTT1, GSTM1, and GSTP1 Ile105Val Gene Polymorphisms and Environmental Risk Factors in Premalignant Gastric Lesions Risk. Negovan A, etal., Biomed Res Int. 2017;2017:7365080. doi: 10.1155/2017/7365080. Epub 2017 Jan 15.
148. A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism. Nicholl DJ, etal., Neurology. 1999 Oct 22;53(7):1415-21.
149. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk. Northwood EL, etal., Pharmacogenet Genomics. 2010 May;20(5):315-26. doi: 10.1097/FPC.0b013e3283395c6a.
150. Association of GSTM1 and GSTT1 gene deletions with risk of head and neck cancer in Pakistan: a case control study. Nosheen M, etal., Asian Pac J Cancer Prev. 2010;11(4):881-5.
151. Glutathione S-transferase genotype and p53 mutations in adenocarcinoma of the small intestine. Nørum Pedersen L, etal., Scand J Gastroenterol. 2003 Aug;38(8):845-9. doi: 10.1080/00365520310003976.
152. Genotypes of glutathione S-transferase M1 and N-acetyltransferase 2 in Japanese patients with gastric cancer. Oda Y, etal., Gastric Cancer. 1999 Nov;2(3):158-164. doi: 10.1007/s101209900012.
153. Transcriptome analysis of rat kidney cells continuously exposed to cadmium using DNA microarray. Ohba K, etal., J Toxicol Sci. 2007 Feb;32(1):103-5.
154. DNA methylation analysis of ALOX12 and GSTM1 in acute myeloid leukaemia identifies prognostically significant groups. Ohgami RS, etal., Br J Haematol. 2012 Oct;159(2):182-90. doi: 10.1111/bjh.12029. Epub 2012 Aug 28.
155. Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. Oldenburg J, etal., J Transl Med. 2007 Dec 27;5:70.
156. GSTM1 and codon 72 P53 polymorphism in multiple myeloma. Ortega MM, etal., Ann Hematol. 2007 Nov;86(11):815-9. Epub 2007 Jul 25.
157. Glutathione s-transferase m1, t1, and p1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Oz O, etal., Eur J Ophthalmol. 2006 Jan - Feb;16(1):105-110. doi: 10.5301/EJO.2008.3524.
158. Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Oz O, etal., Eur J Ophthalmol. 2006 Jan-Feb;16(1):105-10.
159. The impact of smoking on clinical features of Behcet's disease patients with glutathione S-transferase polymorphisms. Ozer HT, etal., Clin Exp Rheumatol. 2012 May-Jun;30(3 Suppl 72):S14-7. Epub 2012 Oct 8.
160. Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population. Pae CU, etal., Psychiatr Genet. 2004 Sep;14(3):147-50.
161. Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component. Perez-Pastene C, etal., Neurosci Lett. 2007 May 17;418(2):181-5. Epub 2007 Mar 14.
162. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
163. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
164. Role of GSTM1 Copy Number Variant in the Prognosis of Thai Colorectal Cancer Patients Treated with 5-FU-based Chemotherapy Pongtheerat T and Saelee P, Asian Pac J Cancer Prev. 2016 Oct 1;17(10):4719-4722. doi: 10.22034/apjcp.2016.17.10.4719.
165. GOA pipeline RGD automated data pipeline
166. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
167. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Rossini A, etal., Carcinogenesis. 2007 Dec;28(12):2537-42. doi: 10.1093/carcin/bgm222. Epub 2007 Oct 4.
168. Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India. Roy N, etal., PLoS One. 2016 Mar 3;11(3):e0149843. doi: 10.1371/journal.pone.0149843. eCollection 2016.
169. Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy. Rudolph A, etal., Int J Cancer. 2012 Sep 1;131(5):E841-8. doi: 10.1002/ijc.27428. Epub 2012 May 29.
170. CYP1A1, GSTM1, GSTT1 and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians. Sakai K, etal., Asian Pac J Cancer Prev. 2016;17(2):781-4. doi: 10.7314/apjcp.2016.17.2.781.
171. Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women. Sakoda LC, etal., Breast Cancer Res Treat. 2008 May;109(1):143-55. Epub 2007 Jul 12.
172. Frequency of glutathione-S-transferase 1 gene deletion and its possible correlation with cataract formation. Sekine Y, etal., Exp Eye Res. 1995 Feb;60(2):159-63.
173. Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients. Senhaji N, etal., Mediators Inflamm. 2015;2015:248060. doi: 10.1155/2015/248060. Epub 2015 Oct 28.
174. Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. Shaheen SO, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1141-8.e7. Epub 2010 Nov 4.
175. [Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]. Shao G, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2000 Dec;21(6):420-3.
176. The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Shao L, etal., Neuroscience. 2008 Jan 24;151(2):518-24. Epub 2007 Nov 13.
177. GSTM1 and GSTT1 polymorphism and susceptibility to esophageal cancer in high- and low-risk regions of India. Sharma A, etal., Tumour Biol. 2013 Oct;34(5):3249-57. doi: 10.1007/s13277-013-0897-6. Epub 2013 Jun 8.
178. A case control study of gene environmental interaction in fetal growth restriction with special reference to organochlorine pesticides. Sharma E, etal., Eur J Obstet Gynecol Reprod Biol. 2012 Apr;161(2):163-9. doi: 10.1016/j.ejogrb.2012.01.008. Epub 2012 Feb 4.
179. Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer. Sharma R, etal., Oral Dis. 2010 Oct;16(7):668-73. doi: 10.1111/j.1601-0825.2010.01676.x.
180. Genetic polymorphisms of CYP2E1 and GSTM1 loci and susceptibility to anti-tuberculosis drug-induced hepatotoxicity. Sharma SK, etal., Int J Tuberc Lung Dis. 2014 May;18(5):588-93. doi: 10.5588/ijtld.13.0344.
181. Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients. Sharma V, etal., Ann Hematol. 2010 Apr;89(4):411-4. doi: 10.1007/s00277-009-0847-y. Epub 2009 Oct 17.
182. Polymorphism in CYP1A1, GSTMI, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias. Shekharyadav C, etal., Hum Exp Toxicol. 2011 Oct;30(10):1464-74. doi: 10.1177/0960327110392402. Epub 2011 Feb 7.
183. [Effects of Yiguanjian Decoction on liver cirrhosis formation:a differential proteomics study in rats]. Shen DZ, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Feb;8(2):158-67.
184. Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer. Shen J, etal., World J Gastroenterol. 2005 Oct 14;11(38):6056-60. doi: 10.3748/wjg.v11.i38.6056.
185. Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, and GSTP1) in Egyptian pediatric patients with sickle cell disease. Shiba HF, etal., Pediatr Dev Pathol. 2014 Jul-Aug;17(4):265-70. doi: 10.2350/14-03-1452-OA.1. Epub 2014 May 19.
186. Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers. Sikdar N, etal., Int J Cancer. 2004 Mar;109(1):95-101. doi: 10.1002/ijc.11610.
187. Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population. Singh H, etal., Am J Obstet Gynecol. 2008 Mar;198(3):303.e1-6. Epub 2008 Feb 21.
188. Total activity of glutathione-S-transferase (GST) and polymorphisms of GSTM1 and GSTT1 genes conferring risk for the development of age related cataracts. Sireesha R, etal., Exp Eye Res. 2012 May;98:67-74. doi: 10.1016/j.exer.2012.03.002. Epub 2012 Mar 16.
189. Glutathione S-transferase M1 null genotype as a risk modifier for solvent-induced chronic toxic encephalopathy. Soderkvist P, etal., Scand J Work Environ Health. 1996 Oct;22(5):360-3.
190. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Srivastava A, etal., Blood. 2004 Sep 1;104(5):1574-7. Epub 2004 May 13.
191. Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes. Stanley JA, etal., Free Radic Biol Med. 2013 Mar 5;61C:179-196. doi: 10.1016/j.freeradbiomed.2013.02.006.
192. Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study. Stanulla M, etal., Blood. 2000 Feb 15;95(4):1222-8.
193. Glutathione-S-transferase T1 and M1 gene polymorphisms in Greek patients with multiple sclerosis: a pilot study. Stavropoulou C, etal., Eur J Neurol. 2007 May;14(5):572-4.
194. DNA damage and related modifier genes in Italian cystic fibrosis patients. Sterpone S, etal., Biol Res. 2009;42(4):477-86. doi: /S0716-97602009000400009. Epub 2010 Jan 29.
195. The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Strange RC, etal., Carcinogenesis. 1991 Jan;12(1):25-8.
196. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
197. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
198. Influence of germline polymorphisms of GSTT1, GSTM1, and GSTP1 in familial versus sporadic breast cancer susceptibility and survival. Syamala VS, etal., Fam Cancer. 2007 Dec 14;.
199. Impact of glutathione S-transferase gene deletion on early relapse in childhood B-precursor acute lymphoblastic leukemia. Takanashi M, etal., Haematologica. 2003 Nov;88(11):1238-44.
200. Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis. Tikly M, etal., Free Radic Biol Med. 2004 Jun 1;36(11):1403-7.
201. Glutathione S-transferase M1 gene polymorphism is related to COPD in patients with non-small-cell lung cancer. Tkacova R, etal., Wien Klin Wochenschr. 2004 Feb 28;116(4):131-4.
202. Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. Tomaki M, etal., Pulm Pharmacol Ther. 2007;20(5):596-605. Epub 2006 Jul 11.
203. Treatment of MDS patients with recombinant human erythropoietin and the role of GSTs. Tsabouri SE, etal., J Exp Clin Cancer Res. 2004 Sep;23(3):417-24.
204. Genetic polymorphisms in CYP1A1 and GSTM1 predispose humans to PCBs/PCDFs-induced skin lesions. Tsai PC, etal., Chemosphere. 2006 May;63(8):1410-8. Epub 2006 Apr 3.
205. Null type of glutathione S-transferase M1 polymorphism is associated with early onset pterygium. Tsai YY, etal., Mol Vis. 2004 Jul 15;10:458-61.
206. Pharmacogenetic influence of GST polymorphisms on anthracycline-based chemotherapy responses and toxicity in breast cancer patients: a multi-analytical approach. Tulsyan S, etal., Mol Diagn Ther. 2013 Dec;17(6):371-9. doi: 10.1007/s40291-013-0045-4.
207. Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment. Van Eyken E, etal., J Med Genet. 2007 Sep;44(9):570-8. Epub 2007 May 18.
208. [Genetic polymorphism in glutathione S-transferase M1 and T1 in children with bronchial asthma] Vavilin VA, etal., Vopr Med Khim. 2000 Jul-Aug;46(4):388-97.
209. Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an. Wang AH, etal., World J Gastroenterol. 2002 Feb;8(1):49-53. doi: 10.3748/wjg.v8.i1.49.
210. Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population. Wang G, etal., Biochem Biophys Res Commun. 2006 Mar 10;341(2):310-3. Epub 2006 Jan 10.
211. [The role of smoking and metabolic enzyme polymorphisms in the organic solvent induced chronic encephalopathy]. Wang HY, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Mar 20;34(3):199-202. doi: 10.3760/cma.j.issn.1001-9391.2016.03.009.
212. GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis. Wang IJ, etal., Ann Allergy Asthma Immunol. 2010 Aug;105(2):124-9. Epub 2010 Jun 11.
213. GSTM1 and GSTT1 gene polymorphisms as major risk factors for bronchopulmonary dysplasia in a Chinese Han population. Wang X, etal., Gene. 2014 Jan 1;533(1):48-51. doi: 10.1016/j.gene.2013.10.004. Epub 2013 Oct 10.
214. A physiogenomic approach to study the regulation of blood pressure. Westhoff TH, etal., Physiol Genomics. 2005 Sep 21;23(1):46-53. Epub 2005 Jun 7.
215. Homozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensitization. Westphal GA, etal., Int Arch Occup Environ Health. 2000 Aug;73(6):384-8.
216. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. Wickliffe JK, etal., Mol Med. 2011 Mar-Apr;17(3-4):241-7. doi: 10.2119/molmed.2010.00130. Epub 2010 Oct 15.
217. Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Wong LL, etal., Hum Exp Toxicol. 2011 Sep;30(9):1369-81. doi: 10.1177/0960327110391388. Epub 2010 Dec 7.
218. The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. Xiang Y, etal., PLoS One. 2014 Jan 23;9(1):e85905. doi: 10.1371/journal.pone.0085905. eCollection 2014.
219. Glutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia. Xiao Z, etal., Leuk Res. 2008 Aug;32(8):1288-91. Epub 2007 Nov 26.
220. Age-associated changes in GSH S-transferase gene/proteins in livers of rats. Xu S, etal., Redox Rep. 2018 Dec;23(1):213-218. doi: 10.1080/13510002.2018.1546985.
221. Glutathione S-transferase gene polymorphisms in Turkish patients with diabetes mellitus. Yalin S, etal., Cell Biochem Funct. 2007 Sep-Oct;25(5):509-13.
222. [Investigation of GSTT1, GSTM1 and NQO1 genes polymorphisms in myelodysplastic syndromes]. Yang L, etal., Zhonghua Xue Ye Xue Za Zhi. 2005 Nov;26(11):674-7.
223. [Relationship between GSTM1 and GSTT1 gene polymorphisms and noise induced hearing loss in Chinese workers]. Yang M, etal., Wei Sheng Yan Jiu. 2005 Nov;34(6):647-9.
224. Is GST gene polymorphism a risk factor in developing exfoliation syndrome? Yilmaz A, etal., Curr Eye Res. 2005 Jul;30(7):575-81.
225. Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment. Yochum CL, etal., Behav Brain Res. 2010 Jul 11;210(2):202-10. Epub 2010 Feb 21.
226. Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer. Yuan JM, etal., Carcinogenesis. 2008 Jul;29(7):1386-93. Epub 2008 Jun 9.
227. MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress. Yuan XP, etal., Oncotarget. 2017 May 30;8(47):82064-82077. doi: 10.18632/oncotarget.18289. eCollection 2017 Oct 10.
228. Glutathione S-transferase M1, T1, and P1 genotypes and rheumatoid arthritis. Yun BR, etal., J Rheumatol. 2005 Jun;32(6):992-7.
229. Combined effects of polymorphisms of DNA-repair protein genes and metabolic enzyme genes on the risk of cholangiocarcinoma. Zeng L, etal., Jpn J Clin Oncol. 2013 Dec;43(12):1190-4. doi: 10.1093/jjco/hyt138. Epub 2013 Sep 18.
230. Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang. Zeng M, etal., Genet Mol Res. 2015 Dec 29;14(4):19102-9. doi: 10.4238/2015.December.29.19.
231. [Correlation of the polymorphism of EC-SOD and GSTM1 and smoking with oral cancer risk]. Zhang C, etal., Wei Sheng Yan Jiu. 2012 Jul;41(4):555-61.
232. Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population. Zhang J, etal., Clin Chim Acta. 2010 Jun 3;411(11-12):878-81. Epub 2010 Mar 11.
233. Zhonghua wai ke za zhi [Chinese journal of surgery] Zhao D and Yang BX, Zhonghua Wai Ke Za Zhi. 2009 Mar 1;47(5):373-6.
234. [The relationship between GSTM1, GSTT1 gene polymorphisms and susceptibility to sporadic colorectal adenocarcinoma]. Zhu Y, etal., Zhonghua Nei Ke Za Zhi. 2002 Aug;41(8):538-40.
235. Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses. Zhuo WL, etal., J Cancer Res Clin Oncol. 2009 Aug;135(8):1081-90. Epub 2009 Feb 28.
236. [Increased frequency of A-G transition at exon 5 of GSTP1 as a genetic risk factor for acute childhood leukaemia]. Zubowska M, etal., Med Wieku Rozwoj. 2004 Apr-Jun;8(2 Pt 1):245-57.
237. The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis. Živkovic M, etal., J Neurol Sci. 2013 Nov 15;334(1-2):6-9. doi: 10.1016/j.jns.2013.07.001. Epub 2013 Aug 9.
Additional References at PubMed
PMID:1416995   PMID:1420139   PMID:1883338   PMID:2226415   PMID:2669745   PMID:2689439   PMID:2875437   PMID:3011803   PMID:3864155   PMID:8110735   PMID:8373352   PMID:8503873  
PMID:8512323   PMID:9084911   PMID:12826697   PMID:15009649   PMID:15299462   PMID:15489334   PMID:16475815   PMID:16672236   PMID:16800819   PMID:17634366   PMID:20387083   PMID:20517701  
PMID:21046276   PMID:25931508   PMID:30053369   PMID:30308595  


Genomics

Comparative Map Data
Gstm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22195,649,845 - 195,655,402 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,292,372 - 203,297,745 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02201,174,485 - 201,179,858 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02195,991,446 - 195,996,819 (-)NCBIRnor_WKY
Rnor_6.02210,803,869 - 210,809,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,803,869 - 210,809,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,272,740 - 230,278,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,575,444 - 203,580,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,538,197 - 203,543,575 (-)NCBI
Celera2188,295,244 - 188,300,621 (-)NCBICelera
Cytogenetic Map2q34NCBI
GSTM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,687,817 - 109,693,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1109,687,814 - 109,709,039 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,230,439 - 110,236,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,031,965 - 110,037,890 (+)NCBINCBI36Build 36hg18NCBI36
Build 341109,942,483 - 109,948,409NCBI
Cytogenetic Map1p13.3NCBI
Gstm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,919,566 - 107,925,289 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,919,571 - 107,925,289 (-)EnsemblGRCm39 Ensembl
GRCm383108,012,250 - 108,017,973 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,012,255 - 108,017,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,815,168 - 107,820,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,140,314 - 108,146,029 (-)NCBIMGSCv36mm8
Celera3110,345,820 - 110,351,544 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
GSTM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11116,495,332 - 116,506,288 (-)NCBINHGRI_mPanPan1
PanPan1.11128,003,736 - 128,009,696 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,979,238 - 128,010,411 (-)Ensemblpanpan1.1panPan2
LOC103224275
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,854,969 - 23,861,634 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023670255134 - 1,611 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gstm1
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:265
Count of miRNA genes:163
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000047139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat

Markers in Region
D2Got198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,650,753 - 195,650,901 (+)MAPPERmRatBN7.2
Rnor_6.02210,804,777 - 210,804,922NCBIRnor6.0
Rnor_5.02230,273,648 - 230,273,793UniSTSRnor5.0
RGSC_v3.42203,576,351 - 203,576,496RGDRGSC3.4
RGSC_v3.42203,576,352 - 203,576,497UniSTSRGSC3.4
RGSC_v3.12203,539,105 - 203,539,250RGD
Celera2188,296,152 - 188,296,297UniSTS
RH 3.4 Map21377.1RGD
RH 3.4 Map21377.1UniSTS
Cytogenetic Map2q34UniSTS
BI281611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,650,110 - 195,650,263 (+)MAPPERmRatBN7.2
Rnor_6.02210,804,134 - 210,804,286NCBIRnor6.0
Rnor_5.02230,273,005 - 230,273,157UniSTSRnor5.0
RGSC_v3.42203,575,709 - 203,575,861UniSTSRGSC3.4
Celera2188,295,509 - 188,295,661UniSTS
RH 3.4 Map21390.1UniSTS
Cytogenetic Map2q34UniSTS
Gstm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,652,603 - 195,653,848 (+)MAPPERmRatBN7.2
Rnor_6.02210,806,625 - 210,807,869NCBIRnor6.0
Rnor_5.02230,275,496 - 230,276,740UniSTSRnor5.0
RGSC_v3.42203,578,200 - 203,579,444UniSTSRGSC3.4
Celera2188,298,000 - 188,299,244UniSTS
Cytogenetic Map2q34UniSTS


Related Rat Strains
The following Strains have been annotated to Gstm1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7 7 7 1
Medium 3 35 50 34 19 34 2 74 35 40 11
Low 8 8 9 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000047139   ⟹   ENSRNOP00000039050
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,649,848 - 195,655,411 (-)Ensembl
Rnor_6.0 Ensembl2210,803,869 - 210,809,306 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104497   ⟹   ENSRNOP00000083172
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109885   ⟹   ENSRNOP00000092984
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)Ensembl
RefSeq Acc Id: NM_017014   ⟹   NP_058710
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22195,649,846 - 195,655,225 (-)NCBI
Rnor_6.02210,803,869 - 210,809,246 (-)NCBI
Rnor_5.02230,272,740 - 230,278,278 (-)NCBI
RGSC_v3.42203,575,444 - 203,580,821 (-)RGD
Celera2188,295,244 - 188,300,621 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101714   ⟹   XP_038957642
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22195,649,845 - 195,655,402 (-)NCBI
RefSeq Acc Id: XM_039101715   ⟹   XP_038957643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22195,649,845 - 195,655,382 (-)NCBI
RefSeq Acc Id: XR_005500238
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22195,649,845 - 195,655,391 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058710   ⟸   NM_017014
- UniProtKB: G3V983 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000039050   ⟸   ENSRNOT00000047139
RefSeq Acc Id: XP_038957642   ⟸   XM_039101714
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957643   ⟸   XM_039101715
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000083172   ⟸   ENSRNOT00000104497
RefSeq Acc Id: ENSRNOP00000092984   ⟸   ENSRNOT00000109885
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04905-F1-model_v2 AlphaFold P04905 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691669
Promoter ID:EPDNEW_R2194
Type:multiple initiation site
Name:Gstm1_1
Description:glutathione S-transferase mu 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,809,281 - 210,809,341EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2755 AgrOrtholog
BioCyc Gene G2FUF-51641 BioCyc
Ensembl Genes ENSRNOG00000029726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000039050 ENTREZGENE
  ENSRNOP00000039050.3 UniProtKB/TrEMBL
  ENSRNOP00000083172.1 UniProtKB/TrEMBL
  ENSRNOP00000092984.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047139 ENTREZGENE
  ENSRNOT00000047139.4 UniProtKB/TrEMBL
  ENSRNOT00000104497 ENTREZGENE
  ENSRNOT00000104497.1 UniProtKB/TrEMBL
  ENSRNOT00000109885.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920688 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_mu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24423 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72887 IMAGE-MGC_LOAD
NCBI Gene 24423 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE MU 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/TrEMBL
  GST_C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GSTM1 RGD
PhenoGen Gstm1 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AIM5_RAT UniProtKB/TrEMBL
  A0A8I6G8J9_RAT UniProtKB/TrEMBL
  G3V983 ENTREZGENE, UniProtKB/TrEMBL
  GSTM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-04 Gstm1  glutathione S-transferase mu 1  Gstm1  glutathione S-transferase M1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-03 Gstm1  glutathione S-transferase M1  Gstm1  glutathione S-transferase, mu 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gstm1  glutathione S-transferase, mu 1      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Gstm1  glutathione S-transferase, mu 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and fibroblast cells 70479
gene_expression secreted by sertoli cells 70307
gene_expression mRNA expressed in prostate 728523
gene_function binds steroids, including testosterone and estradiol 70307
gene_process interacts with one of 13 subunits to form the active enzyme 70479
gene_process functions in converting fat soluble chemicals to water-soluble to inhibit build-up of hydrophobic compounds in adipose tissue 70479
gene_process essential for spermatogenesis 70307
gene_process may be important for androgen-dependent growth of prostate 728523
gene_product member of glutathione-S-transferase family 728523
gene_protein protein has five distinct subunits 70479
gene_protein isoforms share extensive N-terminal homology and molecular mass 70307
gene_regulation mRNA downregulated by androgen in rat prostate 728523