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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1decreases methylationISOGSTM1 (Homo sapiens)6480464CTDLead results in decreased methylation of GSTM1 genePMID:31119761
Gstm1increases response to substanceISOGSTM1 (Homo sapiens)6480464CTDGSTM1 gene mutant form results in increased susceptibility to LeadPMID:23484121
Gstm1multiple interactionsISOGSTM1 (Homo sapiens)6480464CTD[GSTM1 gene mutant form co-treated with GSTT1 gene mutant form] promotes the reaction [Lead results in increased expression of CRP protein]; [GSTM1 gene mutant form co-treated with GSTT1 gene mutant form] results in increased susceptibility to Lead; GSTM1 gene mutant form promotes the reaction [Lead results in increased expression of CRP protein]PMID:23484121
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