RGD Reference Report - Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis. - Rat Genome Database

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Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis.

Authors: Morinobu, S  Morinobu, A  Kanagawa, S  Hayashi, N  Nishimura, K  Kumagai, S 
Citation: Morinobu S, etal., Clin Exp Rheumatol. 2006 May-Jun;24(3):268-73.
RGD ID: 5490994
Pubmed: PMID:16870093   (View Abstract at PubMed)

OBJECTIVE: To investigate the role of polymorphisms of the glutathione S-transferase M1 (GSTM1), GSTT1, and GSTP1 genes in determining susceptibility to rheumatoid arthritis (RA) and association with the clinical features. METHODS: Polymorphisms of the GSTM1, GSTT1, and GSTP1 genes in 108 Japanese patients with RA and in 143 healthy controls were analyzed by polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism. RESULTS: The frequency of the GSTM1 null genotype was significantly higher among RA patients than among control subjects (60.2% and 44.1%, respectively. P = 0.011). Moreover, the female patients with GSTM1 homozygous null genotype showed significantly higher serum MMP-3 level than the female patients with non-null genotype (P = 0.030). Frequencies of the GSTT1 and GSTP1 gene polymorphism were not different between RA patients and controls. CONCLUSION: The GSTM1 homozygous null genotype could be a genetic factor that determines susceptibility to RA and may have influence on the disease process.




  
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Original Reference(s)
GSTM1Humanrheumatoid arthritis susceptibilityIAGP DNA:deletion: :RGD 
Gstm1Ratrheumatoid arthritis susceptibilityISOGSTM1 (Homo sapiens)DNA:deletion: :RGD 
Gstm1Mouserheumatoid arthritis susceptibilityISOGSTM1 (Homo sapiens)DNA:deletion: :RGD 


Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)