RGD Reference Report - Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population. - Rat Genome Database

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Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population.

Authors: Pae, CU  Yu, HS  Kim, JJ  Kim, W  Lee, CU  Lee, SJ  Jun, TY  Lee, C  Paik, IH  Serretti, A 
Citation: Pae CU, etal., Psychiatr Genet. 2004 Sep;14(3):147-50.
RGD ID: 5490265
Pubmed: PMID:15318028   (View Abstract at PubMed)

The association between Glutathione S-Transferase M1 gene (GSTM1) polymorphism and schizophrenia was examined. One hundred and eleven in-patients with schizophrenia and 130 healthy controls were enrolled in this study. Genotyping was performed using a polymerase chain reaction-based method. The GSTM1 null genotype was significantly more frequent in the schizophrenia patients than in the controls (P=0.014, odds ratio=1.93, 95% confidence interval=1.115-3.351). On the other hand, the GSTM1 genotype variants were not associated with tardive dyskinesia or total abnormal involuntary movement scale scores. This study suggests that, at least in the Korean population, the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to tardive dyskinesia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia susceptibilityIAGP 5490265DNA:deletion: :RGD 
schizophrenia susceptibilityISOGSTM1 (Homo sapiens)5490265; 5490265DNA:deletion: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)


Additional Information