RGD Reference Report - Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis. - Rat Genome Database

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Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis.

Authors: Kim, Jeong-Sook  Park, Jong Y  Chung, Won-Yoon  Choi, Min-Ah  Cho, Kyoo-Sung  Park, Kwang-Kyun 
Citation: Kim JS, etal., J Clin Periodontol. 2004 Nov;31(11):959-64. doi: 10.1111/j.1600-051X.2004.00587.x.
RGD ID: 14700983
Pubmed: PMID:15491310   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1600-051X.2004.00587.x   (Journal Full-text)


OBJECTIVES: Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be influenced by the polymorphisms of genes coding for enzymes metabolizing tobacco-derived substances. The object of this study is to investigate roles of genetic polymorphisms of these metabolizing enzymes in the risk for periodontitis.
MATERIAL AND METHODS: We investigated three important enzymes: cytochrome P450 (CYP) 1A1, CYP2E1 and glutathione S-transferase (GST) M1, involved in the metabolic activation and detoxification of tobacco-derived substances. The prevalence of the polymorphisms of these genes was examined in 115 patients with periodontitis as well as in 126 control subjects.
RESULTS: Significantly increased risk for periodontitis was observed for subjects with the polymorphic CYP1A1 m2 allele (odds ratio (OR)=2.3, 95% confidence interval (CI)=1.2-4.4). A significant risk increase for periodontitis associated with the GSTM1 allele was observed (OR=2.1, 95% CI=1.3-3.6). However, no association was observed between the CYP2E1 Pst1 polymorphism and risk for periodontitis (OR=1.3, 95% CI=0.6-2.5).
CONCLUSION: These results suggest that the GSTM1 and CYP1A1 polymorphisms may play an important role in risk for periodontitis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CYP1A1Humanperiodontitis  IAGP  RGD 
Cyp1a1Ratperiodontitis  ISOCYP1A1 (Homo sapiens) RGD 
Cyp1a1Mouseperiodontitis  ISOCYP1A1 (Homo sapiens) RGD 
GSTM1Humanperiodontitis  IAGP  RGD 
Gstm1Ratperiodontitis  ISOGSTM1 (Homo sapiens) RGD 
Gstm1Mouseperiodontitis  ISOGSTM1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)
Gstm1  (glutathione S-transferase mu 1)

Genes (Mus musculus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)
Gstm1  (glutathione S-transferase, mu 1)

Genes (Homo sapiens)
CYP1A1  (cytochrome P450 family 1 subfamily A member 1)
GSTM1  (glutathione S-transferase mu 1)


Additional Information