Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1)

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Gene: Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1) Rattus norvegicus

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Symbol:

Cyp1a1

Name:

cytochrome P450, family 1, subfamily a, polypeptide 1

RGD ID:

2458

Description:

Enables several functions, including flavonoid 3'-monooxygenase activity; heat shock protein binding activity; and oxidoreductase activity, acting on diphenols and related substances as donors. Contributes to oxidoreductase activity. Involved in several processes, including 9-cis-retinoic acid biosynthetic process; hepatocyte differentiation; and xenobiotic metabolic process. Located in mitochondrial inner membrane. Biomarker of end stage renal disease; heart disease; pulmonary hypertension; and renal cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; gefitinib pharmacokinetics pathway; tamoxifen pharmacokinetics pathway; INTERACTS WITH (+)-alpha-Bisabolol; (+)-catechin; (+)-epicatechin-3-O-gallate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CYP1; Cyp45c; Cypc45c; CYPIA1; cytochrome P1-450; cytochrome P450 1A1; cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); cytochrome P450, 1a1; Cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450-C; cytochrome P450-P1; cytochrome P450MT2; dioxin-inducible; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P-450MC; P1-450; P450-C; P450DX; P450form6; P450MT2; xenobiotic monooxygenase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Cyp1a1^em1Mcwi Cyp1a1^em5Mcwi Cyp1a1^em2Mcwi

Genetic Models:

SS-Cyp1a1^em1Mcwi SS-Cyp1a1^em2Mcwi SS-Cyp1a1^em5Mcwi

Is Marker For:

Strains: F344-Tg(Cyp1a1-Ren2)10Jmul

Candidate Gene For:

Mcs4 Hcar3

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	58,096,021 - 58,102,130 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	58,096,077 - 58,102,125 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	63,629,083 - 63,635,108 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	61,906,655 - 61,912,680 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	59,771,206 - 59,777,229 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	62,472,087 - 62,478,122 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	62,472,095 - 62,478,147 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	62,249,046 - 62,255,081 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	61,462,207 - 61,468,237 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	61,481,260 - 61,487,291 (+)	NCBI
Celera	8	57,561,801 - 57,567,827 (+)	NCBI		Celera
RH 3.4 Map	8	671.2	RGD
Cytogenetic Map	8	q24	NCBI

JBrowse:

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Model

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Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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