RGD Reference Report - Contribution of GSTM1, GSTT1, and MTHFR polymorphisms to end-stage renal disease of unknown etiology in Mexicans. - Rat Genome Database

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Contribution of GSTM1, GSTT1, and MTHFR polymorphisms to end-stage renal disease of unknown etiology in Mexicans.

Authors: Gutiérrez-Amavizca, B E  Orozco-Castellanos, R  Ortíz-Orozco, R  Padilla-Gutiérrez, J  Valle, Y  Gutiérrez-Gutiérrez, N  García-García, G  Gallegos-Arreola, M  Figuera, L E 
Citation: Gutiérrez-Amavizca BE, etal., Indian J Nephrol. 2013 Nov;23(6):438-43. doi: 10.4103/0971-4065.120342.
RGD ID: 14700960
Pubmed: PMID:24339523   (View Abstract at PubMed)
PMCID: PMC3841513   (View Article at PubMed Central)
DOI: DOI:10.4103/0971-4065.120342   (Journal Full-text)

Oxidative stress is increased in chronic kidney disease, owing to an imbalance between the oxidative and antioxidant pathways as well as a state of persistent hyperhomocysteinemia. The enzymes glutathione S-transferases (GSTs) and methylenetetrahydrofolate reductase (MTHFR) are implicated in the regulation of these pathways. This study investigates the association between polymorphisms in the Glutathione S-transferase Mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), and MTHFR genes and end-stage renal disease (ESRD) of unknown etiology in patients in Mexico. A Case-control study included 110 ESRD patients and 125 healthy individuals. GSTM1 and GSTT1 genotypes were determined using the multiplex polymerase chain reaction (PCR). The MTHFR C677T polymorphism was studied using a PCR/restriction fragment length polymorphism method. In ESRD patients, GSTM1 and GSTT1 null genotype frequencies were 61% and 7% respectively. GSTM1 genotype frequencies differed significantly between groups, showing that homozygous deletion of the GSTM1 gene was associated with susceptibility to ESRD of unknown etiology (P = 0.007, odds ratios = 2.05, 95% confidence interval 1.21-3.45). The MTHFR C677T polymorphism genotype and allele distributions were similar in both groups (P > 0.05), and the CT genotype was the most common genotype in both groups (45.5% and 46.6%). Our findings suggest that the GSTM1 null polymorphism appears to be associated with the ESRD of unknown etiology in patients in Mexico.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GSTM1Humanend stage renal disease  IAGP  RGD 
Gstm1Ratend stage renal disease  ISOGSTM1 (Homo sapiens) RGD 
Gstm1Mouseend stage renal disease  ISOGSTM1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)


Additional Information