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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1increases expressionEXP 6480464CTDPhenobarbital results in increased expression of GSTM1 mRNA; Phenobarbital results in increased expression of GSTM1 proteinPMID:11328961 PMID:17381134 PMID:19162173 PMID:19695238 PMID:23273579 PMID:8242872
Gstm1multiple interactionsEXP 6480464CTD[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of GSTM1 proteinPMID:20935162
Gstm1decreases expressionISOGSTM1 (Homo sapiens)6480464CTDPhenobarbital results in decreased expression of GSTM1 proteinPMID:7986210
Gstm1increases expressionISOGstm1 (Mus musculus)6480464CTDPhenobarbital results in increased expression of GSTM1 mRNA; Phenobarbital results in increased expression of GSTM1 proteinPMID:18723825 PMID:20403969 PMID:23091169 PMID:26519955 PMID:28541575
Gstm1increases expressionISOGSTM1 (Homo sapiens)6480464CTDPhenobarbital results in increased expression of GSTM1 mRNA; Phenobarbital results in increased expression of GSTM1 proteinPMID:28541575
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