Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1increases expressionEXP 6480464CTDsulforaphane results in increased expression of GSTM1 proteinPMID:18823965
Gstm1affects metabolic processingISOGSTM1 (Homo sapiens)6480464CTDGSTM1 protein affects the metabolism of sulforaphanePMID:7826396
Gstm1affects response to substanceISOGSTM1 (Homo sapiens)6480464CTDGSTM1 gene polymorphism affects the susceptibility to sulforaphanePMID:15623468
Gstm1increases expressionISOGstm1 (Mus musculus)6480464CTDsulforaphane results in increased expression of GSTM1 mRNA; sulforaphane results in increased expression of GSTM1 proteinPMID:11309284 PMID:17942926 PMID:19071154 PMID:19303893 PMID:20932822 PMID:24184564
Gstm1increases expressionISOGSTM1 (Homo sapiens)6480464CTDsulforaphane results in increased expression of GSTM1 proteinPMID:16905640
Gstm1multiple interactionsISOGstm1 (Mus musculus)6480464CTD[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM1 mRNA; NFE2L2 protein promotes the reaction [sulforaphane results in increased expression of GSTM1 mRNA]; sulforaphane inhibits the reaction [fenamidone results in increased expression of GSTM1 mRNA]PMID:17942926 PMID:20932822 PMID:27029645
Gstm1multiple interactionsISOGSTM1 (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [alpha-methylepinine results in increased expression of GSTM1 mRNA]PMID:21871945
Go Back to source page   Continue to Ontology report