Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2) Rattus norvegicus
Analyze
Symbol: Prkab2
Name: protein kinase AMP-activated non-catalytic subunit beta 2
Description: Exhibits protein kinase binding activity. Predicted to contribute to AMP-activated protein kinase activity. Predicted to be involved in positive regulation of cold-induced thermogenesis. Localizes to several cellular components, including the apical plasma membrane; cAMP-dependent protein kinase complex; and nucleotide-activated protein kinase complex. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; hypertrophic cardiomyopathy pathway; insulin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5'-AMP-activated protein kinase subunit beta-2; AMP-activated protein kinase beta-2 regulatory subunit; AMPK beta-2 chain; AMPK subunit beta-2; MGC93432; protein kinase, AMP-activated, beta 2 non-catalytic subunit
Orthologs:
Homo sapiens (human) : PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Prkab2 (protein kinase, AMP-activated, beta 2 non-catalytic subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)
Canis lupus familiaris (dog) : PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2)
Sus scrofa (pig) : PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)
Chlorocebus sabaeus (African green monkey) : PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)
Heterocephalus glaber (naked mole-rat) : Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2)
more info ...
Is Marker For: QTLs:   Bp365  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02199,831,990 - 199,847,623 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,831,990 - 199,847,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,309,807 - 219,325,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,498,430 - 192,510,624 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12192,461,183 - 192,473,369 (+)NCBI
Celera2177,749,772 - 177,761,966 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Prkab2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620905
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.