RGD Reference Report - Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. - Rat Genome Database

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Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.

Authors: Mottillo, Emilio P  Desjardins, Eric M  Crane, Justin D  Smith, Brennan K  Green, Alex E  Ducommun, Serge  Henriksen, Tora I  Rebalka, Irena A  Razi, Aida  Sakamoto, Kei  Scheele, Camilla  Kemp, Bruce E  Hawke, Thomas J  Ortega, Joaquin  Granneman, James G  Steinberg, Gregory R 
Citation: Mottillo EP, etal., Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006.
RGD ID: 13673870
Pubmed: PMID:27411013   (View Abstract at PubMed)
PMCID: PMC5239668   (View Article at PubMed Central)
DOI: DOI:10.1016/j.cmet.2016.06.006   (Journal Full-text)

Brown (BAT) and white (WAT) adipose tissues play distinct roles in maintaining whole-body energy homeostasis, and their dysfunction can contribute to non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. The AMP-activated protein kinase (AMPK) is a cellular energy sensor, but its role in regulating BAT and WAT metabolism is unclear. We generated an inducible model for deletion of the two AMPK ß subunits in adipocytes (iß1ß2AKO) and found that iß1ß2AKO mice were cold intolerant and resistant to ß-adrenergic activation of BAT and beiging of WAT. BAT from iß1ß2AKO mice had impairments in mitochondrial structure, function, and markers of mitophagy. In response to a high-fat diet, iß1ß2AKO mice more rapidly developed liver steatosis as well as glucose and insulin intolerance. Thus, AMPK in adipocytes is vital for maintaining mitochondrial integrity, responding to pharmacological agents and thermal stress, and protecting against nutrient-overload-induced NAFLD and insulin resistance.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Prkab1  (protein kinase AMP-activated non-catalytic subunit beta 1)
Prkab2  (protein kinase AMP-activated non-catalytic subunit beta 2)


Additional Information