Prkaa2 (protein kinase AMP-activated catalytic subunit alpha 2) - Rat Genome Database

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Gene: Prkaa2 (protein kinase AMP-activated catalytic subunit alpha 2) Rattus norvegicus
Symbol: Prkaa2
Name: protein kinase AMP-activated catalytic subunit alpha 2
RGD ID: 620893
Description: Enables AMP-activated protein kinase activity; ATP binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including energy homeostasis; fatty acid homeostasis; and positive regulation of glycolytic process. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; autophagy pathway; INTERACTS WITH (+)-schisandrin B; (R,R)-tramadol; (S)-nicotine.
Type: protein-coding
Previously known as: 5'-AMP-activated protein kinase catalytic subunit alpha-2; ACACA kinase; acetyl-CoA carboxylase kinase; AMP-activated protein kinase; AMPK; AMPK alpha-2 chain; AMPK subunit alpha-2; Ampka2; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 2 catalytic subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25119,807,992 - 119,879,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,813,226 - 119,879,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,434,721 - 122,501,151 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05124,157,776 - 124,224,205 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05124,209,020 - 124,275,446 (-)NCBIRnor_WKY
Rnor_6.05124,568,845 - 124,642,569 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,574,079 - 124,642,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,436,023 - 128,503,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,007,672 - 126,074,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,012,897 - 126,079,238 (-)NCBI
Celera5118,363,351 - 118,429,630 (-)NCBICelera
RH 3.4 Map5688.6RGD
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-Arctigenin  (ISO)
(-)-matairesinol  (ISO)
(R)-lipoic acid  (ISO)
(R,R)-tramadol  (EXP)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,7,9-tetramethyluric acid  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxy-TEMPO  (ISO)
4-nonylphenol  (EXP)
acadesine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
Arctiin  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (EXP,ISO)
Deoxyschizandrin  (ISO)
dibutyl phthalate  (ISO)
dihydroxyacetone  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
econazole  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
gramine  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nitrites  (EXP)
nitrofen  (EXP)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
reactive oxygen species  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sucrose  (EXP)
sulindac  (EXP)
syringin  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
tramadol  (EXP)
triadimefon  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
xylazine  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cellular response to calcium ion  (IEA,IMP,ISO)
cellular response to glucose starvation  (IBA,IEA,ISO,ISS)
cellular response to glucose stimulus  (IEA,IMP,ISO)
cellular response to nutrient levels  (ISO,ISS)
cellular response to organonitrogen compound  (IEP)
cellular response to oxidative stress  (IEA,ISO)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
cholesterol biosynthetic process  (IEA)
chromatin remodeling  (IEA)
energy homeostasis  (IDA)
fatty acid biosynthetic process  (IEA)
fatty acid homeostasis  (IDA)
glucose homeostasis  (ISO,ISS)
intracellular signal transduction  (IBA)
lipid biosynthetic process  (IEA,ISO,ISS)
lipid droplet disassembly  (IEA,ISO,ISS)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of hepatocyte apoptotic process  (IEA,ISO)
negative regulation of TOR signaling  (IBA,IEA,ISO,ISS)
negative regulation of tubulin deacetylation  (IEA,ISO)
positive regulation of autophagy  (IEA,ISO,ISS)
positive regulation of cellular catabolic process  (IEA)
positive regulation of glycolytic process  (IDA)
positive regulation of peptidyl-lysine acetylation  (IEA,ISO)
positive regulation of protein localization  (IEA,ISO)
protein localization to lipid droplet  (IEA,ISO,ISS)
protein phosphorylation  (IBA,IDA,IEA,ISO)
regulation of circadian rhythm  (IEA,ISO,ISS)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (IDA)
regulation of macroautophagy  (IEA,ISO,ISS)
regulation of microtubule cytoskeleton organization  (IEA,ISO)
regulation of stress granule assembly  (IEA,ISO)
response to activity  (IDA)
response to caffeine  (IDA)
response to muscle activity  (IEA,ISO)
rhythmic process  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component
apical plasma membrane  (IDA)
axon  (IEA,IMP,ISO)
cytoplasm  (IDA,IEA,ISO)
cytoplasmic stress granule  (IEA,ISO)
dendrite  (IEA,IMP,ISO)
Golgi apparatus  (IEA,ISO)
neuronal cell body  (IEA,IMP,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (TAS)
nucleotide-activated protein kinase complex  (IBA,IDA,IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IDA)


References - curated
# Reference Title Reference Citation
1. AMP-activated protein kinase (AMPK) is decreased in the mouse brain during experimental cerebral malaria. Apoorv TS, etal., Neurosci Lett. 2018 Jan 1;662:290-294. doi: 10.1016/j.neulet.2017.10.054. Epub 2017 Oct 28.
2. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Bergeron R, etal., Am J Physiol Endocrinol Metab 2001 Dec;281(6):E1340-6.
3. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. Bolster DR, etal., J Biol Chem 2002 Jul 5;277(27):23977-80.
4. Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Cammisotto PG, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F881-9. doi: 10.1152/ajprenal.00373.2007. Epub 2008 Feb 6.
5. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Cheung PC, etal., Biochem J. 2000 Mar 15;346 Pt 3:659-69.
6. Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Egawa T, etal., Metabolism. 2009 Nov;58(11):1609-17. Epub 2009 Jul 15.
7. Catalytic subunits of the porcine and rat 5'-AMP-activated protein kinase are members of the SNF1 protein kinase family. Gao G, etal., Biochim Biophys Acta 1995 Apr 6;1266(1):73-82.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
11. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
12. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Hawley SA, etal., J Biol. 2003;2(4):28. Epub 2003 Sep 24.
13. A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population. Horikoshi M, etal., Diabetes. 2006 Apr;55(4):919-23.
14. AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). Iseli TJ, etal., J Biol Chem. 2005 Apr 8;280(14):13395-400. Epub 2005 Jan 28.
15. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. Kawaguchi T, etal., J Biol Chem 2002 Feb 8;277(6):3829-35.
16. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
17. Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. Koh HJ, etal., Biochem J. 2007 May 1;403(3):473-81.
18. Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Krause U, etal., Eur J Biochem 2002 Aug;269(15):3751-9.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Li J, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1927-34. Epub 2006 Apr 28.
21. Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase. Liangpunsakul S, etal., Arch Biochem Biophys. 2009 May 1;485(1):10-5. Epub 2009 Feb 21.
22. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Marsin AS, etal., Curr Biol. 2000 Oct 19;10(20):1247-55.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. Park H, etal., J Biol Chem 2002 Sep 6;277(36):32571-7.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. Sakoda H, etal., Am J Physiol Endocrinol Metab 2002 Jun;282(6):E1239-44.
31. Polarized activities of AMPK and BRSK in primary hippocampal neurons. Sample V, etal., Mol Biol Cell. 2015 May 15;26(10):1935-46. doi: 10.1091/mbc.E14-02-0764. Epub 2015 Mar 18.
32. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. Steinberg GR, etal., Am J Physiol Endocrinol Metab 2003 Mar;284(3):E648-54.
33. Metformin protects against infection-induced myocardial dysfunction. Tzanavari T, etal., Metabolism. 2016 Oct;65(10):1447-58. doi: 10.1016/j.metabol.2016.06.012. Epub 2016 Jul 9.
34. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. Viollet B, etal., J Clin Invest 2003 Jan;111(1):91-8.
35. The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. Woods A, etal., FEBS Lett. 1996 Nov 18;397(2-3):347-51.
Additional References at PubMed
PMID:7908907   PMID:8910387   PMID:10098881   PMID:11829744   PMID:11902845   PMID:11934664   PMID:12433937   PMID:12759223   PMID:12764152   PMID:12765944   PMID:12813156   PMID:12829625  
PMID:12829626   PMID:14555687   PMID:14614828   PMID:14709557   PMID:14742438   PMID:14747282   PMID:15026306   PMID:15033481   PMID:15068958   PMID:15153111   PMID:15159410   PMID:15161745  
PMID:15262850   PMID:15328075   PMID:15465886   PMID:15561928   PMID:15572372   PMID:15579580   PMID:15607747   PMID:15637122   PMID:15737645   PMID:15774529   PMID:15774530   PMID:15896703  
PMID:15899896   PMID:15928023   PMID:15956049   PMID:16054095   PMID:16054096   PMID:16118254   PMID:16141267   PMID:16186119   PMID:16199527   PMID:16203737   PMID:16224049   PMID:16308421  
PMID:16316631   PMID:16321138   PMID:16340011   PMID:16352671   PMID:16489105   PMID:16569664   PMID:16595700   PMID:16644805   PMID:16648181   PMID:16710744   PMID:16844684   PMID:16902066  
PMID:16920812   PMID:16943243   PMID:17003332   PMID:17093945   PMID:17116308   PMID:17127032   PMID:17179156   PMID:17185376   PMID:17276357   PMID:17324122   PMID:17332269   PMID:17496214  
PMID:17666490   PMID:17717055   PMID:17934342   PMID:18003746   PMID:18034317   PMID:18035054   PMID:18067996   PMID:18157544   PMID:18248608   PMID:18314006   PMID:18358090   PMID:18405894  
PMID:18439900   PMID:18511510   PMID:18535107   PMID:18638456   PMID:18703756   PMID:18790741   PMID:18927218   PMID:19033879   PMID:19073885   PMID:19125418   PMID:19188248   PMID:19224132  
PMID:19228889   PMID:19318515   PMID:19438972   PMID:19477967   PMID:19481554   PMID:19502419   PMID:19531644   PMID:19570894   PMID:19651784   PMID:19698760   PMID:19720831   PMID:19723084  
PMID:19740738   PMID:19780028   PMID:19812359   PMID:19833968   PMID:19903169   PMID:20147366   PMID:20399918   PMID:20647423   PMID:20659426   PMID:20688914   PMID:20701589   PMID:20723579  
PMID:20797423   PMID:20802499   PMID:20826460   PMID:20841353   PMID:21070787   PMID:21097394   PMID:21258367   PMID:21323644   PMID:21459323   PMID:21681559   PMID:21789886   PMID:22452514  
PMID:22507198   PMID:22542793   PMID:22588126   PMID:22797923   PMID:22898567   PMID:22941749   PMID:22989604   PMID:23024365   PMID:23152492   PMID:23159540   PMID:23184732   PMID:23225245  
PMID:23316058   PMID:23332761   PMID:23418591   PMID:23479225   PMID:23523792   PMID:23667684   PMID:23918774   PMID:23922853   PMID:23927948   PMID:23994559   PMID:24096873   PMID:24255018  
PMID:24288442   PMID:24434520   PMID:24444314   PMID:24530802   PMID:24691731   PMID:24708213   PMID:24801390   PMID:24980520   PMID:25097857   PMID:25149877   PMID:25151306   PMID:25687571  
PMID:25759412   PMID:25849133   PMID:25987561   PMID:26136559   PMID:26162096   PMID:26193886   PMID:26578698   PMID:26628404   PMID:26661649   PMID:26675978   PMID:26847932   PMID:26945066  
PMID:27076782   PMID:27102713   PMID:27194296   PMID:27242267   PMID:27258250   PMID:27278959   PMID:27430620   PMID:27453548   PMID:27524625   PMID:27762461   PMID:27793739   PMID:27798124  
PMID:27957796   PMID:28111082   PMID:28161641   PMID:28459365   PMID:28515080   PMID:28712893   PMID:29115402   PMID:29207101   PMID:29371602   PMID:29719042   PMID:29916537   PMID:30267375  
PMID:31172217   PMID:31255733   PMID:31838605   PMID:31927057   PMID:32013667   PMID:32351005   PMID:32643505   PMID:33173986   PMID:33197510   PMID:33920198   PMID:34450172   PMID:35416184  
PMID:36240643   PMID:36980261  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25119,807,992 - 119,879,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,813,226 - 119,879,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,434,721 - 122,501,151 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05124,157,776 - 124,224,205 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05124,209,020 - 124,275,446 (-)NCBIRnor_WKY
Rnor_6.05124,568,845 - 124,642,569 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,574,079 - 124,642,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,436,023 - 128,503,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,007,672 - 126,074,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,012,897 - 126,079,238 (-)NCBI
Celera5118,363,351 - 118,429,630 (-)NCBICelera
RH 3.4 Map5688.6RGD
Cytogenetic Map5q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38156,645,314 - 56,715,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl156,645,314 - 56,715,335 (+)EnsemblGRCh38hg38GRCh38
GRCh37157,110,987 - 57,181,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,883,578 - 56,953,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34156,823,040 - 56,886,142NCBI
Celera155,395,857 - 55,465,885 (+)NCBICelera
Cytogenetic Map1p32.2NCBI
HuRef155,223,513 - 55,293,426 (+)NCBIHuRef
CHM1_1157,226,353 - 57,296,384 (+)NCBICHM1_1
T2T-CHM13v2.0156,524,182 - 56,594,202 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394104,886,846 - 104,967,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4104,887,071 - 104,967,087 (-)EnsemblGRCm39 Ensembl
GRCm384105,029,649 - 105,109,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4105,029,874 - 105,109,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv374104,702,255 - 104,782,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364104,532,922 - 104,607,801 (-)NCBIMGSCv36mm8
Celera4103,380,658 - 103,460,821 (-)NCBICelera
Cytogenetic Map4C6NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554643,003,837 - 3,062,197 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554642,996,608 - 3,062,197 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11169,264,046 - 169,334,110 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0155,928,577 - 55,998,628 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1157,639,731 - 57,702,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl157,664,237 - 57,702,227 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1552,809,792 - 52,855,072 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl552,815,609 - 52,876,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha552,877,206 - 52,944,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0552,996,830 - 53,064,324 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl552,999,820 - 53,064,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1552,940,854 - 53,008,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0552,886,688 - 52,954,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0553,172,006 - 53,239,515 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505870,476,415 - 70,543,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365224,875,046 - 4,939,879 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365224,872,360 - 4,939,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6155,681,784 - 155,754,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,683,392 - 155,754,283 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,547,653 - 143,572,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12076,258,063 - 76,319,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2076,259,763 - 76,319,430 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603340,974,342 - 41,041,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248623,450,078 - 3,496,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248623,443,720 - 3,496,078 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Prkaa2
445 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:92
Interacting mature miRNAs:109
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25119,813,371 - 119,813,540 (+)MAPPERmRatBN7.2
Rnor_6.05124,574,225 - 124,574,393NCBIRnor6.0
Rnor_5.05128,436,169 - 128,436,337UniSTSRnor5.0
RGSC_v3.45126,007,818 - 126,007,986UniSTSRGSC3.4
Celera5118,363,497 - 118,363,665UniSTS
RH 3.4 Map5688.6UniSTS
Cytogenetic Map5q34UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 42 23 16 2 16 8 11 60 27 12 10 8
Low 2 1 34 25 17 25 14 8 29 1
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010680   ⟹   ENSRNOP00000010680
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5119,813,226 - 119,848,290 (-)Ensembl
Rnor_6.0 Ensembl5124,574,079 - 124,642,569 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107016   ⟹   ENSRNOP00000088282
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5119,813,226 - 119,848,100 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109887   ⟹   ENSRNOP00000089715
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5119,813,226 - 119,879,543 (-)Ensembl
RefSeq Acc Id: NM_023991   ⟹   NP_076481
Rat AssemblyChrPosition (strand)Source
mRatBN7.25119,813,226 - 119,879,370 (-)NCBI
Rnor_6.05124,574,079 - 124,642,569 (-)NCBI
Rnor_5.05128,436,023 - 128,503,874 (-)NCBI
RGSC_v3.45126,007,672 - 126,074,012 (-)RGD
Celera5118,363,351 - 118,429,630 (-)RGD
RefSeq Acc Id: XM_039110822   ⟹   XP_038966750
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25119,807,992 - 119,879,987 (-)NCBI
RefSeq Acc Id: XM_039110823   ⟹   XP_038966751
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25119,807,992 - 119,879,189 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_076481   ⟸   NM_023991
- UniProtKB: Q09137 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010680   ⟸   ENSRNOT00000010680
RefSeq Acc Id: XP_038966750   ⟸   XM_039110822
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966751   ⟸   XM_039110823
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000088282   ⟸   ENSRNOT00000107016
RefSeq Acc Id: ENSRNOP00000089715   ⟸   ENSRNOT00000109887
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q09137-F1-model_v2 AlphaFold Q09137 1-552 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693873
Promoter ID:EPDNEW_R4398
Type:initiation region
Description:protein kinase AMP-activated catalytic subunit alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05124,642,635 - 124,642,695EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620893 AgrOrtholog
BioCyc Gene G2FUF-40480 BioCyc
Ensembl Genes ENSRNOG00000007706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010680.3 UniProtKB/TrEMBL
  ENSRNOP00000088282.1 UniProtKB/TrEMBL
  ENSRNOP00000089715.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010680.4 UniProtKB/TrEMBL
  ENSRNOT00000107016.1 UniProtKB/TrEMBL
  ENSRNOT00000109887.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AMPK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMPKA2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKAA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:78975 UniProtKB/Swiss-Prot
Pfam AdenylateSensor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkaa2 PhenoGen
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A5W8_RAT UniProtKB/TrEMBL
  AAPK2_RAT UniProtKB/Swiss-Prot
  G3V715_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkaa2  protein kinase AMP-activated catalytic subunit alpha 2  Prkaa2  protein kinase, AMP-activated, alpha 2 catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Prkaa2  protein kinase, AMP-activated, alpha 2 catalytic subunit    AMP-activated protein kinase  Name updated 625702 APPROVED
2002-08-07 Prkaa2  AMP-activated protein kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs activated by nonspecific chemical activator 5-aminoimidazole-4-carboxamide ribofuranoside (AICAR) 628444
gene_drugs activation of this gene results when animals underwent chronic energy stress when fed beta-guanadinopropionic acid 628444
gene_expression expressed in hepatic cells 628444
gene_function increases oxidation and decreases esterification of fatty acids 631891
gene_process activation inhibits the expression of fatty acid synthase and pyruvate kinase gene in the hepatocytes 628444
gene_process essential for 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced glucose transport in skeletal muscle 625764
gene_process involved in regulation of gene expression 628444
gene_protein the kinase is a heterotrimer composed of a catalytic alpha-subunit, two isoforms of which occur in skeletal muscle (a1 and a2) and two regulatory subunits (beta and gamma) 628444
gene_regulation activated by increases in the AMP/ATP ratio 628444
gene_regulation activated by the decreased ratio of ATP/AMP and the amount of phosphocreatine 628444
gene_regulation activity increased by 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) 628444