RGD Reference Report - The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. - Rat Genome Database

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The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma.

Authors: Strange, RC  Matharoo, B  Faulder, GC  Jones, P  Cotton, W  Elder, JB  Deakin, M 
Citation: Strange RC, etal., Carcinogenesis. 1991 Jan;12(1):25-8.
RGD ID: 7488952
Pubmed: PMID:1988177   (View Abstract at PubMed)

The suggestion that individuals with the GST1 0 phenotype have a greater susceptibility to carcinogens than those with other GST1 phenotypes has been examined by using a starch gel zymogram approach to compare the frequency of this phenotype in control subjects and a group of patients with adenocarcinoma of stomach and colon. A significantly greater proportion of the patients with adenocarcinoma demonstrated the null phenotype, odds ratio analysis indicating that individuals with this polymorphic variant have an approximately 3-fold greater risk of developing these cancers.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GSTM1Humanadenocarcinoma susceptibilityIEP colon and stomach and protein:decreased activity:liver (human)RGD 
Gstm1Ratadenocarcinoma susceptibilityISOGSTM1 (Homo sapiens)colon and stomach and protein:decreased activity:liver (human)RGD 
Gstm1Mouseadenocarcinoma susceptibilityISOGSTM1 (Homo sapiens)colon and stomach and protein:decreased activity:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)

Objects referenced in this article
Gene Gstm2 glutathione S-transferase, mu 2 Mus musculus
Gene Gstm2 glutathione S-transferase mu 2 Rattus norvegicus

Additional Information