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Gene: Gstm2 (glutathione S-transferase mu 2) Rattus norvegicus
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Symbol: Gstm2
Name: glutathione S-transferase mu 2
Description: Exhibits glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Involved in several processes, including aging; glutathione metabolic process; and response to phenylpropanoid. Localizes to the cytosol; plasma membrane; and protein-containing complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); diabetes mellitus (multiple); eye disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM1 (glutathione S-transferase mu 1) and GSTM5 (glutathione S-transferase mu 5); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glutathione S-transferase M2; glutathione S-transferase Yb-2; glutathione S-transferase Yb2 subunit; glutathione S-transferase, mu 2; Glutathione-S-transferase mu type 2 (Yb2); Glutathione-S-transferase, mu type 2 (Yb2); GST 4-4; GST Yb2; GSTA4; GSTM2-2
Orthologs:
Homo sapiens (human) : GSTM2 (glutathione S-transferase mu 2)  HGNC  Alliance
Mus musculus (house mouse) : Gstm2 (glutathione S-transferase, mu 2)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GSTM2 (glutathione S-transferase mu 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02210,778,041 - 210,782,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02230,247,260 - 230,251,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,549,022 - 203,553,380NCBIRGSC3.4rn4RGSC3.4
Celera2188,270,799 - 188,275,157 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gstm2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2756
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.