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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2765
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstt1
Name: glutathione S-transferase theta 1
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstt1increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of GSTT1 mRNAPMID:33354967
Gstt1multiple interactionsEXP 6480464CTDGSTT1 protein affects the metabolism of and results in decreased activity of Aflatoxin B1 metabolitePMID:8951341
Gstt1affects response to substanceISOGstt1 (Mus musculus)6480464CTDGSTT1 gene SNP affects the susceptibility to Aflatoxin B1PMID:12907637
Gstt1decreases expressionISOGSTT1 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of GSTT1 mRNAPMID:22100608 PMID:27153756
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