RGD Reference Report - Influence of glutathione S-transferase T1 donor/recipient mismatch and anti-GSTT1 antibodies in hepatic graft-versus-host-disease. - Rat Genome Database

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Influence of glutathione S-transferase T1 donor/recipient mismatch and anti-GSTT1 antibodies in hepatic graft-versus-host-disease.

Authors: Martínez-Bravo, Maria José  Tallón, Inmaculada  Espigado, Ildefonso  Perez-Simón, José Antonio  Pérez-Romero, Pilar  Gracia-Ahufinger, Irene  Aguilera, Isabel  Núñez-Roldán, Antonio 
Citation: Martínez-Bravo MJ, etal., Immunol Lett. 2011 Dec 30;141(1):140-4. doi: 10.1016/j.imlet.2011.09.005. Epub 2011 Sep 24.
RGD ID: 14700987
Pubmed: PMID:21968078   (View Abstract at PubMed)
DOI: DOI:10.1016/j.imlet.2011.09.005   (Journal Full-text)

B cell responses to minor histocompatibility antigens (mHags) have not been extensively studied after allogeneic hematopoietic stem cell transplantation (HSCT). Glutathione S-transferase T1 (GSTT1) is a drug metabolizing enzyme encoded by a single gene that is highly expressed in liver and kidney. Anti-GSTT1 antibodies have been described in the context of antibody-mediated rejection in kidney and liver transplantation, due to a mismatch between donor and recipient. The aim of the present study was to investigate the specific immune response against GSTT1 in HSCT with production of antibodies and their influence in the development of hepatic graft-versus-host-disease (GVHD). Forty patients and their respective donors were included in the study. The median follow-up time was 35.6 months (range 0.6-76 months) and a total of 349 serum samples were tested for the presence of anti-GSTT1 antibodies by ELISA test. Statistical analysis was performed by defining the GSTT1 null donor/positive recipient as mismatch compared with the other three genetic combinations regarded as GSTT1-matched. Antibodies were found in three patients within the group of null donor/positive recipient and one within the null/null group. Development of liver GVHD, particularly its acute form, was highly associated with the GSTT1-mismatch (P=0.0178) and with the presence of post-transplant anti-GSTT1 antibodies (P=0.0076). We conclude that GSTT1 could be considered as a new mHag in hepatic GVHD. The fact that three donors were parous females and the rapid production of antibodies after HSCT suggests the existence in the graft of memory B-cells specific for the GSTT1 antigen.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GSTT1Humanliver disease  IDA associated with Graft vs Host DiseaseRGD 
Gstt1Ratliver disease  ISOGSTT1 (Homo sapiens)associated with Graft vs Host DiseaseRGD 
Gstt1Mouseliver disease  ISOGSTT1 (Homo sapiens)associated with Graft vs Host DiseaseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstt1  (glutathione S-transferase theta 1)

Genes (Mus musculus)
Gstt1  (glutathione S-transferase, theta 1)

Genes (Homo sapiens)
GSTT1  (glutathione S-transferase theta 1)


Additional Information