RGD Reference Report - Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways. - Rat Genome Database

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Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways.

Authors: Tsai, Hui-Ju  Liu, Xin  Mestan, Karen  Yu, Yunxian  Zhang, Shanchun  Fang, Yaping  Pearson, Colleen  Ortiz, Katherin  Zuckerman, Barry  Bauchner, Howard  Cerda, Sandra  Stubblefield, Phillip G  Xu, Xiping  Wang, Xiaobin 
Citation: Tsai HJ, etal., Hum Genet. 2008 May;123(4):359-69. doi: 10.1007/s00439-008-0485-9. Epub 2008 Mar 5.
RGD ID: 12792239
Pubmed: (View Article at PubMed) PMID:18320229
DOI: Full-text: DOI:10.1007/s00439-008-0485-9

Preterm delivery (PTD, <37 weeks of gestation) is a significant clinical and public health problem. Previously, we reported that maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 synergistically increase the risk of low birth weight. This study investigates the relationship between maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 with preterm delivery (PTD) as a whole and preterm subgroups. This case-control study included 1,749 multi-ethnic mothers (571 with PTD and 1,178 controls) enrolled at Boston Medical Center. After adjusting covariates, regression analyses were performed to identify individual and joint associations of maternal smoking, two functional variants of CYP1A1 and GSTT1 with PTD. We observed a moderate effect of maternal smoking on PTD (OR = 1.6; 95% CI: 1.1-2.2). We found that compared to non-smoking mothers with low-risk genotypes, there was a significant joint association of maternal smoking, CYP1A1 (Aa/aa) and GSTT1 (absent) genotypes with gestational age (beta = -3.37; SE = 0.86; P = 9 x 10(-5)) and with PTD (OR = 5.8; 95% CI: 2.0-21.1), respectively. Such joint association was particularly strong in certain preterm subgroups, including spontaneous PTD (OR = 8.3; 95% CI: 2.7-30.6), PTD < 32 weeks (OR = 11.1; 95% CI: 2.9-47.7), and PTD accompanied by histologic chorioamnionitis (OR = 15.6; 95% CI: 4.1-76.7). Similar patterns were observed across ethnic groups. Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes. Such joint associations were strongest among PTD accompanied by histologic chorioamnionitis.

Annotation

Disease Annotations    
Premature Birth  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Gstt1  (glutathione S-transferase theta 1)

Genes (Mus musculus)
Gstt1  (glutathione S-transferase, theta 1)

Genes (Homo sapiens)
GSTT1  (glutathione S-transferase theta 1)


Additional Information