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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2765
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstt1
Name: glutathione S-transferase theta 1
Acc ID: CHEBI:15767
Term: dichloromethane
Definition: A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.
Chemical ID: MESH:D008752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstt1affects metabolic processingEXP 6480464CTDGSTT1 protein affects the metabolism of Methylene ChloridePMID:14727918
Gstt1increases metabolic processingEXP 6480464CTDGSTT1 protein results in increased metabolism of Methylene ChloridePMID:11453994
Gstt1multiple interactionsEXP 6480464CTDGSTT1 protein results in increased metabolism of and results in increased activity of Methylene ChloridePMID:10413528
Gstt1affects metabolic processingISOGstt1 (Mus musculus)6480464CTDGSTT1 protein affects the metabolism of Methylene ChloridePMID:17827337 PMID:8670055 PMID:9854036
Gstt1affects metabolic processingISOGSTT1 (Homo sapiens)6480464CTDGSTT1 gene polymorphism affects the metabolism of Methylene Chloride; GSTT1 protein affects the metabolism of Methylene ChloridePMID:14727918 PMID:15683365 PMID:7979958
Gstt1affects response to substanceISOGSTT1 (Homo sapiens)6480464CTDGSTT1 protein alternative form affects the susceptibility to Methylene ChloridePMID:20837120
Gstt1increases metabolic processingISOGSTT1 (Homo sapiens)6480464CTDGSTT1 protein results in increased metabolism of Methylene ChloridePMID:11446825 PMID:12054768
Gstt1multiple interactionsISOGstt1 (Mus musculus)6480464CTD[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde; GSTT1 protein affects the metabolism of and results in increased activity of Methylene ChloridePMID:15683365 PMID:16765633 PMID:8761485
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