Mmp11 (matrix metallopeptidase 11)

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Gene: Mmp11 (matrix metallopeptidase 11) Rattus norvegicus

Analyze

Symbol:

Mmp11

Name:

matrix metallopeptidase 11

RGD ID:

3099

Description:

Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within basement membrane organization; collagen fibril organization; and negative regulation of fat cell differentiation. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP11 (matrix metallopeptidase 11); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC103694874; matrix metalloproteinase 11; Matrix metalloproteinase 11 (stromelysin 3); matrix metalloproteinase-11; MMP-11; SL-3; ST3; stromelysin-3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MMP11 (matrix metallopeptidase 11)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mmp11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mmp11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MMP11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MMP11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mmp11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MMP11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MMP11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mmp11 (matrix metallopeptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mmp11 (matrix metallopeptidase 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MMP11 (matrix metallopeptidase 11)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mmp11b (matrix metallopeptidase 11b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	mmp11a (matrix metallopeptidase 11a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	zmp-5	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mmp2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	mmp11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	12,730,846 - 12,739,629 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,730,836 - 12,739,628 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	13,437,476 - 13,446,257 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,798,397 - 12,807,178 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	13,270,190 - 13,278,971 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	13,670,051 - 13,678,834 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	13,670,066 - 13,678,089 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	15,825,614 - 15,834,397 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	13,129,667 - 13,138,449 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	13,129,893 - 13,138,676 (+)	NCBI
Celera	20	14,222,131 - 14,230,914 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

agammaglobulinemia 2 (ISO)

Coffin-Siris syndrome 3 (ISO)

epilepsy (ISO)

genetic disease (ISO)

lung non-small cell carcinoma (ISO)

schizophrenia (ISO)

Spontaneous Abortions (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

3,3',5-triiodo-L-thyronine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acetaldehyde (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (EXP)

arsenic atom (EXP)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

C60 fullerene (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

Cirsimarin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclophosphamide (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

doxorubicin (ISO)

endosulfan (EXP)

flavonoids (EXP)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gamma-linolenic acid (ISO)

hydrogen peroxide (ISO)

indometacin (EXP,ISO)

isoprenaline (ISO)

lipopolysaccharide (ISO)

niclosamide (ISO)

ochratoxin A (ISO)

ozone (EXP,ISO)

paraquat (EXP)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

basement membrane organization (ISO)

collagen catabolic process (IBA,ISO)

collagen fibril organization (ISO)

extracellular matrix organization (IBA,ISO)

negative regulation of fat cell differentiation (ISO)

proteolysis (IEA)

Cellular Component

extracellular matrix (IEA,ISO)

extracellular space (IBA)

Molecular Function

metalloendopeptidase activity (IBA,IEA)

metallopeptidase activity (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues.	Okada A, etal., Gene 1997 Feb 7;185(2):187-93.
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:15489334	PMID:16401721	PMID:18622425

Genomics

Comparative Map Data

Mmp11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	12,730,846 - 12,739,629 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,730,836 - 12,739,628 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	13,437,476 - 13,446,257 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,798,397 - 12,807,178 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	13,270,190 - 13,278,971 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	13,670,051 - 13,678,834 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	13,670,066 - 13,678,089 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	15,825,614 - 15,834,397 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	13,129,667 - 13,138,449 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	13,129,893 - 13,138,676 (+)	NCBI
Celera	20	14,222,131 - 14,230,914 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

MMP11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	23,772,849 - 23,784,316 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	23,768,226 - 23,784,316 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	24,115,036 - 24,126,503 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	22,445,036 - 22,456,503 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	22,439,589 - 22,451,056	NCBI
Celera	22	7,954,127 - 7,965,595 (+)	NCBI		Celera
Cytogenetic Map	22	q11.23	ENTREZGENE
HuRef	22	7,103,103 - 7,114,555 (+)	NCBI		HuRef
CHM1_1	22	24,127,275 - 24,138,742 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	24,220,041 - 24,231,509 (+)	NCBI		T2T-CHM13v2.0

Mmp11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	75,759,056 - 75,768,336 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	75,759,056 - 75,772,330 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	75,923,221 - 75,932,502 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	75,923,222 - 75,936,496 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	75,385,969 - 75,395,208 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	75,366,940 - 75,376,179 (-)	NCBI		MGSCv36	mm8
Celera	10	76,967,909 - 76,977,148 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	38.62	NCBI

Mmp11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	8,459,428 - 8,469,053 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	8,458,622 - 8,464,037 (-)	NCBI	ChiLan1.0	ChiLan1.0

MMP11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	22	36,240,937 - 36,252,465 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	4,528,639 - 4,540,118 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	22,610,626 - 22,625,335 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	22,615,969 - 22,624,567 (+)	Ensembl	panpan1.1		panPan2

MMP11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	28,730,173 - 28,741,506 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	28,727,332 - 28,741,415 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	27,804,212 - 27,813,598 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	30,135,355 - 30,147,019 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	30,135,354 - 30,146,606 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	28,217,197 - 28,226,583 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	27,835,130 - 27,844,514 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	28,823,000 - 28,832,388 (-)	NCBI		UU_Cfam_GSD_1.0

Mmp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	141,433,947 - 141,443,698 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,310,846 - 1,320,062 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936619	1,309,013 - 1,320,062 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MMP11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	49,907,687 - 49,912,617 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	49,907,684 - 49,917,494 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,349,978 - 53,359,794 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MMP11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	6,889,343 - 6,900,563 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	6,889,385 - 6,899,788 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666100	472,421 - 483,648 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mmp11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	10,398,130 - 10,408,376 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	10,398,167 - 10,408,397 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mmp11
22 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	235
Count of miRNA genes:	152
Interacting mature miRNAs:	179
Transcripts:	ENSRNOT00000031400
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	6691706	17489458	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8042410	17617956	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
631265	Iresp1	Immunoglobin response QTL1	8.3		blood anti-double stranded DNA antibody amount (VT:0004762)	serum anti-DNA antibody level (CMO:0001533)	20	9039719	13461775	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat

Markers in Region

AA892528

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	12,739,255 - 12,739,492 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	13,678,461 - 13,678,697	NCBI	Rnor6.0
Rnor_5.0	20	15,834,024 - 15,834,260	UniSTS	Rnor5.0
RGSC_v3.4	20	13,138,077 - 13,138,313	UniSTS	RGSC3.4
Celera	20	14,230,541 - 14,230,777	UniSTS
RH 3.4 Map	20	180.57	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium										20	34	1
Low	3	43	38	24	17	24	2	2	67	15	7	10	2
Below cutoff			17	15	2	15	6	8	7				6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC091362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI291437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK602095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U46034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000031400 ⟹ ENSRNOP00000035334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	12,730,836 - 12,739,623 (+)	Ensembl
Rnor_6.0 Ensembl	20	13,670,066 - 13,678,089 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087725 ⟹ ENSRNOP00000074176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	12,733,298 - 12,739,628 (+)	Ensembl

RefSeq Acc Id:

NM_012980 ⟹ NP_037112

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	12,730,846 - 12,739,629 (+)	NCBI
Rnor_6.0	20	13,670,051 - 13,678,834 (+)	NCBI
Rnor_5.0	20	15,825,614 - 15,834,397 (+)	NCBI
RGSC_v3.4	20	13,129,667 - 13,138,449 (+)	RGD
Celera	20	14,222,131 - 14,230,914 (+)	NCBI

Sequence:

show sequence

GCAGCCCCGGGGCGGATGGCACGGGCCGCCTGTCTCCTCCGCGCGATCTCGCGCGCCCTCCTGC
TCCCGCTTCCTCTGCTGCTCCTGTTGCTGCTTCTCCTGCCGCCGCAGCTGATGGCCCGGGCCAG
GCCACCGGAGAATCACCGTCACCGCCCTGTGAAGAGAGTGCCTCAGCTCCTGCCCGCAGCTCTG
CCTAATAGCTTGCCGTCTGTCCCCGCCTCCCATTGGGTCCCTGGTCCTGCTAGTAGCTCCAGAC
CTCTACGATGTGGTGTGCCTGACCCGCCGGATGTACTGAATGCCCGAAACCGGCAGAAGCGCTT
CGTACTGTCGGGAGGGCGCTGGGAGAAGACAGACCTCACTTATAGGATCCTCCGGTTCCCATGG
CAACTTGTAAGGGAGCAGGTGCGGCAGACGGTGGCAGAGGCCCTCCGGGTATGGAGTGAGGTGA
CTCCGCTCACTTTCACCGAGGTGCACGAGGGACGCGCTGACATCATGATTGACTTCACCAGGTA
CTGGCATGGGGACAACTTGCCATTCGATGGGCCTGGGGGCATCCTGGCCCATGCCTTCTTCCCT
AAGACCCACCGAGAAGGGGATGTACACTTTGACTATGACGAGACTTGGACTATTGGGGACAAGG
GCACAGACCTGCTACAAGTGGCAGCTCATGAATTTGGTCATGTTCTGGGCCTGCAACACACCAC
AGCAGCTAAGGCCCTCATGTCCCCTTTCTACACCTTCCGCTACCCTCTGAGCCTTAGCCCAGAT
GACCGGAGGGGCATCCAGCACCTCTATGGCCGGCCCCAGCTGACCCCCACCTCCCCAACCCCAA
CCTTGAGCTCCCAGGCTGGGACAGATACCAATGAGATTGCACTGCAGGAGCCGGAAGTCCCTCC
AGAAGTCTGTGAGACCTCCTTTGACGCAGTTTCCACCATCCGAGGCGAGCTCTTCTTCTTCAAG
GCGGGCTTTGTGTGGAGGCTGCGCAGTGGGCAACTGCAGCCTGGGTATCCTGCTCTGGCCTCTC
GGCACTGGCAGGGACTACCCAGTCCTGTGGATGCAGCTTTTGAGGATGCCCAGGGCCAGATTTG
GTTCTTCCAAGGTGCTCAGTACTGGGTATATGACGGTGAGAAGCCAGTCCTAGGCCCCGCACCA
CTCTCCAAGCTGGGCCTGCAGGGGTCCCCGGTCCATGCTGCCTTGGTCTGGGGTCCTGAGAAGA
ACAAGATCTACTTCTTCCGAGGTGGAGACTATTGGCGTTTCCACCCCAGAACCCAACGAGTGGA
CAATCCGGTGCCCCGACGTACCACTGACTGGCGGGGGGTACCTTCTGAGATTGATGCTGCTTTC
CAGGATGCTGAGGGCTATGCCTACTTCCTTCGTGGCCATCTCTACTGGAAGTTTGACCCTGTGA
AGGTGAAAGTCCTGGAAAGTTTCCCTCGACCCATAGGTCCCGACTTCTTTGACTGTGCAGAGCC
CGCCAACACTTTCCGCTGACAACACCTCAGATGCATTCAGGGCACTTATATCATTAAAGAGAGC
CACAGCCATATTTGTGGACCTGGGCTTCAGGCATGGGACAGACGGGGCCTAGGTCTCCTCAGGG
GAGTGGGTTGGGGTGCAGCCACTGTTTGCAGGGAGGACCATGCTGGCCATGGTCACCTGCCAAC
AACTGTCTCAGAGAAGGCAAAGGCTTTGACATTACTTAAAAATAAGGGAGGTCTTGGGCTGACA
ATATGTCAGCTACCAGTAATCCACAGTCAACTTGACTGCCAAGCCTCCATCTCTGTCCCACAAA
GAACCCCCACAGGAATTCAGGAACCACAGTGTCTTCATTCTGTTTCTGTAACGAGGTCCCTGTT
GGTAGTGGTGTTGGTAATGAGATGCCAAGGGTACCATGGTAAGGAGATGCCCAGGGTTCCATGC
TGCCACAGCTAAGGACCTGGGCCAGTATCTCTCCTGGTTAAGTTGGCTCTGGAGAGATACTGGA
CTGATTATATTCAGACGAGTTTTTCCTGGAACATAGGCCAAAAGCGACACAGCCAGCCAGGGAG
GCAGCTGCTTCCTCCCAGAGCCTCAGAGGCCTCACATACCTCACAGCCTTGCCCTGGGCCATTT
CTCCCTGGCGCCTTCCCTCTTCCCAGCACCAGTGCCTCCCAAAGCCATGTAAATGTGTATACAG
TGTATAAAGCCTTTTTTAAGAAAGCCGAGACTGTCATTAAACATGAGTGTTTTCTAAGTAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039098460 ⟹ XP_038954388

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	12,734,393 - 12,739,629 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037112	(Get FASTA)	NCBI Sequence Viewer
	XP_038954388	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53061	(Get FASTA)	NCBI Sequence Viewer
	AAH99781	(Get FASTA)	NCBI Sequence Viewer
	EDL97167	(Get FASTA)	NCBI Sequence Viewer
	EDL97168	(Get FASTA)	NCBI Sequence Viewer
	EDL97169	(Get FASTA)	NCBI Sequence Viewer
	Q499S5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037112 ⟸ NM_012980
- Peptide Label:	precursor
- UniProtKB:	P97568 (UniProtKB/Swiss-Prot), Q499S5 (UniProtKB/Swiss-Prot), A6JKF2 (UniProtKB/TrEMBL), A0A8L2R8J4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARAACLLRAISRALLLPLPLLLLLLLLLPPQLMARARPPENHRHRPVKRVPQLLPAALPNSLP SVPASHWVPGPASSSRPLRCGVPDPPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVRE QVRQTVAEALRVWSEVTPLTFTEVHEGRADIMIDFTRYWHGDNLPFDGPGGILAHAFFPKTHRE GDVHFDYDETWTIGDKGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGI QHLYGRPQLTPTSPTPTLSSQAGTDTNEIALQEPEVPPEVCETSFDAVSTIRGELFFFKAGFVW RLRSGQLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLG LQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRTTDWRGVPSEIDAAFQDAEG YAYFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDCAEPANTFR hide sequence

RefSeq Acc Id:

ENSRNOP00000035334 ⟸ ENSRNOT00000031400

RefSeq Acc Id:	XP_038954388 ⟸ XM_039098460
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000074176 ⟸ ENSRNOT00000087725

Protein Domains

Peptidase metallopeptidase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q499S5-F1-model_v2	AlphaFold	Q499S5	1-491	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3099	AgrOrtholog
BioCyc Gene	G2FUF-4166	BioCyc
Ensembl Genes	ENSRNOG00000028344	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000035334	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000074176.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000031400	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000087725.2	UniProtKB/TrEMBL
Gene3D-CATH	2.110.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7933545	IMAGE-MGC_LOAD
InterPro	Hemopexin-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hemopexin-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hemopexin-like_repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hemopexin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	M10A_MMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M10_metallopeptidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M10A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_Metallo	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25481	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124636	IMAGE-MGC_LOAD
NCBI Gene	25481	ENTREZGENE
PANTHER	MATRIX METALLOPROTEINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10201:SF20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Hemopexin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mmp11	PhenoGen
PIRSF	Peptidase_M10A_matrix	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	MATRIXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HEMOPEXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HEMOPEXIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZINC_PROTEASE	UniProtKB/Swiss-Prot
SMART	SM00120	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZnMc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50923	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC229689
UniProt	A0A8L2R8J4	ENTREZGENE, UniProtKB/TrEMBL
	A6JKF1_RAT	UniProtKB/TrEMBL
	A6JKF2	ENTREZGENE, UniProtKB/TrEMBL
	MMP11_RAT	UniProtKB/Swiss-Prot
	P97568	ENTREZGENE
	Q499S5	ENTREZGENE
UniProt Secondary	P97568	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mmp11	matrix metallopeptidase 11	LOC103694874	stromelysin-3	Data Merged	737654	PROVISIONAL
2014-08-25	LOC103694874	stromelysin-3			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-30	Mmp11	matrix metallopeptidase 11		matrix metalloproteinase 11	Name updated	1299863	APPROVED
2002-06-10	Mmp11	Matrix metalloproteinase 11 (stromelysin 3)			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	enriched in adult uterus and ovary	633185
gene_protein	491 amino acids	633185

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD