Vsir (V-set immunoregulatory receptor)

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Gene: Vsir (V-set immunoregulatory receptor) Rattus norvegicus

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Symbol:

Vsir

Name:

V-set immunoregulatory receptor

RGD ID:

1590938

Description:

Predicted to enable endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Predicted to act upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of T cell cytokine production; and positive regulation of BMP signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human VSIR (V-set immunoregulatory receptor); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC690899; MGC112715; platelet receptor Gi24; V-type immunoglobulin domain-containing suppressor of T-cell activation

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	VSIR (V-set immunoregulatory receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Vsir (V-set immunoregulatory receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Vsir (V-set immunoregulatory receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	VSIR (V-set immunoregulatory receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	VSIR (V-set immunoregulatory receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	VSIR (V-set immunoregulatory receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	VSIR (V-set immunoregulatory receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Vsir (V-set immunoregulatory receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CDH23 (cadherin related 23)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	VSIR (V-set immunoregulatory receptor)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Vsir (V-set immunoregulatory receptor)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	vsir	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	vsir	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	28,824,493 - 28,850,175 (+)	NCBI		GRCr8
mRatBN7.2	20	28,281,582 - 28,307,262 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	28,281,596 - 28,303,878 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	29,296,385 - 29,322,002 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	28,682,693 - 28,708,310 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	29,425,156 - 29,450,774 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	29,897,543 - 29,923,381 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	29,897,594 - 29,919,998 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	31,709,023 - 31,734,846 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	27,662,633 - 27,684,891 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	29,719,788 - 29,742,034 (+)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness 12 (ISO)

combined saposin deficiency (ISO)

Experimental Liver Cirrhosis (ISO)

pituitary adenoma 5 (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

Usher syndrome type 1D (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlordecone (ISO)

chrysene (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) chloride (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

diallyl trisulfide (ISO)

Dibutyl phosphate (ISO)

dioxygen (EXP)

doxorubicin (ISO)

ethanol (ISO)

fenofibrate (ISO)

fragrance (ISO)

gentamycin (EXP)

indometacin (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-nitrosodimethylamine (EXP)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tetraphene (ISO)

thioacetamide (EXP)

thiram (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

triticonazole (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

BMP signaling pathway (ISO)

negative regulation of alpha-beta T cell activation (IBA)

negative regulation of CD4-positive, alpha-beta T cell proliferation (ISO)

negative regulation of CD8-positive, alpha-beta T cell proliferation (ISO)

negative regulation of interleukin-10 production (ISO)

negative regulation of interleukin-17 production (ISO)

negative regulation of T cell cytokine production (ISO)

negative regulation of tumor necrosis factor production (ISO)

negative regulation of type II interferon production (ISO)

positive regulation of BMP signaling pathway (ISO)

positive regulation of cell migration (ISO)

positive regulation of collagen catabolic process (ISO)

positive regulation of endopeptidase activity (ISO)

positive regulation of gene expression (ISO)

positive regulation of regulatory T cell differentiation (ISO)

positive regulation of stem cell differentiation (ISO)

stem cell differentiation (ISO)

zymogen activation (ISO)

Cellular Component

external side of plasma membrane (ISO)

plasma membrane (IBA,ISO)

Molecular Function

endopeptidase activator activity (ISO)

enzyme binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:20042595	PMID:20666777	PMID:21383057	PMID:21768399	PMID:22751012	PMID:24691993	PMID:26228159

Genomics

Comparative Map Data

Vsir
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	28,824,493 - 28,850,175 (+)	NCBI		GRCr8
mRatBN7.2	20	28,281,582 - 28,307,262 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	28,281,596 - 28,303,878 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	29,296,385 - 29,322,002 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	28,682,693 - 28,708,310 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	29,425,156 - 29,450,774 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	29,897,543 - 29,923,381 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	29,897,594 - 29,919,998 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	31,709,023 - 31,734,846 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	27,662,633 - 27,684,891 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	29,719,788 - 29,742,034 (+)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

VSIR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	71,747,556 - 71,773,520 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	71,747,556 - 71,773,520 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	73,507,313 - 73,533,277 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	73,177,319 - 73,203,343 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	66,789,752 - 66,815,911 (-)	NCBI		Celera
Cytogenetic Map	10	q22.1	NCBI
HuRef	10	67,501,145 - 67,527,120 (-)	NCBI		HuRef
CHM1_1	10	73,789,445 - 73,815,328 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	72,618,370 - 72,644,252 (-)	NCBI		T2T-CHM13v2.0

Vsir
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	60,182,630 - 60,266,073 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	60,182,630 - 60,208,463 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	60,346,851 - 60,430,294 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	60,346,851 - 60,372,684 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	59,809,599 - 59,835,432 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	59,742,261 - 59,768,041 (+)	NCBI		MGSCv36	mm8
Celera	10	61,443,716 - 61,469,794 (+)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	30.26	NCBI

Vsir
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955437	19,716,466 - 19,743,428 (+)	NCBI	ChiLan1.0	ChiLan1.0

VSIR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	83,898,498 - 83,924,301 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	83,900,069 - 83,929,613 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	68,218,230 - 68,243,687 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	70,742,062 - 70,767,613 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	70,742,062 - 70,767,613 (-)	Ensembl	panpan1.1		panPan2

VSIR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	22,504,888 - 22,530,702 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	22,459,363 - 22,530,687 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	22,640,897 - 22,668,397 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	22,779,509 - 22,807,057 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	22,783,285 - 22,805,226 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	22,685,865 - 22,713,397 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	22,884,409 - 22,911,939 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	23,238,917 - 23,266,458 (-)	NCBI		UU_Cfam_GSD_1.0

VSIR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	74,666,624 - 74,693,281 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	74,667,081 - 74,693,347 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	80,558,168 - 80,584,424 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VSIR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	59,516,012 - 59,538,628 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	59,516,073 - 59,542,242 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	20,159,695 - 20,182,168 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vsir
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	5,665,445 - 5,686,692 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	5,664,899 - 5,686,675 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Vsir
50 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	114
Count of miRNA genes:	94
Interacting mature miRNAs:	103
Transcripts:	ENSRNOT00000057752
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat

Markers in Region

RH131718

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	28,303,636 - 28,303,837 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	29,919,756 - 29,919,956	NCBI	Rnor6.0
Rnor_5.0	20	31,731,221 - 31,731,421	UniSTS	Rnor5.0
RGSC_v3.4	20	27,684,647 - 27,684,847	UniSTS	RGSC3.4
Celera	20	29,741,790 - 29,741,990	UniSTS
Cytogenetic Map	20	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000057752 ⟹ ENSRNOP00000054563

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	28,281,596 - 28,303,878 (+)	Ensembl
Rnor_6.0 Ensembl	20	29,897,594 - 29,919,998 (+)	Ensembl

RefSeq Acc Id:

NM_001044300 ⟹ NP_001037765

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	28,824,515 - 28,850,175 (+)	NCBI
mRatBN7.2	20	28,281,598 - 28,307,262 (+)	NCBI
Rnor_6.0	20	29,897,594 - 29,920,000 (+)	NCBI
Rnor_5.0	20	31,709,023 - 31,734,846 (+)	NCBI
RGSC_v3.4	20	27,662,633 - 27,684,891 (+)	RGD
Celera	20	29,719,788 - 29,742,034 (+)	RGD

Sequence:

show sequence

GTACAGCCGGCTGGCTCCCTGGGCTCTCGGAGCCCCGCTTGCTCCACGCGCGCCCCAGCAGTCT
GTGTCTGCTCTTGCCCGGCTCGACGGCGACATGGGTGTCCCCACGGTCCCAGAGGCCAGTAGTC
TGCGCTGGGGAACCCTGCTCCTCACTATTTTTCTGGCTGCATCCAGAGGTCTGGTAGCAGCCAT
CAAGGTCACCACTCCATATTCTCTGTATGTGTGTCCAGAGGGGCAGAATGTCACCCTCACCTGC
AGGATTCTGGACTCCGTATCCAAAGGGCACGATGCAAACTTCTTAAAGACGTGGTTCCTTAGCT
CTCGAGGCGAGGTTCAAGTGTGCAAAGAACACAGGCCCATACGTAACTTCATATCACACCATCA
ACACCACAGAAGTCACCCGGCAGTCAATGCCAGCCATGACCAGCCCCAGAAACATGGGCTGGAG
ATAGCTTATGACAACCACGGTAACTTCTCTATCACCCTGCACAATGTGACCCTAAGCGACAGCG
GCCTCTACTGCTGTCTGGTGATAGAAGTCAAACACCACCACCCAGAACGGCGGCTCTACGGGTA
CATGGAGCTGCAGGTACAGACAGGCAAAGGCTCAGCATCTACATGCACAGCGTACCCGCCTAAT
GAGCAGGACAGTGACAGCATCACGGCTGCGGCCCTGGCCACGGGCGCCTGCATTGTCGGAATTC
TCTGCCTTCCCCTTATCCTGTTGCTGGTCTATAAGCAGAGGCAGGCGGCCTCTCACCGCCGTGC
CCAGGAGCTGGTGAGGATGGACAGCAACACCCAAGGAATCGAAAACCCAGGCTATGAGACCACT
CCACCCTTCCAGGGGATGCCGGAGGCCAAGACTAGGCCTCCACTGTCCTATGTGGCCCAGCGGC
AACCTTCCGAGTCGGGACGGCACCTGCTGTCTGACCCCAGCACACCTCTGTCCCCTCCAGGCCC
TGGGGATGTCTTCTTCCCATCCCTGGATCCAGTCCCTGACTCCCCTAACTCTGAAGCCATCTAA
ACCAGCTGGGGGACCGTGCCTGGTGCCTGGGTCAGGGATGGATGTACTTGATCGATGACAGGCC
CTTGGACAGACCTTTAGGCACTGATTCCAGTTCCTTGCTCCTGCTCTGAGCCTAGACTCTGCTT
TACGAGATGCACGGACCCTCCTCTGTCACTTTGAGATGTTACTTGGGGGCGGGAGGGGCAGGGA
GAAGATGCTGGATTGCCCATAGCTGTTCTCAAGGTCCTGGGATGCGGAGTTCTCCCTAGAGTCT
TGATCTCGCCAGCCACAGATGTCAAACTACCTGAATTGTACGAGCACCAACTTGGTAACAGCCT
TTCTTCATGGAAACCAGCAGCCCGGATGGGATGAGGTAGGCACCTTGCCACCCTCCCAGGTGAG
AGGCACAAGGTGTGAGAGACTCCTACCCACTGTGGGGGTGTGGCGTGTCTGCTTGCTTGCCTGA
GGATGCTCCTCTGTTGGCCTGGCTCTAACCCCTGGATTCTGGAGTGTGCTTCCCACCAGCAACC
TGAGGGTCTGTCAGCAGTTTAAGTGACTCTGGGCTCTCTTTGCCTGTATAGCTGTCCATAGGGC
TCAGTGGCCAGAAGCTCTAAAACAGCAAGTGCCTGTTAGGTTCAGGAGCTCATTAGTGTCTCGA
GCAATGTGAGGCCTGGACCACCGGACACAGAGGGTGATGAGGGCACGATGGGGACGGTGAGGGG
AGACAAGCCTCCTTCCTGTCCTCAACATCCAATCACTCCCACTGCTCAGTGTAGAGCGATGGCA
AAGGTGACCTCTATAATGTCCTAATGATGCTGGGCTACTTCTAAGTGTGAAAGAGATGCTATTA
AAAAGAAATACGTGAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001399050 ⟹ NP_001385979

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	28,824,515 - 28,850,175 (+)	NCBI
mRatBN7.2	20	28,281,598 - 28,307,262 (+)	NCBI

RefSeq Acc Id:

XM_039099115 ⟹ XP_038955043

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	28,824,493 - 28,846,796 (+)	NCBI
mRatBN7.2	20	28,281,582 - 28,307,262 (+)	NCBI

RefSeq Acc Id:

XM_039099116 ⟹ XP_038955044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	28,824,505 - 28,846,796 (+)	NCBI
mRatBN7.2	20	28,281,583 - 28,307,262 (+)	NCBI

RefSeq Acc Id:

XM_063279554 ⟹ XP_063135624

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	28,830,017 - 28,846,796 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001037765	(Get FASTA)	NCBI Sequence Viewer
	NP_001385979	(Get FASTA)	NCBI Sequence Viewer
	XP_038955043	(Get FASTA)	NCBI Sequence Viewer
	XP_038955044	(Get FASTA)	NCBI Sequence Viewer
	XP_063135624	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98723	(Get FASTA)	NCBI Sequence Viewer
	EDL93048	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000054563.4

RefSeq Acc Id:	NP_001037765 ⟸ NM_001044300
- Peptide Label:	isoform 1
- UniProtKB:	A0A8J8XY95 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGVPTVPEASSLRWGTLLLTIFLAASRGLVAAIKVTTPYSLYVCPEGQNVTLTCRILDSVSKGH DANFLKTWFLSSRGEVQVCKEHRPIRNFISHHQHHRSHPAVNASHDQPQKHGLEIAYDNHGNFS ITLHNVTLSDSGLYCCLVIEVKHHHPERRLYGYMELQVQTGKGSASTCTAYPPNEQDSDSITAA ALATGACIVGILCLPLILLLVYKQRQAASHRRAQELVRMDSNTQGIENPGYETTPPFQGMPEAK TRPPLSYVAQRQPSESGRHLLSDPSTPLSPPGPGDVFFPSLDPVPDSPNSEAI hide sequence

Ensembl Acc Id:

ENSRNOP00000054563 ⟸ ENSRNOT00000057752

RefSeq Acc Id:	XP_038955043 ⟸ XM_039099115
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038955044 ⟸ XM_039099116
- Peptide Label:	isoform X2

RefSeq Acc Id:	NP_001385979 ⟸ NM_001399050
- Peptide Label:	isoform 2
- UniProtKB:	Q4KM76 (UniProtKB/TrEMBL), A6K3X6 (UniProtKB/TrEMBL), G3V9P3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135624 ⟸ XM_063279554
- Peptide Label:	isoform X3

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V9P3-F1-model_v2	AlphaFold	G3V9P3	1-309	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701597

Promoter ID:

EPDNEW_R12120

Type:

multiple initiation site

Name:

Vsir_1

Description:

V-set immunoregulatory receptor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	29,897,577 - 29,897,637	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1590938	AgrOrtholog
BioCyc Gene	G2FUF-3741	BioCyc
Ensembl Genes	ENSRNOG00000000569	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000057752.4	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7377326	IMAGE-MGC_LOAD
InterPro	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
	VISTA	UniProtKB/TrEMBL
KEGG Report	rno:690899	UniProtKB/TrEMBL
MGC_CLONE	MGC:112715	IMAGE-MGC_LOAD
NCBI Gene	690899	ENTREZGENE
PANTHER	PTHR44819	UniProtKB/TrEMBL
	V-TYPE IMMUNOGLOBULIN DOMAIN-CONTAINING SUPPRESSOR OF T-CELL ACTIVATION	UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/TrEMBL
PhenoGen	Vsir	PhenoGen
PROSITE	IG_LIKE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000569	RatGTEx
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A8J8XY95	ENTREZGENE, UniProtKB/TrEMBL
	A6K3X6	ENTREZGENE, UniProtKB/TrEMBL
	G3V9P3	ENTREZGENE, UniProtKB/TrEMBL
	Q4KM76	ENTREZGENE
UniProt Secondary	Q4KM76	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-30	Vsir	V-set immunoregulatory receptor	MGC112715	hypothetical protein LOC690899	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	MGC112715	hypothetical protein LOC690899			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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