Mapk14 (mitogen activated protein kinase 14) - Rat Genome Database

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Gene: Mapk14 (mitogen activated protein kinase 14) Rattus norvegicus
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Symbol: Mapk14
Name: mitogen activated protein kinase 14
RGD ID: 70496
Description: Enables ATP binding activity; MAP kinase activity; and protein C-terminus binding activity. Involved in several processes, including protein autophosphorylation; response to glucose; and stress-activated MAPK cascade. Located in cytosol and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease and anti-basement membrane glomerulonephritis. Orthologous to human MAPK14 (mitogen-activated protein kinase 14); PARTICIPATES IN p38 MAPK signaling pathway; eicosanoid signaling pathway; endothelin signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CRK1; Csaids binding protein; CSBP; Csbp1; Csbp2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; cytokine-supressive anti-inflammatory drug binding protein; Exip; Hog; MAP kinase 14; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38 alpha; MAPK 14; MAX-interacting protein 2; MGC105413; mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38 alpha; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha; p38alpha Exip; p38Hog; Prkm14; Prkm15; reactive kinase; RK; Sapk2A; stress-activated protein kinase 2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2206,749,646 - 6,810,590 (+)NCBI
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Celera208,305,853 - 8,366,371 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4',6-tetrachlorobiphenyl  (EXP)
2,4-dinitroiodobenzene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
afimoxifene  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
arachidonic acid  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
Asiaticoside  (EXP)
atorvastatin calcium  (EXP,ISO)
atropine  (EXP)
aucubin  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
bromobenzene  (ISO)
bupropion  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carvedilol  (EXP)
celecoxib  (ISO)
chalcone  (ISO)
chlorogenic acid  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP)
chromium(6+)  (ISO)
chrysophanol  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coniferyl aldehyde  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (EXP)
diclofenac  (ISO)
Dictamnine  (ISO)
diminazene diaceturate  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ellagic acid  (EXP)
emetine  (ISO)
emodin  (ISO)
endosulfan  (ISO)
ergosterol  (EXP)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
ferric ammonium citrate  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
haloperidol  (EXP)
halothane  (ISO)
hemin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
isoprenaline  (ISO)
KN-93  (EXP)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
limonene  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
lycopene  (EXP,ISO)
lycorine  (ISO)
malvidin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
mesalamine  (EXP)
metam  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP)
mitomycin C  (ISO)
morphine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
ochratoxin A  (ISO)
octanoic acid  (ISO)
oleanolic acid  (ISO)
omeprazole  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenylephrine  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (EXP)
phytosphingosine  (ISO)
pirfenidone  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
prostaglandin E2  (EXP,ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
pyrazoles  (ISO)
pyrimidines  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
salubrinal  (ISO)
SB 203580  (EXP,ISO)
scullcapflavone II  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-chalcone  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
trimethylarsine oxide  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
apoptotic process  (IEA)
bone development  (IEA,ISO)
cartilage condensation  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to ionizing radiation  (IEA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO)
cellular response to virus  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
DNA damage checkpoint signaling  (IEA,ISO)
fatty acid oxidation  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
intracellular signal transduction  (IBA,ISO,ISS,TAS)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
MAPK cascade  (ISO)
myoblast differentiation involved in skeletal muscle regeneration  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of hippo signaling  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
p38MAPK cascade  (IEA,ISO,ISS)
peptidyl-serine phosphorylation  (IEA,ISO)
phosphorylation  (ISO)
placenta development  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of brown fat cell differentiation  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of cyclase activity  (IEA,ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of myoblast differentiation  (IEA,ISO,ISS)
positive regulation of myoblast fusion  (IEA,ISO,ISS)
positive regulation of myotube differentiation  (IEA,ISO,ISS)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
protein autophosphorylation  (IDA)
protein phosphorylation  (IDA,IEA,ISO,TAS)
regulation of cytokine production involved in inflammatory response  (IEA,ISO)
regulation of ossification  (IEA,ISO)
regulation of synaptic membrane adhesion  (IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO,ISS)
regulation of transcription, DNA-templated  (ISO)
response to dietary excess  (ISO)
response to glucose  (IEP)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
signal transduction in response to DNA damage  (ISO)
skeletal muscle tissue development  (IEA,ISO)
stress-activated MAPK cascade  (IDA)
stress-induced premature senescence  (IEA,ISO)
striated muscle cell differentiation  (IEA,ISO)
transmembrane receptor protein serine/threonine kinase signaling pathway  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IDA,IEA,ISO,TAS)
glutamatergic synapse  (IEA,ISO)
mitochondrion  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IBA,IDA,ISO,ISS)
spindle pole  (IEA,ISO)

References

References - curated
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13. Ghosh SK, etal., J Biol Chem 2002 Jun 14;277(24):21325-31.
14. GOA data from the GO Consortium
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16. Holasek SS, etal., Brain Res. 2005 May 31;1045(1-2):185-98. Epub 2005 Apr 25.
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19. KEGG
20. Kerkela R, etal., J Biol Chem 2002 Apr 19;277(16):13752-60.
21. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
22. Lejeune D, etal., J Biol Chem 2002 Sep 13;277(37):33676-82. Epub 2002 Jun 26.
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26. MGD data from the GO Consortium
27. Munoz L, etal., J Neuroinflammation. 2007 Sep 4;4:21.
28. NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Pikkarainen S, etal., J Biol Chem 2003 Feb 7;278(6):3969-75.
30. Pipeline to import KEGG annotations from KEGG into RGD
31. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Pipeline to import SMPDB annotations from SMPDB into RGD
33. RGD automated data pipeline
34. RGD automated import pipeline for gene-chemical interactions
35. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
36. Tamura K, etal., Cell 2000 Jul 21;102(2):221-31.
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38. Tfelt-Hansen J, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E329-37. Epub 2003 Apr 15.
39. Thandavarayan RA, etal., Am J Physiol Heart Circ Physiol. 2009 Jul 17.
40. Toyama K, etal., Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):616-25. doi: 10.1161/ATVBAHA.113.302440. Epub 2013 Dec 26.
41. Varela-Rey M, etal., FEBS Lett 2002 Sep 25;528(1-3):133-8.
42. Wang H, etal., J Biol Chem. 2013 Jun 7;288(23):16761-74. doi: 10.1074/jbc.M112.446633. Epub 2013 Apr 15.
43. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
44. Woo CH and Kim JH, Mol Cells 2002 Jun 30;13(3):470-5.
45. Wu D and Cederbaum AI, J Biol Chem 2003 Jan 10;278(2):1115-24.
46. Yin J, etal., J Pineal Res. 2006 Sep;41(2):124-9.
47. Zhang X, etal., J Biol Chem 2003 Jan 10;278(2):1248-58.
Additional References at PubMed
PMID:7997261   PMID:9513091   PMID:9688607   PMID:10330143   PMID:10391943   PMID:10838079   PMID:10973481   PMID:11035004   PMID:11374881   PMID:11466386   PMID:11790788   PMID:11884367  
PMID:11884615   PMID:11989977   PMID:11994045   PMID:12076985   PMID:12076986   PMID:12091394   PMID:12096921   PMID:12181122   PMID:12225963   PMID:12349907   PMID:12369731   PMID:12409219  
PMID:12409227   PMID:12419320   PMID:12444545   PMID:12477932   PMID:12538734   PMID:12558602   PMID:12564765   PMID:12606350   PMID:12609991   PMID:12637564   PMID:12724128   PMID:12744493  
PMID:12800247   PMID:12802337   PMID:12808090   PMID:12808350   PMID:12837681   PMID:12842450   PMID:12849998   PMID:12857463   PMID:12869527   PMID:12872135   PMID:12876381   PMID:12881212  
PMID:12883833   PMID:12928445   PMID:12937170   PMID:12944406   PMID:12952860   PMID:12957486   PMID:12970901   PMID:14522818   PMID:14530261   PMID:14593093   PMID:14593211   PMID:14602083  
PMID:14606087   PMID:14617573   PMID:14631143   PMID:14633134   PMID:14645111   PMID:14648549   PMID:14660488   PMID:14752292   PMID:14762791   PMID:14764603   PMID:14962831   PMID:14970194  
PMID:14988658   PMID:15001568   PMID:15007040   PMID:15051668   PMID:15051723   PMID:15081310   PMID:15084475   PMID:15167682   PMID:15220210   PMID:15251176   PMID:15271927   PMID:15297444  
PMID:15304486   PMID:15309413   PMID:15365619   PMID:15465893   PMID:15489642   PMID:15509711   PMID:15539417   PMID:15545827   PMID:15590660   PMID:15591055   PMID:15617763   PMID:15634764  
PMID:15647278   PMID:15649892   PMID:15650391   PMID:15664670   PMID:15692051   PMID:15721267   PMID:15748291   PMID:15755725   PMID:15767678   PMID:15826721   PMID:15831522   PMID:15851690  
PMID:15857906   PMID:15883033   PMID:15890335   PMID:15896702   PMID:15937334   PMID:15948190   PMID:15948714   PMID:15994754   PMID:16014723   PMID:16037234   PMID:16040713   PMID:16043884  
PMID:16118209   PMID:16123104   PMID:16157584   PMID:16183734   PMID:16210322   PMID:16246848   PMID:16247337   PMID:16284105   PMID:16316999   PMID:16326014   PMID:16364914   PMID:16365184  
PMID:16409471   PMID:16469826   PMID:16495005   PMID:16531007   PMID:16535835   PMID:16542681   PMID:16575906   PMID:16751295   PMID:16782845   PMID:16813528   PMID:16816533   PMID:16818494  
PMID:16870744   PMID:16891390   PMID:16893669   PMID:16895802   PMID:16911916   PMID:16954198   PMID:16978658   PMID:17034759   PMID:17069850   PMID:17133350   PMID:17151195   PMID:17161379  
PMID:17172269   PMID:17196178   PMID:17202865   PMID:17208994   PMID:17235686   PMID:17285312   PMID:17293487   PMID:17308014   PMID:17333127   PMID:17401436   PMID:17443309   PMID:17459526  
PMID:17467311   PMID:17488713   PMID:17496214   PMID:17513494   PMID:17521827   PMID:17542038   PMID:17545949   PMID:17546627   PMID:17583725   PMID:17603092   PMID:17609504   PMID:17615176  
PMID:17616751   PMID:17644814   PMID:17652167   PMID:17686994   PMID:17705195   PMID:17709097   PMID:17711551   PMID:17882791   PMID:17892505   PMID:17906102   PMID:17906111   PMID:17919885  
PMID:17923327   PMID:17941091   PMID:17943427   PMID:17960568   PMID:17965278   PMID:17988630   PMID:17996195   PMID:17996851   PMID:17997883   PMID:18000819   PMID:18003719   PMID:18006472  
PMID:18071753   PMID:18087667   PMID:18096574   PMID:18177419   PMID:18250162   PMID:18267113   PMID:18277950   PMID:18280691   PMID:18287535   PMID:18289732   PMID:18310079   PMID:18313047  
PMID:18328478   PMID:18338254   PMID:18347059   PMID:18363966   PMID:18374665   PMID:18391505   PMID:18404539   PMID:18408136   PMID:18420382   PMID:18434445   PMID:18440775   PMID:18441197  
PMID:18465250   PMID:18501892   PMID:18511508   PMID:18545259   PMID:18562929   PMID:18566890   PMID:18586681   PMID:18590729   PMID:18664364   PMID:18664382   PMID:18680160   PMID:18686625  
PMID:18729196   PMID:18757484   PMID:18779232   PMID:18789946   PMID:18824646   PMID:18837052   PMID:18850076   PMID:18855936   PMID:18926830   PMID:18982462   PMID:19082728   PMID:19098115  
PMID:19145780   PMID:19201999   PMID:19211730   PMID:19289495   PMID:19292041   PMID:19318515   PMID:19362079   PMID:19363165   PMID:19393619   PMID:19403598   PMID:19404732   PMID:19407223  
PMID:19439112   PMID:19505587   PMID:19524026   PMID:19524113   PMID:19531468   PMID:19548559   PMID:19573526   PMID:19631642   PMID:19653348   PMID:19699199   PMID:19710466   PMID:19725071  
PMID:19774558   PMID:19840222   PMID:19885954   PMID:20043236   PMID:20053668   PMID:20069557   PMID:20111901   PMID:20127044   PMID:20134354   PMID:20160094   PMID:20160708   PMID:20212154  
PMID:20299663   PMID:20375011   PMID:20453549   PMID:20495845   PMID:20497490   PMID:20499363   PMID:20519080   PMID:20568963   PMID:20607863   PMID:20610565   PMID:20655989   PMID:20660302  
PMID:20663305   PMID:20684258   PMID:20730620   PMID:20818504   PMID:20932473   PMID:21084678   PMID:21084714   PMID:21115498   PMID:21180122   PMID:21186613   PMID:21189552   PMID:21215118  
PMID:21228694   PMID:21241662   PMID:21262218   PMID:21263381   PMID:21283629   PMID:21354263   PMID:21474451   PMID:21498515   PMID:21500562   PMID:21549102   PMID:21573888   PMID:21717513  
PMID:21733175   PMID:21768366   PMID:21858143   PMID:21893401   PMID:21953009   PMID:21979577   PMID:21981804   PMID:21993003   PMID:22005927   PMID:22027397   PMID:22031657   PMID:22105890  
PMID:22119396   PMID:22164217   PMID:22194610   PMID:22227208   PMID:22253904   PMID:22292067   PMID:22294037   PMID:22384199   PMID:22393055   PMID:22507553   PMID:22511272   PMID:22525836  
PMID:22537597   PMID:22549003   PMID:22561407   PMID:22623660   PMID:22634758   PMID:22659623   PMID:22676888   PMID:22688014   PMID:22847234   PMID:22851861   PMID:22897442   PMID:22931625  
PMID:23000971   PMID:23053343   PMID:23157661   PMID:23215968   PMID:23222658   PMID:23250488   PMID:23349934   PMID:23376485   PMID:23443926   PMID:23459070   PMID:23483889   PMID:23503893  
PMID:23523564   PMID:23526217   PMID:23592661   PMID:23645665   PMID:23657598   PMID:23660596   PMID:23676944   PMID:23714208   PMID:23727352   PMID:23752611   PMID:23776175   PMID:23826208  
PMID:23832727   PMID:23868758   PMID:23877843   PMID:23948959   PMID:23977283   PMID:23979516   PMID:24008729   PMID:24020812   PMID:24048885   PMID:24064352   PMID:24117073   PMID:24126863  
PMID:24142718   PMID:24179170   PMID:24299952   PMID:24349514   PMID:24352802   PMID:24376630   PMID:24399619   PMID:24455679   PMID:24464634   PMID:24471429   PMID:24479891   PMID:24555431  
PMID:24562313   PMID:24673524   PMID:24691733   PMID:24734256   PMID:24761931   PMID:24792035   PMID:24961950   PMID:24997497   PMID:25004887   PMID:25118288   PMID:25150189   PMID:25151306  
PMID:25245818   PMID:25462588   PMID:25613240   PMID:25695672   PMID:25711402   PMID:25736434   PMID:25752945   PMID:25754930   PMID:25760137   PMID:25766524   PMID:25903824   PMID:25958163  
PMID:26002468   PMID:26116534   PMID:26140333   PMID:26260484   PMID:26300300   PMID:26315345   PMID:26324989   PMID:26386845   PMID:26415098   PMID:26491907   PMID:26530729   PMID:26542462  
PMID:26549199   PMID:26649771   PMID:26700000   PMID:26835911   PMID:26858265   PMID:26884823   PMID:26920805   PMID:26970569   PMID:27035219   PMID:27071784   PMID:27121731   PMID:27155082  
PMID:27178341   PMID:27236300   PMID:27264238   PMID:27301321   PMID:27322569   PMID:27363274   PMID:27363275   PMID:27366753   PMID:27400779   PMID:27402810   PMID:27439108   PMID:27491681  
PMID:27521603   PMID:27544030   PMID:27552519   PMID:27593565   PMID:27659963   PMID:27666960   PMID:27686454   PMID:27706770   PMID:27748573   PMID:27748901   PMID:27765761   PMID:27832635  
PMID:27865869   PMID:27889749   PMID:27957800   PMID:28033732   PMID:28114268   PMID:28188686   PMID:28202578   PMID:28257878   PMID:28469203   PMID:28637870   PMID:28642873   PMID:28676854  
PMID:28694192   PMID:28739872   PMID:28975447   PMID:29115389   PMID:29115603   PMID:29152646   PMID:29196462   PMID:29486613   PMID:29895012   PMID:29896988   PMID:29929196   PMID:29944647  
PMID:29974374   PMID:30028250   PMID:30187999   PMID:30291218   PMID:30292134   PMID:30664172   PMID:30794693   PMID:30816666   PMID:31000329   PMID:31060780   PMID:31160695   PMID:31172341  
PMID:31505169   PMID:31574524   PMID:31715615   PMID:31725126   PMID:32498644   PMID:33053365   PMID:33202984   PMID:33382068   PMID:33760143  


Genomics

Comparative Map Data
Mapk14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2206,749,646 - 6,810,590 (+)NCBI
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Celera208,305,853 - 8,366,371 (+)NCBICelera
Cytogenetic Map20p12NCBI
MAPK14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl636,027,677 - 36,111,236 (+)EnsemblGRCh38hg38GRCh38
GRCh38636,027,711 - 36,122,964 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37635,995,585 - 36,079,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,103,551 - 36,186,513 (+)NCBINCBI36hg18NCBI36
Build 34636,103,550 - 36,186,513NCBI
Celera637,550,014 - 37,633,560 (+)NCBI
Cytogenetic Map6p21.31NCBI
HuRef635,715,466 - 35,798,847 (+)NCBIHuRef
CHM1_1635,997,235 - 36,080,771 (+)NCBICHM1_1
Mapk14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,910,243 - 28,967,379 (+)NCBIGRCm39mm39
GRCm39 Ensembl1728,910,303 - 28,967,380 (+)Ensembl
GRCm381728,691,342 - 28,748,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,691,329 - 28,748,406 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,828,287 - 28,885,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv361728,419,034 - 28,475,994 (+)NCBImm8
Celera1729,246,340 - 29,303,175 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.85NCBI
Mapk14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,838,232 - 3,884,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,836,331 - 3,884,083 (+)NCBIChiLan1.0ChiLan1.0
MAPK14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1636,788,233 - 36,871,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,788,233 - 36,871,114 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0635,586,847 - 35,683,041 (+)NCBIMhudiblu_PPA_v0panPan3
MAPK14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,145,647 - 5,221,558 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,146,037 - 5,220,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,166,000 - 5,239,239 (+)NCBI
ROS_Cfam_1.0125,493,681 - 5,569,596 (+)NCBI
UMICH_Zoey_3.1125,148,463 - 5,221,682 (+)NCBI
UNSW_CanFamBas_1.0125,227,753 - 5,300,687 (+)NCBI
UU_Cfam_GSD_1.0125,327,755 - 5,400,924 (+)NCBI
Mapk14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,650,066 - 40,722,468 (+)NCBI
SpeTri2.0NW_00493647623,237,762 - 23,310,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,790,104 - 31,862,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,791,398 - 31,861,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,725,706 - 36,795,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,012,164 - 36,095,542 (-)NCBI
ChlSab1.1 Ensembl1736,014,454 - 36,095,138 (-)Ensembl
Vero_WHO_p1.0NW_02366604435,975,418 - 36,065,487 (+)NCBI
Mapk14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475421,528,121 - 21,598,064 (-)NCBI

Position Markers
RH134442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,807,058 - 6,807,257 (+)MAPPER
Rnor_6.0205,991,611 - 5,991,809NCBIRnor6.0
Rnor_5.0208,025,182 - 8,025,380UniSTSRnor5.0
RGSC_v3.4206,996,847 - 6,997,045UniSTSRGSC3.4
Celera208,362,840 - 8,363,038UniSTS
RH 3.4 Map2077.1UniSTS
Cytogenetic Map20p12UniSTS
RH144423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,760,549 - 6,760,820 (+)MAPPER
Rnor_6.0205,944,184 - 5,944,454NCBIRnor6.0
Rnor_5.0207,979,420 - 7,979,690UniSTSRnor5.0
RGSC_v3.4206,950,132 - 6,950,402UniSTSRGSC3.4
Celera208,316,740 - 8,317,010UniSTS
RH 3.4 Map2077.8UniSTS
Cytogenetic Map20p12UniSTS
RH141341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,810,320 - 6,810,537 (+)MAPPER
Rnor_6.0205,994,868 - 5,995,084NCBIRnor6.0
Rnor_5.0208,028,439 - 8,028,655UniSTSRnor5.0
RGSC_v3.4207,000,109 - 7,000,325UniSTSRGSC3.4
Celera208,366,102 - 8,366,318UniSTS
RH 3.4 Map2076.7UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2031518156896013Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2031518156896013Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20587544818739210Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990)20485546810800530Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2020187706567419Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2048554689899946Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir24-1rno-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19499150

Predicted Target Of
Summary Value
Count of predictions:1030
Count of miRNA genes:299
Interacting mature miRNAs:389
Transcripts:ENSRNOT00000000617, ENSRNOT00000000618
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 35 11 8
Low 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000617   ⟹   ENSRNOP00000000617
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000000618   ⟹   ENSRNOP00000000618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,933,595 - 5,995,134 (+)Ensembl
RefSeq Acc Id: NM_031020   ⟹   NP_112282
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,749,670 - 6,810,590 (+)NCBI
Rnor_6.0205,933,303 - 5,995,137 (+)NCBI
Rnor_5.0207,968,528 - 8,028,708 (+)NCBI
RGSC_v3.4206,939,249 - 7,000,378 (+)RGD
Celera208,305,853 - 8,366,371 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256142   ⟹   XP_006256204
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,749,646 - 6,810,590 (+)NCBI
Rnor_6.0205,933,296 - 5,995,137 (+)NCBI
Rnor_5.0207,968,528 - 8,028,708 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112282   ⟸   NM_031020
- UniProtKB: Q56A33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256204   ⟸   XM_006256142
- Peptide Label: isoform X1
- UniProtKB: G3V617 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000617   ⟸   ENSRNOT00000000617
RefSeq Acc Id: ENSRNOP00000000618   ⟸   ENSRNOT00000000618
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701435
Promoter ID:EPDNEW_R11957
Type:initiation region
Name:Mapk14_1
Description:mitogen activated protein kinase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,933,300 - 5,933,360EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70496 AgrOrtholog
Ensembl Genes ENSRNOG00000000513 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000617 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000000618 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000617 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000000618 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7313217 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_p38-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p38alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81649 UniProtKB/TrEMBL
MGC_CLONE MGC:105413 IMAGE-MGC_LOAD
NCBI Gene 81649 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk14 PhenoGen
PRINTS P38MAPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V617 ENTREZGENE, UniProtKB/TrEMBL
  MK14_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q56A33 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O08594 UniProtKB/Swiss-Prot
  Q99MG4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Mapk14  mitogen activated protein kinase 14    p38 mitogen activated protein kinase  Name updated 629478 APPROVED
2002-06-10 Mapk14  p38 mitogen activated protein kinase      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in heart ventricle 70317
gene_function phosphorylates and activates Mapkapk2 70317
gene_pathway estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process mediates hypertrophic agonist-induced GATA-4 binding and expression of B-type natriuretic peptide gene in cultured neonatal cardiac myocytes 625524
gene_process important for cytokine production 70317
gene_process important for cytokine production 70572
gene_process functions in stress related transcription and cell cycle regulation as well as in genotoxic stress response 70317
gene_process functions in stress related transcription and cell cycle regulation as well as in genotoxic stress response 70572
gene_product MAP kinase family member 70317
gene_regulation responds to changes in extracellular osmolarity 70572
gene_regulation responds to changes in extracellular osmolarity 625524
gene_regulation activated by estrogen in hippocampus, downregulated by ovariectomy 70572
gene_regulation activated by both receptor tyrosine kinase (RTK) and G protein-coupled receptor (GPCR) agonists 625519
gene_regulation activation requires NADH/NADPH-like oxidase activity in vascular smooth muscle cells (VSMC) 625519