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Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.

Authors: Feng, AW  Yu, C  Mao, Q  Li, N  Li, QR  Li, JS 
Citation: Feng AW, etal., Fitoterapia. 2011 May 27.
Pubmed: (View Article at PubMed) PMID:21641970
DOI: Full-text: DOI:10.1016/j.fitote.2011.05.013

The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased phosphorylation of mucosal p38 MAPK and ATF2 as well as production of ATF2, whereas BBR attenuated these effects. LPS upregulated mucosal peroxisome proliferator-activated receptor gamma (PPARgamma), but BBR reduced this receptor. GW9662 aggravated LPS-induced and reversed BBR-attenuated COX-2 expression. The findings showed that BBR ameliorated COX-2 overexpression partially via modulation of p38 and PPARgamma pathways during acute endotoxemia.


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RGD Object Information
RGD ID: 5135029
Created: 2011-07-11
Species: All species
Last Modified: 2011-07-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.