INTERLEUKIN-6 SIGNALING PATHWAY (PW:0000516)

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Description

Discovered in 1986 as a B-cell differentiation factor, interleukin 6 (Il6) is now known to be the archetypal member of a family of cytokines involved in a broad range of biological processes. Interleukin 6 signaling pathway plays important regulatory roles in immune responses, inflammation, embryonic development, the hematopoietic and nervous systems. Characteristic of Il6 family mediated signaling is the shared use of a co-receptor transducer molecule - Il6st, known as gp130. Il6 is expressed i

Pathway Diagram:

Elsevier Inc. Tocilizumab Adam17 Adam10 IL6st ---> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Grb2 Y759 IL6st --+> Jak-Stat signaling pathway IL6st --+> Jak(s) Jak(s) --+> Stat(s) Tocilizumab ---| sIl6r Stat(s) Jak(s) IL6st sIl6st ---| IL6st Tocilizumab ---| Il6r Il6 Sos2 Ptpn11 Il6r Jak-Stat signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway sIl6r ---- Tocilizumab Il6r ---- Tocilizumab IL6st ---- sIl6r Il6 ---- sIl6r Sos1 IL6st ---- Ptpn11 Grb2 ---- Ptpn11 IL6st ---- Stat(s) sIl6st Adam17 ---> sIl6r sIl6r Adam10 ---> sIl6r sIl6r ---- sIl6st Jak(s) ---> IL6st IL6st ---- Jak(s) Il6r ---- IL6st Il6 ---- Il6r Il6 ---- IL6st Jak(s) ---> Ptpn11
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Genes in Pathway:

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interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:6484113
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:5686846
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:5686834
RGD:5686846
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6484113
G Cebpd CCAAT/enhancer binding protein delta JBrowse link 11 89,008,008 89,009,146 RGD:6484113
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6484113
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:6484113
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6484113
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6484113
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
G Gab2 GRB2-associated binding protein 2 JBrowse link 1 162,082,876 162,283,379 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:5686834
RGD:6484113
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:6484113
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:6484113
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1580493
RGD:11062097
RGD:6484113
RGD:5686839
RGD:5686834
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:5686834
RGD:6484113
RGD:5686839
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:5686834
RGD:6484113
RGD:5686900
RGD:5686839
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:6484113
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:5686839
RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5686839
RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Junb JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link 19 26,092,972 26,094,756 RGD:6484113
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:6484113
G Lmo4 LIM domain only 4 JBrowse link 2 250,218,635 250,235,435 RGD:6484113
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mcl1 MCL1, BCL2 family apoptosis regulator JBrowse link 2 197,786,212 197,788,992 RGD:6484113
G Mitf melanocyte inducing transcription factor JBrowse link 4 130,172,484 130,425,496 RGD:6484113
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6484113
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:6484113
G Pias3 protein inhibitor of activated STAT, 3 JBrowse link 2 198,821,377 198,831,533 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:5686834
RGD:6484113
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6484113
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6484113
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:5686834
RGD:6484113
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:5686834
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:5686834
RGD:6484113
RGD:5686839
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:5686834
RGD:6484113
RGD:5686839
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6484113
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6484113
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:5686839
RGD:6484113
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinsIl6sta soluble form of Il6st that acts as an inhibitor of trans-signaling
ProteinsIl6ra soluble form of the Il6 receptor involved in trans-signaling
PathwayJak-Stat signaling pathwayan important intracellular cascade initiated in response to cytokine signaling
Pathwaythe extracellular signal-regulated Raf/Mek/Erk signaling pathwayan important MAPK cascade downstream of many activated cell surface receptors
Small MoleculeTocilizumabinhibitor of Il6 receptors
Functional ClassStat(s)members of Stat transcription factors associated with Ilst
Functional ClassJak(s)members of the Janus kinase associated with Il6st

Pathway Gene Annotations

Disease Annotations Associated with Genes in the interleukin-6 signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmCrp
Aberrant Crypt FociFos , Myc
Abortion, SpontaneousIl6 , Jak2
Acute Coronary SyndromeCrp , Il6
acute kidney failureA2m , Crp , Il6 , Myc
Acute Liver FailureIl6
Acute Lung InjuryIl6
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesJak1 , Jak2
acute myeloid leukemiaCebpd , Foxo1 , Il6 , Jak1 , Jak2 , Myc , Ptpn11 , Stat3
Acute Necrotizing PancreatitisIl6
acute promyelocytic leukemiaAkt1 , Myc
acute stress disorderCrp
Acute UveitisCrp
Acute-Phase ReactionIl6 , Il6r
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaMyc , Pik3ca , Ptpn11 , Stat3
adenoid cystic carcinomaPik3ca , Stat3
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
adrenoleukodystrophyTimp1
adult respiratory distress syndromeTimp1
adult T-cell leukemiaIl6 , Stat3 , Vav1
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
aggressive periodontitisCrp
AlbuminuriaCrp , Il6
Alcoholic Fatty LiverCrp
alcoholic liver cirrhosisCrp , Il6 , Jak2 , Timp1
allergic conjunctivitisIrf1
allergic hypersensitivity diseaseIl6 , Il6st , Map2k6
Alpha-2-Macroglobulin DeficiencyA2m
Alveolar Bone LossTnfsf11
alveolar rhabdomyosarcomaFoxo1
Alzheimer's diseaseA2m , Adam10 , Adam17 , Akt1 , Cebpb , Crp , Il6 , Il6r , Il6st , Jak2 , Mapk14 , Pik3r1 , Stat3
Alzheimer's disease 1A2m
Alzheimer's disease 18Adam10
amnestic disorderIl6
amphetamine abuseAkt1 , Fos
amyotrophic lateral sclerosisAkt1 , Mapk14
amyotrophic lateral sclerosis type 1Fos
anaplastic large cell lymphomaJunb , Stat3
anemiaIl6 , Jak2
anencephalyLmo4
angiomyolipomaStat1 , Stat3
angiosarcomaJun , Myc , Stat3
Animal Disease ModelsAkt1 , Fos , Myc , Stat3 , Timp1
Animal Mammary NeoplasmsIl6st , Map2k6 , Pik3r1 , Stat3
ankylosing spondylitisCrp , Il6 , Jak2
anti-basement membrane glomerulonephritisMapk14
antiphospholipid syndromeCrp
anxiety disorderCrp , Fos
aortic valve disease 1Il6
aortic valve insufficiencyTimp1
aortic valve stenosisPtpn11
Aortic Valve, Calcification ofAkt1
arrhythmogenic right ventricular cardiomyopathyIl6r
Arsenic PoisoningCrp , Pias1
arteriosclerosisIl6st
arteriovenous malformations of the brainIl6
Ascorbic Acid DeficiencyIl6
aseptic meningitisIl6
aspergillosisCrp
AsphyxiaJun
asthmaCrp , Il6 , Il6r , Irf1
astroblastomaPik3r1
astrocytomaAkt1 , Ptpn11
ataxia telangiectasiaIl6
atherosclerosisAkt1 , Crp , Il6 , Socs3 , Stat3
atopic dermatitisAdam17 , Il6
atrial fibrillationCrp
AtrophyStat3
autism spectrum disorderMapk11
autistic disorderIl6 , Stat3
Autoimmune Disease, Multisystem, Infantile-Onset, 1Stat3
Autoimmune DiseasesIl6 , Stat3 , Timp1
autoimmune hepatitisIl6
autoimmune lymphoproliferative syndrome type 3Prkcd
autoimmune thyroiditisIl6
autosomal dominant mental retardation 48Rac1
autosomal dominant polycystic kidney diseaseFos , Myc
autosomal recessive nonsyndromic deafness 26Gab1
autosomal recessive osteopetrosis 2Tnfsf11
autosomal recessive polycystic kidney diseaseAkt1 , Myc , Pik3ca
B-Cell Chronic Lymphocytic LeukemiaIl6 , Tnfsf11
B-Cell LeukemiaMyc
background diabetic retinopathyA2m
BacteremiaCrp
bacterial infectious diseaseCrp
bacterial meningitisCrp
bacterial pneumoniaIrf1 , Stat3
Bannayan-Riley-Ruvalcaba syndromePik3ca
Barrett's esophagusMcl1
basal cell carcinomaIl6 , Pik3ca
Behcet's diseaseCrp , Il6 , Stat3
berylliosisIl6
beta thalassemiaIl6
Bile Duct NeoplasmsIl6
biliary tract benign neoplasmIl6
bipolar disorderAkt1
bladder urothelial carcinomaAkt1 , Pik3ca
BlisterAdam17
blood coagulation diseaseFgg
Brain ConcussionIl6
Brain DeathMap2k4 , Map2k6
Brain HypoxiaAdam17
Brain InjuriesAkt1 , Cebpb , Crp , Fos , Il6 , Irf1 , Jak2 , Jun , Pias1 , Stat1 , Stat3 , Timp1
Brain Injuries, TraumaticAdam10
brain ischemiaAkt1 , Cebpb , Il6 , Il6st , Jun , Prkcd , Stat3
Brain NeoplasmsPik3ca , Pik3r1 , Ptpn11
breast adenocarcinomaAkt1 , Pik3ca
breast cancerAkt1 , Grb2 , Myc , Pik3ca , Stat1
Breast Cancer, FamilialPik3ca
Breast NeoplasmsAdam10 , Akt1 , Crp , Fos , Il6 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Stat1 , Stat3 , Timp1
bronchiectasisStat1
bronchiolitisCrp
bronchiolitis obliteransIl6
Bruton-type agammaglobulinemiaPik3r1
Budd-Chiari syndromeJak2
Burkitt lymphomaMyc , Pik3r1
BurnsA2m , Crp , Il6 , Lbp , Prkcd , Socs3
Burns, ChemicalIl6
CachexiaIl6
Cadmium PoisoningIl6
Cafe au lait Spots, MultipleSos1
CAKUT2Timp1
calcinosisJak2 , Timp1
Camurati-Engelmann diseaseMitf
cancerMyc , Pik3ca , Pik3r1
Candidiasis, Familial, 6Stat1
cannabis abuseAkt1
carcinomaIl6st , Myc , Pik3r1 , Stat3
cardiac arrestAkt1
Cardiac ArrhythmiasCrp , Map2k4
cardiofaciocutaneous syndromePtpn11
CardiomegalyA2m , Akt1 , Il6 , Il6st , Map2k6 , Myc , Prkcd , Rac1 , Stat3
cardiomyopathyAdam10 , Akt1 , Il6 , Mapk11 , Mapk14 , Stat3
CardiotoxicityRac1
Cardiovascular AbnormalitiesPtpn11
cardiovascular system diseaseCrp
Carotid Artery InjuriesMyc
Castleman diseaseIl6
cataractAdam10
celiac diseaseIl6
Cell Transformation, NeoplasticFos , Il6 , Jun , Mitf , Myc , Rac1 , Stat3
central nervous system diseaseIl6
cerebral infarctionA2m
Cerebral Small Vessel DiseasesFgg
cervix uteri carcinoma in situStat3
Chemical and Drug Induced Liver InjuryCrp , Il6 , Lbp
cholangiocarcinomaIl6
cholangitisTimp1
cholestasisIl6 , Mapk14 , Timp1
cholesteatoma of middle earIl6
chorioamnionitisIl6
Choroidal NeovascularizationStat3
Chromosome BreakageMyc
Chronic Cerebral HypoperfusionMapk14
Chronic HepatitisStat3
chronic lymphocytic leukemiaMyc , Ptpn11
chronic mucocutaneous candidiasisStat1
chronic myeloid leukemiaAkt1 , Gab2 , Jak2 , Mapk14
chronic obstructive pulmonary diseaseCrp , Il6 , Map2k4 , Timp1
Chronic PeriodontitisTnfsf11
Churg-Strauss syndromeStat3
clear cell renal cell carcinomaMyc
cleft lipMyc
cleft palateMyc
cleidocranial dysplasiaCebpb
CLOVES syndromePik3ca
Cocaine-Related DisordersFos , Tyk2
cochlear diseaseIl6
cognitive disorderMapk14
Cognitive DysfunctionAdam10 , Stat1
colitisAdam17 , Il6
COLOBOMA, OSTEOPETROSIS, MICROPHTHALMIA, MACROCEPHALY, ALBINISM, AND DEAFNESSMitf
colon adenocarcinomaRac1
colon adenomaRac1
colon cancerAkt1 , Pik3ca
colon carcinomaAkt1 , Pik3ca
Colonic NeoplasmsA2m , Fos , Jun , Map2k6 , Myc , Pik3ca , Pik3r1 , Stat3
colorectal adenocarcinomaFos , Jun
colorectal adenomaFos , Jun
colorectal cancerAkt1 , Pik3ca , Rac1 , Stat3
Colorectal NeoplasmsAkt1 , Crp , Fos , Il6st , Pik3ca , Pik3r1 , Ptpn11
complex cortical dysplasia with other brain malformationsPik3ca
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPtpn11
congenital afibrinogenemiaFgg
congenital diaphragmatic herniaStat3
congenital heart diseasePtpn11
congenital myopathyFgg
congestive heart failureAdam17 , Crp , Fos , Foxo1 , Il6 , Il6r , Rac1 , Timp1
conjunctival diseaseIl6
Contrast-Induced NephropathyCrp
Copper-Overload CirrhosisStat3
corneal ulcerIl6
coronary artery diseaseAkt1 , Crp , Il6
coronary restenosisMyc
Coronavirus InfectionsIl6
Costello syndromePtpn11
Cowden diseaseAkt1 , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca
Coxsackievirus InfectionsIl6
Crohn's diseaseCrp , Il6 , Jak2 , Stat3 , Tyk2
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 8Mitf
cutaneous T cell lymphomaMcl1
cystic fibrosisIl6 , Irf1 , Timp1
Cytomegalovirus InfectionsStat1
DeafnessMitf
degenerative disc diseaseTimp1
demyelinating diseaseMyc
diabetes mellitusIl6 , Rac1 , Timp1
Diabetes Mellitus, Experimental Akt1 , Crp , Il6 , Map2k6 , Myc , Pik3r1 , Prkcd , Socs3 , Stat1 , Stat3 , Timp1
Diabetic CardiomyopathiesA2m
Diabetic FootCrp
Diabetic NephropathiesCrp , Il6 , Jak2 , Mapk14 , Stat3
diabetic neuropathyMapk14
diabetic retinopathyCrp , Il6
Diaphragmatic HerniaIl6
diffuse large B-cell lymphomaPik3ca
diffuse sclerodermaIl6
dilated cardiomyopathyPtpn11 , Rac1
disease by infectious agentCrp , Stat1
disease of cellular proliferationMyc , Pik3ca , Pik3r1
disease of metabolismCrp , Ptpn11
Disease ProgressionMyc , Pik3ca , Stat1
disseminated intravascular coagulationIl6
Dowling-Degos diseaseAdam10
Down syndromeTimp1
dry eye syndromeIl6
ductal carcinoma in situSocs3
duodenal ulcerStat3
Dysfibrinogenemia, CongenitalFgg
Eales DiseaseIl6
eclampsiaIl6
EdemaIl6 , Map2k6
embryonal rhabdomyosarcomaPtpn11
EmphysemaTimp1
end stage renal failureCrp , Il6
endometrial adenocarcinomaPik3r1
endometrial cancerPik3r1
endometrial carcinomaPik3ca , Pik3r1
Endometrial NeoplasmsGrb2 , Irf1 , Jun , Myc , Pik3ca , Socs3 , Stat3 , Timp1
Endometrioid CarcinomasAkt1
endometriosisFos , Vav1
EndotoxemiaIl6 , Lbp , Mapk14 , Socs3
EntamoebiasisIl6
Epidermal HyperplasiaStat3
epidermal nevusPik3ca
epididymitisIl6
epilepsyAkt1 , Fos , Il6
esophageal carcinomaMyc , Pik3ca
Esophageal NeoplasmsMyc
esophagus adenocarcinomaPik3ca
essential thrombocythemiaJak2
Experimental ArthritisA2m , Adam10 , Adam17 , Akt1 , Crp , Il6 , Il6st , Jak2 , Socs3 , Stat1 , Stat3
Experimental Autoimmune EncephalomyelitisA2m , Adam17 , Il6 , Jak2 , Stat1 , Stat3
Experimental Autoimmune MyocarditisIl6
Experimental Autoimmune UveitisStat3
Experimental Autoimmune UveoretinitisStat3
Experimental ColitisAdam17 , Il6
Experimental Liver CirrhosisA2m , Adam17 , Cebpd , Crp , Fgg , Fos , Hck , Il6 , Jak2 , Lbp , Myc , Prkcd , Timp1 , Vav1
Experimental Liver NeoplasmsIl6 , Jak2 , Myc , Stat3
extrahepatic cholestasisFos , Il6 , Jun , Mapk14 , Timp1
Facial AsymmetryPik3ca
Failure to ThrivePtpn11 , Stat1
familial adenomatous polyposisAkt1
familial erythrocytosis 1Jak2
familial erythrocytosis 2Jak2
familial hyperlipidemiaCrp
familial hypertrophic cardiomyopathySos1
familial Mediterranean feverIl6
fatty liver diseaseCebpb , Il6 , Jak2 , Myc , Prkcd , Socs3
Female InfertilityCebpb
Female Urogenital DiseasesTimp1
Femoral FracturesIl6
Femur Head NecrosisA2m
Fetal Growth RetardationPtpn11
Fetal Inflammatory Response SyndromeIl6
FeverA2m , Il6 , Il6r , Stat3
Fever of Unknown OriginCrp
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Socs3 , Stat3
Fibrous Dysplasia of BoneFos
focal segmental glomerulosclerosisPias1
Foot InjuriesIl6
gallbladder carcinomaPik3ca
gastric adenocarcinomaAkt1 , Irf1 , Pik3ca , Ptpn11
gastric ulcerTimp1
Gastrointestinal NeoplasmsPik3ca
genetic diseaseFgg , Jak1 , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Stat1 , Stat3
gestational diabetesIl6
gingival fibromatosisSos1
gingivitisIl6
glioblastoma multiformeAkt1 , Myc , Pik3ca , Pik3r1
glomerulonephritisFos , Il6
glucose intoleranceJak2
glucosephosphate dehydrogenase deficiencyIl6
Graves' diseaseIl6 , Il6r
Growth DisordersJak2 , Pik3ca
growth hormone secreting pituitary adenomaPtpn11
Hashimoto DiseaseIl6
Head and Neck NeoplasmsPik3ca
head and neck squamous cell carcinomaAkt1 , Pik3ca , Rac1 , Stat3
HeadacheIl6
Hearing LossMitf , Stat1
Hearing Loss, Noise-InducedIl6
Hearing Loss, SuddenIl6
heart diseaseA2m , Crp , Jak2 , Mapk14 , Stat3 , Timp1
heart valve diseaseJak2 , Timp1
Heat Stress DisordersIl6
Heat StrokeFos , Il6 , Il6r , Jun
Helicobacter InfectionsSocs3
hemarthrosisIl6
HematuriaFos
HemimegalencephalyPik3ca
hemolytic anemiaA2m
hemolytic-uremic syndromeFos , Il6
HemorrhageFos
Hepatic InsufficiencyMapk14
Hepatitis C, ChronicCrp , Stat3
hepatocellular adenomaA2m , Ptpn11
hepatocellular carcinomaA2m , Akt1 , Cebpb , Cebpd , Crp , Fos , Il6 , Il6st , Jun , Myc , Pik3ca , Rac1 , Socs3 , Stat1 , Vav1
HepatomegalyMapk14
hereditary multiple exostosesPtpn11
Hereditary Neoplastic SyndromesIrf1 , Mitf , Pik3ca
Heterochromia IridisMitf
HIV Wasting SyndromeIl6
Hodgkin's lymphomaIl6 , Jun , Junb
human immunodeficiency virus infectious diseaseCrp , Il6 , Socs3
Human InfluenzaCrp , Il6 , Stat1
Huntington's diseaseCebpb , Il6 , Il6r
Hyper-IgE Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaFos , Il6 , Il6r , Jak2 , Stat3
hyperandrogenismIl6st
hypercalcemiaIl6 , Tnfsf11
hyperglycemiaIl6
hyperhomocysteinemiaTimp1
hyperinsulinismIl6 , Prkcd
HyperkinesisFos
HyperoxaluriaIl6
HyperoxiaIl6 , Timp1
HyperparathyroidismMyc
HyperplasiaAkt1 , Pik3ca
hypertensionAkt1 , Crp , Fos , Il6 , Il6r , Il6st , Jun , Pik3r1 , Prkcd , Timp1
hypertensive retinopathyCrp
HypertriglyceridemiaCrp , Il6st , Socs3
hypertrophic cardiomyopathyMyc , Ptpn11
hyperuricemiaJak2 , Stat3
HypoalbuminemiaA2m , Il6
Hypodysfibrinogenemia, CongenitalFgg
hypoglycemiaPik3r1
hypogonadismIl6
HypotensionIl6
hypothyroidismStat1
HypoxiaCrp
Hypoxia-Ischemia, BrainCrp , Il6
idiopathic interstitial pneumoniaIl6
idiopathic pulmonary fibrosisStat3
IgA glomerulonephritisTimp1
Immunodeficiency 31AStat1
IMMUNODEFICIENCY 31BStat1
IMMUNODEFICIENCY 31CStat1
Immunodeficiency 36Pik3r1
impotenceAkt1 , Il6
in situ carcinomaAkt1
InflammationA2m , Akt1 , Cebpb , Crp , Fgg , Il6 , Jak2 , Stat3 , Timp1
inflammatory bowel diseaseCrp , Il6 , Stat3
Insulin ResistanceFoxo1 , Il6 , Il6r , Pik3r1 , Prkcd , Socs3
intellectual disabilityFos
intermediate coronary syndromeAkt1 , Crp
interstitial cystitisCrp
interstitial nephritisCrp
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsPrkcd
Intestinal PolypsJun
Intestinal Reperfusion InjuryCrp , Il6 , Jak2 , Lbp
intracranial aneurysmIl6 , Timp1
Intracranial HemorrhagesIl6
Intraventricular HemorrhageIl6
invasive ductal carcinomaAkt1 , Map2k4 , Socs3
iron deficiency anemiaCrp , Il6
irritant dermatitisStat3
ischemiaIl6
Job's syndromeStat3
juvenile myelomonocytic leukemiaPtpn11
juvenile rheumatoid arthritisCrp , Fos , Il6 , Jun , Stat3
Kaposi's sarcomaIl6
Kawasaki diseaseCrp , Timp1
KeloidFgg
keratitisIl6
keratoconjunctivitis siccaIl6
keratoconusFoxo1
kidney failureCrp
Kidney NeoplasmsAkt1 , Jun , Junb
Kidney Reperfusion InjuryAdam17 , Fgg , Fos , Myc
Klebsiella InfectionsIl6
Kuhnt-Junius degenerationCrp , Il6
L-2-hydroxyglutaric aciduriaSos2
Language Development DisordersStat1
learning disabilityIl6
Left Ventricular HypertrophyAdam17 , Crp , Myc , Prkcd , Rac1
leiomyomaMyc
leishmaniasisCrp , Il6 , Mcl1
LEOPARD syndromePtpn11
leukemiaJak2 , Ptpn11
lichen diseaseIl6
limited sclerodermaJak2
Liver AbscessStat1
liver benign neoplasmJun , Mapk14 , Myc , Stat3
liver cancerAkt1 , Pik3ca
liver cirrhosisA2m , Crp , Il6 , Lbp , Stat1 , Stat3
liver diseaseRac1 , Socs3
Liver InjuryFgg , Il6 , Jak2 , Myc , Stat3
Liver Reperfusion InjuryIl6 , Jak2 , Lbp
low tension glaucomaCrp
lung adenocarcinomaAkt1 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1
lung cancerIrf1 , Pik3ca
lung diseaseA2m , Il6 , Irf1
Lung InjuryIl6
Lung NeoplasmsA2m , Akt1 , Crp , Fos , Il6 , Irf1 , Jun , Junb , Mapk14 , Mcl1 , Myc , Pik3ca
Lung Reperfusion InjuryMyc
lung small cell carcinomaAkt1 , Myc , Pik3ca , Pik3r1
lung squamous cell carcinomaAkt1 , Pik3ca , Ptpn11
lupus nephritisCrp
lymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisCrp , Pik3ca , Socs3 , Stat3 , Timp1
lymphomaPtpn11
lymphopeniaVav1
lymphoproliferative syndromeStat3
macular degenerationCrp
macular retinal edemaIl6
malariaCrp
malignant gliomaPik3ca
malignant mesotheliomaIl6
Mammary Neoplasms, ExperimentalAkt1 , Il6st , Myc , Pik3r1 , Socs3 , Stat1 , Stat3
mastoiditisCrp
medulloblastomaMyc , Pik3ca , Stat3 , Vav1
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
melanomaAkt1 , Gab2 , Mitf , Myc , Pik3ca , Pik3r1 , Rac1
membranous glomerulonephritisA2m
Memory DisordersStat3
Meningeal NeoplasmsAkt1
meningiomaAkt1
meningitisCrp
mental depressionCrp , Il6 , Il6r , Jun
Mercury Poisoning, Nervous SystemJun
Merkel cell carcinomaMyc
mesenteric vascular occlusionJak2
Metabolic SyndromeCrp , Il6 , Il6r , Lbp
MetachondromatosisPtpn11
mevalonic aciduriaCrp
Microphthalmia, Syndromic 1Adam17 , Mitf
middle cerebral artery infarctionCrp , Fos , Il6 , Il6r , Il6st , Junb , Stat3
mitochondrial myopathyIl6
mouth diseaseCrp
Mouth NeoplasmsPik3ca
Multiple Hamartoma SyndromePik3ca
multiple myelomaFgg , Il6 , Mcl1 , Pik3ca , Ptpn11
Multiple Organ FailureLbp
multiple sclerosisIl6 , Tyk2
Multisystem Autoimmune Disease, Infantile-OnsetStat3
muscular atrophyAkt1
muscular diseasePrkcd
Mycobacterium InfectionsStat1
Mycoplasma pneumoniae pneumoniaCrp
myelodysplastic syndromeMyc
myelofibrosisJak2
myeloid neoplasmJak2
myeloproliferative neoplasmJak2
myocardial infarctionAkt1 , Crp , Il6 , Il6r , Jak2 , Tnfsf11
Myocardial IschemiaCebpd , Crp , Il6 , Il6st , Irf1 , Jak2 , Junb , Mapk14 , Prkcd , Socs3
Myocardial Reperfusion InjuryAkt1 , Crp , Il6 , Il6r , Jak2 , Map2k6 , Mapk14 , Prkcd , Stat1 , Stat3
myocarditisCrp , Il6 , Tnfsf11
Myoclonus, Familial CorticalMyc
Nasal PolypsJun , Stat3
Nasopharyngeal NeoplasmsPik3ca
NecrosisIl6
Nematode InfectionsPik3r1
Neonatal Inflammatory Skin and Bowel DiseaseAdam17
Neonatal Inflammatory Skin and Bowel Disease 1Adam17
Neoplasm InvasivenessGab2 , Il6 , Timp1
Neoplasm MetastasisGab2 , Il6 , Myc , Pik3ca , Rac1 , Stat1 , Stat3 , Timp1
neovascular glaucomaIl6
nephroblastomaMyc , Stat1 , Stat3
nephronophthisisPias1
nephrotic syndromeA2m , Jak2
nervous system diseaseFos
neuroblastomaMap2k4 , Myc , Pik3ca , Ptpn11
neurodegenerative diseaseIl6
Neurodevelopmental DisordersPtpn11
neuroectodermal tumorMyc
neurofibromaPtpn11
neuromyelitis opticaIl6
neutropeniaStat3
Niemann-Pick disease type C1Jak2 , Stat3
non-arteritic anterior ischemic optic neuropathyCrp
non-Hodgkin lymphomaMyc , Pik3ca
non-small cell lung carcinomaAkt1 , Il6r , Irf1 , Myc , Pik3ca , Stat3
nonalcoholic fatty liver diseaseIl6 , Jak2 , Prkcd , Stat3
Nontuberculous Mycobacterium InfectionsStat1 , Tyk2
Noonan Like SyndromePtpn11 , Sos1
Noonan syndromePtpn11 , Sos1
Noonan syndrome 1Ptpn11
Noonan syndrome 3Ptpn11 , Sos1
Noonan syndrome 4Sos1
Noonan syndrome 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaPtpn11
obesityAkt1 , Crp , Fgg , Il6 , Il6r , Jak2 , Lbp , Myc , Pik3r1 , Prkcd , Socs3 , Stat3 , Timp1 , Tyk2
Obstetric Labor, PrematureIl6
obstructive jaundiceLbp
obstructive lung diseaseA2m
obstructive sleep apneaCrp , Il6
ocular albinism with sensorineural deafnessMitf
oculocutaneous albinismMitf
Ollier diseasePtpn11
Optic Nerve InjuriesJun
oral squamous cell carcinomaIl6
oral submucous fibrosisIl6 , Timp1
orchitisIl6r
osteoarthritisCebpb
OsteochondromaPtpn11
OsteolysisTnfsf11
osteopetrosisJun , Mitf , Tnfsf11
osteoporosisIl6 , Il6r , Mapk14 , Myc , Tnfsf11
osteosarcomaAkt1 , Jun , Myc
otitis externaCrp
otitis mediaCrp , Il6
ovarian cancerAkt1 , Pik3ca
ovarian hyperstimulation syndromeIl6
Ovarian NeoplasmsAkt1 , Il6 , Il6st , Map2k4 , Map2k6 , Myc , Pik3ca , Pik3r1 , Stat3 , Timp1
ovarian serous cystadenocarcinomaPik3ca
Overactive Urinary BladderCrp
Oxygen-Induced RetinopathyStat3
PainAkt1 , Il6st
pancreas diseaseIl6
pancreatic adenocarcinomaPik3ca
pancreatic cancerAkt1 , Map2k4 , Myc , Stat3
pancreatic carcinomaMyc
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisFgg
papillary renal cell carcinomaPik3ca
papillary thyroid carcinomaMyc
papillomaMap2k4
Paranoid DisordersTyk2
paraplegiaAkt1
Parkinson's diseaseA2m , Akt1 , Crp , Il6
Parkinsonian DisordersPrkcd
Pasteurellaceae InfectionsCrp
penile neoplasmPik3ca
periodontal diseaseIl6
periodontitisCrp , Il6 , Lbp
peripartum cardiomyopathyStat3
Peripheral Nerve InjuriesIl6 , Il6r
peripheral nervous system diseaseIl6 , Jun
peripheral vascular diseaseIl6
peritonitisA2m
pharyngoconjunctival feverCrp
Pick's diseaseFos , Map2k6
pigmentation diseaseMitf
Pituitary NeoplasmsIl6st
plasmacytomaPik3ca , Ptpn11
pleomorphic xanthoastrocytomaIl6
pleural diseaseIl6
pleurisyIl6
Pneumococcal MeningitisAdam17 , Il6
Pneumococcal PneumoniaCrp , Il6
pneumoniaCrp , Il6 , Il6st
polycystic kidney diseaseMyc
Polycystic Kidney Disease, Type 1Myc
polycystic ovary syndromeGab1
polycythemiaJak2
polycythemia veraJak1 , Jak2
polymyalgia rheumaticaCrp
PolymyositisIl6
polyneuropathyIl6
Polypoidal Choroidal VasculopathyCrp
portal hypertensionPik3r1 , Prkcd
Postmenopausal OsteoporosisIl6
Postoperative Atrial FibrillationCrp , Il6
pre-eclampsiaTimp1
pre-malignant neoplasmAkt1 , Il6 , Stat3
precursor B lymphoblastic lymphoma/leukemiaStat3
precursor lymphoblastic lymphoma/leukemiaHck , Myc
precursor T-lymphoblastic lymphoma/leukemiaPtpn11 , Stat1 , Tyk2
prediabetes syndromeIl6
Pregnancy ComplicationsJak2
Pregnancy Complications, CardiovascularIl6
Premature AgingFoxo1
Premature BirthIl6
preretinal fibrosisTimp1
primary biliary cirrhosisJak2 , Mapk14 , Tyk2
primary immunodeficiency diseaseStat1
progressive supranuclear palsyMap2k6
prolactinomaCebpd , Myc
proliferative diabetic retinopathyIl6r
proliferative vitreoretinopathyIl6
prostate adenocarcinomaAkt1 , Grb2 , Pik3ca
prostate cancerGrb2 , Pik3ca , Pik3r1 , Sos1
prostate carcinoma in situMap2k4 , Map2k6 , Myc
prostatic hypertrophyMyc
Prostatic NeoplasmsAkt1 , Foxo1 , Hsp90b1 , Il6 , Il6st , Jak1 , Jak2 , Jun , Map2k4 , Map2k6 , Myc , Pik3ca , Pik3r1 , Stat1 , Stat3
proteinuriaIl6
Proteus syndromeAkt1
Pseudomonas Aeruginosa KeratitisIl6
Pseudomonas InfectionsCrp
psoriasisCrp , Il6 , Stat3 , Tyk2
psoriatic arthritisStat3
PTEN hamartoma tumor syndromePik3ca
Pulmonary ContusionIl6
pulmonary embolismFgg
pulmonary emphysemaJun
pulmonary fibrosisCebpb , Il6 , Stat1 , Stat3 , Timp1
pulmonary hypertensionCrp , Foxo1 , Il6 , Myc
pulmonary sarcoidosisCrp
pulmonary tuberculosisCrp , Il6 , Il6r , Irf1 , Jun
pulmonary valve stenosisSos1
pyelonephritisCrp
Pyogenic GranulomaStat3
quadriplegiaIl6
RASopathiesPtpn11 , Sos1
rectal neoplasmFos , Pik3ca
relapsing-remitting multiple sclerosisTimp1
renal carcinomaPik3ca
renal cell carcinomaAkt1 , Crp , Il6 , Il6r , Jun , Mitf , Myc , Pik3ca , Pik3r1 , Stat3 , Timp1
Renal ColicCrp
renal fibrosisAdam17 , Crp , Myc
renal hypertensionCrp , Il6
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Fos , Il6 , Il6r , Il6st , Irf1 , Jak2 , Jun , Pik3r1 , Socs3 , Stat1 , Stat3
respiratory allergyIl6
respiratory syncytial virus infectious diseaseIl6 , Irf1
Respiratory Tract InfectionsIl6r , Irf1
restrictive cardiomyopathyMap2k6 , Mapk14 , Prkcd
reticulate acropigmentation of KitamuraAdam10
Retina Reperfusion InjuryIl6 , Map2k4 , Stat3
retinal artery occlusionIl6
retinal degenerationIl6st
retinal detachmentIl6 , Jak2
retinal vasculitisIl6
retinal vein occlusionCrp , Il6
rhabdoid cancerMyc
rheumatoid arthritisA2m , Cebpb , Crp , Il6 , Il6r , Il6st , Jak2 , Stat1 , Stat3 , Tyk2
Right Ventricular HypertrophyAkt1 , Prkcd
sarcomaMcl1 , Pik3ca
SarcopeniaCebpb , Il6
schizophreniaAkt1 , Il6 , Il6r
sciatic neuropathyIl6 , Il6r
scoliosisPtpn11
scrapieJak2 , Stat1 , Stat3
seborrheic keratosisPik3ca
secondary hyperparathyroidismCrp , Il6
sensorineural hearing lossMitf
SepsisA2m , Cebpb , Cebpd , Crp , Il6 , Jak2 , Lbp , Socs3 , Stat1 , Stat3
Sepsis-Associated EncephalopathyJak2 , Stat3
Septic PeritonitisIl6 , Pik3r1
Shock, HemorrhagicIl6 , Myc
SHORT SyndromePik3r1
Shwartzman phenomenonIl6
Sjogren's syndromeCrp , Il6
skin diseaseIl6 , Pias1
skin melanomaAkt1 , Mitf , Pik3ca , Rac1 , Stat3
Skin NeoplasmsAkt1 , Map2k4 , Stat3
sleep apneaIl6r
Sleep DeprivationMap2k4
small cell carcinomaIl6
Smith-Magenis syndromeGrb2 , Map2k6 , Socs3 , Stat3
Spinal Cord InjuriesAkt1 , Crp , Il6 , Irf1 , Jak2 , Jun
SplenomegalyIl6st
spondyloarthropathyIl6
Sporadic Papillary Renal Cell CarcinomaMyc , Pik3ca
squamous cell carcinomaAkt1 , Il6 , Myc , Pik3ca , Ptpn11 , Stat3
status epilepticusAdam10 , Crp , Fos , Il6st , Jun , Junb , Socs3
stomach cancerIl6st , Irf1 , Pik3ca
Stomach NeoplasmsFgg , Il6 , Il6r , Irf1 , Jun , Myc , Pik3ca , Stat3
StrokeAkt1 , Fgg , Il6 , Irf1 , Jak2 , Pik3ca , Prkcd , Timp1
Subarachnoid HemorrhageStat3
Subretinal FibrosisIl6 , Il6r
substance-induced psychosisAkt1
Sudden Death, CardiacIl6
Systemic Juvenile Rheumatoid ArthritisIl6 , Il6r
systemic lupus erythematosusCrp , Il6 , Jak1 , Jak2 , Junb
systemic sclerodermaIl6
T-cell leukemiaStat3
T-Cell LymphomaAkt1 , Stat3
temporal arteritisCrp
Tendon InjuriesFos
tetralogy of FallotPtpn11
thoracic aortic aneurysmAdam10 , Adam17
Thrombocythemia 3Jak2
thrombocytopeniaIl6
thrombocytopenia-absent radius syndromePias3
thrombocytosisJak2
ThromboembolismJak2
thrombosisCrp
Thrombotic MicroangiopathiesFgg
thyroid cancerMyc
Thyroid NeoplasmsAkt1 , Il6 , Pik3ca
Tibial FracturesTnfsf11
Tietz syndromeMitf
Tietze's syndromeMitf
Tobacco Use DisorderIl6
Tongue NeoplasmsFos , Junb , Stat3
toxic encephalopathyFos , Prkcd
toxic shock syndromeA2m , Il6
Toxoplasma ChorioretinitisIl6
transient cerebral ischemiaJak2 , Map2k4 , Stat3
transitional cell carcinomaAkt1 , Pik3ca , Timp1
Transplant RejectionMyc
Transverse MyelitisIl6
Trauma, Nervous SystemStat1
trigeminal neuralgiaFos
trypanosomiasisA2m
Tubulointerstitial Nephritis and UveitisCrp
Tympanic Membrane PerforationIl6
type 1 diabetes mellitusCrp , Foxo1 , Il6 , Stat3 , Timp1 , Tyk2 , Vav1
type 2 diabetes mellitusAdam17 , Akt1 , Crp , Fgg , Foxo1 , Il6 , Pik3r1 , Socs3 , Stat3 , Timp1
Tyrosine Kinase 2 DeficiencyTyk2
ulcerative colitisJak2 , Stat3
ureteral obstructionAdam10 , Adam17 , Akt1 , Irf1
urinary bladder cancerAkt1 , Map2k4 , Myc
urticariaCrp
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Fos , Jak2 , Map2k6 , Myc , Pias3 , Pik3ca , Sos1 , Stat3
Uterine NeoplasmsPik3ca , Pik3r1 , Rac1 , Sos1
uveal melanomaCrp
uveitisIl6 , Il6r
varicose veinsTimp1
vascular diseaseTimp1
Vascular MalformationsPik3ca
Venous ThrombosisJak2
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftIl6 , Rac1
ventricular septal defectFos
vestibular neuronitisCrp
Viral BronchiolitisIl6
viral infectious diseaseCebpb
visceral leishmaniasisCrp , Il6
visual epilepsyFos , Il6 , Il6r , Il6st , Pik3ca , Prkcd
vitiligoPik3r1
Waardenburg syndrome type 1Mitf
Waardenburg syndrome type 2AMitf
Waardenburg syndrome type 2EMitf
Waardenburg's syndromeMitf
Waldenstroem's macroglobulinemiaIl6
Weight GainLbp , Pik3ca
Wilson diseaseA2m , Il6 , Timp1
withdrawal disorderCrp , Fos
Wounds and InjuriesIl6 , Timp1
X-Linked Epilepsy, with Variable Learning Disabilities and Behavior DisordersTimp1
Pathway Annotations Associated with Genes in the interleukin-6 signaling pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayFgg
acute myeloid leukemia pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2 , Stat3
adenosine signaling pathwayAkt1 , Jun , Map2k6 , Mapk11 , Pik3ca
aldosterone signaling pathwayJak2 , Pias1 , Pik3ca , Pik3r1
alteplase pharmacodynamics pathwayFgg
altered Jak-Stat signaling pathwayJak2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
Alzheimer's disease pathwayA2m , Adam10 , Adam17
aminocaproic acid pharmacodynamics pathwayFgg
amyotrophic lateral sclerosis pathwayMap2k6 , Mapk11 , Mapk14 , Rac1
angiotensin II signaling pathwayJak2
angiotensin II signaling pathway via AT1 receptorJak2 , Tyk2
anistreplase pharmacodynamics pathwayFgg
apoptotic cell death pathwayAkt1 , Pik3ca , Pik3r1
aprotinin pharmacodynamics pathwayFgg
Arf family mediated signaling pathwayRac1
argatroban pharmacodynamics pathwayFgg
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Fos , Grb2 , Jun , Pik3ca , Pik3r1 , Rac1 , Sos1 , Sos2 , Vav1
bivalirudin pharmacodynamics pathwayFgg
brain-derived neurotrophic factor signaling pathwayGrb2
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Rac1
cell cycle pathway, mitoticMyc
ceramide signaling pathwayAkt1 , Jak1 , Map2k4 , Myc , Pik3ca , Pik3r1 , Prkcd , Rac1 , Stat1 , Stat3
Chagas disease pathwayAkt1 , Fos , Il6 , Jun , Map2k4 , Mapk11 , Mapk14 , Pik3ca , Pik3r1
chemokine mediated signaling pathwayAkt1 , Grb2 , Hck , Jak2 , Pik3ca , Pik3r1 , Prkcd , Rac1 , Sos1 , Sos2 , Stat1 , Stat3 , Vav1
chronic myeloid leukemia pathwayAkt1 , Gab2 , Grb2 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Sos2
classical complement pathwayCrp
coagulation cascade pathwayA2m , Fgg
codeine and morphine pharmacodynamics pathwayHsp90b1
codeine and morphine pharmacokinetics pathwayHsp90b1
colorectal cancer pathwayAkt1 , Fos , Jun , Myc , Pik3ca , Pik3r1 , Rac1
complement system pathwayA2m , Fgg
cytokine mediated signaling pathwayIl6 , Il6r , Il6st , Tnfsf11
dicoumarol pharmacodynamics pathwayFgg
E-cadherin signaling pathwayAkt1 , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Hck , Mapk11 , Mapk14 , Prkcd , Rac1
endometrial cancer pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayHsp90b1
endothelin signaling pathwayAkt1 , Fos , Jak2 , Jun , Mapk14 , Prkcd , Rac1
enoxaparin pharmacodynamics pathwayFgg
Entamoebiasis pathwayIl6 , Pik3ca , Pik3r1
ephrin - ephrin receptor bidirectional signaling axisFgg , Grb2 , Hck , Map2k4 , Pik3ca , Pik3r1 , Rac1
epidermal growth factor/neuregulin signaling pathwayAdam10 , Adam17 , Akt1 , Gab1 , Grb2 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Sos2 , Stat1 , Stat3
erythropoietin signaling pathwayGab1 , Grb2 , Jak2 , Mapk14 , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Stat1
etoposide pharmacodynamics pathwayHsp90b1
etoposide pharmacokinetics pathwayHsp90b1
FasL mediated signaling pathwayAkt1 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1
Fc epsilon receptor mediated signaling pathwayAkt1 , Gab2 , Grb2 , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Prkcd , Rac1 , Sos1 , Sos2 , Vav1
Fc gamma receptor mediated signaling pathwayAkt1 , Gab2 , Hck , Pik3ca , Pik3r1 , Prkcd , Rac1 , Vav1
fibrinolysis pathwayFgg
fibroblast growth factor signaling pathwayAkt1 , Fos , Gab1 , Grb2 , Jun , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Stat1
fondaparinux pharmacodynamics pathwayFgg
forkhead class A signaling pathwayAkt1 , Cebpb , Cebpd , Fos , Jun
glioma pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Sos1 , Sos2
glypican signaling pathwayHck
gonadotropin-releasing hormone signaling pathwayGrb2 , Jun , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Prkcd , Sos1 , Sos2
graft-versus-host disease pathwayIl6
granulocyte-macrophage colony-stimulating factor signaling pathwayFos , Gab2 , Grb2 , Jak2 , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Stat1 , Stat3
growth hormone signaling pathwayJak2
Hedgehog signaling pathwayAkt1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
heparin pharmacodynamics pathwayFgg
hepatitis C pathwayAkt1 , Grb2 , Irf1 , Jak1 , Mapk11 , Mapk14 , Pias1 , Pias3 , Pik3ca , Pik3r1 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3
hypertrophic cardiomyopathy pathwayIl6
hypoxia inducible factor pathwayAkt1 , Fos , Jun , Mcl1
ibuprofen pharmacodynamics pathwayHsp90b1
ibuprofen pharmacokinetics pathwayHsp90b1
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A pathwayAkt1 , Il6 , Jak1 , Jak2 , Jun , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Socs3 , Stat1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Rac1
insulin signaling pathwayAkt1 , Foxo1 , Grb2 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Sos1
interleukin-1 signaling pathwayJun , Map2k6 , Pik3ca , Pik3r1
Interleukin-10 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
interleukin-12 signaling pathwayFos , Jak2 , Map2k6 , Mapk14 , Stat1 , Stat3 , Tyk2
interleukin-2 signaling pathwayFos , Gab2 , Grb2 , Jak1 , Jun , Mapk11 , Mapk14 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Stat1 , Stat3
interleukin-23 signaling pathwayIl6 , Jak2 , Pik3ca , Pik3r1 , Socs3 , Stat1 , Stat3 , Tyk2
interleukin-27 signaling pathwayIl6 , Il6st , Jak1 , Jak2 , Stat1 , Stat3 , Tyk2
interleukin-3 signaling pathwayCebpb , Gab2 , Grb2 , Jak2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-4 signaling pathwayAkt1 , Cebpb , Grb2 , Jak1 , Jak2 , Mapk14 , Pik3ca , Pik3r1 , Socs3
interleukin-5 signaling pathwayGrb2 , Jak2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-6 signaling pathwayA2m , Adam10 , Adam17 , Akt1 , Cebpb , Cebpd , Crp , Fgg , Fos , Foxo1 , Gab1 , Gab2 , Grb2 , Hck , Hsp90b1 , Il6 , Il6r , Il6st , Irf1 , Jak1 , Jak2 , Jun , Junb , Lbp , Lmo4 , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Mcl1 , Mitf , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3 , Timp1 , Tnfsf11 , Tyk2 , Vav1
intrinsic apoptotic pathwayMcl1
irinotecan pharmacodynamics pathwayHsp90b1
irinotecan pharmacokinetics pathwayHsp90b1
Jak-Stat signaling pathwayAkt1 , Grb2 , Il6 , Il6r , Il6st , Irf1 , Jak1 , Jak2 , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3 , Tyk2
kallikrein-kinin cascade pathwayA2m
Leishmaniasis pathwayFos , Jak1 , Jak2 , Jun , Mapk11 , Mapk14 , Stat1
leptin system pathwayJak2 , Ptpn11 , Socs3 , Stat3
malaria pathwayIl6
measles pathwayAkt1 , Il6 , Jak1 , Jak2 , Pik3ca , Pik3r1 , Stat1 , Stat3
melanoma pathwayAkt1 , Mitf , Pik3ca , Pik3r1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Fos , Grb2 , Jun , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Myc , Rac1 , Sos1 , Sos2
mTOR signaling pathwayAkt1 , Pik3ca , Pik3r1 , Rac1
myocarditis pathwayRac1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Ptpn11 , Rac1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Gab1 , Grb2 , Jun , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1 , Sos1 , Sos2
NOD-like receptor signaling pathwayHsp90b1 , Il6 , Mapk11 , Mapk14
non-small cell lung carcinoma pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Sos1 , Sos2
Non-Stat, Jak dependent pathwayJak1 , Tyk2
Notch signaling pathwayAdam10 , Adam17 , Myc
nuclear factor kappa B signaling pathwayIrf1 , Mapk14 , Pik3ca , Pik3r1
p38 MAPK signaling pathwayIrf1 , Map2k6 , Mapk11 , Mapk14 , Rac1
p53 signaling pathwayAkt1 , Mapk14 , Prkcd
pancreatic cancer pathwayAkt1 , Jak1 , Pik3ca , Pik3r1 , Rac1 , Stat1 , Stat3
paracetamol pharmacokinetics pathwayHsp90b1
phagocytosis pathwayRac1
phenindione pharmacodynamics pathwayFgg
phenytoin pharmacodynamics pathwayHsp90b1
phosphatidylinositol 3-kinase class I signaling pathwayHck , Pik3ca , Pik3r1 , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Foxo1 , Pik3ca , Pik3r1
phosphoinositide metabolic pathwayPik3ca , Pik3r1
platelet-derived growth factor signaling pathwayFos , Gab1 , Grb2 , Hck , Jak1 , Jak2 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1 , Sos1 , Stat1 , Stat3
prion disease pathwayIl6
prostate cancer pathwayAkt1 , Foxo1 , Grb2 , Hsp90b1 , Pik3ca , Pik3r1 , Sos1 , Sos2
protein kinase C (PKC) signaling pathwayPrkcd
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Gab1 , Grb2 , Jun , Pik3ca , Pik3r1 , Ptpn11 , Rac1 , Sos1 , Sos2
reteplase pharmacodynamics pathwayFgg
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk11 , Mapk14
retinol metabolic pathwayHsp90b1
rheumatoid arthritis pathwayFos , Il6 , Jun , Tnfsf11
Rho/Rac/Cdc42 mediated signaling pathwayJun , Map2k4 , Rac1
scatter factor/hepatocyte growth factor signaling pathwayGab1 , Grb2 , Pik3r1 , Ptpn11
sleeping sickness pathwayIl6
small cell lung carcinoma pathwayAkt1 , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1
somatostatin signaling pathwayJak2 , Ptpn11
sorafenib pharmacokinetics pathwayHsp90b1
sphingosine 1-phosphate signaling pathwayAkt1 , Fos , Jak2 , Jun , Mapk14 , Rac1
Staphylococcus aureus infection pathwayFgg
sumoylation pathwayPias3
syndecan signaling pathwayPrkcd , Rac1
T cell receptor signaling pathwayAkt1 , Fos , Grb2 , Jun , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Sos1 , Sos2 , Vav1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd
thyroid cancer pathwayMyc
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayAkt1 , Fos , Il6 , Jun , Lbp , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Rac1 , Stat1
toxoplasmosis pathwayAkt1 , Jak1 , Jak2 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Stat1 , Stat3
Trail mediated signaling pathwayMap2k4 , Pik3ca , Pik3r1
tranexamic acid pharmacodynamics pathwayFgg
transforming growth factor-beta Smad dependent signaling pathwayA2m , Foxo1 , Grb2 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMyc
tuberculosis pathwayAkt1 , Cebpb , Il6 , Jak1 , Jak2 , Lbp , Mapk11 , Mapk14 , Stat1
tumor necrosis factor mediated signaling pathwayAdam17 , Stat1
type 2 diabetes mellitus pathwayPik3ca , Pik3r1 , Prkcd , Socs3
type II interferon signaling pathwayAkt1 , Cebpb , Irf1 , Jak1 , Jak2 , Pias1 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Stat1 , Stat3
ubiquitin/proteasome degradation pathwayPias1 , Pias3 , Socs3
urinary bladder cancer pathwayMyc
vascular endothelial growth factor signaling pathwayAkt1 , Gab1 , Grb2 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1
vitamin A deficiency pathwayHsp90b1
warfarin pharmacodynamics pathwayFgg
Wnt signaling pathwayJun , Myc , Rac1
Wnt signaling, non-canonical pathwayRac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the interleukin-6 signaling pathway

References Associated with the interleukin-6 signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: