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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14increases expressionISOMAPK14 (Homo sapiens)6480464CTDochratoxin A metabolite results in increased expression of MAPK14 mRNA; ochratoxin A results in increased expression of MAPK14 mRNAPMID:26314263
Mapk14increases response to substanceISOMAPK14 (Homo sapiens)6480464CTDMAPK14 protein results in increased susceptibility to ochratoxin APMID:22230261
Mapk14multiple interactionsISOMAPK14 (Homo sapiens)6480464CTDMAPK14 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CCNB1 protein]; MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]; MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]; MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]; MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]PMID:22230261
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