GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk14 | increases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MAPK14 protein | PMID:15767673 PMID:16213474 PMID:31010378 | Mapk14 | multiple interactions | EXP | | 6480464 | CTD | [SB 203580 results in decreased activity of MAPK14 protein] which results in decreased susceptibility to Doxorubicin; carvedilol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK14 protein]; Razoxane inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK14 protein] | PMID:15936597 PMID:16213474 | Mapk14 | affects activity | ISO | MAPK14 (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the activity of MAPK14 protein | PMID:15870702 | Mapk14 | decreases expression | ISO | MAPK14 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of MAPK14 mRNA | PMID:29803840 | Mapk14 | increases phosphorylation | ISO | MAPK14 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MAPK14 protein | PMID:15557793 | Mapk14 | multiple interactions | ISO | MAPK14 (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with Cyclophosphamide] affects the expression of MAPK14 mRNA; Doxorubicin promotes the reaction [MAPK14 protein results in decreased expression of BCL2L1 protein]; Doxorubicin promotes the reaction [MAPK14 protein results in decreased phosphorylation of BAD protein]; Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK14 protein | PMID:15494689 PMID:16322899 PMID:16843435 | | ||||||||||||||||||||||
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