GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk14 | decreases response to substance | ISO | MAPK14 (Homo sapiens) | 6480464 | CTD | MAPK14 results in decreased susceptibility to Arsenic Trioxide | PMID:16818652 | Mapk14 | increases phosphorylation | ISO | MAPK14 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of MAPK14 protein | PMID:36509116 | Mapk14 | multiple interactions | ISO | MAPK14 (Homo sapiens) | 6480464 | CTD | 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Emodin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein; Emodin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]; MAPK14 mutant form inhibits the reaction [Arsenic Trioxide affects the localization of BAX protein]; MAPK14 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; MAPK14 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]; MAPK14 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein]; MAPK14 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK2 protein]; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] | PMID:12239215 PMID:14610070 PMID:14729614 PMID:16818652 PMID:16972261 PMID:17237268 PMID:18299328 PMID:18412143 PMID:18482988 | Mapk14 | multiple interactions | ISO | Mapk14 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein; MAP2K3 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]; MAP2K6 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] | PMID:16818652 | | ||||||||||||||||||||||
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