Mapk14 (mitogen-activated protein kinase 14) - Rat Genome Database

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Pathways
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Gene: Mapk14 (mitogen-activated protein kinase 14) Heterocephalus glaber
Analyze
Symbol: Mapk14
Name: mitogen-activated protein kinase 14
RGD ID: 18919944
Description: ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN angiogenesis (ortholog); cell morphogenesis (ortholog); cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,527,333 - 21,597,733 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,528,121 - 21,598,064 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
bone development  (IEA)
cartilage condensation  (IEA)
cell morphogenesis  (IEA,ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA,ISO)
cellular response to ionizing radiation  (IEA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to lipoteichoic acid  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to UV-B  (IEA)
cellular response to vascular endothelial growth factor stimulus  (IEA)
cellular response to virus  (IEA)
chondrocyte differentiation  (IEA,ISO)
DNA damage checkpoint signaling  (IEA,ISO)
DNA damage response  (IEA,ISO)
fatty acid oxidation  (IEA,ISO)
glucose import  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
intracellular signal transduction  (IEA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
MAPK cascade  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of hippo signaling  (IEA)
osteoblast differentiation  (IEA)
osteoclast differentiation  (IEA)
p38MAPK cascade  (IEA)
placenta development  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of brown fat cell differentiation  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glucose import  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA)
positive regulation of myoblast differentiation  (IEA)
positive regulation of myoblast fusion  (IEA)
positive regulation of myotube differentiation  (IEA)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of cytokine production involved in inflammatory response  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of ossification  (IEA,ISO)
regulation of synaptic membrane adhesion  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to dietary excess  (IEA)
response to glucose  (ISO)
response to insulin  (IEA)
response to lipopolysaccharide  (IEA,ISO)
response to muramyl dipeptide  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
signal transduction in response to DNA damage  (IEA)
skeletal muscle tissue development  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stress-activated MAPK cascade  (IEA,ISO)
stress-activated protein kinase signaling cascade  (IEA)
stress-induced premature senescence  (IEA)
striated muscle cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mapk14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,527,333 - 21,597,733 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,528,121 - 21,598,064 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MAPK14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,027,808 - 36,124,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,027,782 - 36,111,236 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,995,585 - 36,079,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,103,551 - 36,186,513 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,103,550 - 36,186,513NCBI
Celera637,550,014 - 37,633,560 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,715,466 - 35,798,847 (+)NCBIHuRef
CHM1_1635,997,235 - 36,080,771 (+)NCBICHM1_1
T2T-CHM13v2.0635,848,088 - 35,944,528 (+)NCBIT2T-CHM13v2.0
Mapk14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,910,316 - 28,967,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,910,303 - 28,967,380 (+)EnsemblGRCm39 Ensembl
GRCm381728,691,342 - 28,748,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,691,329 - 28,748,406 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,828,287 - 28,885,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,419,034 - 28,475,994 (+)NCBIMGSCv36mm8
Celera1729,246,340 - 29,303,175 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.85NCBI
Mapk14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,751,288 - 6,812,294 (+)NCBIGRCr8
mRatBN7.2206,749,646 - 6,810,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,462,299 - 7,522,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,824,146 - 6,884,804 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,305,502 - 7,366,242 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Celera208,305,853 - 8,366,371 (+)NCBICelera
Cytogenetic Map20p12NCBI
Mapk14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,838,232 - 3,884,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,836,331 - 3,884,083 (+)NCBIChiLan1.0ChiLan1.0
MAPK14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,493,097 - 50,588,368 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1646,363,113 - 46,457,826 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,586,847 - 35,683,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,788,233 - 36,871,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,788,233 - 36,871,114 (+)Ensemblpanpan1.1panPan2
MAPK14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,145,647 - 5,221,558 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,146,037 - 5,220,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,166,000 - 5,239,239 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,493,681 - 5,569,596 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,493,440 - 5,569,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,148,463 - 5,221,682 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,227,753 - 5,300,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,327,755 - 5,400,924 (+)NCBIUU_Cfam_GSD_1.0
Mapk14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,650,066 - 40,722,468 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,237,277 - 23,310,232 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,237,762 - 23,310,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,790,877 - 31,862,031 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,791,398 - 31,861,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,725,706 - 36,795,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,012,164 - 36,095,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,014,454 - 36,095,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,975,418 - 36,065,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000022404   ⟹   ENSHGLP00000022193
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475421,527,333 - 21,597,733 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000022405   ⟹   ENSHGLP00000022194
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475421,527,333 - 21,597,730 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000022406   ⟹   ENSHGLP00000022195
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475421,537,918 - 21,597,667 (-)Ensembl
RefSeq Acc Id: XM_004846695   ⟹   XP_004846752
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475421,528,121 - 21,598,056 (-)NCBI
RefSeq Acc Id: XM_004846696   ⟹   XP_004846753
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475421,528,121 - 21,598,057 (-)NCBI
RefSeq Acc Id: XM_021259935   ⟹   XP_021115594
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475421,546,034 - 21,598,064 (-)NCBI
RefSeq Acc Id: XM_021259936   ⟹   XP_021115595
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475421,528,121 - 21,558,311 (-)NCBI
RefSeq Acc Id: XM_021259937   ⟹   XP_021115596
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475421,528,121 - 21,580,146 (-)NCBI
RefSeq Acc Id: XM_021259938   ⟹   XP_021115597
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475421,528,121 - 21,596,700 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004846753   ⟸   XM_004846696
- Peptide Label: isoform X2
- UniProtKB: G5BEW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004846752   ⟸   XM_004846695
- Peptide Label: isoform X1
- UniProtKB: A0A0N8ETG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021115597   ⟸   XM_021259938
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021115596   ⟸   XM_021259937
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021115595   ⟸   XM_021259936
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021115594   ⟸   XM_021259935
- Peptide Label: isoform X3
RefSeq Acc Id: ENSHGLP00000022193   ⟸   ENSHGLT00000022404
RefSeq Acc Id: ENSHGLP00000022194   ⟸   ENSHGLT00000022405
RefSeq Acc Id: ENSHGLP00000022195   ⟸   ENSHGLT00000022406


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015825 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100045273 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000022404 ENTREZGENE
  ENSHGLT00000022405 ENTREZGENE
  ENSHGLT00000047786 UniProtKB/TrEMBL
  ENSHGLT00000080106 UniProtKB/TrEMBL
  ENSHGLT00100067192 UniProtKB/TrEMBL
  ENSHGLT00100081406 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_p38-like UniProtKB/TrEMBL
  p38alpha UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report hgl:106007524 UniProtKB/TrEMBL
NCBI Gene Mapk14 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 14 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS P38MAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0N8ETG7 ENTREZGENE, UniProtKB/TrEMBL
  G5BEW2 ENTREZGENE, UniProtKB/TrEMBL