RGD Reference Report - A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. - Rat Genome Database

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.

Authors: Han, J  Lee, JD  Bibbs, L  Ulevitch, RJ 
Citation: Han J, etal., Science. 1994 Aug 5;265(5173):808-11.
RGD ID: 8554460
Pubmed: PMID:7914033   (View Abstract at PubMed)

Mammalian cells respond to endotoxic lipopolysaccharide (LPS) by activation of protein kinase cascades that lead to new gene expression. A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned. The p38 enzyme and the product of the Saccharomyces cerevisiae HOG1 gene, which are both members of the mitogen-activated protein (MAP) kinase family, have sequences at and adjacent to critical phosphorylation sites that distinguish these proteins from most other MAP kinase family members. Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Mapk14Ratintracellular signal transduction involved_inISSUniProtKB:P47811PMID:7914033UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Mapk14RatMAP kinase activity enablesISSUniProtKB:P47811PMID:7914033UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Mapk14  (mitogen activated protein kinase 14)


Additional Information