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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:142921
Term: 3-phenylprop-2-enal
Definition: A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name 'cinnamaldehyde' is widely used to refer to the E (trans) isomer.
Chemical ID: MESH:C012843
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14decreases phosphorylationEXP 6480464CTDcinnamaldehyde results in decreased phosphorylation of MAPK14 proteinPMID:17486422
Mapk14multiple interactionsISOMAPK14 (Homo sapiens)6480464CTDcinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK14 protein; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK14 protein]PMID:15964311
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