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NUCLEAR FACTOR KAPPA B SIGNALING PATHWAY (PW:0000499)

View Ontology Report

Description

Nuclear Factor kappa B (NF-kB) signaling pathway is essential for the proper functioning of the immune system. NF-kB pathway regulates the expression of cytokines, growth factors and other regulatory proteins; its signaling is set in motion in response to the activation of upstream pathways. Tumor necrosis factor (Tnf) alpha via tumor necrosis receptor R1, interleukin-1 via interleukin receptor 1 and lipopolysaccharide (LPS) triggered Toll-like receptors pathways converge on the activation of th

Pathway Diagram:

Elsevier Inc. Nfkb2 RELB K63-ubiquitin M1-Ubiquitin M1-ubiquitination miRNA in NF-kB LUBAC complex SCF ubiquitin ligase complex K63-polyubiquitination NF-kB target genes Tnf receptor superfamily, other upstream activators adapters adapters ---- Ikbkg adapters --+> Map3k14 SCF ubiquitin ligase complex ---| Nfkbia Rel Map3k14 --+> Chuk Chuk Map3k14 Ikbkb ---> Nfkbia Ikbkb ---> Nfkbib Ikbkb ---> Nfkbie Nfkbia Ikbkb Nfkbib K63-ubiquitin ---- Tab3 K63-ubiquitin ---- Tab2 Ikbkg ---- K63-ubiquitin Ikbkg Map3k7 Nfkbie Ikbkb ---- Ikbkg Ikbkg ---- M1-Ubiquitin Nfkbia ---- Rela Nfkbia ---| Rela Nfkb1 ---- Nfkbia Nfkbib ---- Rela Nfkbib ---| Rela Chuk ---- Ikbkg SCF ubiquitin ligase complex ---| Nfkbib SCF ubiquitin ligase complex ---| Nfkbie Chuk ---- Ikbkb Chuk --+> Nfkb2 NF-kB target genes ---> Nfkbia Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb1 ---> NF-kB target genes Rel ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes miRNA in NF-kB ---> NF-kB target genes NF-kB target genes ---> miRNA in NF-kB Rela Nfkb1 Map3k7 --+> Ikbkb LUBAC complex ---> Ikbkg Cyld Tab2 Tab3 Tab1 Cyld ---| K63-polyubiquitination adapters --+> Map3k7 Cyld ---| Map3k7
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Genes in Pathway:


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nuclear factor kappa B signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 ISO PID PID:200021 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atm ATM serine/threonine kinase ISO PID PID:200031 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bcl10 BCL10, immune signaling adaptor ISO PID PID:200031 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bcl3 BCL3, transcription coactivator ISO PID PID:200021 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO PID PID:200031 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:21135871 RGD:5490225 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID
RGD
PMID:18267068 PID:200031 PID:200048, RGD:2292172 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO PID PID:200021 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO PID PID:200021 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
JBrowse link
G Csnk2b casein kinase 2 beta ISO PID PID:200021 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
JBrowse link
G Cul1 cullin 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO PID
RGD
PMID:23312890 PMID:21119682 PID:200031, RGD:7800734, RGD:7800735 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 ISO PID PID:200031 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID
RGD
PMID:18267068 PID:200021 PID:200031, RGD:2292172 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD
PMID:18267068 PID:200031, RGD:2292172 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Irf1 interferon regulatory factor 1 IMP RGD PMID:15141302 RGD:5128786 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200021 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Malt1 MALT1 paracaspase ISO PID PID:200031 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 ISO PID
RGD
PMID:18267068 PID:200048, RGD:2292172 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO RGD PMID:21135871 PMID:30854566 RGD:5490225, RGD:155791647 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200021 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID
RGD
PMID:18267068 PMID:23975431 PID:200021 PID:200031 PID:200048, RGD:2292172, RGD:40902973 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 ISO PID
RGD
PMID:18267068 PID:200048, RGD:2292172 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO PID
RGD
PMID:18267068 PID:200021 PID:200031, RGD:2292172 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbib NFKB inhibitor beta ISO RGD PMID:18267068 RGD:2292172 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nfkbie NFKB inhibitor epsilon ISO RGD PMID:18267068 RGD:2292172 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO PID PID:200031 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200021 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200021 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Prkca protein kinase C, alpha ISO PID PID:200031 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Ran RAN, member RAS oncogene family ISO PID PID:200031 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005
JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO PID
RGD
PMID:18267068 PID:200021, RGD:2292172 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID
RGD
PMID:18267068 PID:200021 PID:200031, RGD:2292172 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO PID PID:200048 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 ISO PID PID:200031 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Rnf31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915
JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955
JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200021 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Sspo SCO-spondin ISO PID PID:200021 PID:200031 PID:200048 NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412
JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200021 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756
JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:49,972,414...50,044,658
Ensembl chr  X:49,972,330...50,042,056
JBrowse link
G Tnf tumor necrosis factor ISO PID PID:200031 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO PID PID:200031 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO PID PID:200031 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Traf6 TNF receptor associated factor 6 ISO PID PID:200031 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 ISO PID PID:200031 NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081
JBrowse link
G Xpo1 exportin 1 ISO PID PID:200031 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupmiRNA in NF-kB
Gene GroupNF-kB target geneslink to a comprehensive list of NF-kB targets and website
ComplexLUBAC complexM1-ubiqutin
ComplexSCF ubiquitin ligase complextargets Nf-kB inhibitory proteins for degradation

Pathway Gene Annotations

Disease Annotations Associated with Genes in the nuclear factor kappa B signaling pathway
Disease TermsGene Symbols
acneNod2 , Tnf , Tnfrsf1a
acquired immunodeficiency syndromeTnf , Tnfrsf1a
Acute Coronary SyndromeTnf
Acute Experimental PancreatitisTnf , Tnfrsf1a
Acute HepatitisTnf
acute kidney failureNfkb1 , Tnf , Tnfrsf1a
Acute Liver FailureAtm , Tnf
Acute Lung InjuryNod2 , Tnf
acute myocardial infarctionIkbkg , Tnf
acute necrotizing pancreatitisNfkbia , Rela
adenocarcinomaAtm , Nfkb1 , Pik3ca , Rela , Tnf
adenoid cystic carcinomaAtm , Pik3ca
Adenoviridae InfectionsNfkbia
adenylosuccinase lyase deficiencyRbx1 , Tab1
adrenocortical carcinomaAtm , Birc2 , Pik3ca
adrenoleukodystrophyIkbkg
adult respiratory distress syndromeTnf , Tnfrsf1a
adult T-cell leukemia/lymphomaCsnk2a1 , Csnk2b
agammaglobulinemia 7Pik3r1
Agenesis of Corpus CallosumPik3ca
Aggressive FibromatosisTnf
Aicardi-Goutieres Syndrome 3Rela
Aicardi-Goutieres Syndrome 5Src
AlbuminuriaTnf
alcohol dependenceArrb2
alcohol use disorderMapk14
Alcoholic Fatty LiverArrb2 , Tnf
alcoholic hepatitisNfkb1 , Nfkbia , Tnf
alcoholic liver cirrhosisRela , Tnf
Alcoholic Liver DiseasesRela , Tnf
allergic bronchopulmonary aspergillosisTnf , Tnfrsf1a
allergic conjunctivitisIrf1 , Lck
allergic contact dermatitisTnf
allergic diseaseTnf , Tnfrsf1a
allergic rhinitisNod2
Alveolar Bone LossTnf
Alzheimer's diseaseAtm , Ikbkb , Mapk14 , Pik3r1 , Tnf , Tnfrsf1a
Amebic Liver AbscessTnf
amenorrheaXpo1
amphetamine abuseArrb2 , Rela
amyloidosisTnf , Tnfrsf1a
amyotrophic lateral sclerosisMapk14 , Tnf
amyotrophic lateral sclerosis type 1Tnf
anaplastic large cell lymphomaRela
anemiaTnf , Tnfrsf1a
Animal Disease ModelsTnf
Animal Mammary NeoplasmsPik3r1 , Ran , Rel , Relb
anogenital venereal wartTnf
AnorexiaTnf , Tnfrsf1a
anterior uveitisTnf
anthracosisTnf
anthrax diseaseTnf
anti-basement membrane glomerulonephritisMapk14 , Syk , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTnf , Tnfrsf1a
anxiety disorderTnf
aortic valve stenosisTnf
aplastic anemiaTnf
Arenaviridae infectious diseaseAtm
Arsenic PoisoningTnf
arteriosclerosisAtm , Map3k7 , Nfkbia , Rela , Tnfrsf1a
Arteriovenous FistulaArrb2
arteriovenous malformationPik3ca
arthritisSyk
asbestosisTnf
asphyxiating thoracic dystrophyBirc2
aspiration pneumoniaTnf
asthmaChuk , Irf1 , Nod2 , Tnf , Tnfrsf1a
astroblastomaPik3r1
astroblastoma, MN1-alteredAtm
ataxia telangiectasiaAtm , Birc2
Ataxia-Telangiectasia VariantAtm
atherosclerosisBcl3 , Nod2 , Tnf
atopic dermatitisNfkbia , Relb , Sharpin , Tnf
atrial fibrillationTnf , Xpo1
atrophic gastritisNfkb1 , Nfkb2 , Rel
autism spectrum disorderCsnk2a1 , Csnk2b
autistic disorderChuk , Ikbkg , Tab3 , Tnf
autoimmune diseaseNod2 , Tnfaip3 , Tnfrsf1a
autoimmune hepatitisTnf
autoimmune thyroiditisTnf
AUTOINFLAMMATION WITH EPISODIC FEVER AND IMMUNE DYSREGULATIONSharpin
Autoinflammatory Disease, Familial, Behcet-Like-3Rela
autosomal dominant familial periodic feverTnfrsf1a
autosomal dominant intellectual developmental disorderCsnk2b
autosomal recessive limb-girdle muscular dystrophy type 2APik3r1
autosomal recessive polycystic kidney diseasePik3ca , Src
autosomal recessive pseudohypoaldosteronism type 1Tnfrsf1a
B-Cell Chronic Lymphocytic LeukemiaAtm , Tnf , Xpo1
BacteremiaNod2
bacterial infectious diseaseNod2
bacterial pneumoniaChuk , Irf1 , Nod2 , Tnf , Tnfrsf1a
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeCsnk2a2 , Rela
Barrett's esophagusRela
Barth syndromeIkbkg
Bartsocas-Papas Syndrome 2Chuk
basal cell carcinomaPik3ca
Behcet's diseaseIkbkg , Nod2 , Tnf , Tnfrsf1a
benign hypertensive renal diseaseMap3k7
berylliosisTnf
beta thalassemiaTnf
beta-ketothiolase deficiencyAtm
beta-mannosidosisNfkb1 , Ube2d3
bilateral breast cancerAtm
bile duct cancerAtm
bilirubin metabolic disorderTnf
Blau syndromeCyld , Nod2
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk
bowenoid papulosisBirc2
brain cancerAtm
brain diseaseTab2
brain edemaMap3k7 , Tnf
Brain Hypoxia-IschemiaMap3k7
brain infarctionArrb2 , Tnf
Brain InjuriesIrf1 , Map3k7 , Rela , Tnf , Tnfrsf1a
brain ischemiaMap3k7 , Nfkb1 , Nfkbia , Prkca , Rela , Src , Tnf , Tnfrsf1a
Brain NeoplasmsAtm , Pik3ca , Pik3r1 , Rela
Brain-Lung-Thyroid SyndromeNfkbia , Rnf31
breast adenocarcinomaPik3ca , Tnf
breast angiosarcomaPik3ca
breast cancerAtm , Birc2 , Csnk2a1 , Ikbkb , Nfkb1 , Nod2 , Pik3ca , Rel , Relb , Tnf , Tnfaip3
Breast Cancer, FamilialAtm , Pik3ca
breast carcinomaAtm , Pik3ca
Breast NeoplasmsAtm , Birc2 , Nfkbia , Pik3ca , Pik3r1 , Prkca , Rela , Src , Tnf , Xpo1
Bronchial HyperreactivityTnf
bronchiectasisTnf
bronchiectasis 1Tnfrsf1a
bronchiolitis obliteransNod2
bronchopulmonary dysplasiaNfkbia , Tnf
Brooke-Spiegler syndromeCyld
Brown-Vialetto-Van Laere syndrome 1Csnk2a1 , Rbck1
Brown-Vialetto-Van Laere syndrome 2Sharpin
Burkitt lymphomaPik3r1
BurnsTnf
CachexiaMap3k7 , Tnf , Tnfrsf1a
calcinosisTnf
Capillary Malformation-Arteriovenous Malformation 1Pik3ca
carcinomaPik3r1 , Ran
Carcinoma, Lewis LungMapk14
cardiac arrestTnf
Cardiac FibrosisMap3k7 , Nfkbia
CardiomegalyMap3k7 , Prkca , Rbck1 , Rela , Src , Tnf
cardiomyopathyMapk14 , Tab2 , Tnf
CardiotoxicityTnf
Cardiovascular AbnormalitiesPik3ca
Cardiovascular Pregnancy ComplicationsTnf
Cardiovirus InfectionsTnf
cataractAtm
cerebellar ataxiaAtm
Cerebral Cavernous Malformation 4Pik3ca
cerebral creatine deficiency syndrome 1Ikbkg
Cerebral HemorrhageNfkb1 , Nfkb2 , Nfkbia , Rela , Relb , Tnf
cerebral infarctionTnf
Cerebral ToxoplasmosisNfkb1
cervical cancerBirc2 , Tnf
cervical squamous cell carcinomaBirc2
cervix uteri carcinoma in situRela
CHARGE syndromeTnfrsf1a
Chediak-Higashi syndromeNod2 , Tnfrsf1a
Chemical and Drug Induced Liver InjuryNfkb1 , Tnf
Chemically-Induced DisordersTnf
Childhood SchizophreniaRela
childhood-onset asthmaNfkbia
chlamydiaTnf
cholangiocarcinomaTnfaip3
cholestasisMapk14 , Rela , Tnf
cholesteatoma of middle earRela , Tnf
chordoid gliomaPrkca
chorioamnionitisTnf
Choroidal NeovascularizationIkbkb
Chromosome 11, Partial Trisomy 11qAtm
Chronic Allograft DysfunctionTnf
Chronic Cerebral HypoperfusionMapk14
Chronic Hepatitis BNfkbia , Tnfaip3
Chronic Hepatitis CNfkb1 , Tnf , Tnfrsf1a
Chronic Intermittent HypoxiaRela , Tnf
chronic kidney diseaseMap3k7
chronic lymphocytic leukemiaXpo1
chronic myeloid leukemiaMapk14
chronic obstructive pulmonary diseaseMap3k7 , Nod2 , Rela , Tab2 , Tnf , Tnfrsf1a
Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosisNfkbia
cicatricial pemphigoidTnf
CLAPO SyndromePik3ca
clear cell renal cell carcinomaAtm
cleft palateChuk
CLOVES syndromePik3ca , Pik3r1
cochlear diseaseTnf
cognitive disorderMapk14
colitisChuk , Ikbkb , Nod2 , Rela , Src , Syk , Tnf
Colitis-Associated NeoplasmsMapk14
colon adenocarcinomaPik3ca , Src
colon cancerAtm , Chuk , Ikbkb , Mapk14 , Src , Tnfaip3
colon carcinomaAtm , Bcl10 , Pik3ca , Src , Tnfrsf1a
Colonic NeoplasmsAtm , Nfkb1 , Nod2 , Pik3r1 , Rela , Src , Tnf
colorectal adenocarcinomaNod2
colorectal adenomaTnfrsf1a
colorectal cancerAtm , Birc2 , Ikbkg , Mapk14 , Nfkb1 , Pik3ca , Pik3r1 , Rel , Src , Tnfaip3 , Xpo1
colorectal carcinomaMapk14 , Pik3ca , Src , Xpo1
Colorectal NeoplasmsPik3ca , Pik3r1 , Src , Tnf , Xpo1
common variable immunodeficiencyIkbkg , Nfkb1 , Nfkb2
common variable immunodeficiency 1Nfkb2
common variable immunodeficiency 10Nfkb2
common variable immunodeficiency 12Nfkb1
common variable immunodeficiency 4Rbx1
complex cortical dysplasia with other brain malformationsPik3ca
congenital diaphragmatic herniaTnf
congenital disorder of glycosylationSrc
Congenital Heart Defects, Multiple TypesTab2
Congenital Heart Defects, Multiple Types, 2Tab2
congenital heart diseaseTab2
Congenital Limb DeformitiesChuk
congenital myopathy 5Pik3ca
congestive heart failureMap3k7 , Prkca , Tnf , Tnfrsf1a
Cor pulmonaleTnf
corneal ulcerTnf
coronary artery diseaseMap3k7 , Nod2 , Tnf , Tnfrsf1a , Traf6
Coronary DiseaseIkbkg
coronary restenosisTnf
Coronavirus infectious diseaseTnf
cortical dysplasia-focal epilepsy syndromeCul1
CoughTnf
COVID-19Nfkbia , Tnf , Tnfaip3 , Tnfrsf1a
Cowden syndromePik3ca
Cowden syndrome 5Pik3ca
Coxsackievirus InfectionsTnf
Crohn's diseaseNod2 , Rela , Tnf , Tnfrsf1a
cryoglobulinemiaTnf
cryptogenic organizing pneumoniaTnfrsf1a
cryptorchidismNfkbia , Rela
Currarino syndromePik3ca
cutaneous leishmaniasisTnf
cutaneous Paget's diseasePik3ca
cystic fibrosisIrf1 , Tnf , Tnfrsf1a
cystitisRela , Tnf
Cytomegalovirus InfectionsNfkbia , Tnf
cytomegalovirus retinitisTnf , Tnfrsf1a
degenerative disc diseaseTnf
demyelinating diseaseTnf
depressive disorderNfkb1
dermatitisIkbkb , Nod2 , Sharpin , Syk , Tnf
dermatitis herpetiformisTnf
dermatomyositisTnf
developmental and epileptic encephalopathyCsnk2a2
Developmental DisabilitiesPik3ca
Developmental DiseaseCsnk2a1
diabetic angiopathyRela , Tnf
Diabetic CardiomyopathiesMap3k7 , Pik3ca , Tnf
Diabetic NephropathiesMapk14 , Rela , Tnf , Tnfrsf1a
diabetic neuropathyMapk14 , Tnf
diabetic retinopathyTnf
diaphragmatic eventrationPik3ca
Diaphragmatic HerniaTnf
diarrheaNfkbia
diffuse large B-cell lymphomaMalt1 , Nfkbia , Pik3ca , Syk
dilated cardiomyopathyAtm , Lck , Map3k7 , Prkca , Tab2 , Tnf
dilated cardiomyopathy 1HTnf
disease by infectious agentTnf
disease of cellular proliferationAtm , Pik3ca , Pik3r1 , Src
Disease ProgressionBirc2 , Pik3ca , Rela , Tnf
disseminated intravascular coagulationTnf
Down syndromePik3ca
drug allergyTnf
Drug EruptionsRela , Tnf
drug psychosisArrb2
Drug-Induced DyskinesiaRela
Drug-Related Side Effects and Adverse ReactionsMapk14 , Tnf
dry eye syndromeTnf
Duchenne muscular dystrophyTab3
ductal carcinoma in situPrkca , Rela , Src
DwarfismRnf31
dyskeratosis congenitaIkbkg
DyslipidemiasBcl3
Eales DiseaseTnf
early infantile epileptic encephalopathyCsnk2a2
ectodermal dysplasia and immune deficiencyIkbkg
ectodermal dysplasia and immunodeficiency 1Ikbkg
ectodermal dysplasia and immunodeficiency 2Nfkbia
EdemaTnf
Embryo LossMap3k7 , Tab2 , Tnfrsf1a
Emery-Dreifuss muscular dystrophyIkbkg
EmphysemaTnf
encephalitisNfkbia , Rela , Tnf
encephalomyelitisTnf
End Stage Liver DiseaseTnfrsf1a
end stage renal diseaseNfkb1 , Rela , Tnf , Tnfrsf1a
endometrial adenocarcinomaIrf1 , Pik3r1
endometrial cancerAtm , Pik3r1 , Tnfrsf1a
endometrial carcinomaAtm , Pik3ca , Pik3r1 , Prkca
Endometrial NeoplasmsPik3ca
endometrial serous adenocarcinomaAtm
endometriosisNfkbia , Tnf
endophthalmitisTnf
EndotoxemiaMapk14 , Nfkbia , Tnf
enophthalmosCsnk2b
EntamoebiasisNfkb1
Enterovirus InfectionsTnfrsf1a
EosinophiliaSharpin
epidermal nevusPik3ca
epidermolysis bullosa simplex with muscular dystrophySharpin
epididymitisTnf
epilepsyCsnk2b , Rela , Tnf , Xpo1
erythema nodosumTnf
Escherichia Coli InfectionsTnf
esophageal cancerPik3ca , Tnfaip3
esophageal carcinomaPik3ca
esophagitisTnf
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaAtm , Tnfaip3 , Xpo1
essential hypertensionTnf
estrogen-receptor positive breast cancerPik3ca
Experimental ArthritisArrb2 , Ikbkb , Ikbkg , Nod2 , Tnf , Tnfrsf1a
Experimental Autoimmune EncephalomyelitisTnf
Experimental Autoimmune NeuritisTnf
Experimental Autoimmune UveoretinitisTnfrsf1a
Experimental ColitisAtm , Nfkbia , Nod2 , Rela , Tnf , Tnfrsf1a
Experimental Diabetes MellitusIkbkb , Nfkb2 , Nfkbia , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a
Experimental Liver CirrhosisArrb2 , Ikbkg , Nfkbia , Nfkbie , Rela , Tnf
Experimental Liver NeoplasmsArrb2 , Ikbkg , Tnf
Experimental Mammary NeoplasmsCsnk2a1 , Pik3r1 , Ran , Rela , Relb , Tnf
Experimental MelanomaIkbkb
Experimental NeoplasmsRela , Tnf
Experimental PancreatitisIkbkg
Experimental Radiation InjuriesTnf
extrahepatic bile duct carcinomaXpo1
extrahepatic cholestasisMap3k7 , Mapk14 , Rela , Tnf
extranodal marginal zone lymphoma of mucosa-associated lymphoid tissueBcl10
extrinsic allergic alveolitisTnf , Tnfrsf1a
eye diseaseTnf
Facial AsymmetryPik3ca
familial adenomatous polyposis 1Irf1 , Skp1
Familial Behcet-Like Autoinflammatory SyndromeTnfaip3
familial Behcet-like autoinflammatory syndrome 1Tnfaip3
familial Mediterranean feverNod2 , Tnfrsf1a
familial multiple nevi flammeiPik3ca
Familial Pancreatic CarcinomaAtm
Familial Prostate CancerAtm
Fanconi anemiaTnf
farmer's lungTnf
favismIkbkg
Febrile SeizuresTnfrsf1a
female breast cancerAtm
Fetal DiseasesChuk
fetal encasement syndromeChuk
FeverTnf , Tnfrsf1a
fibrosarcomaTnfrsf1a
FibrosisAtm , Tnf
focal epilepsySrc
focal segmental glomerulosclerosisTnf , Tnfrsf1a
follicular lymphomaBcl10 , Tnfaip3
Forney Robinson Pascoe SyndromeMap3k7
frontometaphyseal dysplasiaMap3k7
frontometaphyseal dysplasia 2Map3k7
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis-8Cyld
Fungal Lung DiseasesTnf
gallbladder cancerPik3ca
gallbladder carcinomaPik3ca
gastric adenocarcinomaBirc2 , Irf1 , Mapk14 , Pik3ca , Xpo1
gastric ulcerTnf
gastritisNfkbia , Nod2 , Tnf
Gastro-Enteropancreatic Neuroendocrine TumorAtm
gastrointestinal carcinomaNod2
Gastrointestinal NeoplasmsPik3ca
Gaucher's diseaseTnf
genetic diseaseBcl10 , Chuk , Csnk2a1 , Csnk2b , Cyld , Ikbkb , Ikbkg , Malt1 , Map3k7 , Nfkb1 , Nfkb2 , Nfkbia , Nod2 , Pik3ca , Pik3r1 , Rbck1 , Relb , Tab2 , Tnfaip3 , Tnfrsf1a
glaucomaTnf
glioblastomaArrb2 , Atm , Nfkbia , Pik3ca , Pik3r1
glomerulonephritisTnf , Tnfrsf1a
glucose intoleranceIkbkb , Pik3r1
glucosephosphate dehydrogenase deficiencyIkbkg
glycogen storage disease IIPik3ca
glycogen storage disease IVRbck1
glycogen storage disease VRela
graft-versus-host diseaseNod2
GranulomaNod2
Graves ophthalmopathyTnf
Graves' diseaseTnf
Growth DisordersPik3ca
head and neck cancerPik3ca
Head and Neck NeoplasmsPik3ca
head and neck squamous cell carcinomaBirc2 , Pik3ca
Hearing LossTnf
Hearing Loss, Noise-InducedSrc , Tnf
heart diseaseMapk14
Heart InjuriesTnf
heart valve diseaseTnf
Heat StrokeNfkb1 , Nfkb2 , Rel , Rela , Relb , Tnf
Helicobacter InfectionsAtm
Hemifacial MyohyperplasiaPik3ca
HemimegalencephalyPik3ca
hemochromatosisTnf
hemolytic-uremic syndromeTnf
Hemorrhagic ShockNfkbia , Rela , Tnf
hepatic encephalopathyTnf
Hepatic InsufficiencyMapk14 , Rela
hepatitisIkbkg
hepatitis ATnf
hepatitis BIrf1 , Nfkbia , Tnf
hepatitis CNfkbia
hepatoblastomaAtm
hepatocellular carcinomaArrb2 , Atm , Cyld , Ikbkg , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Src , Tnf , Tnfaip3 , Xpo1
HepatomegalyMapk14 , Rela
hepatopulmonary syndromeTnf
hepatorenal syndromeTnf
Hereditary Autoinflammatory DiseasesTnfaip3
hereditary breast ovarian cancer syndromeAtm , Nfkb2
hereditary hemorrhagic telangiectasiaTnf
Hereditary Neoplastic SyndromesAtm , Irf1 , Pik3ca , Skp1
heroin dependenceArrb2
herpes simplex virus keratitisAtm , Tnf
herpes zosterTnf
Herpesviridae InfectionsAtm
hidradenitis suppurativaNod2 , Tnf
high grade gliomaAtm , Pik3ca , Prkca , Rela , Tnf
High MyopiaNfkb1
High-Frequency Hearing LossTnf
Hirschsprung's diseaseIkbkb
HIV Wasting SyndromeTnf
Hodgkin's lymphomaNfkbia , Rel
holoprosencephalySharpin
human immunodeficiency virus infectious diseaseAtm , Birc2 , Lck , Ran , Tnf
Human InfluenzaTnf , Tnfrsf1a
Huntington's diseaseNfkb1
HyperalgesiaSrc , Tnf , Tnfrsf1a
hypercalcemiaTnf
HypercholesterolemiaAtm
hyperhomocysteinemiaTnf
hyperinsulinismTnf
HyperoxaluriaNfkb1
HyperoxiaTnf , Tnfrsf1a
Hyperphosphatemic Familial Tumoral Calcinosis 1Erc1 , Tnfrsf1a
HyperplasiaIkbkb , Pik3ca
HypertelorismPik3ca
hypertensionArrb2 , Ikbkb , Nfkbia , Pik3r1 , Prkca , Rela , Src , Tnf
hypertrophic cardiomyopathyMap3k7 , Traf6
hypochromic microcytic anemiaTnf
Hypoglossal Nerve InjuriesCsnk2b
hypoglycemiaPik3r1 , Tnf
hypohidrotic ectodermal dysplasiaTraf6
HypokinesiaRel
hypomelanosis of ItoIkbkg
HypotensionTnf
HypothermiaTnf
IDH-mutant anaplastic astrocytomaAtm
idiopathic pulmonary fibrosisTnf
IgA glomerulonephritisTnf , Tnfrsf1a
Immunodeficiency 112Map3k14
Immunodeficiency 115Rnf31
Immunodeficiency 117Irf1
immunodeficiency 12Malt1
IMMUNODEFICIENCY 15Ikbkb
immunodeficiency 15AIkbkb
immunodeficiency 15BIkbkb
immunodeficiency 22Lck
immunodeficiency 33Ikbkg
immunodeficiency 36Pik3r1
immunodeficiency 37Bcl10
immunodeficiency 53Relb
Immunodeficiency 82Syk
Immunodeficiency 92Rel
impotenceTnf
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaTnf
infertilityAtm
InflammationChuk , Ikbkb , Tnf , Tnfaip3
inflammatory bowel diseaseIkbkb , Nod2 , Tnf
inflammatory bowel disease 1Nod2
influenza AAtm
Insulin ResistanceAtm , Ikbkb , Pik3r1 , Rela , Tnf , Tnfrsf1a
intellectual disabilityAtm , Birc2 , Csnk2a1 , Csnk2b , Rela , Traf6
intermediate uveitisTnf
interstitial cystitisMapk14 , Tnf
Intervertebral Disc DisplacementTnf
intestinal diseaseNod2
Intestinal HelminthiasisNfkb1 , Nfkb2
Intestinal NeoplasmsPrkca
Intestinal Reperfusion InjuryNfkbia , Rela , Tnf , Traf6
intracranial aneurysmTnf
Intracranial HemorrhagesTnf
intrahepatic cholestasis of pregnancyTnf
intrinsic cardiomyopathyTraf6
iron deficiency anemiaTnf
irritable bowel syndromeIkbkg
ischemiaPrkca , Tnfrsf1a
isolated microphthalmia 3Malt1
Kawasaki diseaseTnf
KeloidRan
keratoacanthomaPik3ca
keratoconjunctivitis siccaTnf
Keratoconus 1Skp1
kidney diseaseRelb , Tnf , Tnfrsf1a
Kidney Reperfusion InjuryAtm , Ikbkb , Src , Tnf , Tnfrsf1a
Klippel-Trenaunay syndromePik3ca
labyrinthitisTnf
large cell carcinomaPrkca
laryngeal carcinomaTraf6
laryngeal squamous cell carcinomaRela
larynx cancerNod2
latent autoimmune diabetes in adultsTab2
learning disabilityIkbkg
Left Ventricular HypertrophyPrkca , Rela
Legionnaires' diseaseNod2 , Tnfrsf1a
leiomyomaCsnk2b
leishmaniasisTnf
leprosyNod2 , Ripk2 , Tnf
leukemiaAtm , Birc2
listeriosisCyld , Tnf
liver cancerAtm , Chuk , Ikbkb , Ikbkg , Mapk14 , Pik3ca
liver cirrhosisArrb2 , Atm , Mapk14 , Rela , Tnf
liver diseaseNfkb1 , Tnf
Liver MetastasisSrc
Liver NeoplasmsMapk14 , Tnf
Liver Reperfusion InjuryIkbkg , Map3k7 , Tnf , Tnfrsf1a
localized sclerodermaTnf
long QT syndromeSyk
low tension glaucomaTnf
lung adenocarcinomaMapk14 , Pik3ca , Pik3r1 , Src , Xpo1
lung cancerAtm , Irf1 , Nfkb1 , Nfkbia , Nod2 , Pik3ca
lung carcinomaPik3ca , Xpo1
lung diseaseIrf1 , Tnf
Lung InjuryNfkbia , Tnf , Tnfrsf1a
lung metastasisSrc
Lung NeoplasmsIkbkg , Irf1 , Mapk14 , Pik3ca , Tnf
lung non-small cell carcinomaAtm , Birc2 , Cyld , Irf1 , Nfkb1 , Pik3ca , Rela , Tab2 , Tnf , Tnfrsf1a , Xpo1
lung oat cell carcinomaPik3ca
Lung Reperfusion InjuryTnf
lung small cell carcinomaAtm , Pik3ca , Pik3r1
lung squamous cell carcinomaAtm , Pik3ca , Src
lupus nephritisTnf , Tnfrsf1a
Lyme diseaseNod2
lymphangiomaPik3ca
Lymphatic MetastasisPik3ca , Rela , Src
lymphocytic choriomeningitisNfkb1 , Nfkb2
lymphomaAtm , Malt1 , Rela
lymphopeniaTnf
lymphoproliferative syndrome 2Tnfrsf1a
Lynch syndrome 1Atm
lysinuric protein intoleranceRnf31
MacrocephalyPik3ca
Macrocephaly, Dysmorphic Facies, and Psychomotor RetardationErc1
malariaIkbkg , Tnf
male infertilityCsnk2a2
malignant mesotheliomaBcl10
Malocclusion, Angle Class IIICsnk2b
Manganese PoisoningTnf
mantle cell lymphomaAtm
marginal zone lymphomaBcl10
mastoiditisRela
maturity-onset diabetes of the young type 1Nfkbib
medulloblastomaPik3ca
megacolonCsnk2b , Tnf
Megalencephaly - Cutis Marmorata Telangiectatica CongenitaPik3ca , Pik3r1
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus SyndromePik3ca
MegalodactylyPik3ca
melanomaAtm , Mapk14 , Nfkb1 , Nfkbia , Nfkbie , Pik3ca , Pik3r1 , Syk , Tnf
Memory DisordersRel
Meningeal TuberculosisTnf
meningococcal meningitisNod2
MesotheliomaBcl10 , Syk
metabolic dysfunction-associated steatohepatitisNfkb1 , Tnf
metabolic dysfunction-associated steatotic liver diseaseIkbkg , Prkca , Tnf , Tnfaip3
Metabolic SyndromeAtm , Tnf , Tnfrsf1a
MetaplasiaNod2
mevalonic aciduriaTnf
microcephalyAtm
Micronuclei, Chromosome-DefectiveTnf
middle cerebral artery infarctionIkbkb , Nfkbia , Nod2 , Tnf , Tnfrsf1a
Middle East respiratory syndromeTnf
migraineTab2 , Tnf
migraine without auraTnf
mitochondrial myopathyTnf
Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal BonesMap3k7
mixed connective tissue diseaseTnf
Mouth NeoplasmsPik3ca
mucocutaneous leishmaniasisTnf
mucopolysaccharidosis VITnf
Multiple AbnormalitiesChuk
multiple endocrine neoplasia type 1Atm
multiple myelomaAtm , Cyld , Nfkbia , Pik3ca , Tnf
Multiple Organ FailureTnf
multiple sclerosisTnf , Tnfaip3 , Tnfrsf1a
Murine Acquired Immunodeficiency SyndromeNfkbia
Muscle WeaknessTnfrsf1a
muscular atrophyChuk , Ikbkb , Relb , Tnf
muscular dystrophyTnf
Mycobacterium avium complex diseaseTnf
Mycoplasma pneumoniae pneumoniaTnf
myelodysplastic syndromeTnf
myelofibrosisSrc
myocardial infarctionAtm , Csnk2a1 , Csnk2b , Map3k7 , Mapk14 , Nfkbia , Tnf , Tnfrsf1a
Myocardial IschemiaIrf1 , Mapk14 , Nfkbia , Tnf
Myocardial Reperfusion InjuryArrb2 , Mapk14 , Nfkbia , Rela , Tnf
myocardial stunningTnf
myocarditisTnf
myositisTnf
Nasal PolypsTnf , Tnfrsf1a
Nasopharyngeal NeoplasmsPik3ca
nasopharynx carcinomaAtm , Mapk14 , Src , Tnfaip3
NauseaTnf
NecrosisTnf
Nematode InfectionsPik3r1 , Tnfrsf1a
Neonatal HyperbilirubinemiaIkbkb
Neoplasm InvasivenessRela , Src , Tnf
Neoplasm MetastasisChuk , Nfkb1 , Nfkbia , Pik3ca , Src , Tnf
Neoplastic Cell TransformationNfkb1 , Rela , Tnfaip3
nephrogenic diabetes insipidusPrkca
nephronophthisis 14Cyld , Nod2
nephronophthisis-like nephropathy 1Rbx1
nephrotic syndromeNfkbia
Nerve DegenerationTnf
nervous system diseaseTnf
NeuralgiaSrc , Tnf
neuroblastomaBirc2 , Pik3ca , Rela , Tnf
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIESPik3ca
Neurodevelopmental DisordersCsnk2a1 , Csnk2b , Irf1 , Pik3r1 , Rbck1 , Skp1 , Tab3
Neurogenic InflammationTnf , Tnfrsf1a
neutropeniaTnf
nicotine dependenceArrb2
non-Hodgkin lymphomaBcl10 , Malt1 , Pik3ca
Nontuberculous Mycobacterium InfectionsTnfaip3
Noonan syndrome 8Pik3ca
obesityIkbkb , Pik3r1 , Rela , Tnf , Tnfrsf1a
obstructive sleep apneaRela , Tnf , Tnfrsf1a
occupational asthmaPrkca , Tnf
Ocular ToxoplasmosisNod2
Okur-Chung Neurodevelopmental SyndromeCsnk2a1
open-angle glaucomaTnf
opiate dependenceArrb2
OpsismodysplasiaMap3k7
Optic Nerve InjuriesTnfrsf1a
oral mucosa leukoplakiaAtm
oral squamous cell carcinomaAtm , Birc2 , Rela , Tnf
oral submucous fibrosisTnf
ornithine carbamoyltransferase deficiencyTab3
osteoarthritisPik3r1 , Ran
OsteolysisTnf
osteoporosisAtm , Mapk14
otitis mediaRela , Tnf
Otitis Media with EffusionTnf
Otorhinolaryngologic NeoplasmsAtm
ovarian cancerAtm , Cyld , Nod2 , Pik3ca , Prkca , Tnf , Tnfrsf1a
ovarian carcinomaAtm , Prkca
ovarian cystNfkb1
Ovarian NeoplasmsAtm , Pik3ca , Pik3r1 , Rela
ovarian serous cystadenocarcinomaPik3ca
ovary epithelial cancerTab2
Oxygen-Induced RetinopathyCsnk2a1 , Csnk2a2 , Csnk2b , Tnf
PainTnf , Tnfrsf1a
pain agnosiaArrb2
Painful NeuropathyTnf
pancreatic acinar cell adenocarcinomaSrc
pancreatic adenocarcinomaBirc2 , Nfkb1 , Pik3ca
pancreatic cancerAtm , Nfkbia , Rela , Tnf , Xpo1
pancreatic carcinomaAtm
pancreatic ductal adenocarcinomaIkbkb
pancreatic ductal carcinomaMap3k7 , Rela
Pancreatic Intraepithelial NeoplasiaIkbkb
pancreatitisIkbkb , Nod2
papillary renal cell carcinomaPik3ca
papillary thyroid carcinomaAtm
paracoccidioidomycosisTnf
paragangliomaBirc2
paraplegiaIkbkg
ParaproteinemiasPik3ca
Parkinson's diseaseAtm , Tnf
ParkinsonismNfkb2 , Rela , Src , Tnf
Pediatric Crohn's DiseaseTnf
Penetrating WoundsTnf
Penile NeoplasmsPik3ca
peptic esophagitisTnf
perinatal necrotizing enterocolitisIkbkg , Nod2 , Tnf
periodontitisTnf
Peripheral Nerve InjuriesTnf
peripheral T-cell lymphomaAtm
peritonitisTnf
periventricular leukomalaciaTnf
periventricular nodular heterotopiaIkbkg
peroxisome biogenesis disorder 11AXpo1
peroxisome biogenesis disorder 2BTnfrsf1a
Peroxisome biogenesis disorder 9BTnfaip3
PFAPA syndromeNod2
Picornaviridae InfectionsTnf
Pituitary NeoplasmsPrkca
placenta diseaseTnf
Plaque, AtheroscleroticTnf
plasma cell neoplasmPik3ca
plasmacytomaTnf
Plasmodium falciparum malariaTnf
Pleural EffusionTnf
pleurisyTnf
Pneumococcal InfectionsNfkbia
Pneumococcal MeningitisAtm , Nod2 , Rela , Tnf
Pneumococcal PneumoniaTnf
pneumoniaIkbkb , Nfkbia , Tnf , Tnfrsf1a
POIRIER-BIENVENU NEURODEVELOPMENTAL SYNDROMECsnk2b
polycystic kidney diseasePik3ca
polycystic ovary syndromeTab1
polycythemia veraAtm
Polyglucosan Body Myopathy 1 with or without ImmunodeficiencyCsnk2a1 , Rbck1 , Rnf31
polymyositisTnf , Tnfrsf1a
PolyuriaPrkca
portal hypertensionArrb2 , Pik3r1 , Tnf
Postmenopausal OsteoporosisTnf
Postoperative Cognitive DysfunctionTnf
pre-eclampsiaTnf
pre-malignant neoplasmAtm , Nfkbia
prediabetes syndromeRelb
Pregnancy ComplicationsNfkbia
Pregnancy-Induced HypertensionTnf
Premature BirthTnf
Prenatal Exposure Delayed EffectsAtm
primary biliary cholangitisMap3k14 , Mapk14 , Nfkb1 , Rela , Tnf , Tnfrsf1a
primary ciliary dyskinesia 3Nfkb1
primary cutaneous T-cell non-Hodgkin lymphomaAtm , Nfkb2 , Tnfaip3
Primary Graft DysfunctionTnf
primary immunodeficiency diseaseNfkb1 , Nfkb2 , Nfkbia , Pik3r1
primary open angle glaucomaTnf
primary sclerosing cholangitisTnf
prion diseaseBcl3 , Nfkb1 , Nfkb2
prostate adenocarcinomaChuk , Ikbkb , Nfkbia , Pik3ca , Rela , Xpo1
prostate cancerAtm , Chuk , Ikbkb , Map3k7 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Src , Tnf
prostate carcinomaPrkca
prostate carcinoma in situAtm , Rela
prostatic hypertrophyRela
Prostatic NeoplasmsAtm , Chuk , Map3k7 , Pik3ca , Pik3r1 , Rela , Rnf31 , Xpo1
proteasome-associated autoinflammatory syndrome 1Csnk2b , Mapk14 , Tnf
Pseudomonas InfectionsTnf , Tnfrsf1a
psoriasisIkbkb , Nfkbia , Rel , Tnf , Tnfaip3 , Tnfrsf1a
psoriatic arthritisNod2 , Tnf
PTEN hamartoma tumor syndromePik3ca
Pulmonary Arterial HypertensionMap3k7
pulmonary edemaTnf
pulmonary emphysemaNfkbia , Tnf
pulmonary fibrosisTab2 , Tnf
pulmonary hypertensionRela , Tnf
pulmonary sarcoidosisNod2 , Tnf
pulmonary tuberculosisIrf1 , Nfkbia , Nod2 , Tnf
pustulosis of palm and soleTnf
pyoderma gangrenosumNod2
Radiation PneumonitisAtm , Tnf , Tnfrsf1a
radiculopathyTnf
rectal benign neoplasmPik3ca
rectum adenocarcinomaBirc2
rectum cancerMapk14
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsRela
Refractory AnemiaTnf
relapsing polychondritisTnf
relapsing-remitting multiple sclerosisNod2
renal cell carcinomaAtm , Birc2 , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
Renal Cell Carcinoma 1Atm , Pik3ca
renal fibrosisArrb2 , Tnfrsf1a
renal hypertensionTnf
renovascular hypertensionRela
Reperfusion InjuryIrf1 , Nod2 , Pik3r1 , Prkca , Rela , Src , Tnf , Tnfrsf1a
respiratory allergyTnf
respiratory syncytial virus infectious diseaseIrf1 , Tnf
respiratory system diseaseTnf
Respiratory Tract InfectionsIrf1 , Tnf
restrictive cardiomyopathyMapk14
Retina Reperfusion InjuryTnf
retinal artery occlusionTnf
retinal degenerationLck
retinal detachmentTnf , Tnfrsf1a
retinal diseaseTnf
RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIESLck
Retroviridae InfectionsAtm
Rhabdoviridae InfectionsAtm
rheumatoid arthritisNfkbie , Pik3r1 , Rel , Tab2 , Tab3 , Tnf , Tnfaip3 , Tnfrsf1a , Traf6
rhinitisNod2 , Tnf
RhinosinusitisTnf
Right Ventricular HypertrophyPrkca , Tnf
root resorptionTnf , Tnfrsf1a
rosette-forming glioneuronal tumorPik3ca
Rubinstein-Taybi syndromeRbx1 , Tab1
SAPHO syndromeTnf
sarcomaPik3ca , Tnf
SarcopeniaNfkbia
schizophreniaTnf , Xpo1
sciatic neuropathyNfkbia , Ran , Tnf , Tnfrsf1a
scleritisTnf
Seasonal Allergic RhinitisNod2
seborrheic keratosisPik3ca
senile cataractAtm
sensorineural hearing lossSrc , Tnf
SepsisAtm , Nfkbia , Nod2 , Rela , Tnf
septic arthritisTnf
Septic PeritonitisPik3r1
severe acute respiratory syndromeRela , Tnf
severe combined immunodeficiencyIkbkb , Lck , Malt1
severe congenital encephalopathy due to MECP2 mutationIkbkg
Sezary's diseaseBcl10
ShockTnf
SHORT syndromePik3r1
sickle cell anemiaTnf
silicosisTnf , Tnfrsf1a
Sjogren's syndromeMap3k14 , Nfkbia , Tnf , Tnfaip3
Skin AbnormalitiesChuk
skin cancerChuk
skin diseaseTnf
skin melanomaBirc2 , Pik3ca , Pik3r1
Skin NeoplasmsCsnk2a1 , Csnk2a2 , Csnk2b , Cyld , Rela
small cell carcinomaTnf
smallpoxIrf1
Smith-Kingsmore SyndromePik3r1
Soft Tissue NeoplasmsTnf
Specific Granule DeficiencyRnf31
Spinal Cord CompressionTnf , Tnfrsf1a
Spinal Cord InjuriesAtm , Irf1 , Nfkbia , Rela , Tnf , Tnfrsf1a
Spine OsteoarthritisTnf
SplenomegalyIkbkg , Nod2
split hand-foot malformationBtrc
spondyloarthropathyTnf
Sporadic Papillary Renal Cell CarcinomaPik3ca
squamous cell carcinomaAtm , Csnk2a1 , Csnk2a2 , Csnk2b , Pik3ca , Tnfrsf1a
Stable AnginaTnf
Staphylococcal PneumoniaNod2
status epilepticusAtm , Rela , Src , Tnf
steatotic liver diseaseIkbkg , Nfkb1 , Rela , Tnf
Stevens-Johnson syndromeCul1 , Rbx1 , Tnf
stomach cancerAtm , Irf1 , Nfkb1 , Pik3ca , Src , Xpo1
stomach carcinomaTnfaip3 , Xpo1
Stomach NeoplasmsAtm , Birc2 , Irf1 , Pik3ca , Rela , Tnf
Streptococcal InfectionsTnf
Streptococcus pneumoniaAtm , Tnf
StrokeIrf1 , Map3k7 , Pik3ca , Src , Tnf
Subarachnoid HemorrhageMap3k7 , Rela , Tnf
Sudden Hearing LossTnf
syndactylyCsnk2b
syndromic X-linked intellectual disability Lubs typeIkbkg , Tab3
Systemic Autoinflammatory Disease, X-LinkedIkbkg
Systemic CandidiasisTnf
systemic lupus erythematosusNod2 , Tab2 , Tab3 , Tnf , Tnfaip3 , Tnfrsf1a
T-cell acute lymphoblastic leukemiaBcl10
T-cell prolymphocytic leukemiaAtm
TachycardiaTnf
Temporomandibular Joint DisordersTnf
Temtamy syndromeTnfrsf1a
testicular cancerBcl10
Testicular Germ Cell TumorBcl10 , Birc2
thalassemiaTnf
thrombocytopeniaTnf
Thrombocytopenia 6Src
thrombosisTnf
thymomaBirc2 , Cyld
thyroid cancerAtm
Thyroid NeoplasmsPik3ca , Tnf
TinnitusTnf
Tobacco Use DisorderArrb2
Tongue NeoplasmsTnf
tongue squamous cell carcinomaBirc2
torsion dystonia 6Ikbkb
Townes-Brocks syndromeCyld , Nod2
toxic shock syndromeNfkbia , Tnf
toxoplasmosisNfkbia
trachomaTnf
transient cerebral ischemiaIkbkb , Map3k7 , Nfkb1 , Nod2 , Tnf , Tnfrsf1a
transitional cell carcinomaPik3ca , Rel , Relb , Tnf
Transplant RejectionArrb2 , Ikbkb , Nfkbia , Rela , Relb , Tnf
Trauma and Stressor Related DisordersSrc
traumatic brain injuryRela , Tnf
TremorRel
trichinosisTnf
Trichoepithelioma, Multiple Familial, 2Cyld
trigeminal neuralgiaTnf
tropical spastic paraparesisNfkb1
tuberculosisTnf
type 1 diabetes mellitusRan , Tnf
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusArrb2 , Ikbkb , Nfkb1 , Nfkbib , Pik3r1 , Rela , Src , Tnf , Tnfrsf1a
typhoid feverTnf
ulcerative colitisNod2 , Rela , Ripk2 , Tnf , Tnfaip3
ureteral obstructionIrf1 , Rela , Relb , Tnf , Tnfrsf1a
urinary bladder cancerAtm , Pik3ca , Prkca , Rela , Src , Tnf
urticariaTnf
uterine cancerPik3ca , Pik3r1 , Xpo1
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsCyld , Pik3ca , Rela
uterine corpus cancerAtm
uveitisNod2 , Rela , Tnf , Tnfrsf1a
vascular dementiaTnf
vascular diseaseIkbkb , Tnf
Vascular MalformationsPik3ca , Pik3r1
Vascular System InjuriesTnf
vasculitisNfkbia
Venous ThromboembolismTnf
Ventilator-Induced Lung InjuryNfkbia
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftAtm , Pik3ca
Viral BronchiolitisNfkb1 , Nfkbia , Tnf
viral pneumoniaTnf
visceral leishmaniasisTnf
visual epilepsyTnf , Tnfrsf1a
vitiligoPik3r1 , Tnf
Vogt-Koyanagi-Harada diseaseTnf
Vulvar VestibulitisTnf
Weaver syndromeCul1
Weight GainPik3ca , Tnf
Weill-Marchesani syndromeTnf
Williams-Beuren syndromeSrc
Wilson diseaseTnf
Wolff-Parkinson-White syndromeMap3k7
Wounds and InjuriesTnf
X-linked adrenal hypoplasia congenitaTab3
X-linked agammaglobulinemiaPik3r1
YAO SYNDROMENod2
Pathway Annotations Associated with Genes in the nuclear factor kappa B signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
adenosine signaling pathwayChuk , Ikbkb , Nfkb1 , Nfkb2 , Nfkbia , Pik3ca
aldosterone signaling pathwayPik3ca , Pik3r1 , Prkca
allograft rejection pathwayTnf
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered Reelin signaling pathwaySrc
altered ubiquitin/proteasome degradation pathwayUbe2d3
Alzheimer's disease pathwayTnf , Tnfrsf1a , Ube2d3
amyotrophic lateral sclerosis pathwayMapk14 , Tnf , Tnfrsf1a
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAtm , Birc2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
asthma pathwayTnf
ataxia telangiectasia-mutated (ATM) signaling pathwayAtm
B cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Malt1 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Syk
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2
calcium/calcium-mediated signaling pathwayPrkca
cell cycle pathway, mitoticAtm , Cul1 , Rbx1 , Skp1
ceramide signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
Chagas disease pathwayChuk , Ikbkb , Ikbkg , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
chemokine mediated signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
colorectal cancer pathwayPik3ca , Pik3r1
corticotropin-releasing hormone signaling pathwayArrb2
CRM1 export pathwayRan , Xpo1
cytokine mediated signaling pathwayTnf , Tnfrsf1a
dilated cardiomyopathy pathwayTnf
dopamine signaling pathwaySrc
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayArrb2 , Lck , Mapk14 , Prkca , Src , Syk
endocytosis pathwayArrb2 , Src , Traf6
endometrial cancer pathwayPik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayCul1 , Rbx1 , Skp1 , Ube2d3
endothelin signaling pathwayMapk14 , Prkca , Src
Entamoebiasis pathwayNfkb1 , Pik3ca , Pik3r1 , Prkca , Rela , Tnf
ephrin - ephrin receptor bidirectional signaling axisLck , Map3k7 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayPik3ca , Pik3r1 , Prkca , Src
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayMapk14 , Nfkb1 , Pik3r1
estrogen signaling pathwaySrc
FasL mediated signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Mapk14 , Pik3ca , Pik3r1 , Src , Syk
Fc epsilon receptor mediated signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Syk , Tnf
Fc gamma receptor mediated signaling pathwayPik3ca , Pik3r1 , Prkca , Syk
fibroblast growth factor signaling pathwayPik3ca , Pik3r1 , Src
glioma pathwayPik3ca , Pik3r1 , Prkca
glutamate signaling pathwayPrkca
glypican signaling pathwayLck , Src
gonadotropin-releasing hormone signaling pathwayMapk14 , Prkca , Src
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1 , Syk
Hedgehog signaling pathwayArrb2 , Btrc , Pik3ca , Pik3r1 , Sspo , Xpo1
hepatitis C pathwayChuk , Ikbkb , Ikbkg , Irf1 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
homologous recombination pathway of double-strand break repairAtm
hypertrophic cardiomyopathy pathwayTnf
hypoxia inducible factor pathwayRbx1
influenza A pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a , Xpo1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca
insulin-like growth factor signaling pathwayPik3ca , Pik3r1
integrin mediated signaling pathwaySharpin
interleukin-1 signaling pathwayChuk , Erc1 , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Traf6
interleukin-12 signaling pathwayLck , Mapk14 , Nfkb1 , Nfkb2 , Rela , Relb , Ripk2
interleukin-2 signaling pathwayLck , Mapk14 , Pik3ca , Pik3r1 , Syk
interleukin-23 signaling pathwayNfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf
interleukin-27 signaling pathwayTnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayMapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayIrf1 , Mapk14 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayIrf1 , Pik3ca , Pik3r1
kinin signaling pathwayArrb2
Leishmaniasis pathwayMap3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
long term depressionPrkca
long term potentiationPrkca
malaria pathwayTnf
measles pathwayChuk , Csnk2a1 , Csnk2a2 , Csnk2b , Map3k7 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Traf6
melanoma pathwayPik3ca , Pik3r1
microRNA pathwayRan
mitochondrial autophagy pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Src
mitogen activated protein kinase signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Prkca , Rela , Tnf , Tnfrsf1a , Traf6
mTOR signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca , Sspo
N-cadherin signaling pathwayPik3ca , Pik3r1
neddylation pathwayCul1 , Rbx1
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Ripk2 , Traf6
NOD-like receptor signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nod2 , Rela , Ripk2 , Tnf , Traf6
non-small cell lung carcinoma pathwayPik3ca , Pik3r1 , Prkca
Notch signaling pathwayCul1 , Skp1 , Sspo
nuclear factor kappa B signaling pathwayArrb2 , Atm , Bcl10 , Bcl3 , Birc2 , Btrc , Chuk , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Cyld , Erc1 , Ikbkb , Ikbkg , Irf1 , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Nfkbia , Nfkbib , Nfkbie , Nod2 , Pik3ca , Pik3r1 , Prkca , Ran , Rbck1 , Rbx1 , Rel , Rela , Relb , Ripk2 , Rnf31 , Sharpin , Skp1 , Src , Sspo , Syk , Tab1 , Tab2 , Tab3 , Tnf , Tnfaip3 , Tnfrsf1a , Traf6 , Ube2d3 , Xpo1
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Cul1 , Ikbkb , Rbx1 , Skp1
nucleotide excision repair pathwayRbx1
p38 MAPK signaling pathwayAtm , Irf1 , Map3k7 , Mapk14 , Tab1 , Tab2 , Traf6
p53 signaling pathwayAtm , Mapk14
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayLck , Pik3ca , Pik3r1 , Src , Syk
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1 , Prkca
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3r1 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3r1
platelet-derived growth factor signaling pathwayCsnk2a1 , Lck , Pik3ca , Pik3r1 , Prkca , Src
primary immunodeficiency pathwayIkbkg , Lck
pro-inflammatory cytokine mediated pathwayNfkb1 , Tnf
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1 , Rbx1
protein kinase C (PKC) signaling pathwayLck , Prkca
Reelin signaling pathwayPik3ca , Pik3r1 , Src
renal cell carcinoma pathwayPik3ca , Pik3r1 , Rbx1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
rheumatoid arthritis pathwayTnf
ribosome biogenesis pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Ran , Xpo1
RNA transport pathwayRan , Xpo1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
sleeping sickness pathwayPrkca , Tnf
small cell lung carcinoma pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Traf6
somatostatin signaling pathwaySrc
sphingosine 1-phosphate signaling pathwayMapk14 , Src
syndecan signaling pathwayPrkca , Src
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Tnf
Toll-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Tnf , Traf6
toxoplasmosis pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayCul1 , Rbx1 , Skp1 , Tnf
tuberculosis pathwayBcl10 , Malt1 , Mapk14 , Nfkb1 , Nod2 , Rela , Ripk2 , Src , Syk , Tnf , Tnfrsf1a , Traf6
tumor necrosis factor mediated signaling pathwayBirc2 , Chuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rbck1 , Rela , Rnf31 , Sharpin , Tab1 , Tab2 , Tab3 , Tnf , Tnfaip3 , Tnfrsf1a
type 1 diabetes mellitus pathwayTnf
type 2 diabetes mellitus pathwayIkbkb , Pik3ca , Pik3r1 , Tnf
type II interferon signaling pathwayIrf1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayBirc2 , Btrc , Cul1 , Rbx1 , Skp1 , Src , Traf6 , Ube2d3
vascular endothelial growth factor signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Src
visual phototransduction pathwayArrb2
Wnt signaling pathwayBtrc , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Map3k7 , Prkca , Rbx1 , Skp1
Wnt signaling, canonical pathwayBtrc
Wnt signaling, non-canonical pathwayArrb2 , Map3k7 , Tab1 , Tab2
Phenotype Annotations Associated with Genes in the nuclear factor kappa B signaling pathway

References Associated with the nuclear factor kappa B signaling pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: