Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | polycystic ovary syndrome | | ISO | TAB1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21411543 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | polycystic ovary syndrome | | ISO | TAB1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21411543 | |
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# | Reference Title | Reference Citation |
1. | TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. | Brown J, etal., J Dent Res. 2011 Apr;90(4):417-27. Epub 2010 Oct 12. |
2. | Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. | Du CS, etal., Front Pharmacol. 2010;1:111. Epub 2010 Aug 24. |
3. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
4. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
5. | Expanding role of ubiquitination in NF-kappaB signaling. | Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7. |
6. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
7. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
9. | TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. | Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78. |
10. | Interleukin-1 (IL-1) pathway. | Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1. |
11. | Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. | Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13. |
12. | RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. | Yuan L, etal., Cardiovasc Res. 2022 Mar 30:cvac039. doi: 10.1093/cvr/cvac039. |
Tab1 (Rattus norvegicus - Norway rat) |
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TAB1 (Homo sapiens - human) |
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Tab1 (Mus musculus - house mouse) |
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Tab1 (Chinchilla lanigera - long-tailed chinchilla) |
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TAB1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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TAB1 (Canis lupus familiaris - dog) |
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Tab1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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TAB1 (Sus scrofa - pig) |
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TAB1 (Chlorocebus sabaeus - green monkey) |
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Tab1 (Heterocephalus glaber - naked mole-rat) |
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Variants in Tab1
153 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH141717 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 36 | 39 | 23 | 19 | 23 | 5 | 8 | 74 | 35 | 34 | 11 | 5 |
Low | 7 | 18 | 18 | 18 | 3 | 3 | 7 | 3 | |||||
Below cutoff |
RefSeq Transcripts | NM_001109976 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_063263616 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC127784 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BP466072 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BP483385 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB605878 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB706441 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB779067 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB802111 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473950 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CO385750 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CO567997 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
DN948807 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
DY311072 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EV771639 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ211519 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000067904 ⟹ ENSRNOP00000059322 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000092614 ⟹ ENSRNOP00000075816 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_001109976 ⟹ NP_001103446 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_063263616 ⟹ XP_063119686 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001103446 | (Get FASTA) | NCBI Sequence Viewer |
XP_063119686 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | EDM15764 | (Get FASTA) | NCBI Sequence Viewer |
Ensembl Protein | ENSRNOP00000059322.2 | ||
ENSRNOP00000075816 | |||
ENSRNOP00000075816.2 |
RefSeq Acc Id: | NP_001103446 ⟸ NM_001109976 |
- UniProtKB: | A6HSV8 (UniProtKB/TrEMBL), A0A0U1RRU5 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000075816 ⟸ ENSRNOT00000092614 |
RefSeq Acc Id: | ENSRNOP00000059322 ⟸ ENSRNOT00000067904 |
RefSeq Acc Id: | XP_063119686 ⟸ XM_063263616 |
- Peptide Label: | isoform X1 |
- UniProtKB: | D4A6C6 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-A0A0U1RRU5-F1-model_v2 | AlphaFold | A0A0U1RRU5 | 1-502 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13695495 | ||||||||
Promoter ID: | EPDNEW_R6019 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Tab1_1 | ||||||||
Description: | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1306216 | AgrOrtholog |
BioCyc Gene | G2FUF-32713 | BioCyc |
Ensembl Genes | ENSRNOG00000017285 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000067904.4 | UniProtKB/TrEMBL |
ENSRNOT00000092614 | ENTREZGENE | |
ENSRNOT00000092614.2 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.60.40.10 | UniProtKB/TrEMBL |
InterPro | PP2C-like | UniProtKB/TrEMBL |
PPM-type_dom_sf | UniProtKB/TrEMBL | |
Protein_Pase_2C | UniProtKB/TrEMBL | |
KEGG Report | rno:315139 | UniProtKB/TrEMBL |
NCBI Gene | 315139 | ENTREZGENE |
PANTHER | PP2C | UniProtKB/TrEMBL |
TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 | UniProtKB/TrEMBL | |
Pfam | PP2C | UniProtKB/TrEMBL |
PhenoGen | Tab1 | PhenoGen |
PROSITE | PPM_2 | UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000017285 | RatGTEx |
SMART | PP2Cc | UniProtKB/TrEMBL |
Superfamily-SCOP | PP2C-related | UniProtKB/TrEMBL |
UniProt | A0A0U1RRU5 | ENTREZGENE, UniProtKB/TrEMBL |
A6HSV8 | ENTREZGENE, UniProtKB/TrEMBL | |
D4A6C6 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2011-09-08 | Tab1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | Map3k7ip1 | mitogen-activated protein kinase kinase kinase 7 interacting protein 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-04-30 | Map3k7ip1 | mitogen-activated protein kinase kinase kinase 7 interacting protein 1 | Map3k7ip1_predicted | mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (predicted) | 'predicted' is removed | 2292626 | APPROVED |
2005-01-12 | Map3k7ip1_predicted | mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |