Tab1 (TGF-beta activated kinase 1/MAP3K7 binding protein 1) - Rat Genome Database

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Gene: Tab1 (TGF-beta activated kinase 1/MAP3K7 binding protein 1) Rattus norvegicus
Analyze
Symbol: Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
RGD ID: 1306216
Description: Enables mitogen-activated protein kinase p38 binding activity. Involved in positive regulation of MAP kinase activity. Part of protein-containing complex. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC315139; Map3k7ip1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Tak1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,556,157 - 113,587,351 (+)NCBIGRCr8
mRatBN7.27111,675,829 - 111,707,058 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,686,371 - 111,707,058 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,430,333 - 113,461,541 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,653,881 - 115,685,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,623,239 - 115,654,452 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,350,953 - 121,382,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,350,965 - 121,382,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,340,948 - 121,371,923 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,368,997 - 118,402,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,403,087 - 118,435,710 (+)NCBI
Celera7108,004,014 - 108,035,121 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. Brown J, etal., J Dent Res. 2011 Apr;90(4):417-27. Epub 2010 Oct 12.
2. Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. Du CS, etal., Front Pharmacol. 2010;1:111. Epub 2010 Aug 24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
10. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
11. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
12. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, etal., Cardiovasc Res. 2022 Mar 30:cvac039. doi: 10.1093/cvr/cvac039.
Additional References at PubMed
PMID:12464436   PMID:16407200   PMID:20730577   PMID:25807483  


Genomics

Comparative Map Data
Tab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,556,157 - 113,587,351 (+)NCBIGRCr8
mRatBN7.27111,675,829 - 111,707,058 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,686,371 - 111,707,058 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,430,333 - 113,461,541 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,653,881 - 115,685,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,623,239 - 115,654,452 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,350,953 - 121,382,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,350,965 - 121,382,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,340,948 - 121,371,923 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,368,997 - 118,402,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,403,087 - 118,435,710 (+)NCBI
Celera7108,004,014 - 108,035,121 (+)NCBICelera
Cytogenetic Map7q34NCBI
TAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,399,780 - 39,437,132 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,399,778 - 39,437,060 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,795,785 - 39,833,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,125,705 - 38,163,078 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,120,258 - 38,157,632NCBI
Celera2223,597,809 - 23,635,185 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,760,425 - 22,797,733 (+)NCBIHuRef
CHM1_12239,754,498 - 39,791,875 (+)NCBICHM1_1
T2T-CHM13v2.02239,870,398 - 39,907,761 (+)NCBIT2T-CHM13v2.0
Tab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,017,333 - 80,045,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,017,328 - 80,045,908 (+)EnsemblGRCm39 Ensembl
GRCm381580,133,127 - 80,161,707 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,133,127 - 80,161,707 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,963,584 - 79,992,132 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,960,409 - 79,988,957 (+)NCBIMGSCv36mm8
Celera1582,249,914 - 82,278,414 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Tab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,290,828 - 25,313,969 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,290,733 - 25,315,267 (+)NCBIChiLan1.0ChiLan1.0
TAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,244,509 - 49,279,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,935,877 - 51,970,474 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,303,547 - 20,343,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,122,835 - 38,158,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,122,835 - 38,162,705 (+)Ensemblpanpan1.1panPan2
TAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,623,381 - 25,657,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,623,940 - 25,657,543 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,559,053 - 25,593,235 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,375,000 - 26,409,197 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,375,011 - 26,409,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,089,607 - 26,123,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,409,038 - 26,443,015 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,584,751 - 26,618,730 (-)NCBIUU_Cfam_GSD_1.0
Tab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,196,563 - 9,224,198 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,210,197 - 2,234,489 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,207,147 - 2,234,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,826,840 - 8,852,776 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,827,363 - 8,852,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,122,718 - 6,146,897 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,971,362 - 22,004,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045103,706,687 - 103,740,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,913,900 - 8,937,329 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,912,467 - 8,937,313 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tab1
153 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:335
Count of miRNA genes:212
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000067904
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH141717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,706,779 - 111,706,975 (+)MAPPERmRatBN7.2
Rnor_6.07121,381,822 - 121,382,017NCBIRnor6.0
Rnor_5.07121,371,645 - 121,371,840UniSTSRnor5.0
RGSC_v3.47118,402,650 - 118,402,845UniSTSRGSC3.4
Celera7108,034,843 - 108,035,038UniSTS
RH 3.4 Map7857.5UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP466072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP483385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB605878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB706441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB779067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB802111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO385750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO567997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN948807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY311072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV771639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067904   ⟹   ENSRNOP00000059322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,686,371 - 111,707,036 (+)Ensembl
Rnor_6.0 Ensembl7121,361,415 - 121,382,088 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092614   ⟹   ENSRNOP00000075816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,692,309 - 111,707,058 (+)Ensembl
Rnor_6.0 Ensembl7121,350,965 - 121,380,878 (+)Ensembl
RefSeq Acc Id: NM_001109976   ⟹   NP_001103446
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,556,157 - 113,587,351 (+)NCBI
mRatBN7.27111,675,858 - 111,707,058 (+)NCBI
Rnor_6.07121,350,953 - 121,382,100 (+)NCBI
Rnor_5.07121,340,948 - 121,371,923 (+)NCBI
RGSC_v3.47118,368,997 - 118,402,928 (+)RGD
Celera7108,004,014 - 108,035,121 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263616   ⟹   XP_063119686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,566,672 - 113,587,351 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001103446 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119686 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15764 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059322.2
  ENSRNOP00000075816.2
RefSeq Acc Id: NP_001103446   ⟸   NM_001109976
- UniProtKB: A6HSV8 (UniProtKB/TrEMBL),   A0A0U1RRU5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075816   ⟸   ENSRNOT00000092614
Ensembl Acc Id: ENSRNOP00000059322   ⟸   ENSRNOT00000067904
RefSeq Acc Id: XP_063119686   ⟸   XM_063263616
- Peptide Label: isoform X1
- UniProtKB: D4A6C6 (UniProtKB/TrEMBL)
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0U1RRU5-F1-model_v2 AlphaFold A0A0U1RRU5 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695495
Promoter ID:EPDNEW_R6019
Type:multiple initiation site
Name:Tab1_1
Description:TGF-beta activated kinase 1/MAP3K7 binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07121,350,960 - 121,351,020EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306216 AgrOrtholog
BioCyc Gene G2FUF-32713 BioCyc
Ensembl Genes ENSRNOG00000017285 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067904.4 UniProtKB/TrEMBL
  ENSRNOT00000092614.2 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C-like UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  Protein_Pase_2C UniProtKB/TrEMBL
KEGG Report rno:315139 UniProtKB/TrEMBL
NCBI Gene 315139 ENTREZGENE
PANTHER PP2C UniProtKB/TrEMBL
  TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PhenoGen Tab1 PhenoGen
PROSITE PPM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017285 RatGTEx
SMART PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP PP2C-related UniProtKB/TrEMBL
UniProt A0A0U1RRU5 ENTREZGENE, UniProtKB/TrEMBL
  A6HSV8 ENTREZGENE, UniProtKB/TrEMBL
  D4A6C6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-08 Tab1  TGF-beta activated kinase 1/MAP3K7 binding protein 1   Map3k7ip1  mitogen-activated protein kinase kinase kinase 7 interacting protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Map3k7ip1  mitogen-activated protein kinase kinase kinase 7 interacting protein 1   Map3k7ip1_predicted  mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k7ip1_predicted  mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED